| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nianhang Chen, Judy Rickey, Maarten E A Reit. Na+ stimulates binding of dopamine to the dopamine transporter in cells but not in cell-free preparations. Journal of neurochemistry. vol 86. issue 3. 2003-09-11. PMID:12859681. |
although na+ is crucial for the function of the dopamine (da) transporter (dat), its role in the substrate binding step has been questioned. |
2003-09-11 |
2023-08-12 |
Not clear |
| Raul R Gainetdinov, Marc G Caro. Monoamine transporters: from genes to behavior. Annual review of pharmacology and toxicology. vol 43. 2003-09-09. PMID:12359863. |
these transporters for dopamine (dat), serotonin (sert), and norepinephrine (net), which are expressed selectively on the corresponding neurons, are established targets of many psychostimulants, antidepressants, and neurotoxins. |
2003-09-09 |
2023-08-12 |
mouse |
| Wen-Sheng Huang, Yung-Hsiao Chiang, Jiann-Chyun Lin, Yuan-Hwa Chou, Cheng-Yi Cheng, Ren-Shyan Li. Crossover study of (99m)Tc-TRODAT-1 SPECT and (18)F-FDOPA PET in Parkinson's disease patients. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 44. issue 7. 2003-09-04. PMID:12843212. |
99mtc-trodat-1 ([2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3,2,1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiolato(3-)-n2,n2',s2,s2']oxo-[1r-(exo-exo)]) is a potential agent for dopamine transporter (dat) spect, whereas 6-(18)f-fluoro-l-dopa ((18)f-fdopa) pet has been used for the quantitative assessment of presynaptic nigrostriatal dopaminergic function. |
2003-09-04 |
2023-08-12 |
Not clear |
| Tatiana Sorkina, Suzanne Doolen, Emilia Galperin, Nancy R Zahniser, Alexander Sorki. Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy. The Journal of biological chemistry. vol 278. issue 30. 2003-08-26. PMID:12746456. |
to examine the oligomeric state and trafficking of the dopamine transporter (dat) in different compartments of living cells, human dat was fused to yellow (yfp) or cyan fluorescent protein (cfp). |
2003-08-26 |
2023-08-12 |
human |
| Peter C Meltzer, Paul Blundell, Thomas Zona, Lihua Yang, Hong Huang, Ali A Bonab, Eli Livni, Alan Fischman, Bertha K Madra. A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain. Journal of medicinal chemistry. vol 46. issue 16. 2003-08-26. PMID:12877586. |
the dopamine transporter (dat), located presynaptically on dopamine neurons, provides a marker for parkinson's disease (pd) and attention deficit hyperactivity disorder (adhd). |
2003-08-26 |
2023-08-12 |
Not clear |
| Peter C Meltzer, Paul Blundell, Thomas Zona, Lihua Yang, Hong Huang, Ali A Bonab, Eli Livni, Alan Fischman, Bertha K Madra. A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain. Journal of medicinal chemistry. vol 46. issue 16. 2003-08-26. PMID:12877586. |
the depletion of dat levels also corresponds with the loss of dopamine. |
2003-08-26 |
2023-08-12 |
Not clear |
| D Stanic, C L Parish, W M Zhu, E V Krstew, A J Lawrence, J Drago, D I Finkelstein, M K Horn. Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the SNpc. Journal of neurochemistry. vol 86. issue 2. 2003-08-21. PMID:12871574. |
this study examined the structure and function of these reinnervated terminals, defining characteristics of dopamine uptake and release, density and affinity of the dopamine transporter (dat) and ultrastructural morphology of dopamine terminals in the reinnervated dorsal striatum. |
2003-08-21 |
2023-08-12 |
Not clear |
| D Stanic, C L Parish, W M Zhu, E V Krstew, A J Lawrence, J Drago, D I Finkelstein, M K Horn. Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the SNpc. Journal of neurochemistry. vol 86. issue 2. 2003-08-21. PMID:12871574. |
dopamine transport was markedly reduced 16 weeks after lesioning along with reduced density and affinity of dat. |
2003-08-21 |
2023-08-12 |
Not clear |
