| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Cecilia Manenti Alexandre, Niuany Viel Mendes, Carolina Antunes Torres, Samira Leila Baldin, Henrique Teza Bernardo, Rahisa Scussel, Suelen Baggio, Ben Hur Marins Mussulini, Kamila Cagliari Zenki, Maria Inês da Rosa, Eduardo Pacheco Ric. Weekly ethanol exposure alters dopaminergic parameters in zebrafish brain. Neurotoxicology and teratology. vol 75. 2020-05-01. PMID:31421226. |
brain dopaminergic function was assessed by the activity of the dopamine transporters (dat); monoamine oxidase (mao) activity; dopamine and noradrenaline levels by chromatography. |
2020-05-01 |
2023-08-13 |
zebrafish |
| Man-Yi Jing, Xiao Han, Tai-Yun Zhao, Zhi-Yuan Wang, Guan-Yi Lu, Ning Wu, Rui Song, Jin L. Re-examining the role of ventral tegmental area dopaminergic neurons in motor activity and reinforcement by chemogenetic and optogenetic manipulation in mice. Metabolic brain disease. vol 34. issue 5. 2020-04-30. PMID:31313126. |
in the present study, we investigated the fundamental role of vta daergic neurons in reward-related movement and reinforcement by employing dopamine transporter (dat)-cre transgenic mice expressing hm3dq, hm4di or channelrhodopsin 2 (chr2) in vta daergic neurons through cre-inducible adeno-associated viral vector transfection. |
2020-04-30 |
2023-08-13 |
mouse |
| Jason Massa, Lana M Chahin. Revision of Diagnosis in Early Parkinsonism with Abnormal Dopamine Transporter Imaging. Journal of Parkinson's disease. vol 9. issue 2. 2020-04-27. PMID:30958313. |
dopamine transporter (dat) spect imaging can help improve diagnostic accuracy. |
2020-04-27 |
2023-08-13 |
Not clear |
| Seunghyeon Shin, Keunyoung Kim, Kyoungjune Pak, Hyun-Yeol Nam, Seong-Jang Kim, In Joo Ki. Effects of Maturation on Striatal Dopamine Transporter Availability in Rats. Nuklearmedizin. Nuclear medicine. vol 58. issue 5. 2020-04-27. PMID:31430766. |
we investigated the effects of maturation on dopamine transporter (dat) availability in the rat via longitudinal monitoring with positron emission tomography (pet). |
2020-04-27 |
2023-08-13 |
rat |
| Takuro Shiiba, Yuki Arimura, Miku Nagano, Tenma Takahashi, Akihiro Takak. Improvement of classification performance of Parkinson's disease using shape features for machine learning on dopamine transporter single photon emission computed tomography. PloS one. vol 15. issue 1. 2020-04-27. PMID:31978154. |
to assess the classification performance between parkinson's disease (pd) and normal control (nc) when semi-quantitative indicators and shape features obtained on dopamine transporter (dat) single photon emission computed tomography (spect) are combined as a feature of machine learning (ml). |
2020-04-27 |
2023-08-13 |
Not clear |
| Alexander G Zestos, Colleen Carpenter, Youngsoo Kim, Malcolm J Low, Robert T Kennedy, Margaret E Gneg. Ruboxistaurin Reduces Cocaine-Stimulated Increases in Extracellular Dopamine by Modifying Dopamine-Autoreceptor Activity. ACS chemical neuroscience. vol 10. issue 4. 2020-04-24. PMID:30384585. |
cocaine blocks normal uptake function at the dopamine transporter (dat), thus increasing extracellular dopamine. |
2020-04-24 |
2023-08-13 |
mouse |
| Jacqueline D Keighron, Juliana C Quarterman, Jianjing Cao, Emily M DeMarco, Mark A Coggiano, Apre Gleaves, Rachel D Slack, Claudio Zanettini, Amy Hauck Newman, Gianluigi Tand. Effects of ( R)-Modafinil and Modafinil Analogues on Dopamine Dynamics Assessed by Voltammetry and Microdialysis in the Mouse Nucleus Accumbens Shell. ACS chemical neuroscience. vol 10. issue 4. 2020-04-24. PMID:30645944. |
recent discoveries have improved our understanding of the physiological and pathological roles of the dopamine transporter (dat); however, only a few drugs are clinically available for dat-implicated disorders. |
2020-04-24 |
2023-08-13 |
mouse |
