| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lijuan C Wang, Xiao-Nan Cui, Nianhang Chen, Maarten E A Reit. Binding of cocaine-like radioligands to the dopamine transporter at 37 degrees C: effect of Na+ and substrates. Journal of neuroscience methods. vol 131. issue 1-2. 2004-03-01. PMID:14659820. |
although dopamine (da) translocation by the da transporter (dat) requires na+, a role for na+ in the da recognition step in the translocation cycle has been questioned. |
2004-03-01 |
2023-08-12 |
human |
| Jun Zhu, Thomas Green, Michael T Bardo, Linda P Dwoski. Environmental enrichment enhances sensitization to GBR 12935-induced activity and decreases dopamine transporter function in the medial prefrontal cortex. Behavioural brain research. vol 148. issue 1-2. 2004-03-01. PMID:14684252. |
the present study determined whether environmental enrichment differentially alters the effects of gbr 12935 administration, a selective dopamine transporter (dat) inhibitor. |
2004-03-01 |
2023-08-12 |
rat |
| Jun Zhu, Thomas Green, Michael T Bardo, Linda P Dwoski. Environmental enrichment enhances sensitization to GBR 12935-induced activity and decreases dopamine transporter function in the medial prefrontal cortex. Behavioural brain research. vol 148. issue 1-2. 2004-03-01. PMID:14684252. |
kinetic analysis of dat function in medial prefrontal cortex (mpfc) revealed that the maximal velocity of [3h]dopamine ([3h]da) uptake in ec rats was less than in ic rats (4.9 +/- 0.6 and 7.7 +/- 0.6 pmol/min/mg, respectively), but not in striatum or nucleus accumbens. |
2004-03-01 |
2023-08-12 |
rat |
| Ramona M Rodriguiz, Richard Chu, Marc G Caron, William C Wetse. Aberrant responses in social interaction of dopamine transporter knockout mice. Behavioural brain research. vol 148. issue 1-2. 2004-03-01. PMID:14684259. |
the dopamine (da) transporter (dat) controls the temporal and spatial resolution of dopaminergic neurotransmission. |
2004-03-01 |
2023-08-12 |
mouse |
| Yolanda Mateo, Evgeny A Budygin, Carrie E John, Sara R Jone. Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 1. 2004-02-25. PMID:14691264. |
it is generally accepted that the ability of cocaine to inhibit the dopamine transporter (dat) is directly related to its reinforcing actions. |
2004-02-25 |
2023-08-12 |
mouse |
| R Kaiser, A Hofer, A Grapengiesser, T Gasser, A Kupsch, I Roots, J Brockmölle. L -dopa-induced adverse effects in PD and dopamine transporter gene polymorphism. Neurology. vol 60. issue 11. 2004-02-24. PMID:12796525. |
to assess whether polymorphisms in the dopamine receptor genes and in the dopamine transporter gene (dat ) are predictors of adverse effects of l -dopa. |
2004-02-24 |
2023-08-12 |
Not clear |
| Y Muramatsu, R Kurosaki, H Watanabe, M Michimata, M Matsubara, Y Imai, T Arak. Cerebral alterations in a MPTP-mouse model of Parkinson's disease--an immunocytochemical study. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 10. 2004-02-12. PMID:14523625. |
we investigated the immunohistochemical alterations of neuronal nitric oxide synthase (nnos), endothelial nos (enos), tyrosine hydroxylase (th), microtubule-associated protein 2a,b (map 2), glial fibrillary acidic protein (gfap), parvalbumin (pv), and dopamine transporter (dat) in the striatum and substantia nigra following the application of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in mice. |
2004-02-12 |
2023-08-12 |
mouse |
| Lisa S Middleton, Wayne A Cass, Linda P Dwoski. Nicotinic receptor modulation of dopamine transporter function in rat striatum and medial prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 308. issue 1. 2004-02-11. PMID:14563785. |
nicotine activates nicotinic acetylcholine receptors (nachrs) on dopamine (da) terminals to evoke da release, which subsequently is taken back up into the terminal via the da transporter (dat). |
2004-02-11 |
2023-08-12 |
rat |
| Wynne K Schiffer, Jean Logan, Stephen L Dewe. Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 12. 2004-02-10. PMID:12888780. |
in addition, we explored the hypotheses that gabaergic pathways as well as molecular targets beyond the n-methyl-d-aspartate (nmda) receptor complex (ie dopamine transporter proteins, dat) contribute to pcp's effects. |
2004-02-10 |
2023-08-12 |
Not clear |
| Joshua M Gulley, Brian R Hoover, Gaynor A Larson, Nancy R Zahnise. Individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 12. 2004-02-10. PMID:12902997. |
concomitant measurement of dopamine clearance in these rats revealed that the differential behavioral responses are associated with the magnitude of dopamine transporter (dat) inhibition by cocaine. |
2004-02-10 |
2023-08-12 |
rat |
| Barbara K Lipska, Daniel N Lerman, Zin Z Khaing, Daniel R Weinberge. The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrain. The European journal of neuroscience. vol 18. issue 11. 2004-01-29. PMID:14656305. |
we used in situ hybridization histochemistry to assess expression of mrnas for dopamine transporter (dat), tyrosine hydroxylase (th) and glutamate decarboxylase-67 (gad67) in the midbrain of adult rats with neonatal and adult ibotenic acid lesions of the ventral hippocampus. |
