| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deborah Pareto, Albert Cot, Javier Pavía, Carles Falcón, Ignacio Juvells, Francisco Lomeña, Domènec Ro. Iterative reconstruction with correction of the spatially variant fan-beam collimator response in neurotransmission SPET imaging. European journal of nuclear medicine and molecular imaging. vol 30. issue 10. 2004-07-02. PMID:12845485. |
the dopamine transporter (dat) has been shown to be a sensitive indicator of nigrostriatal dopamine function. |
2004-07-02 |
2023-08-12 |
Not clear |
| Kimberly P Lindsey, Kristin M Wilcox, John R Votaw, Mark M Goodman, Christophe Plisson, F Ivy Carroll, Kenner C Rice, Leonard L Howel. Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging. The Journal of pharmacology and experimental therapeutics. vol 309. issue 3. 2004-07-01. PMID:14982963. |
the dopamine transporter (dat) is a critical recognition site for cocaine and contributes to its significant abuse liability. |
2004-07-01 |
2023-08-12 |
human |
| Kimberly P Lindsey, Kristin M Wilcox, John R Votaw, Mark M Goodman, Christophe Plisson, F Ivy Carroll, Kenner C Rice, Leonard L Howel. Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging. The Journal of pharmacology and experimental therapeutics. vol 309. issue 3. 2004-07-01. PMID:14982963. |
the drugs studied included a selective dat inhibitor, [1-(2[bis(4-fluorophenyl-) methoxy]ethyl)-4-(3-phenylpropyl)piperazine] bimesylate hydrate (gbr 12909); an inhibitor with equal potency at dopamine and norepinephrine transporters, [3beta-(4-chlorophenyl)tropane-2beta-(3-phenylisoxazol-5-yl)] hcl (rti-177); and a nonselective inhibitor of dopamine, norepinephrinem and serotonin transporters, [(-)-3beta-(3'-methyl-4-chlorophenyl)tropane-2beta-carboxylic acid methyl ester] tartrate (rti-112). |
2004-07-01 |
2023-08-12 |
human |
| R H Segman, T Goltser, U Heresco-Levy, B Finkel, R Shalem, M Schlafman, A Yakir, D Greenberg, R Strous, A Lerner, A Shelevoy, B Lere. Association of dopaminergic and serotonergic genes with tardive dyskinesia in patients with chronic schizophrenia. The pharmacogenomics journal. vol 3. issue 5. 2004-06-29. PMID:14583797. |
we examined three polymorphisms in the dopamine d2 receptor gene (drd2), two sites in the 3' region of the dopamine transporter (dat) gene, two sites in the promoter and coding region of the dopamine d4 (drd4) receptor gene, as well as polymorphic sites in the serotonin 6 receptor gene, the serotonin transporter gene and the tryptophan hydroxylase gene, for association with td susceptibility. |
2004-06-29 |
2023-08-12 |
Not clear |
| Trent J Volz, M Kim, James O Schen. Covalent and noncovalent chemical modifications of arginine residues decrease dopamine transporter activity. Synapse (New York, N.Y.). vol 52. issue 4. 2004-06-24. PMID:15103693. |
rotating disk electrode voltammetry was used to measure dopamine (da) transport in rat striatum and in human embryonic kidney cells expressing the rat dopamine transporter (dat). |
2004-06-24 |
2023-08-12 |
human |
| Anita Sidhu, Christophe Wersinger, Philippe Vernie. alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease. FEBS letters. vol 565. issue 1-3. 2004-06-23. PMID:15135042. |
here, we review a vital role of alpha-synuclein in the modulation of dopamine transporter (dat) function, and describe how disruption of this modulatory process permits increased re-uptake of high levels of intracellular dopamine by dat, causing profound neurotoxicity. |
2004-06-23 |
2023-08-12 |
Not clear |
| Michael W Jakowec, Kerry Nixon, Elizabeth Hogg, Tom McNeill, Giselle M Petzinge. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. Journal of neuroscience research. vol 76. issue 4. 2004-06-21. PMID:15114626. |
