| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ralph Buchert, Carsten Buhmann, Ivayla Apostolova, Philipp T Meyer, Jürgen Gallina. Nuclear Imaging in the Diagnosis of Clinically Uncertain Parkinsonian Syndromes. Deutsches Arzteblatt international. vol 116. issue 44. 2020-07-08. PMID:31774054. |
in particular, cerebral single-photon emission computed tomography (spect) with dopamine transporter (dat) ligands may be helpful. |
2020-07-08 |
2023-08-13 |
Not clear |
| Elena V Cherepkova, Vladimir N Maksimov, Alexandr P Kushnarev, Igor I Shakhmatov, Lyubomir I Aftana. The polymorphism of dopamine receptor D4 (DRD4) and dopamine transporter (DAT) genes in the men with antisocial behaviour and mixed martial arts fighters. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 20. issue 5. 2020-07-07. PMID:28797200. |
the polymorphism of dopamine receptor d4 (drd4) and dopamine transporter (dat) genes in the men with antisocial behaviour and mixed martial arts fighters. |
2020-07-07 |
2023-08-13 |
Not clear |
| Danielle E Bolland, Amy E Moritz, Daniel J Stanislowski, Roxanne A Vaughan, James D Foste. Palmitoylation by Multiple DHHC Enzymes Enhances Dopamine Transporter Function and Stability. ACS chemical neuroscience. vol 10. issue 6. 2020-07-07. PMID:30965003. |
the dopamine transporter (dat) is a plasma membrane protein that mediates the reuptake of extracellular dopamine (da) and controls the spatiotemporal dynamics of dopaminergic neurotransmission. |
2020-07-07 |
2023-08-13 |
human |
| Bai Xue, Wen Xiao, Hong Tia. Nei-like 1 inhibition results in motor dysfunction and promotes inflammation in Parkinson's disease mice model. Biochemical and biophysical research communications. vol 521. issue 1. 2020-07-06. PMID:31653343. |
furthermore, da neuronal loss was further accelerated by neil1 deletion in 6-ohda-injected mice, as evidenced by the significantly reduced expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2020-07-06 |
2023-08-13 |
mouse |
| Hye Ran Park, Seunggyun Ha, Dong Soo Lee, Hyung-Jun Im, Sun Ha Pae. Determination of Parkinson Disease Laterality After Deep Brain Stimulation Using 123I FP-CIT SPECT. Clinical nuclear medicine. vol 45. issue 4. 2020-07-06. PMID:32108695. |
this study aimed to evaluate the changes of laterality after deep brain stimulation (dbs) and the association between dopamine transporter spect using i fp-cit (dat spect) and symptom laterality in pd before and after dbs. |
2020-07-06 |
2023-08-13 |
Not clear |
| Predrag Kalaba, Marija Ilić, Nilima Y Aher, Vladimir Dragačević, Marcus Wieder, Martin Zehl, Judith Wackerlig, Stanislav Beyl, Simone B Sartori, Karl Ebner, Alexander Roller, Natalie Lukic, Tetyana Beryozkina, Eduardo Rene Perez Gonzalez, Philip Neill, Jawad Akbar Khan, Vasiliy Bakulev, Johann Jakob Leban, Steffen Hering, Christian Pifl, Nicolas Singewald, Jana Lubec, Ernst Urban, Harald H Sitte, Thierry Langer, Gert Lube. Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters. Journal of medicinal chemistry. vol 63. issue 1. 2020-06-29. PMID:31841637. |
our continuous effort to find modafinil analogues with higher inhibitory activity on and selectivity toward the dopamine transporter (dat) has previously led to the promising thiazole-containing derivatives ce-103, ce-111, ce-123, and ce-125. |
2020-06-29 |
2023-08-13 |
Not clear |
| Rafieh Alizadeh, Zohreh Bagher, Seyed Kamran Kamrava, Masoumeh Falah, Hatef Ghasemi Hamidabadi, Mahdi Eskandarian Boroujeni, Fatemeh Mohammadi, Sepideh Khodaverdi, Arash Zare-Sadeghi, Arta Olya, Ali Komeil. Differentiation of human mesenchymal stem cells (MSC) to dopaminergic neurons: A comparison between Wharton's Jelly and olfactory mucosa as sources of MSCs. Journal of chemical neuroanatomy. vol 96. 2020-06-15. PMID:30639339. |
however, it was demonstrated that having the same neuroectodermal origin as the nervous system, the olfactory ectomesenchymal stem cells (oe-mscs) expressed the neural marker map2 as well as dopaminergic markers such as tyrosine hydroxylase (th), dopamine transporter (dat) and pitx3 to a greater extent than the wj-mscs both at the level of mrna and protein. |
