| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Filippi, C Bruni, F Padovano, O Schillaci, G Simonett. The Value of Semi-Quantitative Analysis of 123I-FP-CIT SPECT in Evaluating Patients with Parkinson's Disease. The neuroradiology journal. vol 21. issue 4. 2013-11-26. PMID:24256955. |
(123)i-fp-cit spect binding to striatal dopamine transporter (dat) is markedly reduced in patients with parkinson's disease (pd) and it may also help in identifyng pre-symptomatic nigrostriatal dysfunction in subjects at risk. |
2013-11-26 |
2023-08-12 |
human |
| Tatiana Sorkina, John Caltagarone, Alexander Sorki. Flotillins regulate membrane mobility of the dopamine transporter but are not required for its protein kinase C dependent endocytosis. Traffic (Copenhagen, Denmark). vol 14. issue 6. 2013-11-19. PMID:23418867. |
flotillins were proposed to mediate clathrin-independent endocytosis, and recently, flotillin-1 was implicated in the protein kinase c (pkc)-triggered endocytosis of the dopamine transporter (dat). |
2013-11-19 |
2023-08-12 |
mouse |
| Matthew C Havrda, Brenton R Paolella, Nora M Ward, Kathryn B Holroy. Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice. Disease models & mechanisms. vol 6. issue 3. 2013-10-29. PMID:23264561. |
reduced dopamine transporter (dat) expression was observed at early ages in id2(-/-) mice and dat expression was dependent on id2 expression in an in vitro dopaminergic differentiation model. |
2013-10-29 |
2023-08-12 |
mouse |
| Thomas Stockner, Therese R Montgomery, Oliver Kudlacek, Rene Weissensteiner, Gerhard F Ecker, Michael Freissmuth, Harald H Sitt. Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model. PLoS computational biology. vol 9. issue 2. 2013-10-28. PMID:23436987. |
the high-resolution crystal structure of the leucine transporter (leut) is frequently used as a template for homology models of the dopamine transporter (dat). |
2013-10-28 |
2023-08-12 |
human |
| Florence Cormier, Julia Muellner, Jean-Christophe Corvo. Genetics of impulse control disorders in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 4. 2013-10-25. PMID:23232665. |
recent genetic studies have investigated associations between icd and polymorphisms of genes involved in the dopamine metabolism pathway (comt, dat), dopamine receptors (drd1, drd2, drd3, drd4), serotonin receptors and its transporter (htr2a, 5htt), and glutamate receptors (grin2b). |
2013-10-25 |
2023-08-12 |
Not clear |
| Takafumi Sai, Kazuyuki Uchida, Hiroyuki Nakayam. Biochemical evaluation of the neurotoxicity of MPTP and MPP⁺ in embryonic and newborn mice. The Journal of toxicological sciences. vol 38. issue 3. 2013-10-23. PMID:23665943. |
mpp⁺ has high affinity for the dopamine transporter (dat) on dopaminergic neurons, and is taken up into the cell to cause cell death. |
2013-10-23 |
2023-08-12 |
mouse |
| Ling Chen, Enping Huang, Huijun Wang, Pingming Qiu, Chao Li. RNA interference targeting α-synuclein attenuates methamphetamine-induced neurotoxicity in SH-SY5Y cells. Brain research. vol 1521. 2013-10-23. PMID:23688541. |
the expression levels of tyrosine hydroxylase (th), dopamine transporter (dat) and vesicular monoamine transporter 2(vmat-2) were significantly decreased and the activity/levels of reactive oxygen species (ros), nitric oxide synthase (nos) and nitrogen (no) were notably increased after meth treatment. |
2013-10-23 |
2023-08-12 |
human |
