| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gianluca Trifirò, Ilaria Marcianò, Paola M Cutroneo, Edoardo Spina, Eliana Mirabelli, Costantino J Trombetta, Francesca Morgant. Long-Term Intravitreal Ranibizumab as a Potential Additional Risk Factor for Neurodegeneration in Parkinson's Disease: A Case Report. Frontiers in pharmacology. vol 9. 2020-09-29. PMID:29937731. |
single photon emission computerized tomography of the dopamine transporter with (123i) ioflupane documented a low dopamine transporter (dat) uptake mostly in the right striatum. |
2020-09-29 |
2023-08-13 |
Not clear |
| Diptaman Chatterjee, Mansi Bhatt, David Butler, Erwin De Genst, Christopher M Dobson, Anne Messer, Jeffrey H Kordowe. Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson's disease model. NPJ Parkinson's disease. vol 4. 2020-09-29. PMID:30155513. |
vh14*pest showed considerable maintenance of striatal dopaminergic tone in comparison to saline-treated and nbsyn87*pest-treated animals as measured by tyrosine hydroxylase immunoreactivity (optical density), dat immunoreactivity (optical density), and dopamine concentration (high-performance liquid chromatography). |
2020-09-29 |
2023-08-13 |
rat |
| Cong Zheng, Guiqin Chen, Yang Tan, Weiqi Zeng, Qiwei Peng, Ji Wang, Chi Cheng, Xiaoman Yang, Shuke Nie, Yan Xu, Zhentao Zhang, Stella M Papa, Keqiang Ye, Xuebing Ca. TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect. Frontiers in cellular neuroscience. vol 12. 2020-09-29. PMID:30555300. |
the da-releasing effect of taltirelin was alleviated by reserpine, vanoxerine (gbr12909) or ampt, indicating a mechanism involving vesicular monoamine transporter-2 (vmat-2), dopamine transporter (dat) and tyrosine hydroxylase (th). |
2020-09-29 |
2023-08-13 |
rat |
| Shuo-Fu Chen, Chuen-Yu Chuang, Chih-Chang Chao, Yi-Hua Yang, Chi-Yun Chu, Chang-Yu Yao, Yu-Chen Su, Ya-Huei Huang, Ruey-Ming Lia. Task-Dependent Differences in Operant Behaviors of Rats With Acute Exposure to High Ambient Temperature: A Potential Role of Hippocampal Dopamine Reuptake Transporters. Frontiers in behavioral neuroscience. vol 13. 2020-09-29. PMID:30778291. |
western blot assays of dopamine (da) d1 and d2 receptor, da transporter (dat) and brain-derived neurotrophic factor (bdnf) were conducted for the sample tissues collected in six brain areas from all the subjects after acute high ta exposure. |
2020-09-29 |
2023-08-13 |
human |
| Qi Chen, Shurong Li, Yuping Han, Xiaohong Wei, Juan Du, Xiaolin Wang, Bingyin Su, Jun L. Toxicological effects of propofol abuse on the dopaminergic neurons in ventral tegmental area and corpus striatum and its potential mechanisms. The Journal of toxicological sciences. vol 45. issue 7. 2020-09-29. PMID:32612007. |
at the 1st (t1) and 30th (t2) day of drug discontinuance (t2), 15 mice of each group were selected to perform the open field test; then the mice underwent perfusion fixation, and the midbrain and corpus striatum were separated for immunofluorescence assay with anti-tyrosine hydroxylase (th) and anti- dopamine transporter (dat) antibodies. |
2020-09-29 |
2023-08-13 |
mouse |
| Carla Ramon-Duaso, Thomas Gener, Marta Consegal, Cristina Fernández-Avilés, Juan José Gallego, Laura Castarlenas, Maurice S Swanson, Rafael de la Torre, Rafael Maldonado, M Victoria Puig, Patricia Robled. Methylphenidate Attenuates the Cognitive and Mood Alterations Observed in Mbnl2 Knockout Mice and Reduces Microglia Overexpression. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 7. 2020-09-28. PMID:30060068. |
in the mpfc, ko mice showed an overexpression of proinflammatory microglia, increased transcriptional levels of dat, drd1, and drd2, exacerbated dopamine levels, and abnormal neural spiking and oscillatory activities in the mpfc and hpc. |
2020-09-28 |
2023-08-13 |
mouse |
