| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael J Tomlinson, Danielle Krout, Akula Bala Pramod, John R Lever, Amy Hauck Newman, L Keith Henry, Roxanne A Vaugha. Identification of the benztropine analog [ Neurochemistry international. vol 123. 2019-12-26. PMID:30125594. |
identification of the benztropine analog [ the dopamine transporter (dat) is a neuronal membrane protein that is responsible for reuptake of dopamine (da) from the synapse and functions as a major determinant in control of da neurotransmission. |
2019-12-26 |
2023-08-13 |
Not clear |
| Moriah J Hovde, Garret H Larson, Roxanne A Vaughan, James D Foste. Model systems for analysis of dopamine transporter function and regulation. Neurochemistry international. vol 123. 2019-12-26. PMID:30179648. |
the dopamine transporter (dat) plays a critical role in dopamine (da) homeostasis by clearing transmitter from the extraneuronal space after vesicular release. |
2019-12-26 |
2023-08-13 |
Not clear |
| Felix P Mayer, Diethart Schmid, Marion Holy, Lynette C Daws, Harald H Sitt. "Polytox" synthetic cathinone abuse: A potential role for organic cation transporter 3 in combined cathinone-induced efflux. Neurochemistry international. vol 123. 2019-12-26. PMID:30248432. |
mdpv and mephedrone interfere with the function of the high affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert), resulting in increased extracellular levels of these monoamines, though their mechanism of action differs. |
2019-12-26 |
2023-08-13 |
Not clear |
| Kevin G Mulvihil. Presynaptic regulation of dopamine release: Role of the DAT and VMAT2 transporters. Neurochemistry international. vol 122. 2019-12-26. PMID:30465801. |
presynaptic regulation of dopamine release: role of the dat and vmat2 transporters. |
2019-12-26 |
2023-08-13 |
Not clear |
| Kevin G Mulvihil. Presynaptic regulation of dopamine release: Role of the DAT and VMAT2 transporters. Neurochemistry international. vol 122. 2019-12-26. PMID:30465801. |
key regulators of transmitter release and the signaling dynamics of dopamine are the plasma membrane reuptake transporter (dat) and the vesicular monoamine transporter (vmat2). |
2019-12-26 |
2023-08-13 |
Not clear |
| Ryosuke Shimizu, Naotaka Horiguchi, Koji Yano, Masashi Sakuramoto, Naoki Kanegawa, Shunji Shinohara, Shuichi Ohnish. Pharmacokinetic-Pharmacodynamic Modeling of Brain Dopamine Levels Based on Dopamine Transporter Occupancy after Administration of Methylphenidate in Rats. The Journal of pharmacology and experimental therapeutics. vol 369. issue 1. 2019-12-26. PMID:30674560. |
this study was aimed at developing a pharmacokinetic-pharmacodynamic (pk-pd) model based on dopamine transporter (dat) occupancies that could describe changes in extracellular dopamine levels in brain after administration of methylphenidate (a dat inhibitor) to rat. |
2019-12-26 |
2023-08-13 |
human |
| Ryosuke Shimizu, Naotaka Horiguchi, Koji Yano, Masashi Sakuramoto, Naoki Kanegawa, Shunji Shinohara, Shuichi Ohnish. Pharmacokinetic-Pharmacodynamic Modeling of Brain Dopamine Levels Based on Dopamine Transporter Occupancy after Administration of Methylphenidate in Rats. The Journal of pharmacology and experimental therapeutics. vol 369. issue 1. 2019-12-26. PMID:30674560. |
these data were analyzed using the mechanism-based pk-pd model, which incorporates dopamine biosynthesis, release from a synapse, reuptake via dat into a synapse, and elimination from a synapse. |
2019-12-26 |
2023-08-13 |
human |
| Marcel M van Gaalen, Christina Schlumbohm, Joost H Folgering, Saugat Adhikari, Chandrali Bhattacharya, Douglas Steinbach, Robert E Stratfor. Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine. The Journal of pharmacology and experimental therapeutics. vol 369. issue 1. 2019-12-26. PMID:30733244. |
acute central nervous system exposure to dextroamphetamine (d-amphetamine) elicits a multitude of effects, including dual action on the dopamine transporter (dat) to increase extracellular dopamine, and induction of a negative feedback response to limit the dopamine increase. |
2019-12-26 |
2023-08-13 |
rat |
| Marcel M van Gaalen, Christina Schlumbohm, Joost H Folgering, Saugat Adhikari, Chandrali Bhattacharya, Douglas Steinbach, Robert E Stratfor. Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine. The Journal of pharmacology and experimental therapeutics. vol 369. issue 1. 2019-12-26. PMID:30733244. |
in both rats and nonhuman primates (nhps), d-amphetamine stimulation of dopamine outflow (reverse transport) through dat was primarily responsible for the dose-linear increase in dopamine. |
2019-12-26 |
2023-08-13 |
rat |
| Fukie Yaoita, Masahiro Tsuchiya, Yuichiro Arai, Takeshi Tadano, Koichi Tan-N. Involvement of catecholaminergic and GABAAergic mediations in the anxiety-related behavior in long-term powdered diet-fed mice. Neurochemistry international. vol 124. 2019-12-24. PMID:30529642. |
