| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin Niethammer, Chris C Tang, Yilong Ma, Paul J Mattis, Ji Hyun Ko, Vijay Dhawan, David Eidelber. Parkinson's disease cognitive network correlates with caudate dopamine. NeuroImage. vol 78. 2014-01-06. PMID:23578575. |
in this study, 17 non-demented pd patients underwent positron emission tomography (pet) imaging with [(18)f]-fluorodeoxyglucose to measure pdcp expression, and [(18)f]-fluoropropyl-β-cit (fpcit) to measure dopamine transporter (dat) binding. |
2014-01-06 |
2023-08-12 |
human |
| Candan Depboylu, Lukas Maurer, Andreas Matusch, Guido Hermanns, Andrea Windolph, Martin Béhé, Wolfgang H Oertel, Günter U Höglinge. Effect of long-term treatment with pramipexole or levodopa on presynaptic markers assessed by longitudinal [123I]FP-CIT SPECT and histochemistry. NeuroImage. vol 79. 2014-01-06. PMID:23631981. |
a previous clinical trial studied the effect of long-term treatment with levodopa (ld) or the dopamine agonist pramipexole (ppx) on disease progression in parkinson disease using spect with the dopamine transporter (dat)-radioligand [(123)i]β-cit as surrogate marker. |
2014-01-06 |
2023-08-12 |
mouse |
| Jordy van Enkhuizen, Mark A Geyer, Klaas Kooistra, Jared W Youn. Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice. The international journal of neuropsychopharmacology. vol 16. issue 5. 2014-01-03. PMID:23164454. |
this abnormal profile is also observed in mice with reduced function of the dopamine transporter (dat) through either constitutive genetic [knockdown (kd)] or acute pharmacological (gbr12909) means. |
2014-01-03 |
2023-08-12 |
mouse |
| Craig F Ferris, Mathieu Marella, Brian Smerkers, Thomas M Barchet, Benjamin Gershman, Akemi Matsuno-Yagi, Takao Yag. A phenotypic model recapitulating the neuropathology of Parkinson's disease. Brain and behavior. vol 3. issue 4. 2014-01-01. PMID:24381808. |
levels of vesicular monoamine transporter 2 (vmat2) were significantly reduced in the dorsal striatum; however, there was an unexpected increase in dopamine transporter (dat) levels. |
2014-01-01 |
2023-08-12 |
rat |
| Luke R Gabriel, Sijia Wu, Patrick Kearney, Karl D Bellvé, Clive Standley, Kevin E Fogarty, Haley E Melikia. Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 45. 2013-12-30. PMID:24198373. |
the presynaptic dopamine (da) transporter (dat) recaptures released da, thereby limiting synaptic da availability and maintaining dopaminergic tone. |
2013-12-30 |
2023-08-12 |
mouse |
| Seyed Khosrow Tayebati, Daniele Tomassoni, Innocent Ejike Nwankwo, Antonio Di Stefano, Piera Sozio, Laura Serafina Cerasa, Francesco Ament. Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain. CNS & neurological disorders drug targets. vol 12. issue 1. 2013-12-23. PMID:23244432. |
the present study was designed to assess the influence of treatment for 7 days with choline-equivalent doses (cdp-choline: 325 mg/kg/day; gpc: 150 mg/kg/day) of these compounds on brain dopamine (da), and serotonin (5-ht) levels and on da plasma membrane transporter (dat), vesicular monoamine transporters (vmat1 and vmat2), serotonin transporter (sert), and norepinephrine transporter (net) in the rat. |
2013-12-23 |
2023-08-12 |
rat |
| Cheng-Kuan Wu, Kao Chin Chen, Po See Chen, Nan-Tsing Chiu, Tzung Lieh Yeh, I Hui Lee, Yen Kuang Yan. No changes in striatal dopamine transporter in antidepressant-treated patients with major depression. International clinical psychopharmacology. vol 28. issue 3. 2013-12-23. PMID:23524636. |
eight participants with major depressive disorder were administered single-photon emission computed tomography with [(99m)tc] trodat-1 both before and after 24 weeks of antidepressant treatment to evaluate the change in striatal dopamine transporter (dat) availability. |
2013-12-23 |
2023-08-12 |
human |
| Meredith A Fox, Micaella G Panessiti, F Scott Hall, George R Uhl, Dennis L Murph. An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice. Psychopharmacology. vol 227. issue 4. 2013-12-18. PMID:23417514. |
an evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (dat) knockout mice. |
2013-12-18 |
2023-08-12 |
mouse |
| Meredith A Fox, Micaella G Panessiti, F Scott Hall, George R Uhl, Dennis L Murph. An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice. Psychopharmacology. vol 227. issue 4. 2013-12-18. PMID:23417514. |
mice lacking the dopamine transporter (dat) display major behavioral alterations that include hyperactivity, perseverative locomotor patterns, and reduced prepulse inhibition of the acoustic startle reflex. |
2013-12-18 |
2023-08-12 |
mouse |
