| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vera S Kerstens, Patrik Fazio, Mathias Sundgren, Granville J Matheson, Erika Franzén, Christer Halldin, Simon Cervenka, Per Svenningsson, Andrea Varron. Reliability of dopamine transporter PET measurements with [ EJNMMI research. vol 10. issue 1. 2020-09-28. PMID:32797307. |
reliability of dopamine transporter pet measurements with [ reliable quantification of dopamine transporter (dat), a biomarker for parkinson's disease (pd), is essential for diagnostic purposes as well as for evaluation of potential disease-modifying treatment. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chih-Hsin Lin, Pei-Cih Wei, Chiung-Mei Chen, Yu-Ting Huang, Jia-Lan Lin, Yen-Shi Lo, Jia-Li Lin, Chung-Yin Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Che. Lactulose and Melibiose Attenuate MPTP-Induced Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32848705. |
treatment with mptp generated significant motor deficits, inhibited dopamine levels, and down-regulated dopamine transporter (dat) in the striatum. |
2020-09-28 |
2023-08-13 |
mouse |
| Wei-Lun Sun, Pamela M Quizon, Yaxia Yuan, Matthew J Strauss, Richard McCain, Chang-Guo Zhan, Jun Zh. Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport. Scientific reports. vol 9. issue 1. 2020-09-24. PMID:30846720. |
dysregulation of dopaminergic system induced by hiv-1 tat protein-mediated direct inhibition of the dopamine transporter (dat) has been implicated as a mediating factor of hiv-1 associated neurocognitive disorders. |
2020-09-24 |
2023-08-13 |
human |
| Wei-Lun Sun, Pamela M Quizon, Yaxia Yuan, Matthew J Strauss, Richard McCain, Chang-Guo Zhan, Jun Zh. Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport. Scientific reports. vol 9. issue 1. 2020-09-24. PMID:30846720. |
we have reported that single point mutations on human dat (hdat) at tyrosine88 (y88f), lysine92 (k92m), and histidine547 (h547a) differentially regulate basal dopamine uptake but diminish tat-induced inhibition of dopamine uptake by changing dopamine transport process. |
2020-09-24 |
2023-08-13 |
human |
| Wei-Lun Sun, Pamela M Quizon, Yaxia Yuan, Matthew J Strauss, Richard McCain, Chang-Guo Zhan, Jun Zh. Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport. Scientific reports. vol 9. issue 1. 2020-09-24. PMID:30846720. |
this study evaluated the effects of double (y88f/h547a) and triple (y88f/k92m/h547a) mutations on basal dopamine uptake, tat-induced inhibition of dat function, and dynamic transport process. |
2020-09-24 |
2023-08-13 |
human |
| Zongbo Sun, Ye Ma, Lei Xie, Jinzhuang Huang, Shouxing Duan, Ruiwei Guo, Yao Xie, Junyao Lv, Zhirong Lin, Shuhua M. Behavioral Changes and Neuronal Damage in Rhesus Monkeys after 10 Weeks of Ketamine Administration Involve Prefrontal Cortex Dopamine D2 Receptor and Dopamine Transporter. Neuroscience. vol 415. 2020-09-23. PMID:31330230. |
the dopamine d2 receptor (drd2) and dopamine transporter (dat) play a regulatory role in dopaminergic neurotransmission and thus play an important role in drug addiction. |
2020-09-23 |
2023-08-13 |
monkey |
| Jordan T Yorgason, David M Hedges, J Daniel Obray, Eun Young Jang, Kyle B Bills, Mark Woodbury, Ben Williams, Mandy J Parsons, Marilou A Andres, Scott C Steffense. Methamphetamine increases dopamine release in the nucleus accumbens through calcium-dependent processes. Psychopharmacology. vol 237. issue 5. 2020-09-22. PMID:31965252. |
methamphetamine (meth) enhances exocytotic dopamine (da) signals and induces da transporter (dat)-mediated efflux in brain striatal regions such as the nucleus accumbens (nac). |
