| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akatsuki Kubota, Jun Shimizu, Atsushi Unuma, Meiko Maeda, Yuichiro Shirota, Masato Kadoya, Naohiro Uchio, Yoshio Sakiyama, Noritoshi Arai, Yasushi Shiio, Yoshikazu Uesaka, Hideji Hashida, Nobue K Iwata, Jun Goto, Ran Nakashima, Tsuneyo Mimori, Tatsushi Tod. Alanine transaminase is predominantly increased in the active phase of anti-HMGCR myopathy. Neuromuscular disorders : NMD. 2021-12-17. PMID:34916121. |
a higher alanine transaminase (alt) level and a lower aspartate transaminase (ast)/alt ratio were observed in anti-hmgcr myopathy patients [alt, 265.7 ± 213.3 u/l (mean ± standard deviation); ast/alt ratio, 0.88 ± 0.32] than in anti-srp-myopathy patients (alt, 179.3 ± 111.2 u/l, p < 0.05; ast/alt ratio, 1.28 ± 0.40, p < 0.01). |
2021-12-17 |
2023-08-13 |
Not clear |
| Cebrail Gursul, Adalet Ozcicek, Mustafa Ozkaraca, Ali Sefa Mendil, Taha Abdulkadir Coban, Aynur Arslan, Fatih Ozcicek, Halis Suleyma. Amelioration of oxidative damage parameters by carvacrol on methanol-induced liver injury in rats. Experimental animals. 2021-12-16. PMID:34911876. |
additionally, the levels of malondialdehyde (mda), total oxidant status (tos), alanine aminotransferase (alt), and aspartate aminotransferase (ast) were significantly higher, and total glutathione (tgsh) and total antioxidant status (tas) were significantly lower in the mtm group compared to hg (p<0.001). |
2021-12-16 |
2023-08-13 |
rat |
| Nicholas Gilbo, Tine Wylin, Veerle Heedfeld, Ina Jochmans, Jacques Pirenne, Peter Friend, Diethard Monbali. Porcine Liver Normothermic Machine Perfusion: Methodological Framework and Potential Pitfalls. Transplantation direct. vol 8. issue 1. 2021-12-16. PMID:34912950. |
perfusate oxygenation, hemodynamics, markers of hepatic injury (aspartate transaminase [ast]), function (lactate, perfusate ph, bile production), and histology were analyzed. |
2021-12-16 |
2023-08-13 |
Not clear |
| Wei Zhou, Xi Li, Yanting Jiang, Sihui Li, Min Jin, Jingzhe Sui, Jian Wan. The Significance of Blood Index and Biochemistry Index in Patients with Rheumatoid Arthritis. Clinical laboratory. vol 67. issue 12. 2021-12-15. PMID:34910425. |
the aim of this study is to demonstrate the clinical significance of the platelet-to-lymphocyte ratio (plr) and the ratio of aspartate aminotransferase (ast) to alanine aminotransferase (alt) in patients with rheumatoid arthritis (ra). |
2021-12-15 |
2023-08-13 |
Not clear |
| Reza Hakimizad, Rasool Soltani, Farzin Khorvash, Majid Marjani, Farzaneh Dasta. The Effect of acetyl-L-carnitine, Alpha-lipoic Acid, and Coenzyme Q10 Combination in Preventing Anti-tuberculosis Drug-induced Hepatotoxicity: A Randomized, Double-blind, Placebo-controlled Clinical Trial. Iranian journal of pharmaceutical research : IJPR. vol 20. issue 3. 2021-12-14. PMID:34903999. |
the mean serum levels of aspartate aminotransferase (ast), alanine aminotransferase (alt), and total bilirubin (tbil) at the end of the first and second weeks as well as the incidence of dili during the intervention were recorded and compared between the two groups. |
2021-12-14 |
2023-08-13 |
Not clear |
| Qinglan Shi, Wenjie Bai, Dewen Mao, Yueqiao Chen, Kejing Wang, Hua Qiu, Jinyu W. Detoxification II Prescription Suppresses the Th-17/IL-17 Inflammatory Axis to Improve the Liver Function of ACLF-Rats via Inactivating the P38MAPK Pathway. Journal of healthcare engineering. vol 2021. 2021-12-13. PMID:34900202. |
in this study, the rats were injected with d-galactosamine to establish aclf-rat models, and the levels of cholinesterase (che), alanine aminotransferase (alt), aspartate aminotransferase (ast), albumin (alb), and total bilirubin (tbil) were measured with the related kits to reflect the liver functions of the rats. |
2021-12-13 |
2023-08-13 |
rat |
| Öner Bozan, Şeref Emre Atiş, Bora Çekmen, Mücahit Şentürk, Mehmet Muzaffer İslam, Sevilay Ünver, Asim Kalka. Factors Predicting the Frequency of Second Seizures in Patients Presenting to the Emergency Department With Seizures: A Prospective Observational Study. Cureus. vol 13. issue 11. 2021-12-13. PMID:34900464. |
when the differences between the groups in terms of various variables were examined, no statistically significant difference was found in the univariate analysis, except for wbc, aspartate aminotransferase (ast), and alanine aminotransferase (alt) values. |
2021-12-13 |
2023-08-13 |
Not clear |
| Punam Pahwa, Luan Chu, Chandima Karunanayake, Palok Aich, Markus Hecker, Anurag Saxena, Philip Griebel, Som Niyog. Predictive biomarkers of cardiovascular disease in adult Canadian population. Journal of diabetes and metabolic disorders. vol 20. issue 2. 2021-12-13. PMID:34900772. |