we also examined the effects of diazepam, benzodiazepine anti-anxiety drug, bicuculline, gaba-a receptor antagonist, methylphenidate, dopamine transporter (dat) and noradrenaline transporter (nat) inhibitor, atomoxetine, selective nat inhibitor, gbr12909, selective dat inhibitor, and pd168077, selective dopamine d4 receptor agonist, on the changes of the epm in powdered diet-fed mice. |
2019-12-24 |
2023-08-13 |
mouse |
| Ruchee Phonchai, Tassanee Phermthai, Narisorn Kitiyanant, Wilasinee Suwanjang, Naiphinich Kotchabhakdi, Banthit Chetsawan. Potential effects and molecular mechanisms of melatonin on the dopaminergic neuronal differentiation of human amniotic fluid mesenchymal stem cells. Neurochemistry international. vol 124. 2019-12-24. PMID:30593827. |
the levels of tuj1, th, map2, nurr1 and dopamine transporter (dat) were significantly increased in all treated groups when compared with control-untreated cells. |
2019-12-24 |
2023-08-13 |
human |
| Emmanuel Quansah, Tyra S C Zetterströ. Chronic methylphenidate preferentially alters catecholamine protein targets in the parietal cortex and ventral striatum. Neurochemistry international. vol 124. 2019-12-24. PMID:30660754. |
mph is well known to acutely block the dopamine (dat) and noradrenaline (net) transporters. |
2019-12-24 |
2023-08-13 |
rat |
| Emmanuel Quansah, Tyra S C Zetterströ. Chronic methylphenidate preferentially alters catecholamine protein targets in the parietal cortex and ventral striatum. Neurochemistry international. vol 124. 2019-12-24. PMID:30660754. |
for this purpose, the density of dat, net, the vesicular monoamine transporter 2 (vmat2), the rate limiting enzyme for catecholamine synthesis tyrosine hydroxylase (th) and the dopamine d |
2019-12-24 |
2023-08-13 |
rat |
| Achut P Silwal, H Peter L. Mode-Selective Raman Imaging of Dopamine-Human Dopamine Transporter Interaction in Live Cells. ACS chemical neuroscience. vol 9. issue 12. 2019-12-23. PMID:30024721. |
dopamine transporter (dat) interacts with da to maintain da's homeostasis in synaptic and perisynaptic space. |
2019-12-23 |
2023-08-13 |
human |
| Toshiyuki Hayashi, Masahiro Mishina, Masanori Sakamaki, Yuki Sakamoto, Satoshi Suda, Kazumi Kimur. Effect of brain atrophy in quantitative analysis of Annals of nuclear medicine. vol 33. issue 8. 2019-12-23. PMID:31140153. |
effect of brain atrophy in quantitative analysis of dopamine transporter (dat) imaging such as |
2019-12-23 |
2023-08-13 |
Not clear |
| Federico Massa, Dario Arnaldi, Francesca De Cesari, Nicola Girtler, Andrea Brugnolo, Matteo Grazzini, Matteo Bauckneht, Riccardo Meli, Silvia Morbelli, Matteo Pardini, Gianmario Sambuceti, Fabrizio De Carli, Pietro Tiraboschi, Flavio Nobil. Neuroimaging findings and clinical trajectories of Lewy body disease in patients with MCI. Neurobiology of aging. vol 76. 2019-12-06. PMID:30611093. |
neuropsychological tests, dopamine transporter (dat) single photon emission computed tomography, and |
2019-12-06 |
2023-08-13 |
Not clear |
| Carla L Busceti, Rosangela Ferese, Domenico Bucci, Larisa Ryskalin, Stefano Gambardella, Michele Madonna, Ferdinando Nicoletti, Francesco Forna. Corticosterone Upregulates Gene and Protein Expression of Catecholamine Markers in Organotypic Brainstem Cultures. International journal of molecular sciences. vol 20. issue 12. 2019-11-27. PMID:31197099. |
in detail, corticosterone administration to organotypic mouse brainstem cultures significantly increases tyrosine hydroxylase (th) and dopamine transporter (dat), while phenylethanolamine n-methyltransferase (pnmt) is not affected. |
2019-11-27 |
2023-08-13 |
mouse |
| Mitsuma, Rhue, Hirooka, Kayama, Wago, Takagi, Adachi, Ping, Ohtake, Nogimori, Saka. Distribution of Dopamine Transporter in the Rat: an Immunohistochemical Study. Endocrine regulations. vol 32. issue 2. 2019-11-20. PMID:10330520. |
objective: to investigate the organ distribution of dopamine transporter (dat) in rats by immunohistochemical method. |
2019-11-20 |
2023-08-12 |
rat |
| Mitsuma, Rhue, Hirooka, Kayama, Wago, Takagi, Adachi, Ping, Ohtake, Nogimori, Saka. Distribution of Dopamine Transporter in the Rat: an Immunohistochemical Study. Endocrine regulations. vol 32. issue 2. 2019-11-20. PMID:10330520. |
methods: dopamine transporter (dat) was identified immunohistochemically in the tissues using specific antipeptide antiserum raised in new zealand white rabbits immunized with a conjugate of synthetic dat peptide (29-45) with bovine serum albumin. |
2019-11-20 |
2023-08-12 |
rat |
| Alan Frazer, Greg A. Gerhardt, Lynette C. Daw. New views of biogenic amine transporter function: implications for neuropsychopharmacology. The international journal of neuropsychopharmacology. vol 2. issue 4. 2019-11-20. PMID:11285147. |
biogenic amine transporters, namely the dopamine (da), norepinephrine (ne) and 5-hydroxytryptamine (serotonin, 5-ht) transporters (dat, net and 5-htt, respectively) appear to be the key elements in regulating biogenic amine neurotransmission. |
2019-11-20 |
2023-08-12 |
Not clear |