| Soyon Ahn, Anthony G Phillip. Daily monitoring of dopamine efflux reveals a short-lasting occlusion of the dopamine agonist properties of d-amphetamine by dopamine transporter blockers GBR 12909 and methylphenidate. ACS chemical neuroscience. vol 4. issue 5. 2013-10-22. PMID:23586444. |
in vivo brain microdialysis was used in conjunction with "reverse-dialysis" of the dopamine-transporter (dat) blockers gbr 12909 and methylphenidate (mph) to observe the temporal course of their effects on d-amphetamine (d-amph)-induced increases in dopamine (da) efflux in the rat nucleus accumbens (nac). |
2013-10-22 |
2023-08-12 |
rat |
| Trisha L Vickrey, Ning Xiao, B Jill Vento. Kinetics of the dopamine transporter in Drosophila larva. ACS chemical neuroscience. vol 4. issue 5. 2013-10-22. PMID:23600464. |
dopamine transporters (dat) regulate neurotransmission and are important in diseases such as addiction and attention deficit hyperactivity disorder. |
2013-10-22 |
2023-08-12 |
drosophila_melanogaster |
| Trisha L Vickrey, Ning Xiao, B Jill Vento. Kinetics of the dopamine transporter in Drosophila larva. ACS chemical neuroscience. vol 4. issue 5. 2013-10-22. PMID:23600464. |
the drosophila dopamine transporter (ddat) is analogous to the mammalian dat, but michaelis-menten kinetic parameters have not been characterized in vivo. |
2013-10-22 |
2023-08-12 |
drosophila_melanogaster |
| Trisha L Vickrey, Ning Xiao, B Jill Vento. Kinetics of the dopamine transporter in Drosophila larva. ACS chemical neuroscience. vol 4. issue 5. 2013-10-22. PMID:23600464. |
the clearance rate was significantly reduced following treatment with the dat inhibitor cocaine in wild-type flies, but not in fumin mutants, which indicates that serotonin transporter is not contributing significantly to dopamine clearance in these larvae. |
2013-10-22 |
2023-08-12 |
drosophila_melanogaster |
| Richard J Karpowicz, Matthew Dunn, David Sulzer, Dalibor Same. APP+, a fluorescent analogue of the neurotoxin MPP+, is a marker of catecholamine neurons in brain tissue, but not a fluorescent false neurotransmitter. ACS chemical neuroscience. vol 4. issue 5. 2013-10-22. PMID:23647019. |
app+ is a substrate for the dopamine transporter (dat), norepinephrine transporter (net), and serotonin transporter (sert), and as such represented a candidate for the development of new ffn probes. |
2013-10-22 |
2023-08-12 |
mouse |
| Klaus Tatsch, Gabriele Poepper. Nigrostriatal dopamine terminal imaging with dopamine transporter SPECT: an update. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 54. issue 8. 2013-10-21. PMID:23864718. |
this article gives an update on nigrostriatal dopamine terminal imaging, with emphasis on spect performed with the presynaptic dopamine transporter (dat) ligand (123)i-fp-cit. |
2013-10-21 |
2023-08-12 |
Not clear |
| Lisa Lit, Janelle M Belanger, Debby Boehm, Nathan Lybarger, Anouck Haverbeke, Claire Diederich, Anita M Oberbaue. Characterization of a dopamine transporter polymorphism and behavior in Belgian Malinois. BMC genetics. vol 14. 2013-10-17. PMID:23718893. |
in the dog, the dopamine transporter gene (dat) contains a 38-base pair variable number tandem repeat (dat-vntr); alleles have either one or two copies of the 38-base pair sequence. |
2013-10-17 |
2023-08-12 |
dog |
| Inah Choi, Pitna Kim, So Hyun Joo, Min Kyeong Kim, Jin Hee Park, Hee Jin Kim, Jong Hoon Ryu, Jae Hoon Cheong, Chan Young Shi. Effects of Preconceptional Ethanol Consumption on ADHD-Like Symptoms in Sprague-Dawley Rat Offsprings. Biomolecules & therapeutics. vol 20. issue 2. 2013-10-11. PMID:24116300. |
