| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F S Hall, K Itokawa, A Schmitt, R Moessner, I Sora, K P Lesch, G R Uh. Decreased vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function in knockout mice affects aging of dopaminergic systems. Neuropharmacology. vol 76 Pt A. 2014-06-05. PMID:23978383. |
dopamine (da) is accumulated and compartmentalized by the dopamine transporter (dat; slc3a6) and the vesicular monoamine transporter 2 (vmat2; slc18a2). |
2014-06-05 |
2023-08-12 |
mouse |
| Dean G Brown, Peter R Bernstein, Ye Wu, Rebecca A Urbanek, Christopher W Becker, Scott R Throner, Bruce T Dembofsky, Gary B Steelman, Lois A Lazor, Clay W Scott, Michael W Wood, Steven S Wesolowski, David A Nugiel, Stephanie Koch, Jian Yu, Donald E Pivonka, Shuang Li, Carol Thompson, Anna Zacco, Charles S Elmore, Patricia Schroeder, JianWei Liu, Christopher A Hurley, Stuart Ward, Hazel J Hunt, Karen Williams, Joseph McLaughlin, Valerie Hoesch, Simon Sydserff, Donna Maier, David Aharon. Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. ACS medicinal chemistry letters. vol 4. issue 1. 2014-06-05. PMID:24900562. |
herein, we describe the discovery of inhibitors of norepinephrine (net) and dopamine (dat) transporters with reduced activity relative to serotonin transporters (sert). |
2014-06-05 |
2023-08-13 |
rat |
| Soyoung Jin, Minyoung Oh, Seung Jun Oh, Jungsu S Oh, Sang Ju Lee, Sun Ju Chung, Chong Sik Lee, Jae Seung Ki. Differential Diagnosis of Parkinsonism Using Dual-Phase F-18 FP-CIT PET Imaging. Nuclear medicine and molecular imaging. vol 47. issue 1. 2014-06-04. PMID:24895507. |
dopamine transporter (dat) imaging can demonstrate presynaptic dopaminergic neuronal loss in parkinson's disease (pd). |
2014-06-04 |
2023-08-13 |
Not clear |
| Erin S Calipari, Mark J Ferris, Benjamin A Zimmer, David C S Roberts, Sara R Jone. Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 12. 2014-06-03. PMID:23719505. |
the dopamine transporter (dat) is responsible for terminating dopamine (da) signaling and is the primary site of cocaine's reinforcing actions. |
2014-06-03 |
2023-08-12 |
Not clear |
| Susanne Nikolaus, Markus Beu, Hubertus Hautzel, Angelica M De Souza Silva, Christina Antke, Andreas Wirrwar, Joseph P Huston, Hans-Wilhelm Mülle. Effects of L-DOPA on striatal iodine-123-FP-CIT binding and behavioral parameters in the rat. Nuclear medicine communications. vol 34. issue 12. 2014-05-30. PMID:23982164. |
the effect of clinical l-3,4-dihydroxyphenylalanine (l-dopa) doses on the binding of [121i]n-Ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (121[i]fp-cit) to the rat dopamine transporter (dat) was investigated using small animal single-photon emission computed tomography. |
2014-05-30 |
2023-08-12 |
rat |
| Goran Laćan, Hoa Dang, Blake Middleton, Marcus A Horwitz, Jide Tian, William P Melega, Daniel L Kaufma. Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Journal of neuroscience research. vol 91. issue 10. 2014-05-28. PMID:23907992. |
we previously showed that, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model of parkinson's disease (pd), vaccination with bacillus calmette-guerin (bcg) prior to mptp exposure limited the loss of striatal dopamine (da) and dopamine transporter (dat) and prevented the activation of nigral microglia. |
2014-05-28 |
2023-08-12 |
mouse |