| Susumu Hara, Shigeki Arawaka, Hiroyasu Sato, Youhei Machiya, Can Cui, Asuka Sasaki, Shingo Koyama, Takeo Kat. Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner. Molecular biology of the cell. vol 24. issue 11. 2013-12-17. PMID:23576548. |
however, wild-type and s129a α-syn equally increase the cell surface expression of dopamine transporter (dat) in sh-sy5y cells and nonneuronal hek293 cells. |
2013-12-17 |
2023-08-12 |
Not clear |
| Weimin C Hong, Susan G Amar. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 8. 2013-12-16. PMID:23612789. |
the dopamine transporter (dat) clears the extracellular dopamine released during neurotransmission and is a major target for both therapeutic and addictive psychostimulant amphetamines. |
2013-12-16 |
2023-08-12 |
rat |
| Weimin C Hong, Susan G Amar. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 8. 2013-12-16. PMID:23612789. |
however, in dopamine neurons, the trafficking itinerary and fate of internalized dat has not been elucidated. |
2013-12-16 |
2023-08-12 |
rat |
| Weimin C Hong, Susan G Amar. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 8. 2013-12-16. PMID:23612789. |
by monitoring surface-labeled dat in transfected dopamine neurons from embryonic rat mesencephalic cultures, we find distinct sorting and fates of internalized dat after amphetamine or pma treatment. |
2013-12-16 |
2023-08-12 |
rat |
| Weimin C Hong, Susan G Amar. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 8. 2013-12-16. PMID:23612789. |
although both drugs promote dat internalization above constitutive endocytosis in dopamine neurons, pma induces ubiquitination of dat and leads to accumulation of dat on lamp1-positive endosomes. |
2013-12-16 |
2023-08-12 |
rat |
| Weimin C Hong, Susan G Amar. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 8. 2013-12-16. PMID:23612789. |
furthermore, quantitative assessment of dat recycling using an antibody-feeding assay reveals that significantly less dat returns to the surface of dopamine neurons after internalization by pma, compared with vehicle or amphetamine treatment. |
2013-12-16 |
2023-08-12 |
rat |
| Weimin C Hong, Susan G Amar. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 8. 2013-12-16. PMID:23612789. |
these results demonstrate that, in neurons, the dat is sorted differentially to recycling and degradative pathways after psychostimulant exposure or pkc activation, which may allow for either the transient or sustained inhibition of dat during dopamine neurotransmission. |
2013-12-16 |
2023-08-12 |
rat |
| S Mandillo, E Golini, D Marazziti, C Di Pietro, R Matteoni, G P Tocchini-Valentin. Mice lacking the Parkinson's related GPR37/PAEL receptor show non-motor behavioral phenotypes: age and gender effect. Genes, brain, and behavior. vol 12. issue 4. 2013-12-11. PMID:23574697. |
gpr37 interacts with the dopamine transporter (dat), modulating nigro-striatal dopaminergic signaling and behavioral responses to amphetamine and cocaine. |
2013-12-11 |
2023-08-12 |
mouse |
| Stacy S Drury, Zoë H Brett, Caitlin Henry, Michael Scheering. The association of a novel haplotype in the dopamine transporter with preschool age posttraumatic stress disorder. Journal of child and adolescent psychopharmacology. vol 23. issue 4. 2013-12-09. PMID:23647133. |
three previous studies have demonstrated an association between ptsd and the nine repeat allele of the 3' untranslated region (3'utr) variable number tandem repeat (vntr) in the dopamine transporter (dat, rs28363170). |
2013-12-09 |
2023-08-12 |
Not clear |
| Stacy S Drury, Zoë H Brett, Caitlin Henry, Michael Scheering. The association of a novel haplotype in the dopamine transporter with preschool age posttraumatic stress disorder. Journal of child and adolescent psychopharmacology. vol 23. issue 4. 2013-12-09. PMID:23647133. |
to provide enhanced support for the role of dat and striatal dopamine regulation in the development of ptsd, this study examined the impact of a haplotype defined by the c allele of rs27072 and the nine repeat allele of the 3'vntr on ptsd diagnosis in young trauma-exposed children. |
2013-12-09 |
2023-08-12 |
Not clear |
| Mattias Rickhag, William A Owens, Marie-Therese Winkler, Kristine Nørgaard Strandfelt, Mette Rathje, Gunnar Sørensen, Bjørn Andresen, Kenneth L Madsen, Trine Nygaard Jørgensen, Gitta Wörtwein, David P D Woldbye, Harald Sitte, Lynette C Daws, Ulrik Gethe. Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release. The Journal of biological chemistry. vol 288. issue 38. 2013-11-26. PMID:23884410. |
the dopamine transporter (dat) is responsible for sequestration of extracellular dopamine (da). |
2013-11-26 |
2023-08-12 |
mouse |