2020-09-22 |
2023-08-13 |
Not clear |
| Zhemin Huang, Chengfeng Jiang, Ling Li, Qian Xu, Jingjie Ge, Ming Li, Yihui Guan, Jianjun Wu, Jian Wang, Chuantao Zuo, Huan Yu, Ping W. Correlations between dopaminergic dysfunction and abnormal metabolic network activity in REM sleep behavior disorder. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 3. 2020-09-21. PMID:30741074. |
striatal dopamine transporter (dat) deficiency and abnormal expression of parkinson's disease (pd)-related pattern (pdrp) have been observed in patients with idiopathic rem sleep behavior disorder (irbd). |
2020-09-21 |
2023-08-13 |
human |
| Jennifer B Dwyer, Anjelica Cardenas, Ryan M Franke, YiLing Chen, Yu Bai, James D Belluzzi, Shahrdad Lotfipour, Frances M Lesli. Prenatal nicotine sex-dependently alters adolescent dopamine system development. Translational psychiatry. vol 9. issue 1. 2020-09-21. PMID:31740669. |
gn enhanced cocaine-induced locomotor activity in females, concomitant with gn-induced reductions in striatal dopamine transporter (dat) binding. |
2020-09-21 |
2023-08-13 |
Not clear |
| Tomoyoshi Kuribara, Rei Enatsu, Mayumi Kitagawa, Masayasu Arihara, Ayaka Sasagawa, Tsukasa Hirano, Hime Suzuki, Rintaro Yokoyama, Takeshi Mikami, Nobuhiro Mikun. Neuroimaging and neurophysiological evaluation of severity of Parkinson's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 74. 2020-09-18. PMID:32070672. |
in this study, we evaluated the utility of dopamine transporter (dat) imaging and subthalamic nucleus (stn) activities as indicators of pd severity. |
2020-09-18 |
2023-08-13 |
Not clear |
| I Navalpotro-Gomez, R Dacosta-Aguayo, F Molinet-Dronda, A Martin-Bastida, A Botas-Peñin, H Jimenez-Urbieta, M Delgado-Alvarado, B Gago, A Quiroga-Varela, Maria C Rodriguez-Oro. Nigrostriatal dopamine transporter availability, and its metabolic and clinical correlates in Parkinson's disease patients with impulse control disorders. European journal of nuclear medicine and molecular imaging. vol 46. issue 10. 2020-09-14. PMID:31273436. |
previous studies in patients with parkinson's disease (pd) and impulse control disorders (icds) have produced heterogeneous results regarding striatal dopamine transporter (dat) binding and activity in the mesocorticolimbic network. |
2020-09-14 |
2023-08-13 |
Not clear |
| Maarten E A Reith, Margaret E Gneg. Molecular Mechanisms of Amphetamines. Handbook of experimental pharmacology. vol 258. 2020-09-14. PMID:31286212. |
in the first part of this review, the interaction of amphetamine with the dopamine transporter (dat), crucially involved in its behavioral effects, is covered, as well as the role of dopamine synthesis, the vesicular monoamine transporter vmat2, and organic cation 3 transporter (oct3). |
2020-09-14 |
2023-08-13 |
Not clear |
| Giulia Coarelli, Béatrice Garcin, Emmanuel Roze, Marie Vidailhet, Bertrand Dego. Invalidation of Parkinson's disease diagnosis after years of follow-up based on clinical, radiological and neurophysiological examination. Journal of the neurological sciences. vol 406. 2020-09-14. PMID:31525530. |
accurate neurological examination is required but dopamine transporter (dat) single photon emission computed tomography (spect) could be perfomed to support the diagnosis in ambiguous cases. |
2020-09-14 |
2023-08-13 |
Not clear |
| Barkha J Yadav-Samudrala, Jose M Eltit, Richard A Glenno. Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors. ACS chemical neuroscience. vol 10. issue 9. 2020-09-10. PMID:31369229. |
