| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurence Barrier, Guylène Page, Stéphanie Barc, Alain Piriou, Jacques Portoukalia. Sulfatide and GM1 ganglioside modulate the high-affinity dopamine uptake in rat striatal synaptosomes: evidence for the involvement of their ionic charges. Neurochemistry international. vol 42. issue 4. 2003-04-17. PMID:12470704. |
after 1h of incubation, gm1 stably bound to synaptosomes and modified the activity of the neuronal dopamine transporter (dat). |
2003-04-17 |
2023-08-12 |
rat |
| G Berding, Th Brücke, P Odin, D J Brooks, H Kolbe, P Gielow, H Harke, B O Knoop, R Dengler, W H Knap. [[123I]beta-CIT SPECT imaging of dopamine and serotonin transporters in Parkinson's disease and multiple system atrophy. Nuklearmedizin. Nuclear medicine. vol 42. issue 1. 2003-04-17. PMID:12601452. |
definition of the regional pattern of dopamine transporter (dat) dysfunction in advanced parkinson's disease (pd) and evaluation of a potential correlation between dat binding and symptoms; elucidation of the role of dat imaging in the differential diagnosis of pd and multiple system atrophy (msa); assessment and comparison of serotonin transporter (sert) binding in pd and msa. |
2003-04-17 |
2023-08-12 |
Not clear |
| Ruggero Galici, Aurelio Galli, David J Jones, Teresa A Sanchez, Christine Saunders, Alan Frazer, Georgianna G Gould, Richard Z Lin, Charles P Franc. Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats. Neuroendocrinology. vol 77. issue 2. 2003-04-11. PMID:12624535. |
the dopamine transporter (dat) regulates extracellular dopamine da levels and is an important site of action for amphetamine and cocaine. |
2003-04-11 |
2023-08-12 |
rat |
| Mark M Goodman, Ping Chen, Christophe Plisson, Laurent Martarello, James Galt, John R Votaw, Clinton D Kilts, Gene Malveaux, Vernon M Camp, Bing Shi, Timothy D Ely, Leonard Howell, Jon McConathy, Charles B Nemerof. Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography. Journal of medicinal chemistry. vol 46. issue 6. 2003-04-07. PMID:12620070. |
competition binding in cells stably expressing the transfected human sert, dopamine transporter (dat), and norepinephrine transporter (net) using [(3)h]citalopram, [(3)h]win 35,428, and [(3)h]nisoxetine, respectively, demonstrated the following order of sert affinity (k(i) in nm): zient (0.05) > nor-cit (0.12) >> eient (1.15) > fluvoxamine (1.46). |
2003-04-07 |
2023-08-12 |
human |
| A Antonini, R M Moresco, C Gobbo, R De Notaris, A Panzacchi, P Barone, V Bonifati, G Pezzoli, F Fazi. Striatal dopaminergic denervation in early and late onset Parkinson's disease assessed by PET and the tracer [11C]FECIT: preliminary findings in one patient with autosomal recessive parkinsonism (Park2). Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 23 Suppl 2. 2003-03-28. PMID:12548339. |
neuroimaging studies of striatal dopamine transporters (dat) have shown that this measurement is a specific marker of dopaminergic degeneration in patients with parkinson's disease. |
2003-03-28 |
2023-08-12 |
human |
| Yossef Itzhak, Julio L Martin, Syed F Al. Methamphetamine-induced dopaminergic neurotoxicity in mice: long-lasting sensitization to the locomotor stimulation and desensitization to the rewarding effects of methamphetamine. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 6. 2003-03-26. PMID:12452543. |
the administration of the high dose of meth resulted in significant depletion of dopamine (da) and its metabolites and dopamine transporter (dat) binding sites in the striatum. |
2003-03-26 |
2023-08-12 |
mouse |
