| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Davide Viggiano, Lucia A Ruocco, Adolfo G Sadil. Dopamine phenotype and behaviour in animal models: in relation to attention deficit hyperactivity disorder. Neuroscience and biobehavioral reviews. vol 27. issue 7. 2004-01-15. PMID:14624807. |
therefore, the behavioural profile of dopamine transporter (dat), tyrosine hydroxylase (th), da and camp-regulated phosphoprotein (darpp 32), and d1, d2, d3, d4 and d5 dopamine receptors knockouts (and their combination) is reviewed.th, d1, d2, d4 ko mice exhibit decreased locomotor activity, perhaps due to decreased motivational level. |
2004-01-15 |
2023-08-12 |
mouse |
| Davide Viggiano, Lucia A Ruocco, Adolfo G Sadil. Dopamine phenotype and behaviour in animal models: in relation to attention deficit hyperactivity disorder. Neuroscience and biobehavioral reviews. vol 27. issue 7. 2004-01-15. PMID:14624807. |
it is possible that the increased dopamine levels in dat ko mice enhance motivation. |
2004-01-15 |
2023-08-12 |
mouse |
| Xiao-qing Xi, Ren-yuan Chu, Xing-tao Zhou, Yi Lu, Xing-dang Li. [Studies of retinal dopamine transporter in experimental myopia]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. vol 39. issue 6. 2004-01-12. PMID:12895363. |
to investigate the distribution of dopamine transporter (dat) in the chicken eye and to explore the role of dat in the occurrence of experimental myopia. |
2004-01-12 |
2023-08-12 |
chicken |
| Susan M Learned-Coughlin, Mats Bergström, Irina Savitcheva, John Ascher, Virginia D Schmith, Bengt Långstro. In vivo activity of bupropion at the human dopamine transporter as measured by positron emission tomography. Biological psychiatry. vol 54. issue 8. 2004-01-12. PMID:14550679. |
converging lines of evidence are consistent with an inhibitory effect of the antidepressant and smoking-cessation aid bupropion on dopamine and norepinephrine reuptake, but the in vivo effects of the drug at the human dopamine transporter (dat) have not been studied to date. |
2004-01-12 |
2023-08-12 |
human |
| D J Brooks, K A Frey, K L Marek, D Oakes, D Paty, R Prentice, C W Shults, A J Stoess. Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease. Experimental neurology. vol 184 Suppl 1. 2004-01-08. PMID:14597329. |
one approach, which has been extensively explored, is neuroimaging with radiotracers that interact with processes central to dopaminergic neurotransmission in the nigrostriatal dopaminergic axons-conversion of levodopa to dopamine through aromatic amino acid decarboxylase (aadc), [(18)f]fluorodopa pet, storage of dopamine in synaptic vesicles via the vesicular monoamine transporter 2 (vmat2), (+)-[(11)c]dihydrotetrabenazine pet, and reuptake of dopamine into axons via the dopamine transporter (dat), [(123)i]beta-cit spect, and a number of other pet and spect ligands. |
2004-01-08 |
2023-08-12 |
human |
| Cecilia T Giambalvo, Lawrence H Pric. Effects of fenfluramine and antidepressants on protein kinase C activity in rat cortical synaptoneurosomes. Synapse (New York, N.Y.). vol 50. issue 3. 2004-01-06. PMID:14515339. |
unlike d-fenfluramine, the d/l-fenfluramine-induced increase in pkc activity was partially resistant to pcpa pretreatment but was attenuated with bupropion, a dopamine transporter (dat) inhibitor. |
2004-01-06 |
2023-08-12 |
rat |
| A Antonini, R Benti, R De Notaris, S Tesei, A Zecchinelli, G Sacilotto, N Meucci, M Canesi, C Mariani, G Pezzoli, P Gerundin. 123I-Ioflupane/SPECT binding to striatal dopamine transporter (DAT) uptake in patients with Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 24. issue 3. 2004-01-06. PMID:14598060. |
123i-ioflupane/spect binding to striatal dopamine transporter (dat) uptake in patients with parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. |
2004-01-06 |
2023-08-12 |
human |
| A Antonini, R Benti, R De Notaris, S Tesei, A Zecchinelli, G Sacilotto, N Meucci, M Canesi, C Mariani, G Pezzoli, P Gerundin. 123I-Ioflupane/SPECT binding to striatal dopamine transporter (DAT) uptake in patients with Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 24. issue 3. 2004-01-06. PMID:14598060. |
we used spect and the tracer (123)i-ioflupane to measure dopamine transporter (dat) binding in the caudate nucleus and the putamen of 70 patients with parkinson's disease (pd), 10 with multiple system atrophy (msa-p type), and 10 with progressive supranuclear palsy (psp). |
2004-01-06 |
2023-08-12 |
human |
| A Antonini, R Benti, R De Notaris, S Tesei, A Zecchinelli, G Sacilotto, N Meucci, M Canesi, C Mariani, G Pezzoli, P Gerundin. 123I-Ioflupane/SPECT binding to striatal dopamine transporter (DAT) uptake in patients with Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 24. issue 3. 2004-01-06. PMID:14598060. |