| Kevin D Lominac, Courtney L McKenna, Lisa M Schwartz, Paige N Ruiz, Melissa G Wroten, Bailey W Miller, John J Holloway, Katherine O Travis, Ganesh Rajasekar, Dan Maliniak, Andrew B Thompson, Lawrence E Urman, Tamara J Phillips, Karen K Szumlinsk. Mesocorticolimbic monoamine correlates of methamphetamine sensitization and motivation. Frontiers in systems neuroscience. vol 8. 2014-05-21. PMID:24847220. |
biochemical studies of c57bl/6j (b6) mice revealed short- (1 day), as well as longer-term (21 days), changes in extracellular dopamine, dat and/or d2 receptors during withdrawal from 10, once daily, 2 mg/kg ma injections. |
2014-05-21 |
2023-08-13 |
mouse |
| Yanshu Li, Yan Sun, Junwei Yang, Yanping Wu, Jia Yu, Baixiang L. The long-term effects of the herbicide atrazine on the dopaminergic system following exposure during pubertal development. Mutation research. Genetic toxicology and environmental mutagenesis. vol 763. 2014-05-16. PMID:24561379. |
the content of dopamine (da) was examined in striatum samples by hplc-fl, and the mrna and protein expression of tyrosine hydroxylase (th), orphan nuclear hormone (nurr1), dopamine transporter (dat) and vesicular monoaminetransporter 2 (vmat2) were examined in samples of the ventral mid-brain by use of fluorescence pcr and western-blot analysis when the rats reached the age of one year. |
2014-05-16 |
2023-08-12 |
human |
| Adam W Oaks, Nicholas Marsh-Armstrong, Jessica M Jones, Joel J Credle, Anita Sidh. Synucleins antagonize endoplasmic reticulum function to modulate dopamine transporter trafficking. PloS one. vol 8. issue 8. 2014-05-14. PMID:23967127. |
synaptic re-uptake of dopamine is dependent on the dopamine transporter (dat), which is regulated by its distribution to the cell surface. |
2014-05-14 |
2023-08-12 |
Not clear |
| Dorothy J Yamamoto, Anna M Nelson, Bruce H Mandt, Gaynor A Larson, Jacki M Rorabaugh, Christopher M C Ng, Kelsey M Barcomb, Toni L Richards, Richard M Allen, Nancy R Zahnise. Rats classified as low or high cocaine locomotor responders: a unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors. Neuroscience and biobehavioral reviews. vol 37. issue 8. 2014-05-08. PMID:23850581. |
lcrs have higher basal numbers of striatal dopamine transporters (dats) than hcrs and exhibit marginal cocaine inhibition of in vivo dat activity and cocaine-induced increases in extracellular da. |
2014-05-08 |
2023-08-12 |
rat |
| Bianca C Wittmann, Geoffrey C Tan, John E Lisman, Raymond J Dolan, Emrah Düze. DAT genotype modulates striatal processing and long-term memory for items associated with reward and punishment. Neuropsychologia. vol 51. issue 11. 2014-05-08. PMID:23911780. |
to that end, participants were selected on the basis of their genotype for a variable number of tandem repeat polymorphism of the dopamine transporter (dat) gene. |
2014-05-08 |
2023-08-12 |
human |
| Jia Liu, Jinlong Gao, Shaoang Tu, Shasha Xu, Ying Liu, Weihu Shang, Chenxin Gu, Yiyun Huang, Mei Ha. Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson's Disease: Involvement of the Dopamine System. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-05-06. PMID:24799940. |
we previously demonstrated that jtt treatment led to increased level of dopamine transporter (dat) in the striatum, thus indicating that jtt might have therapeutic potential for parkinson's disease (pd), which is characterized by dysregulated dopamine (da) transmission and decreased striatal dat expression. |
2014-05-06 |
2023-08-13 |
mouse |
| Jia Liu, Jinlong Gao, Shaoang Tu, Shasha Xu, Ying Liu, Weihu Shang, Chenxin Gu, Yiyun Huang, Mei Ha. Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson's Disease: Involvement of the Dopamine System. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-05-06. PMID:24799940. |