the purpose of this study was to analyze proteins and mrna transcripts of genes involved in dopamine biosynthesis (tyrosine hydroxylase; th) and uptake (dopamine transporter; dat) with regard to time course (7-90 days) after mptp lesioning. |
2004-06-21 |
2023-08-12 |
mouse |
| Michael W Jakowec, Kerry Nixon, Elizabeth Hogg, Tom McNeill, Giselle M Petzinge. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. Journal of neuroscience research. vol 76. issue 4. 2004-06-21. PMID:15114626. |
these results suggest that th and dat may differ in their time course of expression in surviving dopaminergic neurons and may play a role in mediating the return of striatal dopamine. |
2004-06-21 |
2023-08-12 |
mouse |
| Ruth Reeves, Mona Thiruchelvam, Eric K Richfield, Deborah A Cory-Slecht. Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon. Pharmacology, biochemistry, and behavior. vol 76. issue 2. 2004-06-18. PMID:14592684. |
tdf induction/expression of behavioral sensitization was associated with long-term, perhaps permanent modulation of dopaminergic function that included increases in striatal dihydroxyphenylacetic acid (dopac) and da turnover, increases in medial prefrontal cortex (mpfc) dopamine transporter (dat) binding, as well as decreases in da d1 and increases in da d2 and dat receptor binding that appeared to target the nucleus accumbens shell (nas) subregion. |
2004-06-18 |
2023-08-12 |
mouse |
| Anthony J Baucum, Kristi S Rau, Evan L Riddle, Glen R Hanson, Annette E Fleckenstei. Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 13. 2004-06-18. PMID:15056723. |
multiple high-dose administrations of methamphetamine (meth) both rapidly (within hours) decrease plasmalemmal dopamine (da) uptake and cause long-term deficits in da transporter (dat) levels and other dopaminergic parameters persisting weeks to months in rat striatum. |
2004-06-18 |
2023-08-12 |
rat |
| Michael Byas-Smith, John Votaw, Jian Hua, Ronald Voll, Laurent Martarello, Allan I Levey, Mark Goodma. Phenylephrine and norepinephrine increase dopamine transporter ligand binding in striatum. Molecular imaging and biology. vol 5. issue 4. 2004-06-15. PMID:14499136. |
8-(2-[18f]fluoroethyl)-2 beta-carbomethoxy-3beta-(4-chlorophenyl)nortropane ([18f]fecnt) is a radiotracer for positron emission tomography (pet) used to trace the location and binding potential (bp) of the dopamine transporter (dat). |
2004-06-15 |
2023-08-12 |
Not clear |
| Christophe Wersinger, Philippe Vernier, Anita Sidh. Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant. Biochemistry. vol 43. issue 5. 2004-06-08. PMID:14756560. |
trypsin increased dopamine uptake in rat primary mesencephalic neurons, suggesting that dat activity is also subjected to modulation by alpha-synuclein in these neurons that endogenously coexpress both proteins. |
2004-06-08 |
2023-08-12 |
human |
| Karen Minzer, Olivia Lee, John J Hong, Harvey S Singe. Increased prefrontal D2 protein in Tourette syndrome: a postmortem analysis of frontal cortex and striatum. Journal of the neurological sciences. vol 219. issue 1-2. 2004-06-04. PMID:15050438. |
samples from caudate, putamen, ventral striatum, and prefrontal cortex (brodmann's area 9, ba9) were analyzed by semiquantitative immunoblotting for relative densities of dopamine receptors (d1, d2), transporter (dat), monoamine terminals (vesicular monoamine transporter type 2), vesicular docking and release proteins (vamp-2, synaptotagmin, snap-25, syntaxin, synaptophysin), and receptors inhibiting dopamine release (alpha 2-adrenergic receptors, alpha-2a). |
2004-06-04 |
2023-08-12 |
human |