| Ryuji Sakakibara, Fuyuki Tateno, Yosuke Aiba, Tsuyoshi Ogata, Masahiko Kishi, Hitoshi Terada, Tsutomu Inaoka, Tomoya Nakatsuka, Katsuyoshi Matsuok. MIBG Myocardial Scintigraphy Identifies Premotor PD/DLB During a Negative DAT Scan Period: Second Report. Movement disorders clinical practice. vol 6. issue 1. 2020-09-28. PMID:30746415. |
neuroimaging markers for parkinson's disease (pd)/dementia with lewy bodies (dlb) include dopamine transporter (dat) scanning and metaiodobenzylguanidine (mibg) myocardial scintigraphy. |
2020-09-28 |
2023-08-13 |
Not clear |
| So Hyeon Park, Yoo Sung Song, Byung Seok Moon, Byung Chul Lee, Hyun Soo Park, Sang Eun Ki. Combination of Experimental neurobiology. vol 28. issue 5. 2020-09-28. PMID:31698552. |
combination of synaptic dopamine (da) is mainly regulated by the presynaptic da transporter (dat). |
2020-09-28 |
2023-08-13 |
Not clear |
| Hiroyuki Watanabe, Manabu Ikeda, Etsuro Mor. Primary Progressive Aphasia as a Prodromal State of Dementia With Lewy Bodies: A Case Report. Frontiers in neurology. vol 11. 2020-09-28. PMID:32132965. |
she showed reduced dopamine transporter (dat) uptake (assessed by dat single-photon emission computed tomography imaging) in the striatum and decreased cardiac uptake (determined by |
2020-09-28 |
2023-08-13 |
Not clear |
| Hongliang Li, Shigeki Hirano, Shogo Furukawa, Yoshikazu Nakano, Kazuho Kojima, Ai Ishikawa, Hong Tai, Takuro Horikoshi, Takashi Iimori, Takashi Uno, Hiroshi Matsuda, Satoshi Kuwabar. The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32184717. |
the aim of this study was to elucidate the association among age-related changes in the striatal dopamine transporter (dat) and cognitive function in healthy subjects. |
2020-09-28 |
2023-08-13 |
human |
| Prerna Jha, Lotten Ragnarsson, Richard J Lewi. Structure-Function of the High Affinity Substrate Binding Site (S1) of Human Norepinephrine Transporter. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32210813. |
the human norepinephrine transporter (hnet) is a member of the neurotransmitter/sodium symporter family, which also includes the neuronal monoamine transporters for serotonin (sert) and dopamine (dat). |
2020-09-28 |
2023-08-13 |
human |
| Fabrizio Sanna, Jessica Bratzu, Maria Pina Serra, Damiana Leo, Marina Quartu, Marianna Boi, Stefano Espinoza, Raul R Gainetdinov, Maria Rosaria Melis, Antonio Argiola. Altered Sexual Behavior in Dopamine Transporter (DAT) Knockout Male Rats: A Behavioral, Neurochemical and Intracerebral Microdialysis Study. Frontiers in behavioral neuroscience. vol 14. 2020-09-28. PMID:32372926. |
altered sexual behavior in dopamine transporter (dat) knockout male rats: a behavioral, neurochemical and intracerebral microdialysis study. |
2020-09-28 |
2023-08-13 |
rat |
| Fabrizio Sanna, Jessica Bratzu, Maria Pina Serra, Damiana Leo, Marina Quartu, Marianna Boi, Stefano Espinoza, Raul R Gainetdinov, Maria Rosaria Melis, Antonio Argiola. Altered Sexual Behavior in Dopamine Transporter (DAT) Knockout Male Rats: A Behavioral, Neurochemical and Intracerebral Microdialysis Study. Frontiers in behavioral neuroscience. vol 14. 2020-09-28. PMID:32372926. |
recently, a dopamine transporter knockout (dat ko) rat has been developed, which displays several behavioral dysfunctions that have been related to increased extracellular dopamine levels and altered dopamine turnover secondary to dat gene silencing. |
2020-09-28 |
2023-08-13 |
rat |
| Fabrizio Sanna, Jessica Bratzu, Maria Pina Serra, Damiana Leo, Marina Quartu, Marianna Boi, Stefano Espinoza, Raul R Gainetdinov, Maria Rosaria Melis, Antonio Argiola. Altered Sexual Behavior in Dopamine Transporter (DAT) Knockout Male Rats: A Behavioral, Neurochemical and Intracerebral Microdialysis Study. Frontiers in behavioral neuroscience. vol 14. 2020-09-28. PMID:32372926. |
extracellular dopamine and glutamic acid concentrations were also measured in the dialysate obtained by intracerebral microdialysis from the nucleus accumbens (acb) shell of dat ko, het and wt rats, which underwent five copulatory tests, when put in the presence of an inaccessible sexually receptive female rat and when copulation was allowed. |