| T Lee Gilman, W Anthony Owens, Christina M George, Lauren Metzel, Melissa Vitela, Livia Ferreira, Melodi A Bowman, Georgianna G Gould, Glenn M Toney, Lynette C Daw. Age- and Sex-Specific Plasticity in Dopamine Transporter Function Revealed by Food Restriction and Exercise in a Rat Activity-Based Anorexia Paradigm. The Journal of pharmacology and experimental therapeutics. vol 371. issue 2. 2020-04-24. PMID:31481515. |
at the end of the paradigm, measures of plasma volume, blood hormone levels, dopamine transporter (dat) expression and function, acute cocaine-induced locomotion, and brain water weight were taken. |
2020-04-24 |
2023-08-13 |
human |
| Steven Vetel, Sophie Sérrière, Johnny Vercouillie, Jackie Vergote, Gabrielle Chicheri, Jean-Bernard Deloye, Frédéric Dollé, Sylvie Bodard, Claire Tronel, Lydie Nadal-Desbarats, Antoine Lefèvre, Patrick Emond, Sylvie Chalo. Extensive exploration of a novel rat model of Parkinson's disease using partial 6-hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches. Synapse (New York, N.Y.). vol 73. issue 3. 2020-04-22. PMID:30368914. |
the degenerative process was assessed through in vivo positron emission tomography (pet) imaging and in vitro autoradiographic quantitation of the striatal dopamine transporter (dat) and immunostaining of tyrosine hydroxylase (th). |
2020-04-22 |
2023-08-13 |
rat |
| Sergey A Apryatin, Vladimir A Shipelin, Nikita V Trusov, Kristina V Mzhelskaya, Victoria S Evstratova, Natalya V Kirbaeva, Jorge S Soto, Zoia S Fesenko, Raul R Gainetdinov, Ivan V Gmoshinsk. Comparative analysis of the influence of a high-fat/high-carbohydrate diet on the level of anxiety and neuromotor and cognitive functions in Wistar and DAT-KO rats. Physiological reports. vol 7. issue 4. 2020-04-21. PMID:30784211. |
we compared anxiety, neuromotor, and cognitive functions in mutant rats with different allelic variants of dopamine transporter dat knockout receiving balanced or excess in fat and fructose diet. |
2020-04-21 |
2023-08-13 |
rat |
| Sergey A Apryatin, Vladimir A Shipelin, Nikita V Trusov, Kristina V Mzhelskaya, Victoria S Evstratova, Natalya V Kirbaeva, Jorge S Soto, Zoia S Fesenko, Raul R Gainetdinov, Ivan V Gmoshinsk. Comparative analysis of the influence of a high-fat/high-carbohydrate diet on the level of anxiety and neuromotor and cognitive functions in Wistar and DAT-KO rats. Physiological reports. vol 7. issue 4. 2020-04-21. PMID:30784211. |
the consumption of excess fat and fructose significantly modified the effects produced by dat gene allelic variants presumably due to the influence on the processes of dopamine metabolism. |
2020-04-21 |
2023-08-13 |
rat |
| Nicholas B Miner, Tamara J Phillips, Aaron Janowsk. The Role of Biogenic Amine Transporters in Trace Amine-Associated Receptor 1 Regulation of Methamphetamine-Induced Neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 371. issue 1. 2020-04-20. PMID:31320495. |
methamphetamine (ma) impairs vesicular monoamine transporter 2 (vmat2) and dopamine transporter (dat) function and expression, increasing intracellular da levels that lead to neurotoxicity. |
2020-04-20 |
2023-08-13 |
Not clear |
| Xiaohong Li, Qizhou Zhang, Yongde Qin, Yubin Li, Nazimuguli Mutaerbieke, Xiaojia Zhao, Amina Yibulayi. Positron emission tomography/computed tomography dual imaging using 18-fluorine flurodeoxyglucose and 11C-labeled 2-β-carbomethoxy-3-β-(4-fluorophenyl) tropane for the severity assessment of Parkinson disease. Medicine. vol 99. issue 14. 2020-04-08. PMID:32243399. |
the value of dual imaging mode for the severity assessment of parkinson disease (pd) is explored by conducting positron emission tomography computed tomography (pet/ct) double imaging using combined 18-fluorine flurodeoxyglucose (f-fdg) brain metabolism and 11c-2β-carbomethoxy-3β-(4-fluorophenyl) tropane (c-cft) brain dopamine transporter (dat).a total of 102 patients with pd and 50 healthy people in the control group are enrolled for the pet/ct dual imaging of f-fdg brain metabolism and c-cft brain dat. |