| Toshihiro Dohi, Shigeo Kitayama, Key Kumagai, Wataru Hashimoto, Katsuya Morit. [Pharmacology of monoamine neurotransmitter transporters]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 120. issue 5. 2003-03-12. PMID:12491807. |
following exocytotic release, the biogenic amine neurotransmitters, norepinephrine, dopamine, and serotonin are removed from the synaptic cleft by the respective transporter, net, dat, and sert, located on the plasma membrane and then re-stored into synaptic vesicles by vesicular monoamine transporter, vmat. |
2003-03-12 |
2023-08-12 |
Not clear |
| Päivi Marjamäki, Jörg Zessin, Olli Eskola, Tove Grönroos, Merja Haaparanta, Jörgen Bergman, Pertti Lehikoinen, Sarita Forsback, Peter Brust, Jörg Steinbach, Olof Soli. S-[18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats. Synapse (New York, N.Y.). vol 47. issue 1. 2003-03-07. PMID:12422372. |
gbr12909 and nisoxetine, selective inhibitors for dopamine transporter (dat) and norepinephrine transporter (net), respectively, showed no significant effects on the uptake of [(18)f]fme-mcn. |
2003-03-07 |
2023-08-12 |
rat |
| Peter C Meltzer, Shanghao Liu, Heather Blanchette, Paul Blundell, Bertha K Madra. Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. Bioorganic & medicinal chemistry. vol 10. issue 11. 2003-03-04. PMID:12213473. |
the search for a functional antagonist to the addictive properties of cocaine has focused on the discovery of a molecule that can inhibit cocaine binding to the dopamine transporter (dat) but continue to allow dopamine transport by the dat. |
2003-03-04 |
2023-08-12 |
Not clear |
| Peter C Meltzer, Shanghao Liu, Heather Blanchette, Paul Blundell, Bertha K Madra. Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. Bioorganic & medicinal chemistry. vol 10. issue 11. 2003-03-04. PMID:12213473. |
a unique approach is utilized to deliver an inhibitor that binds irreversibly to the dat, then cleaves and leaves behind a small fragment attached to the dat that blocks access by cocaine but permits dopamine transport. |
2003-03-04 |
2023-08-12 |
Not clear |
| Peter C Meltzer, Shanghao Liu, Heather Blanchette, Paul Blundell, Bertha K Madra. Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. Bioorganic & medicinal chemistry. vol 10. issue 11. 2003-03-04. PMID:12213473. |
this concept of a mechanism based irreversible dopamine-sparing cocaine antagonist has now been demonstrated to be viable and, as example, the unsaturated 6 showed inhibition of cocaine (63%) at the dat after 24h incubation, while at that point considerably less inhibition of dopamine is manifested (23%). |
2003-03-04 |
2023-08-12 |
Not clear |
| Gonzalo E Torres, Ana Carneiro, Katie Seamans, Chiara Fiorentini, Ava Sweeney, Wei-Dong Yao, Marc G Caro. Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter. The Journal of biological chemistry. vol 278. issue 4. 2003-03-04. PMID:12429746. |
the dopamine transporter (dat) is a presynaptic plasma membrane protein responsible for the termination of dopaminergic neurotransmission in the central nervous system. |
2003-03-04 |
2023-08-12 |
human |
| R H Segman, R Cooper-Kazaz, F Macciardi, T Goltser, Y Halfon, T Dobroborski, A Y Shale. Association between the dopamine transporter gene and posttraumatic stress disorder. Molecular psychiatry. vol 7. issue 8. 2003-02-25. PMID:12232785. |
given previous findings of abnormal dopamine (da) function in ptsd, and given the putative effect of dopamine neurotransmission in shaping the responses to stress in animals, this study examined the association of the dopamine transporter (dat) slc6a3 3' variable number tandem repeat (vntr) polymorphism with ptsd. |
2003-02-25 |
2023-08-12 |
Not clear |