synthetic cathinones are, primarily, stimulant drugs of abuse that act at monoamine transporters (e.g., the dopamine transporter or dat) as releasing agents or as reuptake inhibitors. |
2020-09-10 |
2023-08-13 |
Not clear |
| Yaoyu Pu, Lijia Chang, Youge Qu, Siming Wang, Kai Zhang, Kenji Hashimot. Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain. Aging. vol 11. issue 17. 2020-09-02. PMID:31479418. |
mptp significantly decreased dopamine transporter (dat) immunoreactivity in the striatum and tyrosine hydroxylase (th) immunoreactivity in the substantia nigra of water-treated mice. |
2020-09-02 |
2023-08-13 |
mouse |
| Rachel D Slack, Therese C Ku, Jianjing Cao, JoLynn B Giancola, Alessandro Bonifazi, Claus J Loland, Alexandra Gadiano, Jenny Lam, Rana Rais, Barbara S Slusher, Mark Coggiano, Gianluigi Tanda, Amy Hauck Newma. Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability. Journal of medicinal chemistry. vol 63. issue 5. 2020-08-31. PMID:31661268. |
atypical dopamine transporter (dat) inhibitors have shown therapeutic potential in preclinical models of psychostimulant abuse. |
2020-08-31 |
2023-08-13 |
rat |
| Dareia S Roos, Jos W R Twisk, Pieter G H M Raijmakers, Richard L Doty, Henk W Berends. Hyposmia as a marker of (non-)motor disease severity in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 11. 2020-08-24. PMID:31515655. |
in a subgroup of patients (n = 155) with a dopamine transporter (dat) spect scan, a similar statistical analysis was performed, now including striatal dat binding. |
2020-08-24 |
2023-08-13 |
Not clear |
| Jin Cheng, Siyi Wang, Weiwei Lin, Nan Wu, Yuanqiang Wang, Maozi Chen, Xiang-Qun Xie, Zhiwei Fen. Computational Systems Pharmacology-Target Mapping for Fentanyl-Laced Cocaine Overdose. ACS chemical neuroscience. vol 10. issue 8. 2020-08-18. PMID:31257858. |
sequentially, we looked into the detail of (1) the addiction to cocaine and fentanyl by binding to the dopamine transporter and the μ opioid receptor (dat and μor, respectively), (2) the potential drug-drug interaction of cocaine and fentanyl via p-glycoprotein (p-gp) efflux, (3) the metabolism of cocaine and fentanyl in cyp3a4, and (4) the physiologically based pharmacokinetic (pbpk) model for two drugs and their drug-drug interaction at the absorption, distribution, metabolism, and excretion (adme) level. |
2020-08-18 |
2023-08-13 |
Not clear |
| Adithya Gopinath, Andria Doty, Phillip M Mackie, Basil Hashimi, Madison Francis, Leila Saadatpour, Kaustuv Saha, Gerry Shaw, Adolfo Ramirez-Zamora, Michael S Okun, Wolfgang J Streit, Habibeh Khoshboue. A novel approach to study markers of dopamine signaling in peripheral immune cells. Journal of immunological methods. vol 476. 2020-08-17. PMID:31634479. |
human monocytes express known markers of dopamine synthesis, storage and clearance, including dopamine transporter (dat), tyrosine hydroxylase (th), all subtypes of dopamine receptors and vesicular monoamine transporter 2 (vmat2). |
2020-08-17 |
2023-08-13 |
human |
| Adithya Gopinath, Andria Doty, Phillip M Mackie, Basil Hashimi, Madison Francis, Leila Saadatpour, Kaustuv Saha, Gerry Shaw, Adolfo Ramirez-Zamora, Michael S Okun, Wolfgang J Streit, Habibeh Khoshboue. A novel approach to study markers of dopamine signaling in peripheral immune cells. Journal of immunological methods. vol 476. 2020-08-17. PMID:31634479. |
the use of dopamine signaling could also be explored as a technique to monitor therapeutic interventions particularly those targeting dat and th in the periphery. |
2020-08-17 |
2023-08-13 |
human |