2020-04-08 |
2023-08-13 |
Not clear |
| Juan Pablo González-Gutiérrez, Hernán Armando Pessoa-Mahana, Patricio Ernesto Iturriaga-Vásquez, Miguel Iván Reyes-Parada, Nicolas Esteban Guerra-Díaz, Martin Hodar-Salazar, Franco Viscarra, Pablo Paillali, Gabriel Núñez-Vivanco, Marcos Antonio Lorca-Carvajal, Jaime Mella-Raipán, María Carolina Zúñig. Synthesis of Novel Nicotinic Ligands with Multimodal Action: Targeting Acetylcholine α4β2, Dopamine and Serotonin Transporters. Molecules (Basel, Switzerland). vol 24. issue 20. 2020-04-06. PMID:31652614. |
nicotinic acetylcholine receptors (nachrs), serotonin transporters (sert) and dopamine transporters (dat) represent targets for the development of novel nicotinic derivatives acting as multiligands associated with different health conditions, such as depressive, anxiety and addiction disorders. |
2020-04-06 |
2023-08-13 |
Not clear |
| Anne Zwartsen, Carlijn H C Litjens, Laura Hondebrink, Jeroen J M W van den Heuvel, Rick Greupink, Frans G M Russel, Dylan W de Lange, Juliette Legler, Jan B Koenderink, Remco H S Westerin. Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT). Toxicology. vol 422. 2020-04-03. PMID:31009648. |
differential effects of psychoactive substances on human wildtype and polymorphic t356m dopamine transporters (dat). |
2020-04-03 |
2023-08-13 |
human |
| Akihiro Fujikawa, Yukihiro Noda, Hideko Yamamoto, Naomi Tanga, Gaku Sakaguchi, Satoko Hattori, Wen-Jie Song, Ichiro Sora, Toshitaka Nabeshima, Goro Katsuura, Masaharu Nod. Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty. PloS one. vol 14. issue 8. 2020-04-02. PMID:31430310. |
methamphetamine (meth), a commonly abused drug, elevates extracellular dopamine (da) levels by inducing da efflux through the da transporter (dat). |
2020-04-02 |
2023-08-13 |
mouse |
| Amy Hauck Newman, Jianjing Cao, Jacqueline D Keighron, Chloe J Jordan, Guo-Hua Bi, Ying Liang, Ara M Abramyan, Alicia J Avelar, Christopher W Tschumi, Michael J Beckstead, Lei Shi, Gianluigi Tanda, Zheng-Xiong X. Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 8. 2020-03-31. PMID:30858517. |
efforts to develop potential pharmacotherapies have led to the identification of a promising lead molecule, jjc8-091, that demonstrates a novel binding mode at the dopamine transporter (dat). |
2020-03-31 |
2023-08-13 |
mouse |
| Heeyoung Kim, Minyoung Oh, Jungsu S Oh, Hyojeong Moon, Sun Ju Chung, Chong Sik Lee, Jae Seung Ki. Association of striatal dopaminergic neuronal integrity with cognitive dysfunction and cerebral cortical metabolism in Parkinson's disease with mild cognitive impairment. Nuclear medicine communications. vol 40. issue 12. 2020-03-27. PMID:31584466. |
we investigated the association of striatal dopamine transporter (dat) loss with cognitive function and cerebral cortical metabolism in pd. |
2020-03-27 |
2023-08-13 |
Not clear |
| Emma A Honkanen, Nina Kemppainen, Tommi Noponen, Marko Seppänen, Juho Joutsa, Valtteri Kaasine. Bupropion Causes Misdiagnosis in Brain Dopamine Transporter Imaging for Parkinsonism. Clinical neuropharmacology. vol 42. issue 5. 2020-03-23. PMID:31361666. |
the objective of this study was to report long-lasting effects of bupropion on brain dopamine transporter (dat) in a patient with depression and parkinsonism. |
2020-03-23 |
2023-08-13 |
Not clear |
| June P Kampangkaew, Catherine J Spellicy, Ellen M Nielsen, Mark J Harding, An Ye, Sara C Hamon, Thomas R Kosten, David A Nielse. Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction. The American journal on addictions. vol 28. issue 4. 2020-03-20. PMID:31087723. |
patients with two slc6a3 (dat1) rs28363170 10-repeat alleles who have with genetically high dopamine transporter (dat) levels may benefit from increased dopamine levels resulting from disulfiram treatment. |
2020-03-20 |
2023-08-13 |
Not clear |