| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed A Elwan, Takashi Ishii, Norio Sakuragaw. Characterization of the dopamine transporter gene expression and binding sites in cultured human amniotic epithelial cells. Neuroscience letters. vol 342. issue 1-2. 2003-07-31. PMID:12727318. |
in this study we sought to investigate whether the dopamine transporter, dat, and its binding sites are expressed in the human amniotic epithelial cells (haec) using reverse transcription-polymerase chain reaction (rt-pcr) and radioligand binding studies, respectively. |
2003-07-31 |
2023-08-12 |
human |
| Erkki Tupala, Håkan Hall, Kim Bergström, Tuija Mantere, Pirkko Räsänen, Terttu Särkioja, Jukka Hiltunen, Jari Tiihone. Different effect of age on dopamine transporters in the dorsal and ventral striatum of controls and alcoholics. Synapse (New York, N.Y.). vol 48. issue 4. 2003-07-25. PMID:12687640. |
the aim of this study was to compare putative age-related alterations of dopamine transporters (dat) in dorsal and ventral striatum of healthy controls and alcoholics. |
2003-07-25 |
2023-08-12 |
human |
| Margaret R Davis, John R Votaw, J Douglas Bremner, Michael G Byas-Smith, Tracy L Faber, Ronald J Voll, John M Hoffman, Scott T Grafton, Clinton D Kilts, Mark M Goodma. Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 44. issue 6. 2003-07-24. PMID:12791810. |
the aim of this study was to do an initial assessment of the usefulness of 2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-(18)f-fluoroethyl)nortropane ((18)f-fecnt) pet scanning in determining in vivo brain dopamine transporter (dat) density in healthy humans and subjects with parkinson's disease (pd). |
2003-07-24 |
2023-08-12 |
human |
| R Kurosaki, Y Muramatsu, H Watanabe, M Michimata, M Matsubara, Y Imai, T Arak. Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. Metabolic brain disease. vol 18. issue 2. 2003-07-24. PMID:12822832. |
we investigated the alterations of dopamine transporter (dat)-immunopositive cells against mptp neurotoxicity, in comparison with tyrosine hydroxylase (th)-immunopositive neurons and glial fibrillary acidic protein (gfap)-immunopositive cells. |
2003-07-24 |
2023-08-12 |
mouse |
| P Montagna, S Cevoli, N Marzocchi, G Pierangeli, L A Pini, P Cortelli, M Moch. The genetics of chronic headaches. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 24 Suppl 2. 2003-07-23. PMID:12811592. |
in cdh, analgesic abuse was significantly associated with specific functional polymorphisms at the drd 4 and at the dopamine transporter (dat) genes, findings implicating dopamine-related genes in cdh with drug abuse. |
2003-07-23 |
2023-08-12 |
Not clear |
| Merewyn K Loder, Haley E Melikia. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. The Journal of biological chemistry. vol 278. issue 24. 2003-07-22. PMID:12682063. |
the dopamine transporter (dat) removes dopamine from the extracellular milieu and is potently inhibited by number of psychoactive drugs, including cocaine, amphetamines, and methylphenidate (ritalin). |
2003-07-22 |
2023-08-12 |
rat |
| Merewyn K Loder, Haley E Melikia. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. The Journal of biological chemistry. vol 278. issue 24. 2003-07-22. PMID:12682063. |
multiple lines of evidence demonstrate that protein kinase c (pkc) down-regulates dopamine transport, primarily by redistributing dat from the plasma membrane to endosomal compartments, although the mechanisms facilitating transporter sequestration are not defined. |
2003-07-22 |
2023-08-12 |
rat |
| Thomas M Loonam, Pierre A H Noailles, Jing Yu, Judy P Q Zhu, Jesus A Angul. Substance P and cholecystokinin regulate neurochemical responses to cocaine and methamphetamine in the striatum. Life sciences. vol 73. issue 6. 2003-07-17. PMID:12801594. |
exposure to meth (10 mg/kg 4x at two-hour intervals) produced deficits of dopamine transporters (dat) in mice striatum that are detectable three days after the treatment and are long lasting. |
2003-07-17 |
2023-08-12 |
mouse |
| Rudolph Spangler, Noel L Goddard, Nicole M Avena, Bartley G Hoebel, Sarah F Leibowit. Elevated D3 dopamine receptor mRNA in dopaminergic and dopaminoceptive regions of the rat brain in response to morphine. Brain research. Molecular brain research. vol 111. issue 1-2. 2003-07-16. PMID:12654507. |
tissues were assayed for d1, d2 and d3 dopamine receptor mrnas (d1r, d2r and d3r), as well as for mrnas for tyrosine hydroxylase (th) and the dopamine transporter (dat). |
2003-07-16 |
2023-08-12 |
rat |
