| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kamalakaran Anand Solomon, Srinivasan Sundararajan, Veluchamy Abiram. QSAR studies on N-aryl derivative activity towards Alzheimer's disease. Molecules (Basel, Switzerland). vol 14. issue 4. 2009-06-05. PMID:19384276. |
a quantitative structure activity relationship (qsar) study has been an attempted on a series of 88 n-aryl derivatives which display varied inhibitory activity towards both acetylcholinesterase (ache) and butyrylcholinesterase (bche), targets in alzheimer's drug discovery. |
2009-06-05 |
2023-08-12 |
Not clear |
| Agneta Nordberg, Taher Darreh-Shori, Elaine Peskind, Hilkka Soininen, Malahat Mousavi, Gina Eagle, Roger Lan. Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients. Current Alzheimer research. vol 6. issue 1. 2009-05-08. PMID:19199870. |
the current study aimed to compare the effects of different cholinesterase inhibitors on acetylcholinesterase (ache) and butyrylcholinesterase (buche) activities and protein levels, in the cerebrospinal fluid (csf) of alzheimer disease (ad) patients. |
2009-05-08 |
2023-08-12 |
Not clear |
| R Jazi, R Lalonde, S Qian, C Straziell. Regional brain evaluation of acetylcholinesterase activity in PS1/A246E transgenic mice. Neuroscience research. vol 63. issue 2. 2009-03-17. PMID:19056437. |
ps1/a246e transgenic mice had altered ache activity in several regions also vulnerable in alzheimer pathology. |
2009-03-17 |
2023-08-12 |
mouse |
| Martina Zimmermann, Martin S Westwell, Susan A Greenfiel. Impact of detergents on the activity of acetylcholinesterase and on the effectiveness of its inhibitors. Biological chemistry. vol 390. issue 1. 2009-03-12. PMID:19007306. |
acetylcholinesterase (ache) plays a central role in the development of alzheimer's disease: ache inhibition for preventing the characteristic dwindling of acetylcholine levels constitutes the current standard treatment for the disorder. |
2009-03-12 |
2023-08-12 |
Not clear |
| You Yin, Liuqing Huang, Yan Liu, Shaqi Huang, JianHua Zhuang, Xiaoyan Chen, Lin Zhang, Huijuan Wu, Fuyuan Shao, Zhongxin Zha. Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer's disease rat model. Clinical and investigative medicine. Medecine clinique et experimentale. vol 31. issue 5. 2009-03-10. PMID:18980714. |
to determine the influence of tanshinone on the levels of nitric oxide synthase (nos) and acetylcholinesterase (ache) in the brain of an alzheimer's disease (ad) rat model and on its potential therapeutic mechanism. |
2009-03-10 |
2023-08-12 |
rat |
| Christian Fleck, Dorothea Appenroth, Michael Decker, Jochen Lehman. A new way of data interpretation for cognition tests in rats used to characterise six choline esterase inhibitors with heterocyclic nitrogen bridgehead structure. Application in Alzheimer therapy. Arzneimittel-Forschung. vol 58. issue 11. 2009-02-23. PMID:19137904. |
six new tri- and tetracyclic nitrogen bridgehead compounds known to be moderate to potent inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in vitro were tested in vivo as experimental therapeutics for treatment of alzheimer's disease. |
2009-02-23 |
2023-08-12 |
rat |
| M Weinstock, E Grone. Rational design of a drug for Alzheimer's disease with cholinesterase inhibitory and neuroprotective activity. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18457821. |
the rate and duration of inhibition of recombinant human acetylcholinesterase (ache) and human butyrylcholinesterase (buche) by nine n-methyl,n-alkyl derivatives of (r)-3-prop-2-ynylamino-indan, designed as potential treatment of alzheimer's disease, was obtained from measurement of the carbamylation k(i) and decarbamylation k(3) rate constants. |
2008-12-10 |
2023-08-12 |
human |
| María-Salud García-Ayllón, María-Ximena Silveyra, Javier Sáez-Valer. Association between acetylcholinesterase and beta-amyloid peptide in Alzheimer's cerebrospinal fluid. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18554581. |
the altered expression of acetylcholinesterase (ache) in the brains of patients with alzheimer's disease (ad) has raised much interest of late. |
2008-12-10 |
2023-08-12 |
Not clear |
| Kuldeep K Roy, Anshuman Dixit, Anil K Saxen. An investigation of structurally diverse carbamates for acetylcholinesterase (AChE) inhibition using 3D-QSAR analysis. Journal of molecular graphics & modelling. vol 27. issue 2. 2008-12-09. PMID:18515163. |
these studies may provide important insights into structural variations leading to the development of novel ache inhibitors which may be useful in the development of novel molecules for the treatment of alzheimer's disease. |
2008-12-09 |
2023-08-12 |
Not clear |
| D Muñoz-Torrer. Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease. Current medicinal chemistry. vol 15. issue 24. 2008-10-31. PMID:18855672. |
the therapeutic arsenal for the treatment of alzheimer's disease (ad) remains confined to a group of four inhibitors of ache and one nmda receptor antagonist, which are used to provide a relief of the very late symptoms of the dementia, i.e. |