2020-06-15 |
2023-08-13 |
human |
| Linda D Simmler, Randy D Blakel. The SERT Met172 Mouse: An Engineered Model To Elucidate the Contributions of Serotonin Signaling to Cocaine Action. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30817127. |
it is well-known that essential aspects of cocaine's addictive actions involve the drug's ability to block the presynaptic dopamine (da) transporter (dat), thereby elevating extracellular levels of da in brain circuits that subserve reward, reinforcement, and habit. |
2020-06-11 |
2023-08-13 |
mouse |
| Diane Stephenson, Derek Hill, Jesse M Cedarbaum, Maria Tome, Spiros Vamvakas, Klaus Romero, Daniela J Conrado, David T Dexter, John Seibyl, Danna Jennings, Timothy Nicholas, Dawn Matthews, Zhiyong Xie, Syed Imam, Paul Maguire, David Russell, Mark Forrest Gordon, Glenn T Stebbins, Ed Somer, Jill Gallagher, Arthur Roach, Peter Basseches, Donald Grosset, Kenneth Mare. The Qualification of an Enrichment Biomarker for Clinical Trials Targeting Early Stages of Parkinson's Disease. Journal of Parkinson's disease. vol 9. issue 3. 2020-06-02. PMID:31306141. |
members of the critical path for parkinson's consortium formally submitted documentation to the european medicines agency (ema) supporting the use of dopamine transporter (dat) neuroimaging in early pd. |
2020-06-02 |
2023-08-13 |
human |
| Junpei Kobayashi, Takafumi Hasegawa, Naoto Sugeno, Shun Yoshida, Tetsuya Akiyama, Koki Fujimori, Hiroyasu Hatakeyama, Yasuo Miki, Arata Tomiyama, Yasushi Kawata, Mitsunori Fukuda, Ichiro Kawahata, Tohru Yamakuni, Michinori Ezura, Akio Kikuchi, Toru Baba, Atsushi Takeda, Makoto Kanzaki, Koichi Wakabayashi, Hideyuki Okano, Masashi Aok. Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 9. 2020-05-27. PMID:31211923. |
altogether, these findings revealed a novel role of extracellular α-syn on cellular trafficking of dat and may provide a rationale for the cell type-specific, functional, and pathologic alterations in pd.-kobayashi, j., hasegawa, t., sugeno, n., yoshida, s., akiyama, t., fujimori, k., hatakeyama, h., miki, y., tomiyama, a., kawata, y., fukuda, m., kawahata, i., yamakuni, t., ezura, m., kikuchi, a., baba, t., takeda, a., kanzaki, m., wakabayashi, k., okano, h., aoki, m. extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis. |
2020-05-27 |
2023-08-13 |
Not clear |
| Gabriella E DiCarlo, Jenny I Aguilar, Heinrich Jg Matthies, Fiona E Harrison, Kyle E Bundschuh, Alyssa West, Parastoo Hashemi, Freja Herborg, Mattias Rickhag, Hao Chen, Ulrik Gether, Mark T Wallace, Aurelio Gall. Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors. The Journal of clinical investigation. vol 129. issue 8. 2020-05-26. PMID:31094705. |
the precise regulation of synaptic dopamine (da) content by the dopamine transporter (dat) ensures the phasic nature of the da signal, which underlies the ability of da to encode reward prediction error, thereby driving motivation, attention, and behavioral learning. |
2020-05-26 |
2023-08-13 |
mouse |
| Sandra Arancibia, Matías Marambio, Jorge M Campusano, Angélica Fierr. Modeling of the Binding of Octopamine and Dopamine in Insect Monoamine Transporters Reveals Structural and Electrostatic Differences. ACS chemical neuroscience. vol 10. issue 5. 2020-05-21. PMID:30605598. |
here, we used molecular modeling methodologies to obtain three-dimensional insights for the dopamine transporter (dat) and oat in a common agricultural pest insect, trichoplusia ni (tni). |
2020-05-21 |
2023-08-13 |
drosophila_melanogaster |
| Jing Tang, Bao Yang, Matthew P Adams, Nikolay N Shenkov, Ivan S Klyuzhin, Sima Fotouhi, Esmaeil Davoodi-Bojd, Lijun Lu, Hamid Soltanian-Zadeh, Vesna Sossi, Arman Rahmi. Artificial Neural Network-Based Prediction of Outcome in Parkinson's Disease Patients Using DaTscan SPECT Imaging Features. Molecular imaging and biology. vol 21. issue 6. 2020-05-21. PMID:30847821. |
