| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ole V Mortensen, Susan G Amar. Dynamic regulation of the dopamine transporter. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612147. |
in the mammalian central nervous system the dopamine transporter (dat) is the primary mechanism for clearance of dopamine from the extracellular space. |
2004-07-20 |
2023-08-12 |
Not clear |
| Claus Juul Loland, Kristine Norgaard-Nielsen, Ulrik Gethe. Probing dopamine transporter structure and function by Zn2+-site engineering. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612149. |
the biogenic amine transporters belong to the class of na+/cl--coupled solute carriers and include the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert). |
2004-07-20 |
2023-08-12 |
human |
| Jean-Jacques Bonne. Interactions of cations and anions with the binding of uptake blockers to the dopamine transporter. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612150. |
uptake blockers and substrates are likely to recognise a common binding domain on the dopamine neuronal transporter (dat). |
2004-07-20 |
2023-08-12 |
Not clear |
| Jean-Jacques Bonne. Interactions of cations and anions with the binding of uptake blockers to the dopamine transporter. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612150. |
several metals impair binding to the dat and/or the dopamine transport, but, under specific conditions, some of them, and chiefly zn2+, stimulate binding. |
2004-07-20 |
2023-08-12 |
Not clear |
| Jean-Jacques Bonne. Interactions of cations and anions with the binding of uptake blockers to the dopamine transporter. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612150. |
the dependence of the binding of dopamine on ions could be involved in its preferential inward transport and used by uptake blockers for their own binding to the dat. |
2004-07-20 |
2023-08-12 |
Not clear |
| James O Schenk, Shannon E George, Paul Dietrich Schumache. What can be learned from studies of multisubstrate mechanisms of neuronal dopamine transport? European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612152. |
the dopamine transporter (dat) is a na+- and cl--dependent transporter and, with respect to its three apparent substrates, both partially random sequential as well as ordered mechanisms have been reported. |
2004-07-20 |
2023-08-12 |
Not clear |
| James O Schenk, Shannon E George, Paul Dietrich Schumache. What can be learned from studies of multisubstrate mechanisms of neuronal dopamine transport? European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612152. |
here we describe some of the features of dat, such as the coupling of energy to concentrate dopamine and the properties of slippage and leakage. |
2004-07-20 |
2023-08-12 |
Not clear |
| Hans J C Berger, Alexander R Cools, Martin W I M Horstink, Wim J G Oyen, Elisabeth W M Verhoeven, Sieberen P van der Wer. Striatal dopamine and learning strategy-an (123)I-FP-CIT SPECT study. Neuropsychologia. vol 42. issue 8. 2004-07-19. PMID:15093146. |
the aim of this study was to assess the relation between striatal dopamine activity as revealed by single photon emission computed tomography (spect) with (123)i-fp-cit, a ligand for the dopamine transporter (dat), and type of learning strategy, as identified by the california verbal learning task (cvlt) in 19 patients with probable pd. |
2004-07-19 |
2023-08-12 |
human |
| Hans J C Berger, Alexander R Cools, Martin W I M Horstink, Wim J G Oyen, Elisabeth W M Verhoeven, Sieberen P van der Wer. Striatal dopamine and learning strategy-an (123)I-FP-CIT SPECT study. Neuropsychologia. vol 42. issue 8. 2004-07-19. PMID:15093146. |
the results showed a robust inverse correlation between striatal dopamine dat binding and the externally guided, serial learning strategy: the lower the dat in caudate nucleus as well as in putamen, the more the patient group appeared to rely on externally structured learning. |
2004-07-19 |
2023-08-12 |
human |
| Margaret E Gnegy, Habibeh Khoshbouei, Kelly A Berg, Jonathan A Javitch, William P Clarke, Minjia Zhang, Aurelio Gall. Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter. Molecular pharmacology. vol 66. issue 1. 2004-07-15. PMID:15213305. |
although it is clear that amphetamine-induced dopamine (da) release mediated by the dopamine transporter (dat) is integral to the behavioral actions of this psychostimulant, the mechanism of this release is not clear. |
2004-07-15 |
2023-08-12 |
human |
| Margaret E Gnegy, Habibeh Khoshbouei, Kelly A Berg, Jonathan A Javitch, William P Clarke, Minjia Zhang, Aurelio Gall. Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter. Molecular pharmacology. vol 66. issue 1. 2004-07-15. PMID:15213305. |