2008-10-31 |
2023-08-12 |
Not clear |
| Aleksandra Siwicka, Zuzanna Moleda, Krystyna Wojtasiewicz, Anna Zawadzka, Jan K Maurin, Mirosława Panasiewicz, Tadeusz Pacuszka, Zbigniew Czarnock. The oxidation products of melatonin derivatives exhibit acetylcholinesterase and butyrylcholinesterase inhibitory activity. Journal of pineal research. vol 45. issue 1. 2008-10-28. PMID:18284552. |
the compounds obtained possess the 2,3,8,8a-tetrahydropyrrolo[2,3-b]indole heterocyclic system which is a structural motif characteristic of alkaloids, physostigmine and phenserine, that are potent acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitors used in the alzheimer's disease treatment. |
2008-10-28 |
2023-08-12 |
human |
| Marko Zivin, Peter Pregel. Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system. Psychiatria Danubina. vol 20. issue 2. 2008-09-26. PMID:18587286. |
donepezil is a reversible, primarily non-competitive, selective inhibitor of ache used in patients with alzheimer's disease for the improvement of cognitive deficits. |
2008-09-26 |
2023-08-12 |
Not clear |
| Ilkay Orhan, Fatma Tosun, Bilge Sene. Coumarin, anthroquinone and stilbene derivatives with anticholinesterase activity. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 63. issue 5-6. 2008-08-26. PMID:18669022. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are the key enzymes in pathogenesis of alzheimer's disease (ad), which is characterized by a deficit in central cholinergic transmission. |
2008-08-26 |
2023-08-12 |
Not clear |
| Juan Chen, Yuan Long, Min Han, Ting Wang, Qiang Chen, Rui Wan. Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice. Pharmacology, biochemistry, and behavior. vol 90. issue 3. 2008-08-25. PMID:18485465. |
these results indicated that wsdp may mitigate amnesia in vivo through inhibition of ache activity in the hippocampus, which suggested propolis may have potential as a pharmaceutical of brain protection with elderly population for preventing alzheimer's disease (ad) and other neurodegenerative diseases. |
2008-08-25 |
2023-08-12 |
mouse |
| A Kadir, T Darreh-Shori, O Almkvist, A Wall, M Grut, B Strandberg, A Ringheim, B Eriksson, G Blomquist, B Långström, A Nordber. PET imaging of the in vivo brain acetylcholinesterase activity and nicotine binding in galantamine-treated patients with AD. Neurobiology of aging. vol 29. issue 8. 2008-08-21. PMID:17379359. |
the effect of galantamine treatment on cortical acetylcholinesterase (ache) activity and nicotinic receptor binding was investigated by positron emission tomography (pet) in 18 patients with mild alzheimer's disease (ad) in relation to galantamine concentration and the patients' cognitive performances. |
2008-08-21 |
2023-08-12 |
Not clear |
| Létitia Jean, Chiu Fan Lee, Michael Shaw, David J Vau. Structural elements regulating amyloidogenesis: a cholinesterase model system. PloS one. vol 3. issue 3. 2008-08-08. PMID:18350169. |
ache(586-599) was chosen due to its fibrilization tractability and ache involvement in alzheimer's disease. |
2008-08-08 |
2023-08-12 |
Not clear |
| Jiri Patocka, Daniel Jun, Kamil Kuc. Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease. Current drug metabolism. vol 9. issue 4. 2008-06-30. PMID:18473751. |
tacrine belongs to the group of acetylcholinesterse (ache) inhibitors used as drugs for treatment of alzheimer's disease (ad). |
2008-06-30 |
2023-08-12 |
Not clear |
| Scott D Bembenek, John M Keith, Michael A Letavic, Richard Apodaca, Ann J Barbier, Lisa Dvorak, Leah Aluisio, Kirsten L Miller, Timothy W Lovenberg, Nicholas I Carruther. Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling. Bioorganic & medicinal chemistry. vol 16. issue 6. 2008-06-13. PMID:18249544. |
currently, the only clinically effective treatment for alzheimer's disease (ad) is the use of acetylcholinesterase (ache) inhibitors. |
2008-06-13 |
2023-08-12 |
Not clear |
| Min Wang, Ji-Quan Wang, Mingzhang Gao, Qi-Huang Zhen. Facile synthesis of new carbon-11 labeled conformationally restricted rivastigmine analogues as potential PET agents for imaging AChE and BChE enzymes. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 66. issue 4. 2008-06-10. PMID:18155915. |
rivastigmine is a newer-generation inhibitor with a dual inhibitory action on both acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes, and is used for the treatment of ache- and bche-related diseases such as brain alzheimer's disease and cardiovascular disease. |
2008-06-10 |
2023-08-12 |
Not clear |
| T Leyhe, Elke Stransky, G W Eschweiler, G Buchkremer, C Lask. Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer's disease. European archives of psychiatry and clinical neuroscience. vol 258. issue 2. 2008-05-15. PMID:17990049. |
alzheimer's disease (ad) can be treated with inhibitors of the enzyme acetylcholinesterase (ache). |
2008-05-15 |
2023-08-12 |
Not clear |