| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiu-Ying Duan, Rui-Jiao Ma, Chung-Der Hsiao, Zhen-Zhou Jiang, Lu-Yong Zhang, Yun Zhang, Ke-Chun Li. Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish. Chinese journal of natural medicines. vol 19. issue 10. 2021-11-25. PMID:34688465. |
the main manifestations were elevated levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast), significant liver atrophy, vacuoles in liver tissue, sparse cytoplasm, and unclear hepatocyte contours. |
2021-11-25 |
2023-08-13 |
zebrafish |
| Shumin Wei, Xiaoying Y. Efficacy of resveratrol supplementation on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis. Complementary therapies in medicine. vol 57. 2021-11-24. PMID:33271299. |
the aim of this systematic review was to summarize evidence of the effects of resveratrol supplementation on alanine aminotransferase (alt), and aspartate aminotransferase (ast) levels in patients with nafld by performing a meta-analysis of rcts. |
2021-11-24 |
2023-08-13 |
Not clear |
| Alejandro Gonzalez-Vazquez, Ana-Karina Aguilar-Peralta, Constantino Tomas-Sanchez, Victor-Manuel Blanco-Alvarez, Daniel Martinez-Fong, Juan-Antonio Gonzalez-Barrios, Samuel Treviño, Lourdes Millán-Perez Peña, Victorino Alatriste, Guadalupe Soto-Rodriguez, Eduardo Brambila, Bertha Alicia Leon-Chave. Taurine Increases Zinc Preconditioning-Induced Prevention of Nitrosative Stress, Metabolic Alterations, and Motor Deficits in Young Rats following Intrauterine Ischemia. Oxidative medicine and cellular longevity. vol 2021. 2021-11-24. PMID:34040692. |
enzymes of neuronal energetic pathways, such as aspartate aminotransferase (ast), alanine aminotransferase (alt), and lactate dehydrogenase (ldh), were also evaluated. |
2021-11-24 |
2023-08-13 |
rat |
| Asmaa Elsayed, Ashraf Elkomy, Reda Elkammar, Gehan Youssef, Ehab Yahya Abdelhiee, Walied Abdo, Sabreen Ezzat Fadl, Ahmed Soliman, Mohamed Aboubak. Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats. Scientific reports. vol 11. issue 1. 2021-11-24. PMID:34234176. |
the activities of alanine aminotransferase (alt), aspartate aminotransferase (ast), and alkaline phosphatase (apk), and levels of urea, creatinine, and lipids (cholesterol, triglycerides, and low-density lipoprotein-cholesterol) increased after cp injection in the serum. |
2021-11-24 |
2023-08-13 |
rat |
| Ophelia Yin, Hamim Zahir, Jonathan French, Daniel Polhamus, Xiaoning Wang, Michiel van de Sande, William D Tap, Hans Gelderblom, Andrew J Wagner, John H Healey, Jonathan Greenberg, Dale Shuster, Silvia Stacchiott. Exposure-response analysis of efficacy and safety for pexidartinib in patients with tenosynovial giant cell tumor. CPT: pharmacometrics & systems pharmacology. vol 10. issue 11. 2021-11-24. PMID:34585528. |
safety included hepatic parameters (i.e., alanine aminotransferase [alt], aspartate aminotransferase [ast], and total bilirubin). |
2021-11-24 |
2023-08-13 |
Not clear |
| Maryam Mirzaei, Mehrdad Bouyeh, Afshin Zahedi, Alireza Seidavi, Rifat Ullah Khan, Vincenzo Tufarelli, Vito Laudadio, Mohamed E Abd El-Hack, Marco Ragni, Ayman E Taha, Ayman A Swelu. Influence of dietary L-carnitine and lysine-methionine levels on reproductive performance and blood metabolic constituents of breeder ducks. Reproduction in domestic animals = Zuchthygiene. 2021-11-23. PMID:34787945. |
laying performance and reproductive traits were evaluated; additionally, uric acid, total protein total, triglycerides, total cholesterol, low-density lipoprotein, high-density lipoprotein, aspartate aminotransferase (ast) and alanine aminotransferase (alt) were assessed. |
2021-11-23 |
2023-08-13 |
Not clear |
| Kaori Nakanishi, Chisaki Ishibashi, Seiko Ide, Ryohei Yamamoto, Makoto Nishida, Izumi Nagatomo, Toshiki Moriyama, Keiko Yamauchi-Takihar. Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects. Scientific reports. vol 11. issue 1. 2021-11-23. PMID:34799626. |
fgf21 levels correlated with age, body mass index (bmi), waist circumference (wc), systolic blood pressure (sbp), diastolic blood pressure (dbp), aspartate aminotransferase (ast), alanine aminotransferase (alt), gamma-glutamyl transpeptidase (γ-gtp), uric acid, total cholesterol (tc), triglycerides (tg), high-density lipoprotein cholesterol (hdlc), fasting plasma glucose (fpg), and hba1c. |