| Brian Dean, Robyn Bradbury, David Leon Copolo. Cannabis-sensitive dopaminergic markers in postmortem central nervous system: changes in schizophrenia. Biological psychiatry. vol 53. issue 7. 2003-07-11. PMID:12679236. |
this study investigated if changes in pre-synaptic markers on dopaminergic neurons (dopamine transporter [dat], tyrosine hydroxylase [th]) were present in the caudate from subjects with schizophrenia who had delta(9)(-)tetrahydrocannabinol (thc) in their blood at autopsy. |
2003-07-11 |
2023-08-12 |
human |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
phosphatidylinositol 3-kinase, protein kinase c, and mek1/2 kinase regulation of dopamine transporters (dat) require n-terminal dat phosphoacceptor sites. |
2003-07-10 |
2023-08-12 |
Not clear |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
the dopamine transporter (dat) modulates dopamine neurotransmission and is a primary target for psychostimulant influences on locomotion and reward. |
2003-07-10 |
2023-08-12 |
Not clear |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
selective dat expression by dopaminergic neurons has led to use of cocaine analog dat radioligands to assess rates of progression of dopamine neuronal degeneration in parkinson's disease. |
2003-07-10 |
2023-08-12 |
Not clear |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
pi3k and mek1/2 modulators exert strong effects on dat expression patterns and dopamine uptake vmax. |
2003-07-10 |
2023-08-12 |
Not clear |
| Jos L Venero, Mati Revuelta, Leila Atiki, Marti Santiago, Mayka C Toms-Camardiel, Josefina Cano, Alberto Machad. Evidence for dopamine-derived hydroxyl radical formation in the nigrostriatal system in response to axotomy. Free radical biology & medicine. vol 34. issue 1. 2003-07-07. PMID:12498986. |
short-term adaptive axotomy-induced changes in substantia nigra included downregulation of nigral tyrosine hydroxylase (th) and dopamine transporter (dat) mrna expression and more intense th immunoreactivity. |
2003-07-07 |
2023-08-12 |
Not clear |
| Rohit B Kolhatkar, Sujit K Ghorai, Clifford George, Maarten E A Reith, Aloke K Dutt. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine. Journal of medicinal chemistry. vol 46. issue 11. 2003-06-23. PMID:12747792. |
all novel compounds were tested for their affinity at the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in competing for the binding of [3h]win 35 428, [3h]citalopram, and [3h]nisoxetine, respectively. |
2003-06-23 |
2023-08-12 |
Not clear |
| Masanari Itokawa, Zhicheng Lin, George R Uh. Dopamine efflux via wild-type and mutant dopamine transporters: alanine substitution for proline-572 enhances efflux and reduces dependence on extracellular dopamine, sodium and chloride concentrations. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480180. |
the dopamine transporter (dat) can mediate not only inward uptake of dopamine, but also its outward efflux by mechanisms that have been only partially elucidated. |
2003-06-16 |
2023-08-12 |
Not clear |
| Masanari Itokawa, Zhicheng Lin, George R Uh. Dopamine efflux via wild-type and mutant dopamine transporters: alanine substitution for proline-572 enhances efflux and reduces dependence on extracellular dopamine, sodium and chloride concentrations. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480180. |
alanine substitutions for six proline residues located in or near dat transmembrane domains increase apparent affinity and decrease v(max) values for dopamine efflux mediated by these mutant transporters. |
2003-06-16 |
2023-08-12 |
Not clear |
| Masanari Itokawa, Zhicheng Lin, George R Uh. Dopamine efflux via wild-type and mutant dopamine transporters: alanine substitution for proline-572 enhances efflux and reduces dependence on extracellular dopamine, sodium and chloride concentrations. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480180. |
mutant 12p572a displays increased dat efflux with reduced dependence on ion or dopamine concentrations. |
2003-06-16 |
2023-08-12 |
Not clear |
| Juei-Jueng Lin, Kuo-Chu Yueh, Dar-Cheng Chang, Chung-Yao Chang, Yung-Hsiang Yeh, Shinn-Zong Li. The homozygote 10-copy genotype of variable number tandem repeat dopamine transporter gene may confer protection against Parkinson's disease for male, but not to female patients. Journal of the neurological sciences. vol 209. issue 1-2. 2003-06-16. PMID:12686408. |
we investigated the role of variable number tandem repeat (vntr) polymorphism of the dopamine transporter gene (dat) in the pathogenesis of parkinson's disease (pd) in taiwanese. |
2003-06-16 |
2023-08-12 |
Not clear |