| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anjali Rao, Alexander Sorkin, Nancy R Zahnise. Mice expressing markedly reduced striatal dopamine transporters exhibit increased locomotor activity, dopamine uptake turnover rate, and cocaine responsiveness. Synapse (New York, N.Y.). vol 67. issue 10. 2014-02-21. PMID:23564231. |
variations in the expression levels of the dopamine transporter (dat) can influence responsiveness to psychostimulant drugs like cocaine. |
2014-02-21 |
2023-08-12 |
mouse |
| J Li, Z Xia, X Sun, R Zhang, G Huang, R Hickling, Z Xia, Y Hu, Y Zhan. Reversal of dopamine neurons and locomotor ability degeneration in aged rats with smilagenin. Neuroscience. vol 245. 2014-02-19. PMID:23624370. |
likewise, the dopamine receptor density and the striatal dopamine transporter (dat) density ((125)i-2β-carbomethoxy-3β-(4-iodophenyl)-n-(3-fluoropropyl) nortropane [(125)i-fp-cit] autoradiography) were significantly lowered in aged rats as compared to young rats, and treatment with smilagenin significantly elevated the dopamine receptor and dat density in aged rats. |
2014-02-19 |
2023-08-12 |
rat |
| Ashlee Van't Veer, Anita J Bechtholt, Sara Onvani, David Potter, Yujun Wang, Lee-Yuan Liu-Chen, Günther Schütz, Elena H Chartoff, Uwe Rudolph, Bruce M Cohen, William A Carlezo. Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 8. 2014-02-13. PMID:23446450. |
by breeding these mice with lines that express cre-recombinase (cre) in early embryogenesis (eiia-cre) or only in da neurons (dopamine transporter (dat)-cre), we developed constitutive kor knockouts (kor(-/-)) and conditional knockouts that lack kors in da-containing neurons (dat-kor(lox/lox)). |
2014-02-13 |
2023-08-12 |
mouse |
| John D Elsworth, D Eugene Redmond, Robert H Rot. Coordinated expression of dopamine transporter and vesicular monoamine transporter in the primate striatum during development. Synapse (New York, N.Y.). vol 67. issue 9. 2014-02-13. PMID:23468413. |
several addictive or neurotoxic drugs are dependent on the dopamine transporter (dat) and/or vesicular monoamine transporter (vmat2) to exert their detrimental effects on dopamine neurons. |
2014-02-13 |
2023-08-12 |
Not clear |
| John D Elsworth, D Eugene Redmond, Robert H Rot. Coordinated expression of dopamine transporter and vesicular monoamine transporter in the primate striatum during development. Synapse (New York, N.Y.). vol 67. issue 9. 2014-02-13. PMID:23468413. |
for example, methamphetamine and mptp are substrates for both dat and vmat2, with the ratio of dat to vmat2 in striatum being a determinant of the degree of toxicity inflicted by these drugs on dopamine neurons. |
2014-02-13 |
2023-08-12 |
Not clear |
| John D Elsworth, D Eugene Redmond, Robert H Rot. Coordinated expression of dopamine transporter and vesicular monoamine transporter in the primate striatum during development. Synapse (New York, N.Y.). vol 67. issue 9. 2014-02-13. PMID:23468413. |
thus, the susceptibility of dopamine neurons to agents whose pharmacology involves dat and vmat2 may vary during development if the ontogeny of dat and vmat2 differs, and this is relevant as exposure of dopamine neurons to toxic agents during development is hypothesized to underlie some neurological or psychiatric disorders. |
2014-02-13 |
2023-08-12 |
Not clear |
| Rajeev I Desai, David K Grandy, Carl R Lupica, Jonathan L Kat. Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist. The Journal of pharmacology and experimental therapeutics. vol 348. issue 1. 2014-02-10. PMID:24194528. |
an n-butyl analog of benztropine, jhw007 [n-(n-butyl)-3α-[bis(4'-fluorophenyl)methoxy]-tropane], binds to dopamine transporters (dat) but has reduced cocaine-like behavioral effects and antagonizes various effects of cocaine. |
2014-02-10 |
2023-08-12 |
mouse |
| Henry A Spiller, Hannah L Hays, Alfred Alegua. Overdose of drugs for attention-deficit hyperactivity disorder: clinical presentation, mechanisms of toxicity, and management. CNS drugs. vol 27. issue 7. 2014-02-03. PMID:23757186. |
amphetamine, dextroamphetamine, and methylphenidate act as substrates for the cellular monoamine transporter, especially the dopamine transporter (dat) and less so the norepinephrine (net) and serotonin transporter. |
2014-02-03 |
2023-08-12 |
human |
| Elisabeth Funke, Andreas Kupsch, Ralph Buchert, Winfried Brenner, Michail Plotki. Impact of subcortical white matter lesions on dopamine transporter SPECT. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 7. 2014-01-29. PMID:23344720. |
the aim of the present study was to examine the striatal dopamine transporter (dat) density in patients with parkinsonism and sae. |
2014-01-29 |
2023-08-12 |
Not clear |
| Arati A Inamdar, Muhammad M Hossain, Alison I Bernstein, Gary W Miller, Jason R Richardson, Joan Wennstrom Bennet. Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 48. 2014-01-27. PMID:24218591. |
furthermore, 1-octen-3-ol also inhibited uptake of dopamine in human cell lines expressing the human plasma membrane dopamine transporter (dat) and human vmat ortholog, vmat2. |
2014-01-27 |
2023-08-12 |
human |
| Marguerite Matthews, Corina Bondi, Gonzalo Torres, Bita Moghadda. Reduced presynaptic dopamine activity in adolescent dorsal striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 7. 2014-01-24. PMID:23358239. |