2020-09-28 |
2023-08-13 |
rat |
| Fabrizio Sanna, Jessica Bratzu, Maria Pina Serra, Damiana Leo, Marina Quartu, Marianna Boi, Stefano Espinoza, Raul R Gainetdinov, Maria Rosaria Melis, Antonio Argiola. Altered Sexual Behavior in Dopamine Transporter (DAT) Knockout Male Rats: A Behavioral, Neurochemical and Intracerebral Microdialysis Study. Frontiers in behavioral neuroscience. vol 14. 2020-09-28. PMID:32372926. |
these differences occurred with differential changes in dopamine and glutamic acid concentrations in acb dialysates during sexual behavior, with lower increases of dopamine and glutamic acid in dat ko vs. wt and het rats, and a lower expression of the markers investigated, mainly in the mpfc, in dat ko vs. wt rats. |
2020-09-28 |
2023-08-13 |
rat |
| Fabrizio Sanna, Jessica Bratzu, Maria Pina Serra, Damiana Leo, Marina Quartu, Marianna Boi, Stefano Espinoza, Raul R Gainetdinov, Maria Rosaria Melis, Antonio Argiola. Altered Sexual Behavior in Dopamine Transporter (DAT) Knockout Male Rats: A Behavioral, Neurochemical and Intracerebral Microdialysis Study. Frontiers in behavioral neuroscience. vol 14. 2020-09-28. PMID:32372926. |
together these findings confirm a key role of dopamine in sexual behavior and provide evidence that the permanently high levels of dopamine triggered by dat gene silencing cause alterations in both the frontocortical glutamatergic neurons projecting to the acb and vta and in the mesolimbic dopaminergic neurons, leading to specific brain regional changes in trophic support and neuroplastic processes, which may have a role in the sexual behavior differences found among the three rat genotypes. |
2020-09-28 |
2023-08-13 |
rat |
| Helen Schmitz-Steinkrüger, Catharina Lange, Ivayla Apostolova, Holger Amthauer, Wencke Lehnert, Susanne Klutmann, Ralph Bucher. Impact of the size of the normal database on the performance of the specific binding ratio in dopamine transporter SPECT. EJNMMI physics. vol 7. issue 1. 2020-09-28. PMID:32435936. |
this study investigated the impact of the size of the normal database on the classification performance of the specific binding ratio (sbr) in dopamine transporter (dat) spect with [ |
2020-09-28 |
2023-08-13 |
Not clear |
| Barbara Loi, Michelle A Sahai, Maria Antonietta De Luca, Hana Shiref, Jolanta Opacka-Juffr. The Role of Dopamine in the Stimulant Characteristics of Novel Psychoactive Substances (NPS)-Neurobiological and Computational Assessment Using the Case of Desoxypipradrol (2-DPMP). Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32670057. |
stimulants increase extracellular dopamine levels in the brain, including the reward and addiction pathways, through interacting with dopamine transporter (dat). |
2020-09-28 |
2023-08-13 |
Not clear |
| Barbara Loi, Michelle A Sahai, Maria Antonietta De Luca, Hana Shiref, Jolanta Opacka-Juffr. The Role of Dopamine in the Stimulant Characteristics of Novel Psychoactive Substances (NPS)-Neurobiological and Computational Assessment Using the Case of Desoxypipradrol (2-DPMP). Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32670057. |
this work aimed to assess the molecular and atomistic mechanisms of stimulant nps actions at dat, which translate into biological outcomes such as dopamine release in the brain's reward pathway. |
2020-09-28 |
2023-08-13 |
Not clear |
| Takao Kanzaki, Tetsuya Higuchi, Yasuyuki Takahashi, Takayuki Suto, Yoshito Tsushim. Improvement of diagnostic accuracy of Parkinson's disease on I-123-ioflupane single photon emission computed tomography ( Asia Oceania journal of nuclear medicine & biology. vol 8. issue 2. 2020-09-28. PMID:32714996. |
improvement of diagnostic accuracy of parkinson's disease on i-123-ioflupane single photon emission computed tomography ( i-123-ioflupane single photon emission computed tomography (fp-cit-spect) has been used to assess dopamine transporter (dat) loss in parkinson's disease. |
2020-09-28 |
2023-08-13 |
Not clear |