2021-11-23 |
2023-08-13 |
human |
| Weimin Xu, Peng Wang, Dalong Wang, Ke Liu, Shuaishuai Zhang, Wei Zhao, Guoqing Li. S-ketamine alleviates carbon tetrachloride-induced hepatic injury and oxidative stress by targeting the Nrf2/HO-1 signaling pathway. Canadian journal of physiology and pharmacology. vol 99. issue 12. 2021-11-22. PMID:34310894. |
blood was collected to measure biochemical parameters (alanine transaminase (alt), aspartate transaminase (ast), alkaline phosphatase (alp), total bilirubin (tb) and γ-glutamyltransferase (γ-gt)) and the liver was harvested for histopathological analysis of enzymes related to the antioxidant response (malondialdehyde (mda), superoxide dismutase (sod), glutathione (gsh), and glutathione peroxidase (gsh-px)). |
2021-11-22 |
2023-08-13 |
Not clear |
| Azubuike Peter Ebokaiwe, Doris Olachi Obasi, Rex Clovis C Njoku, Sharon Osawe, Olasiende Olusanya, Winner O Kal. Cyclophosphamide instigated hepatic-renal oxidative/inflammatory stress aggravates immunosuppressive indoleamine 2,3-dioxygenase in male rats: Abatement by quercetin. Toxicology. vol 464. 2021-11-22. PMID:34748891. |
additionally, quercetin attenuated cyp-induced reduction in antioxidant enzyme activities and enhanced hepatic-renal function markers, namely aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp), and levels of urea and creatinine. |
2021-11-22 |
2023-08-13 |
rat |
| Talat Roome, Maha Qasim, Sabahat Aziz, Ahsana Dar Farooq, Anam Razzaq, Syed Farooq Al. Assessment of acute, sub-acute, chronic and genotoxicity of polyherbal formulation DCD-684 in mice. Pakistan journal of pharmaceutical sciences. vol 34. issue 4(Supplementary). 2021-11-22. PMID:34799324. |
however, at 18 and 36 ml/kg.bw, liver demonstrated mild inflammation correlating with raised aspartate transaminase (ast), alkaline phosphatase (alp) and alpha fetoprotein (afp) levels. |
2021-11-22 |
2023-08-13 |
mouse |
| Yingwen Mu, Jiayin Sun, Ziyuan Li, Wanxin Zhang, Zuodong Liu, Chao Li, Cheng Peng, Guanqun Cui, Hua Shao, Zhongjun D. Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice. Chemosphere. 2021-11-21. PMID:34793849. |
results revealed that mps could damage liver structure and function with broken and reduced mitochondrial cristae, as well as increased levels of aspartate minotransferase (ast), alanine aminotransferase (alt), ast/alt, alkaline phosphatase (alp) and lactate dehydrogenase (ldh). |
2021-11-21 |
2023-08-13 |
mouse |
| Guozhen Wang, Siyi Jin, Weichang Huang, Yang Li, Jun Wang, Xuguang Ling, Yun Huang, Ye Hu, Congcong Li, Ying Meng, Xu L. LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome. Cell death discovery. vol 7. issue 1. 2021-11-20. PMID:34743181. |
serum hmgb1, alt (alanine aminotransferase), ast (aspartate aminotransferase), ldh (lactate dehydrogenase) and mpo (myeloperoxidase) were measured using a commercial kit. |
2021-11-20 |
2023-08-13 |
Not clear |
| Xiuqin An, Jinchun Liu, Yue Li, Zhangfeng Dou, Ning Li, Yuhong Suo, Yanan Ma, Meiqing Sun, Zhongyuan Tian, Lijun X. Chemerin/CMKLR1 ameliorates nonalcoholic steatohepatitis by promoting autophagy and alleviating oxidative stress through the JAK2-STAT3 pathway. Peptides. vol 135. 2021-11-19. PMID:33144092. |
in this study, chemerin was found to significantly ameliorate high-fat diet (hfd) induced nash, marked by decreased serum levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), interleukin (il)-1β, il-6, and tumor necrosis factor-α (tnf-α), decreased insulin resistance (ir) and leptin resistance (lr), and improved liver lesions. |
2021-11-19 |
2023-08-13 |
mouse |
| Yangfei Zhao, Jinming Wang, Jianhai Zhang, Zilong Sun, Ruiyan Niu, Ram Kumar Manthari, Mohammad Mehdi Ommati, Shaolin Wang, Jundong Wan. Fluoride exposure induces mitochondrial damage and mitophagy via activation of the IL-17A pathway in hepatocytes. The Science of the total environment. vol 804. 2021-11-19. PMID:34517333. |