| Nianhang Chen, Juan Zhen, Maarten E A Reit. Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine. Journal of neurochemistry. vol 89. issue 4. 2004-06-04. PMID:15140185. |
the different psychomotor-stimulant effects of cocaine, gbr12909, and benztropine may partially stem from their different molecular actions on the dopamine transporter (dat). |
2004-06-04 |
2023-08-12 |
Not clear |
| Christer Halldin, Nina Erixon-Lindroth, Stefan Pauli, Yuan-Hwa Chou, Yoshiro Okubo, Per Karlsson, Camilla Lundkvist, Hans Olsson, Denis Guilloteau, Patrick Emond, Lars Fard. [(11)C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain. European journal of nuclear medicine and molecular imaging. vol 30. issue 9. 2004-06-01. PMID:12811422. |
the aim of this study was to explore the potential of a new selective dopamine transporter (dat) compound as a radioligand for positron emission tomography (pet) examination of dat in the human brain. |
2004-06-01 |
2023-08-12 |
human |
| Steven P Presgraves, Tariq Ahmed, Sabine Borwege, Jeffrey N Joyc. Terminally differentiated SH-SY5Y cells provide a model system for studying neuroprotective effects of dopamine agonists. Neurotoxicity research. vol 5. issue 8. 2004-05-25. PMID:15111235. |
we characterized undifferentiated (un) and three differentiation conditions of the sh-sy5y neuroblastoma cell line for phenotypic markers of dopaminergic cells, sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium ion (mpp+), the requirement to utilize the dopamine (da) transporter (dat) for mpp+ toxicity, and the neuroprotective effects of pramipexole. |
2004-05-25 |
2023-08-12 |
mouse |
| Marina Romero-Ramos, Jose L Venero, Sonia Garcia-Rodriguez, Antonio Ayala, Alberto Machado, Josefina Can. Semichronic inhibition of glutathione reductase promotes oxidative damage to proteins and induces both transcription and translation of tyrosine hydroxylase in the nigrostriatal system. Free radical research. vol 37. issue 9. 2004-05-20. PMID:14670008. |
we also studied the mrna levels for tyrosine hydroxylase (th) and the dopamine transporter (dat) by in situ hybridization. |
2004-05-20 |
2023-08-12 |
rat |
| Chin-Chang Huang, Tzu-Chen Yen, Tung-Sheng Shih, Ho-Yuan Chang, Nai-Shin Ch. Dopamine transporter binding study in differentiating carbon disulfide induced parkinsonism from idiopathic parkinsonism. Neurotoxicology. vol 25. issue 3. 2004-05-19. PMID:15019297. |
we performed clinical examinations, and laboratory studies including magnetic resonance imaging (mri) and dopamine transporter (dat) studies with (99m)tc-trodat-1 brain single photon emission computed tomography (spect) in three workers who had long-term exposure to cs(2). |
2004-05-19 |
2023-08-12 |
Not clear |
| Christophe Wersinger, Melanie Banta, Anita Sidh. Comparative analyses of alpha-synuclein expression levels in rat brain tissues and transfected cells. Neuroscience letters. vol 358. issue 2. 2004-05-19. PMID:15026157. |
protein levels of alpha-synuclein, and its binding partner, the dopamine transporter (dat), were examined and semi-quantified in different rat brain regions and compared to the amounts of alpha-synuclein expressed in ltk(-) cells after transfection with known amounts of dna. |
2004-05-19 |
2023-08-12 |
rat |
| Alexander Storch, Yu-I Hwang, Debra A Gearhart, J Warren Beach, Edward J Neafsey, Michael A Collins, Johannes Schwar. Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake. Journal of neurochemistry. vol 89. issue 3. 2004-05-19. PMID:15086525. |
we addressed the importance of the dopamine transporter (dat) for selective dopaminergic toxicity by testing the differential cytotoxicity and cellular uptake of 12 betacs in human embryonic kidney hek-293 cells ectopically expressing the dat gene. |
2004-05-19 |
2023-08-12 |
human |