| John Votaw, Michael Byas-Smith, Jian Hua, Ronald Voll, Laurent Martarello, Allan I Levey, F DuBois Bowman, Mark Goodma. Interaction of isoflurane with the dopamine transporter. Anesthesiology. vol 98. issue 2. 2003-02-25. PMID:12552200. |
because the dopamine transporter (dat) is a key regulator of da, it is likely affected by isoflurane. |
2003-02-25 |
2023-08-12 |
Not clear |
| Stefan Paula, Michael R Tabet, Susan M Keenan, William J Welsh, W James Bal. Three-dimensional structure-activity relationship modeling of cocaine binding to two monoclonal antibodies by comparative molecular field analysis. Journal of molecular biology. vol 325. issue 3. 2003-02-19. PMID:12498800. |
furthermore, using previously published data, a 3d-qsar model was developed for cocaine binding to the dopamine reuptake transporter (dat) that was compared to the mab models. |
2003-02-19 |
2023-08-12 |
Not clear |
| Hideo Saji, Yasuhiko Iida, Hidekazu Kawashima, Mikako Ogawa, Youji Kitamura, Takahiro Mukai, Seiichiro Shimazu, Fumiro Yoned. In vivo imaging of brain dopaminergic neurotransmission system in small animals with high-resolution single photon emission computed tomography. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 19. issue 1. 2003-02-13. PMID:12558026. |
thus, we applied the high-resolution spect to in vivo imaging of the brain dopaminergic neurotransmission system in common marmosets using two radiolabeled ligands, [123i]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane (beta-cit) as a dopamine transporter (dat) ligand and [123i]iodobenzamide (ibzm) as a dopamine d2 receptor (d2r) ligand. |
2003-02-13 |
2023-08-12 |
Not clear |
| M K Hahn, R D Blakel. Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. The pharmacogenomics journal. vol 2. issue 4. 2003-02-10. PMID:12196911. |
the norepinephrine, dopamine and serotonin transporters (net, dat and sert, respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as targets for antidepressants and drugs of abuse, emphasizing the integral role these molecules play in neurotransmission and pathology. |
2003-02-10 |
2023-08-12 |
human |
| Bruce R Stevens, Daniel H Feldman, Zhilin Liu, William R Harve. Conserved tyrosine-147 plays a critical role in the ligand-gated current of the epithelial cation/amino acid transporter/channel CAATCH1. The Journal of experimental biology. vol 205. issue Pt 16. 2003-02-07. PMID:12124378. |
this tyrosine residue is conserved within the third transmembrane domain in members of the na(+):neurotransmitter transporter family (snf), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (sert), dopamine (dat) and norepinephrine (net) transporters. |
2003-02-07 |
2023-08-12 |
xenopus_laevis |
| Masami Nakai, Atsushi Mori, Akihito Watanabe, Yasuhide Mitsumot. 1-methyl-4-phenylpyridinium (MPP+) decreases mitochondrial oxidation-reduction (REDOX) activity and membrane potential (Deltapsi(m)) in rat striatum. Experimental neurology. vol 179. issue 1. 2003-01-30. PMID:12504872. |
at this time point, tyrosine hydroxylase (th) and dopamine transporter (dat) protein levels were not altered, but both decreased at 7 days after mpp+ (40 nmol) infusion. |
2003-01-30 |
2023-08-12 |
rat |
| Masami Nakai, Atsushi Mori, Akihito Watanabe, Yasuhide Mitsumot. 1-methyl-4-phenylpyridinium (MPP+) decreases mitochondrial oxidation-reduction (REDOX) activity and membrane potential (Deltapsi(m)) in rat striatum. Experimental neurology. vol 179. issue 1. 2003-01-30. PMID:12504872. |
in addition, gbr-12909 partially attenuated mpp+ (40 nmol)-caused a loss of striatal nerve terminal as indicated by decreases in th and dat immunoreactivities as well as dopamine and its metabolites levels. |
2003-01-30 |
2023-08-12 |
rat |