these studies demonstrate that amphetamine-induced dat-mediated currents and substrate efflux require internal ca(2+) and that amphetamine can stimulate dopamine efflux by regulating cytoplasmic ca(2+) levels through its interaction with dat. |
2004-07-15 |
2023-08-12 |
human |
| Elzbieta Lorenc-Koci, Lucyna Antkiewicz-Michaluk, Jadwiga Wardas, Małgorzata Zapała, Joanna Wierońsk. Effect of 1,2,3,4,-tetrahydroisoquinoline administration under conditions of CYP2D inhibition on dopamine metabolism, level of tyrosine hydroxylase protein and the binding of [3H]GBR 12,935 to dopamine transporter in the rat nigrostriatal, dopaminergic system. Brain research. vol 1009. issue 1-2. 2004-07-12. PMID:15120584. |
twice daily for 14 days) markedly decreased the level of tyrosine hydroxylase protein (th) in the str; however, this effect was not accompanied by reduction of dopamine (da) concentration and [(3)h]gbr 12,935 binding to dopamine transporter (dat). |
2004-07-12 |
2023-08-12 |
rat |
| John G Nutt, Julie H Carter, Gary J Sexto. The dopamine transporter: importance in Parkinson's disease. Annals of neurology. vol 55. issue 6. 2004-07-12. PMID:15174010. |
the dopamine transporter (dat) may be the single most important determinant of extracellular dopamine concentrations. |
2004-07-12 |
2023-08-12 |
Not clear |
| Santosh S Kulkarni, Peter Grundt, Theresa Kopajtic, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation. Journal of medicinal chemistry. vol 47. issue 13. 2004-07-09. PMID:15189035. |
one of the most potent and dopamine transporter (dat) selective n-substituted benztropine analogues (n-(4-phenyl-n-butyl)-3alpha-(bis[4-fluorophenyl]methoxy)tropane, 1c) is devoid of cocaine-like behaviors in rodent models but is also highly lipophilic (clogd = 5.01), which compromises its water solubility and may adversely affect its pharmacokinetic properties. |
2004-07-09 |
2023-08-12 |
rat |
| Santosh S Kulkarni, Peter Grundt, Theresa Kopajtic, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation. Journal of medicinal chemistry. vol 47. issue 13. 2004-07-09. PMID:15189035. |
most of the analogues showed high dat affinity (12-50 nm), selectivity (10- to 120-fold), potent inhibition of dopamine uptake, and lower lipophilicities as predicted by clogd values. |
2004-07-09 |
2023-08-12 |
rat |
| Peter C Meltzer, Mark McPhee, Bertha K Madra. Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes. Bioorganic & medicinal chemistry letters. vol 13. issue 22. 2004-07-06. PMID:14592523. |
tropane analogues of cocaine, targeted to the dopamine transporter (dat), are a significant focus of drug design for cocaine addiction medications. |
2004-07-06 |
2023-08-12 |
rat |
| Peter C Meltzer, Mark McPhee, Bertha K Madra. Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes. Bioorganic & medicinal chemistry letters. vol 13. issue 22. 2004-07-06. PMID:14592523. |
it is therefore likely that the binding site for these compounds on the dat is not the same as that for dopamine. |
2004-07-06 |
2023-08-12 |
rat |
| Kristopher M Kahlig, Jonathan A Javitch, Aurelio Gall. Amphetamine regulation of dopamine transport. Combined measurements of transporter currents and transporter imaging support the endocytosis of an active carrier. The Journal of biological chemistry. vol 279. issue 10. 2004-07-06. PMID:14699142. |
dopaminergic neurotransmission is fine-tuned by the rate of removal of dopamine (da) from the extracellular space via the na(+)/cl(-)-dependent da transporter (dat). |
2004-07-06 |
2023-08-12 |
human |
| Evgeny A Budygin, Mark S Brodie, Tatyana D Sotnikova, Yolanda Mateo, Carrie E John, Michel Cyr, Raul R Gainetdinov, Sara R Jone. Dissociation of rewarding and dopamine transporter-mediated properties of amphetamine. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 20. 2004-07-06. PMID:15136721. |
the interaction of amphetamine (amph) with the dopamine (da) transporter (dat) is thought to be critically important for the da-elevating actions of this drug. |
2004-07-06 |
2023-08-12 |
mouse |
| Shupeng Li, Kun Yang Kim, Jong Hun Kim, Jin Hoi Kim, Moon Seok Park, Jong Yoon Bahk, Myeong Ok Ki. Chronic nicotine and smoking treatment increases dopamine transporter mRNA expression in the rat midbrain. Neuroscience letters. vol 363. issue 1. 2004-07-06. PMID:15157990. |
previous pharmacokinetics and electrophysiological results indicated an important role of nicotine in the modulation of dopamine transporter (dat). |
2004-07-06 |
2023-08-12 |
rat |