our results confirm that dat binding can provide an accurate and highly sensitive measure of dopamine degeneration. |
2004-01-06 |
2023-08-12 |
human |
| Xilu Jiao, William P Paré, Shanaz Tejani-But. Strain differences in the distribution of dopamine transporter sites in rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 6. 2004-01-05. PMID:14499307. |
since the mesolimbic dopamine (da) system is involved in cognitive, emotional, and motivational behaviors, this study examined the distribution of dopamine transporter (dat) sites in the brains of wky compared to wistar (wis) and s-d rats. |
2004-01-05 |
2023-08-12 |
rat |
| Hanne Hastrup, Namita Sen, Jonathan A Javitc. The human dopamine transporter forms a tetramer in the plasma membrane: cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:14519759. |
using cysteine cross-linking, we demonstrated previously that the dopamine transporter (dat) is at least a homodimer, with the extracellular end of transmembrane segment (tm) 6 at a symmetrical dimer interface. |
2003-12-24 |
2023-08-12 |
human |
| Hanne Hastrup, Namita Sen, Jonathan A Javitc. The human dopamine transporter forms a tetramer in the plasma membrane: cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:14519759. |
in contrast, two substrates of dat, dopamine and tyramine, did not significantly impact cross-linking. |
2003-12-24 |
2023-08-12 |
human |
| Christian A Heidbreder, Massimiliano Bianchi, Laurent P Lacroix, Stefania Faedo, Elisabetta Perdona, Rosaria Remelli, Paolo Cavanni, Francesco Cresp. Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo. Synapse (New York, N.Y.). vol 50. issue 4. 2003-12-19. PMID:14556231. |
accordingly, we first examined the potency of mpep to bind to or inhibit uptake at the net as well as the dopamine and serotonin transporters (dat and sert, respectively). |
2003-12-19 |
2023-08-12 |
human |
| Simone M Smits, Tiia Ponnio, Orla M Conneely, J Peter H Burbach, Marten P Smid. Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. The European journal of neuroscience. vol 18. issue 7. 2003-12-19. PMID:14622207. |
neonatal nurr1 knockout mice lack expression of the dopamine transporter (dat), the vesicular monoamine transporter 2 (vmat2) and l-aromatic amino acid decarboxylase (aadc) in addition to th specifically in mesda neurons. |
2003-12-19 |
2023-08-12 |
mouse |
| Iwona E Misiuta, Lynn Anderson, Michael P McGrogan, Paul R Sanberg, Alison E Willing, Tanja Zigov. The transcription factor Nurr1 in human NT2 cells and hNT neurons. Brain research. Developmental brain research. vol 145. issue 1. 2003-12-16. PMID:14519498. |
our previous in vitro experiments showed that hnt cells possess immunocytochemically detectable markers typical of dopaminergic (da) ventral mesencephalic (vm) neurons, including tyrosine hydroxylase (th), dopamine transporter (dat), dopamine receptor (d2), and aldehyde dehydrogenase (ahd-2). |
2003-12-16 |
2023-08-12 |
human |
| Limen Chi, Maarten E A Reit. Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975490. |
dopamine transporter (dat) trafficking was assessed by functional measurements of dopamine uptake and by biotinylation of surface proteins followed by gel electrophoresis and western blotting. |
2003-12-10 |
2023-08-12 |
human |
| Limen Chi, Maarten E A Reit. Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975490. |
in human embryonic kidney (hek)-293 cells expressing human dat (hek-hdat), pretreatment with dopamine (0.1-100 microm) followed by washout caused reductions in subsequent dopamine uptake (reflected in vmax) with effective dopamine concentrations in the 10 to 100 microm range and pretreatment times of 10 to 60 min. |
2003-12-10 |
2023-08-12 |
human |
| Limen Chi, Maarten E A Reit. Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975490. |
reductions assessed after 60-min pretreatment with 100 microm dopamine corresponded with decreases measured in surface dat by the noncleavable biotin method, which were caused, at least in part, by enhanced endocytosis as monitored with cleavable biotin. |
2003-12-10 |
2023-08-12 |
human |
| Limen Chi, Maarten E A Reit. Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975490. |
pretreatment of rat striatal synaptosomes with dopamine (10 and 100 microm) also caused reductions in dat uptake activity (vmax), and again the underlying mechanism seemed to be a diminished presence of dat at the surface of synaptosomes as measured by the noncleavable biotin method. |
2003-12-10 |
2023-08-12 |
human |
| Limen Chi, Maarten E A Reit. Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975490. |
the copresence of cocaine during pretreatment with dopamine prevented the down-regulation of surface dat. |
2003-12-10 |
2023-08-12 |
human |