tyrosine hydroxylase th-positive neurons in the substantia nigra and dat and dopamine d2 receptor (d2r) levels in the striatum were detected by immunohistochemical staining and/or autoradiography. |
2014-05-06 |
2023-08-13 |
mouse |
| Anat Maoz, Martin J Hicks, Shankar Vallabhjosula, Michael Synan, Paresh J Kothari, Jonathan P Dyke, Douglas J Ballon, Stephen M Kaminsky, Bishnu P De, Jonathan B Rosenberg, Diana Martinez, George F Koob, Kim D Janda, Ronald G Crysta. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 11. 2014-05-05. PMID:23660705. |
to assess the efficacy of dad5gne in a large animal model, positron emission tomography (pet) and the radiotracer [(11)c]pe2i were used to measure cocaine occupancy of the dopamine transporter (dat) in nonhuman primates. |
2014-05-05 |
2023-08-12 |
Not clear |
| A B Pizzo, C S Karam, Y Zhang, H Yano, R J Freyberg, D S Karam, Z Freyberg, A Yamamoto, B D McCabe, J A Javitc. The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila. Molecular psychiatry. vol 18. issue 7. 2014-05-02. PMID:22710269. |
the dopamine transporter (dat) is the primary molecular target responsible for the rewarding properties of the psychostimulants amphetamine (amph) and cocaine. |
2014-05-02 |
2023-08-12 |
drosophila_melanogaster |
| Idaira Oliva, Miriam Fernández, Eduardo D Martí. Dopamine release regulation by astrocytes during cerebral ischemia. Neurobiology of disease. vol 58. 2014-04-23. PMID:23800715. |
our data indicate that ischemia induces massive release of da by dual mechanisms: one which operates via vesicular exocytosis and is action potential dependent and another involving reverse transport by the dopamine transporter (dat). |
2014-04-23 |
2023-08-12 |
mouse |
| Idaira Oliva, Miriam Fernández, Eduardo D Martí. Dopamine release regulation by astrocytes during cerebral ischemia. Neurobiology of disease. vol 58. 2014-04-23. PMID:23800715. |
simultaneous blockade of astrocyte glutamate transporters and dat prevented the massive release of dopamine and reduced the brain tissue damage. |
2014-04-23 |
2023-08-12 |
mouse |
| G Thomsen, M Ziebell, P S Jensen, S da Cuhna-Bang, G M Knudsen, L H Pinbor. No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I. Obesity (Silver Spring, Md.). vol 21. issue 9. 2014-04-22. PMID:23696269. |
in striatum, dopamine is inactivated by reuptake via the dopamine transporter (dat). |
2014-04-22 |
2023-08-12 |
human |
| Linda D Simmler, Anna Rickli, York Schramm, Marius C Hoener, Matthias E Liecht. Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives. Biochemical pharmacology. vol 88. issue 2. 2014-04-22. PMID:24486525. |
we investigated norepinephrine (ne), dopamine (da), and serotonin (5-hydroxytryptamine [5-ht]) uptake inhibition using human embryonic kidney 293 (hek 293) cells that express the respective human monoamine transporters (net, dat, and sert). |
2014-04-22 |
2023-08-12 |
human |
| Oluyomi M Okunola-Bakare, Jianjing Cao, Theresa Kopajtic, Jonathan L Katz, Claus J Loland, Lei Shi, Amy Hauck Newma. Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues. Journal of medicinal chemistry. vol 57. issue 3. 2014-04-15. PMID:24494745. |
2-[(diphenylmethyl)sulfinyl]acetamide (modafinil, (±)-1) is a unique dopamine uptake inhibitor that binds the dopamine transporter (dat) differently than cocaine and may have potential for the treatment of psychostimulant abuse. |
2014-04-15 |
2023-08-12 |
Not clear |