| Annemette Løkkegaard, Lene M Werdelin, Lars Friber. Clinical impact of diagnostic SPET investigations with a dopamine re-uptake ligand. European journal of nuclear medicine and molecular imaging. vol 29. issue 12. 2003-08-15. PMID:12458397. |
imaging of presynaptic dopamine transporters (dat receptors) has provided a possible diagnostic probe in the evaluation of parkinson's disease. |
2003-08-15 |
2023-08-12 |
human |
| Istvan J Enyedy, Sukumar Sakamuri, Wahiduz A Zaman, Kenneth M Johnson, Shaomeng Wan. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565962. |
simple substituted pyridines were discovered as novel dopamine transporter (dat) inhibitors through pharmacophore-based 3d-database search. |
2003-08-15 |
2023-08-12 |
Not clear |
| Ling-Wei Hsin, Thomas Prisinzano, Chavon R Wilkerson, Christina M Dersch, Robert Horel, Arthur E Jacobson, Richard B Rothman, Kenner C Ric. Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565970. |
a series of optically pure phenyl-and non-phenyl-substituted 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines was synthesized and their binding affinity for dopamine transporter (dat) was investigated. |
2003-08-15 |
2023-08-12 |
Not clear |
| Louis R Lucas, Claudia A Grillo, Bruce S McEwe. Involvement of mesolimbic structures in short-term sodium depletion: in situ hybridization and ligand-binding analyses. Neuroendocrinology. vol 77. issue 6. 2003-08-15. PMID:12845226. |
however, as found previously in doca-treated rats, there were increased enkephalin (enk)-mrna and decreased dopamine transporter (dat) binding levels throughout the striatum in lasix+salt and decreased enk-mrna in lasixnosalt rats versus vehicle. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
cocaine initiates its euphoric effects by binding to the dopamine transporter (dat), blocking uptake of synaptic dopamine. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
it has been hypothesized that the dat transmembrane aspartic acid residue d79 forms an ionic interaction with charged nitrogen atoms in both dopamine and cocaine. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
we examined the consequences of novel and previously studied mutations of the d79 residue on dat uptake of [3h]dopamine, dat binding of the cocaine analog [3h]win 35,428, and drug inhibition of each process, all under identical conditions. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
the rat d79e dat mutation decreased dopamine uptake vmax by 7-fold and decreased dopamine turnover by 4-fold. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
we propose that at least two discrete inhibitor-binding dat conformations or populations exist and that the dat conformation/population responsible for inhibitor high-affinity binding is less responsible for dopamine uptake. |
2003-08-15 |
2023-08-12 |
rat |
| C J Hong, C Y Cheng, L R R Shu, C Y Yang, S J Tsa. Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 4. 2003-08-08. PMID:12658362. |
the dopamine transporter (dat) and the serotonin transporter (5-htt) play important roles in methamphetamine (meth) dependence because they are the target of meth action. |
2003-08-08 |
2023-08-12 |
Not clear |
| Mu-Fa Zou, Theresa Kopajtic, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter. Journal of medicinal chemistry. vol 46. issue 14. 2003-08-07. PMID:12825932. |
extensive structure-activity relationships at the dopamine transporter (dat) have been developed around two classes of tropane-based ligands. |
2003-08-07 |
2023-08-12 |
rat |
| Mu-Fa Zou, Theresa Kopajtic, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter. Journal of medicinal chemistry. vol 46. issue 14. 2003-08-07. PMID:12825932. |
to further investigate this hypothesis, a series of (s)-2beta-carboalkoxy-3alpha-(bis[4-fluorophenyl]methoxy)tropanes (11a-f, 13-16) and their identically (r)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes (3, 5a-d) were prepared and evaluated for binding at the dat and for inhibition of [(3)h]dopamine uptake in rat brain. |
2003-08-07 |
2023-08-12 |
rat |