and reduction of striatal dopamine transporter (dat) level was observed by western blot in the etoh group, compared to control (con) group, while the immunohistochemical analysis exhibited increased expression of norepinephrine transporter (net) in the frontal cortex. |
2013-10-11 |
2023-08-12 |
rat |
| Zhi Yi Ong, Ayumi F Wanasuria, Mark Z P Lin, Jennifer Hiscock, Beverly S Muhlhausle. Chronic intake of a cafeteria diet and subsequent abstinence. Sex-specific effects on gene expression in the mesolimbic reward system. Appetite. vol 65. 2013-09-30. PMID:23402719. |
the nucleus accumbens (nac) was isolated and mrna expression of tyrosine hydroxylase (th), dopamine active transporter (dat), d1 and d2 dopamine receptors, and μ-opioid receptor determined by qrt-pcr. |
2013-09-30 |
2023-08-12 |
rat |
| Takafumi Sai, Kazuyuki Uchida, Hiroyuki Nakayam. Involvement of monoamine oxidase-B in the acute neurotoxicity of MPTP in embryonic and newborn mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 4. 2013-09-26. PMID:22281418. |
in the present study, we attempted to reveal the involvement of monoamine oxidase b (mao-b) in the metabolism of mptp to mpp(+) and dopamine transporter (dat) in the neuronal cellular uptake of mpp(+) during the acute toxicity of mptp in both embryonic and newborn mice. |
2013-09-26 |
2023-08-12 |
mouse |
| Sebastián Rodríguez, Kazuyuki Uchida, Hiroyuki Nakayam. Immunohistochemical changes of nigrostriatal tyrosine hydroxylase and dopamine transporter in the golden hamster after a single intrastriatal injection of 6-hydroxydopamine. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 4. 2013-09-26. PMID:22357095. |
significant decreases in tyrosine hydroxylase (th)-positive area and dopamine transporter (dat)-positive area were found in the ipsilateral striatum 3 days after the injection. |
2013-09-26 |
2023-08-12 |
rat |
| Robert A Comley, Cristian A Salinas, Mark Slifstein, Marcella Petrone, Carmine Marzano, Idriss Bennacef, Paul Shotbolt, Jasper Van der Aart, Marta Neve, Laura Iavarone, Roberto Gomeni, Marc Laruelle, Frank A Gray, Roger N Gunn, Eugenii A Rabine. Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography. The Journal of pharmacology and experimental therapeutics. vol 346. issue 2. 2013-09-25. PMID:23685546. |
studies were performed in baboons (papio anubis) to determine the relationship between plasma concentration and occupancy of brain serotonin reuptake transporter (sert), dopamine reuptake transporter (dat), and norepinephrine uptake transporter (net) using the radioligands [(11)c]dasb [(n,n-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine], [(11)c]pe2i [n-(3-iodoprop-2e-enyl)-2β-carbomethoxy-3β-(4-methylphenyl)nortropane], and [(11)c]2-[(2-methoxyphenoxy)phenylmethyl]morpholine (also known as [(11)c]mrb) and in humans using [(11)c]dasb and [(11)c]pe2i. |
2013-09-25 |
2023-08-12 |
Not clear |
| M Mishina, K Ishii, M Suzuki, S Kitamura, K Ishibashi, M Sakata, K Oda, M Hamamoto, S Kominami, S Kobayashi, Y Katayama, K Ishiwat. Striatal Distribution of Dopamine Transporters and Dopamine D2 Receptors at Different Stages of Parkinson's Disease. A CFT and RAC PET Study. The neuroradiology journal. vol 24. issue 2. 2013-09-25. PMID:24059613. |
we investigated the alteration of dopaminergic system in striata of parkinson's disease (pd) at different stages using positron emission tomography (pet), [(11)c]2β-carbomethoxy-3β-(4-fluorophenyl)tropane (cft) for dopamine transporter (dat), and [(11)c]raclopride (rac) for dopamine d2 receptor (d2r). |
2013-09-25 |
2023-08-12 |
human |