the results showed that fluoride reduced the bodyweight and liver coefficient, increased the bone fluoride content, the aspartate aminotransferase (ast), alanine aminotransferase (alt), glutamate dehydrogenase (gdh) levels, caspase 8 and caspase 9 activities, and induced liver morphology and ultrastructure damage. |
2021-11-19 |
2023-08-13 |
mouse |
| Ambrin Farizah Babu, Susanne Csader, Johnson Lok, Carlos Gómez-Gallego, Kati Hanhineva, Hani El-Nezami, Ursula Schwa. Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-Analysis. Nutrients. vol 13. issue 9. 2021-11-19. PMID:34579012. |
overall, exercise without significant weight loss significantly reduced the intrahepatic lipid (ihl) content (smd: -0.76, 95% ci: -1.04, -0.48) and concentrations of alanine aminotransaminase (alt) (smd: -0.52, 95% ci: -0.90, -0.14), aspartate aminotransaminase (ast) (smd: -0.68, 95% ci: -1.21, -0.15), low-density lipoprotein cholesterol (smd: -0.34, 95% ci: -0.66, -0.02), and triglycerides (tg) (smd: -0.59, 95% ci: -1.16, -0.02). |
2021-11-19 |
2023-08-13 |
Not clear |
| Zhang Chi, Wu Zhao, Jia-Wen Li, Hui Liu, Chen Shao, Hong Zhao, Wang Gui-Qian. Combination of quantitative hepatitis B core antibody (qHBcAb) and aspartate aminotransferase (AST) can accurately diagnose immune tolerance of chronic hepatitis B virus infection based on liver biopsy. Clinics and research in hepatology and gastroenterology. vol 45. issue 6. 2021-11-18. PMID:33272888. |
combination of quantitative hepatitis b core antibody (qhbcab) and aspartate aminotransferase (ast) can accurately diagnose immune tolerance of chronic hepatitis b virus infection based on liver biopsy. |
2021-11-18 |
2023-08-13 |
Not clear |
| Xu Yan, Jinlan Ho. miR-22 Host Gene Enhances Nuclear Factor-kappa B Activation to Aggravate Hypoxia-induced Injury in AC16 Cardiomyocytes. Cell transplantation. vol 30. 2021-11-17. PMID:33631962. |
cell viability, lactate dehydrogenase release, levels of aspartate aminotransferase (ast) and creatine kinase-mb (ck-mb), and apoptosis were detected by cell counting kit-8, lactate dehydrogenase (ldh) release assay, commercial enzyme-linked immune sorbent assay kits, and flow cytometry analysis, respectively. |
2021-11-17 |
2023-08-13 |
Not clear |
| Keiko Suzuki, Hideshi Okada, Kazuyuki Sumi, Hiroyuki Tomita, Ryo Kobayashi, Takuma Ishihara, Yoshinori Kakino, Kodai Suzuki, Naomasa Yoshiyama, Ryu Yasuda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Haruka Okamoto, Tomoaki Doi, Takahiro Yoshida, Shozo Yoshida, Shinji Ogura, Akio Suzuk. Serum syndecan-1 reflects organ dysfunction in critically ill patients. Scientific reports. vol 11. issue 1. 2021-11-17. PMID:33893369. |
analysis using mixed effects models for repeated measures with adjustment for age and sex showed that serum sdc-1 levels measured the day before significantly affected several outcomes, including aspartate aminotransferase (ast), alanine transaminase (alt), creatinine (cre), blood urea nitrogen (bun), antithrombin iii, fibrin degradation products, and d-dimer. |
2021-11-17 |
2023-08-13 |
Not clear |
| Wenjun Chen, Mingjin Zh. Drug-induced hepatotoxicity linked to zoledronic acid in the treatment of an elderly man with primary osteoporosis. International journal of clinical pharmacology and therapeutics. vol 59. issue 11. 2021-11-17. PMID:34423770. |
the patient had femoral neck and vertebral fractures, and 3 days after za 5-mg infusion, serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) increased 23.4- and 15.3-fold, respectively, compared with pre-treatment values. |
2021-11-17 |
2023-08-13 |
Not clear |
| Tung-Ho Wu, Pei-Wen Wang, Tung-Yi Lin, Pei-Ming Yang, Wen-Tai Li, Chau-Ting Yeh, Tai-Long Pa. Antioxidant properties of red raspberry extract alleviate hepatic fibrosis via inducing apoptosis and transdifferentiation of activated hepatic stellate cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 144. 2021-11-17. PMID:34626932. |
serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) were increased in the dimethylnitrosamine (dmn)-applied samples, whereas treatment of rbe significantly suppressed the activities of these enzymes. |
2021-11-17 |
2023-08-13 |
rat |