| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E García-Palomero, P Muñoz, P Usan, P Garcia, E Delgado, C De Austria, R Valenzuela, L Rubio, M Medina, A Martíne. Potent beta-amyloid modulators. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322376. |
peripheral or dual binding site inhibitors of ache may simultaneously alleviate the cognitive and behavioral deficits in alzheimer's disease (ad) patients and, more importantly, act as disease-modifying agents delaying amyloid plaque formation. |
2008-05-15 |
2023-08-12 |
mouse |
| L Cibicková, V Palicka, N Cibicek, E Cermáková, S Micuda, L Bartosová, D Ju. Differential effects of statins and alendronate on cholinesterases in serum and brain of rats. Physiological research. vol 56. issue 6. 2008-04-09. PMID:17087598. |
acetylcholinesterase (ache) inhibitors represent standard treatment of alzheimer's disease. |
2008-04-09 |
2023-08-12 |
rat |
| Toshiaki Sunazuka, Tomoyasu Hirose, Satoshi Omur. Efficient total synthesis of novel bioactive microbial metabolites. Accounts of chemical research. vol 41. issue 2. 2008-04-08. PMID:18217720. |
fo-4259 by our screening of microbial metabolites that strongly inhibit acetylcholinesterase (ache) in order to create novel medicines for alzheimer's disease (ad). |
2008-04-08 |
2023-08-12 |
human |
| Hitoshi Shinoto. [Imaging of brain acetylcholinesterase activity in dementias and extrapyramidal disorders]. Rinsho shinkeigaku = Clinical neurology. vol 47. issue 11. 2008-04-04. PMID:18210807. |
in alzheimer's disease (ad), there is a significant loss of ache activity in the cerebral cortex in association with mental decline. |
2008-04-04 |
2023-08-12 |
Not clear |
| Pulok K Mukherjee, Venkatesan Kumar, Peter J Houghto. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytotherapy research : PTR. vol 21. issue 12. 2008-04-03. PMID:17639556. |
ache inhibitors are currently the only approved therapy for the treatment of alzheimer's disease; only a limited number of drugs are commercially available. |
2008-04-03 |
2023-08-12 |
cattle |
| Maria Laura Bolognesi, Andrea Cavalli, Luca Valgimigli, Manuela Bartolini, Michela Rosini, Vincenza Andrisano, Maurizio Recanatini, Carlo Melchiorr. Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease. Journal of medicinal chemistry. vol 50. issue 26. 2008-04-03. PMID:18047264. |
a design strategy to convert a dual-binding site ache inhibitor into triple functional compounds with promising in vitro profile against multifactorial syndromes, such as alzheimer's disease, is proposed. |
2008-04-03 |
2023-08-12 |
human |
| AiLin Liu, HongMei Guang, LiYa Zhu, GuanHua Du, Simon M Y Lee, YiTao Wan. 3D-QSAR analysis of a new type of acetylcholinesterase inhibitors. Science in China. Series C, Life sciences. vol 50. issue 6. 2008-03-18. PMID:17914643. |
acetylcholinesterase (ache) inhibitors are an important class of medicinal agents used for the treatment of alzheimer's disease. |
2008-03-18 |
2023-08-12 |
Not clear |
| Amélia P Rauter, Isabel Branco, Rui G Lopes, Jorge Justino, Filipa V M Silva, João P Noronha, Eurico J Cabrita, Ignacio Brouard, Jaime Bermej. A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides. Fitoterapia. vol 78. issue 7-8. 2008-03-06. PMID:17570616. |
the acetone, ethanol, butanol and water extracts of the plant were screened for the in vitro inhibitory activity of acetylcholinesterase (ache) and butyrilcholinesterase (bche), enzymes which play a role in the alzheimer disease. |
2008-03-06 |
2023-08-12 |
Not clear |
| Atsunori Nakao, David J Kaczorowski, Brian S Zuckerbraun, Jing Lei, Gaetano Faleo, Kentaro Deguchi, Kenneth R McCurry, Timothy R Billiar, Shinichi Kann. Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction. Biochemical and biophysical research communications. vol 367. issue 3. 2008-03-04. PMID:18174021. |
galantamine, a reversible inhibitor of acetylcholine esterase (ache), is a novel drug treatment for mild to moderate alzheimer's disease and vascular dementia. |
2008-03-04 |
2023-08-12 |
rat |
| Atsunori Nakao, David J Kaczorowski, Brian S Zuckerbraun, Jing Lei, Gaetano Faleo, Kentaro Deguchi, Kenneth R McCurry, Timothy R Billiar, Shinichi Kann. Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction. Biochemical and biophysical research communications. vol 367. issue 3. 2008-03-04. PMID:18174021. |
interestingly, it has been suggested that galantamine treatment is associated with more clinical benefit in patients with mild-to-moderate alzheimer disease compared to other ache inhibitors. |
2008-03-04 |
2023-08-12 |
rat |
| T Darreh-Shori, A Kadir, O Almkvist, M Grut, A Wall, G Blomquist, B Eriksson, B Långström, A Nordber. Inhibition of acetylcholinesterase in CSF versus brain assessed by 11C-PMP PET in AD patients treated with galantamine. Neurobiology of aging. vol 29. issue 2. 2008-02-21. PMID:17196712. |