the dopamine transporter (dat) inhibitor, nomifensine, similarly inhibited basal and amphetamine-induced dopamine release in either regions of both the age groups, suggesting that the reduced effectiveness of amphetamine is not due to differences in dat function. |
2014-01-24 |
2023-08-12 |
rat |
| A Pasini, L Sinibaldi, C Paloscia, S Douzgou, M B Pitzianti, E Romeo, P Curatolo, A Pizzut. Neurocognitive effects of methylphenidate on ADHD children with different DAT genotypes: a longitudinal open label trial. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. vol 17. issue 4. 2014-01-23. PMID:23541676. |
the variable number of tandem repeat polymorphism in the 3'-untranslated region of the dopamine transporter gene (dat) may influence the variability of the therapeutic response to methylphenidate (mph) in attention deficit/hyperactivity disorder (adhd). |
2014-01-23 |
2023-08-12 |
Not clear |
| A Pasini, L Sinibaldi, C Paloscia, S Douzgou, M B Pitzianti, E Romeo, P Curatolo, A Pizzut. Neurocognitive effects of methylphenidate on ADHD children with different DAT genotypes: a longitudinal open label trial. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. vol 17. issue 4. 2014-01-23. PMID:23541676. |
10/10 dat allele seems to be associated with an increased expression level of the dopamine transporter and seems to mediate the mph treatment response in adhd patients. |
2014-01-23 |
2023-08-12 |
Not clear |
| Jerome Brunelin, Shirley Fecteau, Marie-Françoise Suaud-Chagn. Abnormal striatal dopamine transmission in schizophrenia. Current medicinal chemistry. vol 20. issue 3. 2014-01-17. PMID:23157632. |
da function was studied at several levels: i) at a presynaptic level where neuroimaging studies investigating dopa uptake capacity clearly show an increase of da synthesis in patients with schizophrenia; ii) at a synaptic level where neuroimaging studies investigating dopamine transporter availability (dat) does not bring any evidence of dysfunction; iii) and finally, neuroimaging studies investigating da receptor density show a mild increase of d2 receptor density in basic condition and, an hyperreactivity of da system in dynamic condition. |
2014-01-17 |
2023-08-12 |
human |
| Thomas J Spencer, Joseph Biederman, Stephen V Faraone, Bertha K Madras, Ali A Bonab, Darin D Dougherty, Holly Batchelder, Allison Clarke, Alan J Fischma. Functional genomics of attention-deficit/hyperactivity disorder (ADHD) risk alleles on dopamine transporter binding in ADHD and healthy control subjects. Biological psychiatry. vol 74. issue 2. 2014-01-17. PMID:23273726. |
the main aim of this study was to examine the relationship between dopamine transporter (dat) binding in the striatum in individuals with and without attention-deficit/hyperactivity disorder (adhd), attending to the 3'-untranslated region of the gene (3'-utr) and intron8 variable number of tandem repeats (vntr) polymorphisms of the dat (slc6a3) gene. |
2014-01-17 |
2023-08-12 |
human |
| Matthew F Covington, Natalie A McMillan, Ryan J Avery, Phillip H Ku. The semicolon sign: dopamine transporter imaging artifact from head tilt. Journal of nuclear medicine technology. vol 41. issue 2. 2014-01-15. PMID:23520210. |
dopamine transporter (dat) imaging is a valuable tool to aid in the diagnosis of parkinson disease and other parkinsonian syndromes. |
2014-01-15 |
2023-08-12 |
Not clear |
| Roxanne A Vaughan, James D Foste. Mechanisms of dopamine transporter regulation in normal and disease states. Trends in pharmacological sciences. vol 34. issue 9. 2014-01-10. PMID:23968642. |
the dopamine (da) transporter (dat) controls the spatial and temporal dynamics of da neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons. |
2014-01-10 |
2023-08-12 |
Not clear |
| Jennie Garcia-Olivares, Delany Torres-Salazar, William A Owens, Tracy Baust, David P Siderovski, Susan G Amara, Jun Zhu, Lynette C Daws, Gonzalo E Torre. Inhibition of dopamine transporter activity by G protein βγ subunits. PloS one. vol 8. issue 3. 2014-01-07. PMID:23555781. |
uptake through the dopamine transporter (dat) is the primary mechanism of terminating dopamine signaling within the brain, thus playing an essential role in neuronal homeostasis. |
2014-01-07 |
2023-08-12 |
mouse |
| Jennie Garcia-Olivares, Delany Torres-Salazar, William A Owens, Tracy Baust, David P Siderovski, Susan G Amara, Jun Zhu, Lynette C Daws, Gonzalo E Torre. Inhibition of dopamine transporter activity by G protein βγ subunits. PloS one. vol 8. issue 3. 2014-01-07. PMID:23555781. |
over the last 15 years, several studies have revealed a plethora of mechanisms influencing the activity and cellular distribution of dat; suggesting that fine-tuning of dopamine homeostasis occurs via an elaborate interplay of multiple pathways. |
2014-01-07 |
2023-08-12 |
mouse |
| Pablo Pandolfo, Nuno J Machado, Attila Köfalvi, Reinaldo N Takahashi, Rodrigo A Cunh. Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 4. 2014-01-06. PMID:22561003. |
shr were hyperactive and had poorer performance in the attentional set-shifting and y-maze paradigms and also displayed increased dopamine transporter (dat) density and increased dopamine uptake in frontocortical and striatal terminals compared with wky rats. |
2014-01-06 |
2023-08-12 |
rat |