2004-01-29 |
2023-08-12 |
human |
| David R Lynch, P David Mozley, Set Sokol, Nicole M C Maas, Laura J Balcer, Andrew D Siderow. Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT-1 in striatum of asymptomatic volunteers and patients with Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 18. issue 7. 2004-01-28. PMID:12815660. |
we tested whether polymorphisms in the genes for catechol-o-methyltransferase (comt), monoamine-oxidase b (mao-b), and the dopamine transporter (dat) influence dopamine uptake parameters in the striatum in vivo in asymptomatic volunteers and patients with pd as measured with (99)tc-trodat-1. |
2004-01-28 |
2023-08-12 |
human |
| Valérie Cochen, Maria-Joao Ribeiro, Jean-Paul Nguyen, Jean-Marc Gurruchaga, Gabriel Villafane, Christian Loc'h, Gilles Defer, Yves Samson, Marc Peschanski, Philippe Hantraye, Pierre Cesaro, Philippe Rem. Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue. Movement disorders : official journal of the Movement Disorder Society. vol 18. issue 8. 2004-01-28. PMID:12889084. |
we compared the striatal uptake of [(18)f]fluorodopa with [(76)br]-fe-cbt, a positron emission tomography (pet) ligand of the dopamine transporter (dat), which estimates the density of dopamine nerve terminals, in 6 patients with parkinson's disease grafted with fetal mesencephalic cells. |
2004-01-28 |
2023-08-12 |
Not clear |
| Jaturaporn Chagkutip, Roxanne A Vaughan, Piyarat Govitrapong, Manuchair Ebad. 1-Methyl-4-phenylpyridinium-induced down-regulation of dopamine transporter function correlates with a reduction in dopamine transporter cell surface expression. Biochemical and biophysical research communications. vol 311. issue 1. 2004-01-21. PMID:14575693. |
we have shown that dopamine transporter (dat) is required for mpp(+)-mediated cytotoxicity in hek-293 cells stably transfected with human dat. |
2004-01-21 |
2023-08-12 |
human |
| Benoit Gagné, Sylvie Gélinas, Geneviève Bureau, Bruno Lagacé, Charles Ramassamy, Keith Chiasson, Barbara Valastro, Maria-Grazia Martinol. Effects of estradiol, phytoestrogens, and Ginkgo biloba extracts against 1-methyl-4-phenyl-pyridine-induced oxidative stress. Endocrine. vol 21. issue 1. 2004-01-20. PMID:12777708. |
western blot analysis demonstrated that mpp+ injuries might modulate dopamine transporter (dat) protein expression but not estrogen receptor beta (erbeta) protein expression. |
2004-01-20 |
2023-08-12 |
Not clear |
| Juan E Ferrario, Marina A Delfino, Andrea V Stefano, Virginia Zbarsky, Aicha Douhou, M Gustavo Murer, Rita Raisman-Vozari, Oscar S Gershani. Effects of orally administered levodopa on mesencephalic dopaminergic neurons undergoing a degenerative process. Neuroscience research. vol 47. issue 4. 2004-01-16. PMID:14630347. |
no significant differences between levodopa or vehicle-treated rats were found in: (i) striatal immunoautoradiographic labeling for tyrosine hydroxylase (th) and the membrane dopamine transporter (dat); (ii) cell counts of th-immunoreactive (th-ir) neurons remaining in the substantia nigra and ventral tegmental area (vta); (iii) surface area of remaining th-immunoreactive neurons in the substantia nigra. |
2004-01-16 |
2023-08-12 |
rat |
| Aurelio Orjales, Ramón Mosquera, Antonio Toledo, M Carmen Pumar, Neftalí García, Lourdes Cortizo, Luis Labeaga, Ana Innerárit. Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters. Journal of medicinal chemistry. vol 46. issue 25. 2004-01-16. PMID:14640559. |
some of these racemic mixtures were resolved to their enantiomers and tested for binding to norepinephrine (ne) transporter (net), dopamine (da) transporter (dat), and alpha(2) receptor. |
2004-01-16 |
2023-08-12 |
Not clear |
| Chin-Chang Huang, Yi-Hsin Weng, Chin-Song Lu, Nai-Shin Chu, Tzu-Chen Ye. Dopamine transporter binding in chronic manganese intoxication. Journal of neurology. vol 250. issue 11. 2004-01-16. PMID:14648150. |
(99m)tc-trodat-1 is a cocaine analogue that can bind to the dopamine transporter (dat) site reflecting the function of presynaptic dopaminergic terminals. |
2004-01-16 |
2023-08-12 |
human |
| Klaus Henning Krause, Stefan H Dresel, Johanna Krause, Christian la Fougere, Manfred Ackenhei. The dopamine transporter and neuroimaging in attention deficit hyperactivity disorder. Neuroscience and biobehavioral reviews. vol 27. issue 7. 2004-01-15. PMID:14624805. |
for instance, dopaminergic psychostimulants, the drugs of first choice in adhd, interact directly with the dopamine transporter (dat). |
2004-01-15 |
2023-08-12 |
Not clear |
| J M Swanson, N D Volko. Serum and brain concentrations of methylphenidate: implications for use and abuse. Neuroscience and biobehavioral reviews. vol 27. issue 7. 2004-01-15. PMID:14624806. |
when used to treat children with attention deficit hyperactivity disorder, methylphenidate (mph) acts primarily by blocking the dopamine (da) transporter (dat) and increasing extracellular da in the striatum. |
2004-01-15 |
2023-08-12 |
Not clear |