the relationship between acetylcholinesterase (ache) activity in the csf and brain of patients with alzheimer's disease (ad) was investigated in 18 mild ad patients following galantamine treatment. |
2008-02-21 |
2023-08-12 |
Not clear |
| Tatsuya Kikuchi, Toshimitsu Okamura, Kiyoshi Fukushi, Kazuhiro Takahashi, Jun Toyohara, Maki Okada, Ming-Rong Zhang, Toshiaki Iri. Cerebral acetylcholinesterase imaging: development of the radioprobes. Current topics in medicinal chemistry. vol 7. issue 18. 2007-12-18. PMID:17979787. |
n-[(11)c]methylipiperidin-4-yl acetate (mp4a) and n-[(11)c]methylpiperidin-4-yl propionate (mp4p) have been used for clinical studies of other demented disorders including alzheimer's disease (ad), and the probes have demonstrated not only the reduction of ache activity in the cerebral cortex of patients with ad but also the inhibitory effects of donepezil and rivastigmine on ache activity in the brain of ad patients. |
2007-12-18 |
2023-08-12 |
Not clear |
| Floria Pancetti, Cristina Olmos, Alexies Dagnino-Subiabre, Carlos Rozas, Bernardo Morale. Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. Journal of toxicology and environmental health. Part B, Critical reviews. vol 10. issue 8. 2007-12-13. PMID:18049927. |
this enzyme is more sensitive than ache to some organophosphates (op), including dichlorvos, which is the parent compound for metrifonate, a therapeutic agent used in the treatment of cognitive impairment associated to alzheimer's disease. |
2007-12-13 |
2023-08-12 |
Not clear |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
alzheimer's disease: case-control association study of polymorphisms in ache, chat, and bche genes in a sardinian sample. |
2007-12-06 |
2023-08-12 |
human |
| Young Ee Kwon, Jung Youl Park, Kyung Tai No, Jae Hong Shin, Sung Kwang Lee, Jae Soon Eun, Jae Heon Yang, Tae Yong Shin, Dae Keun Kim, Byung Sook Chae, Jae-Yoon Leem, Kuk Hwan Ki. Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics. Bioorganic & medicinal chemistry. vol 15. issue 20. 2007-12-06. PMID:17681794. |
with the goal of developing alzheimer's disease therapeutics, we have designed and synthesized new piperidine derivatives having dual action of acetylcholinesterase (ache) and beta-amyloid peptide (abeta) aggregation inhibition. |
2007-12-06 |
2023-08-12 |
Not clear |
| S López-Pousa, J Garre-Olmo, J Vilalta-Franc. [Galanthamine versus donepezil in the treatment of Alzheimer's disease]. Revista de neurologia. vol 44. issue 11. 2007-10-10. PMID:17557224. |
to use comparative studies on the utilisation of the acetylcholinesterase inhibitors (ache), galanthamine and donepezil, to evaluate the effectiveness and tolerance of the two drugs in the treatment of the symptoms of alzheimer's disease (ad). |
2007-10-10 |
2023-08-12 |
Not clear |
| Ion Anghelescu, Isabella Heuse. [Acetylcholinesterase inhibitors for dementia--an update]. MMW Fortschritte der Medizin. vol 149 Suppl 2. 2007-09-27. PMID:17724973. |
presently three ache inhibitors are approved for the treatment of mild to moderately severe alzheimer dementia: donepezil, rivastigmine and galantamine. |
2007-09-27 |
2023-08-12 |
Not clear |
| Carlos H T P da Silva, Ivone Carvalho, C A Taf. Virtual screening, molecular interaction field, molecular dynamics, docking, density functional, and ADMET properties of novel AChE inhibitors in Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 24. issue 6. 2007-09-18. PMID:17508773. |
virtual screening, molecular interaction field, molecular dynamics, docking, density functional, and admet properties of novel ache inhibitors in alzheimer's disease. |
2007-09-18 |
2023-08-12 |
Not clear |
| Carlos H T P da Silva, Ivone Carvalho, C A Taf. Virtual screening, molecular interaction field, molecular dynamics, docking, density functional, and ADMET properties of novel AChE inhibitors in Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 24. issue 6. 2007-09-18. PMID:17508773. |
we have focused in this work on the usage of computer-aided molecular design by virtual screening, molecular dynamics with implicit and explicit water solvation, density functional, molecular interaction field studies, docking procedures, admet predictions in order to propose novel potential ache inhibitor for the treatment of alzheimer's disease. |
2007-09-18 |
2023-08-12 |
Not clear |
| b' Zbyn\\xc4\\x95k Svoboda, Jaroslav Kv\\xc4\\x95tina, Josef Herink, Jir\\xc3\\xad Bajgar, Lucie Bartosov\\xc3\\xa1, Vladim\\xc3\\xadr Palicka, Pavel Zivn\\xc3\\xb. Galantamine antiacetylcholinesterase activity in rat brain influenced by L-carnitine. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 149. issue 2. 2007-08-28. PMID:16601783.' |
galantamine (gal) is a selective, competitive and reversible acetylcholinesterase (ache) inhibitor, which increases the activity of the cholinergic system and hence gives rise to an improvement of cognitive functions in patients suffering from dementia of alzheimer type. |
2007-08-28 |
2023-08-12 |
rat |