quantitative analysis of dopamine transporter (dat) single-photon emission computed tomography (spect) images can enhance diagnostic confidence and improve their potential as a biomarker to monitor the progression of parkinson's disease (pd). |
2020-05-21 |
2023-08-13 |
Not clear |
| Daniel A Monti, George Zabrecky, Daniel Kremens, Tsao-Wei Liang, Nancy A Wintering, Anthony J Bazzan, Li Zhong, Brendan K Bowens, Inna Chervoneva, Charles Intenzo, Andrew B Newber. N-Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease. Clinical pharmacology and therapeutics. vol 106. issue 4. 2020-05-13. PMID:31206613. |
participants received prebrain and postbrain imaging with ioflupane (datscan) to measure dopamine transporter (dat) binding. |
2020-05-13 |
2023-08-13 |
human |
| Giovanni Palermo, Roberto Ceravol. Molecular Imaging of the Dopamine Transporter. Cells. vol 8. issue 8. 2020-05-11. PMID:31405186. |
dopamine transporter (dat) single-photon emission tomography (spect) with (123)ioflupane is a widely used diagnostic tool for patients with suspected parkinsonian syndromes, as it assists with differentiating between parkinson's disease (pd) or atypical parkinsonisms and conditions without a presynaptic dopaminergic deficit such as essential tremor, vascular and drug-induced parkinsonisms. |
2020-05-11 |
2023-08-13 |
Not clear |
| Giovanni Palermo, Roberto Ceravol. Molecular Imaging of the Dopamine Transporter. Cells. vol 8. issue 8. 2020-05-11. PMID:31405186. |
however, the interpretation of dat-spect imaging may be challenged by several factors including the loss of dat receptor density with age and the effect of certain drugs on dopamine uptake. |
2020-05-11 |
2023-08-13 |
Not clear |
| Maria Papathanou, Sylvie Dumas, Hanna Pettersson, Lars Olson, Åsa Wallén-Mackenzi. Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry. eNeuro. vol 6. issue 5. 2020-05-08. PMID:31481399. |
off-target effects in transgenic mice: characterization of dopamine transporter (dat)-cre transgenic mouse lines exposes multiple non-dopaminergic neuronal clusters available for selective targeting within limbic neurocircuitry. |
2020-05-08 |
2023-08-13 |
mouse |
| Márcio Bonesso Alves, Daniela Pereira Laureano, Roberta Dalle Molle, Tania Diniz Machado, Ana Paula de Ascenção Salvador, Patrícia Maidana Miguel, Derek Lupinsky, Carla Dalmaz, Patrícia Pelufo Silveir. Intrauterine growth restriction increases impulsive behavior and is associated with altered dopamine transmission in both medial prefrontal and orbitofrontal cortex in female rats. Physiology & behavior. vol 204. 2020-05-04. PMID:30880239. |
in vivo dopamine responses to sweet food intake were measured by voltammetry, and d1, d2 and dat levels were accessed by western blot. |
2020-05-04 |
2023-08-13 |
rat |
| Ya-Qiu Tang, Zhuo-Ran Li, Shao-Zhi Zhang, Ping Mi, Dong-Yan Chen, Xi-Zeng Fen. Venlafaxine plus melatonin ameliorate reserpine-induced depression-like behavior in zebrafish. Neurotoxicology and teratology. vol 76. 2020-05-04. PMID:31518687. |
we tested the depressive behavior of adult zebrafish through a novel tank test, and evaluated the levels of serotonin (5-ht), dopamine (da) and noradrenaline (na) in zebrafish brain using enzyme-linked immunosorbent assay (elisa), besides that the gene expression of serotonin transporters a (serta), dopamine transporters (dat) and norepinephrine transporters (net), vesicular monoamine transporter2 (vmat2) and monoamine oxidase (mao) were evaluated by qrt-pcr. |
2020-05-04 |
2023-08-13 |
zebrafish |
| Kamil Łątka, Jakub Jończyk, Marek Bajd. γ-Aminobutyric acid transporters as relevant biological target: Their function, structure, inhibitors and role in the therapy of different diseases. International journal of biological macromolecules. 2020-05-03. PMID:32360967. |
the important structural features were described based on published data, including sequence analysis, mutagenesis studies, and comparison with known slc6 transporters for leucine (leut), dopamine (dat) and serotonin (sert). |
2020-05-03 |
2023-08-13 |
Not clear |