elevated levels of the enzymes gamma-glutamyltransferase (ggt), alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp), and c-reactive protein (crp) have been shown to be associated with increased risk of cardiovascular disease (cvd). |
2021-12-13 |
2023-08-13 |
Not clear |
| Vikram Nimbalkar, Neeraj Vyawahar. L-carnitine ameliorates bile duct ligation induced liver fibrosis via reducing the nitrosative stress in experimental animals: preclinical evidences. Heliyon. vol 7. issue 11. 2021-12-13. PMID:34901512. |
the bile duct was ligated and serum aspartate transaminase (ast), alanine transaminase (alt), total bilirubin and albumin, hepatic hydroxyproline (hp), reduced glutathione (gsh), and malondialdehyde (mda) and cytokines were measured. |
2021-12-13 |
2023-08-13 |
rat |
| Valentina Rodriguez Paris, Melissa C Edwards, Ali Aflatounian, Michael J Bertoldo, William L Ledger, David J Handelsman, Robert B Gilchrist, Kirsty A Walter. Pathogenesis of Reproductive and Metabolic PCOS Traits in a Mouse Model. Journal of the Endocrine Society. vol 5. issue 6. 2021-12-12. PMID:34056500. |
dht treatment also led to an increase in circulating cholesterol after 2 weeks of exposure and had an overall effect on fasting glucose levels, but not triglycerides, aspartate transaminase (ast) and alanine transaminase (alt) levels, or hepatic steatosis. |
2021-12-12 |
2023-08-13 |
mouse |
| Hualiang Liang, Xianping Ge, Dong Xia, Mingchun Ren, Haifeng Mi, Liangkun Pa. The role of dietary chromium supplementation in relieving heat stress of juvenile blunt snout bream Megalobrama amblycephala. Fish & shellfish immunology. vol 120. 2021-12-11. PMID:34774732. |
after hs, compared with the control group, 1.6 mg/kg and 12.0 mg/kg cr supplementation groups significantly lowered the plasma glucose level and aspartate transaminase (ast) activity (p < 0.05), and 0.4 mg/kg and 1.6 mg/kg cr supplementation groups significantly lowered alanine aminotransferase (alt) activity (p < 0.05). |
2021-12-11 |
2023-08-13 |
cat |
| Huan Liu, Wenna Han, Siyu Zhu, Zhongyi Li, Chunhong Li. Effect of DEHP and DnOP on mitochondrial damage and related pathways of Nrf2 and SIRT1/PGC-1α in HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 158. 2021-12-11. PMID:34822940. |
the results showed that dehp and dnop caused increase in oxygen species (ros), malondialdehyde (mda), alanine aminotransferase (alt) and aspartate transaminase (ast). |
2021-12-11 |
2023-08-13 |
Not clear |
| Fang Li, Qian Li, Yu Zhang, Xianrong Zhou, Ruokun Yi, Xin Zha. Effects of Xylooligosaccharides on Lipid Metabolism, Inflammation, and Gut Microbiota in C57BL/6J Mice Fed a High-Fat Diet. Frontiers in pharmacology. vol 12. 2021-12-11. PMID:34880767. |
moreover, xos reduced the activity of alanine aminotransferase (alt) and aspartate aminotransferase (ast), and alleviated the damage to the liver caused by the high-fat diet. |
2021-12-11 |
2023-08-13 |
mouse |
| Rafaela Capelli, Yuki Kitano, Marcelo Linhares, Doris Da Silva, Nicolas Golse, Vincent Karam, Antonio Sa Cunha, Eric Vibert, Daniel Azoulay, Daniel Cherqui, René Adam, Marc-Antoine Allar. The prognostic significance of serum aspartate transaminase and gamma-glutamyl transferase in liver deceased donors. Transplant international : official journal of the European Society for Organ Transplantation. vol 34. issue 11. 2021-12-10. PMID:34288136. |
the impact of aspartate transaminases (ast) and gamma-glutamyl transferase (ggt) in serum of deceased donors on outcomes after liver transplantation (lt) is unclear. |
2021-12-10 |
2023-08-13 |
Not clear |
| Qinghua Ji, Xudong Chu, Yugui Zhou, Xuan Liu, Wei Zhao, Wei Y. Safety and efficacy of grazoprevir/elbasvir in the treatment of acute hepatitis C in hemodialysis patients. Journal of medical virology. vol 94. issue 2. 2021-12-10. PMID:34599755. |
serum alanine transaminase (alt), aspartate aminotransferase (ast), total bilirubin (tbil), and hcv rna levels were monitored during treatment and follow-up periods. |
2021-12-10 |
2023-08-13 |
Not clear |
| Yaxian Ma, Li Yang, Yuhan Bao, Yang Yang, Liting Chen, Miao Zhen. Case Report: Post-CAR-T Infusion HBV Reactivation in Two Lymphoma Patients Despite Entecavir Preventive Therapy. Frontiers in immunology. vol 12. 2021-12-10. PMID:34691067. |
liver function assay indicated elevated levels of alanine transaminase (alt) and aspartate transaminase (ast), combined with increased levels of total bilirubin (tbil) and direct bilirubin (dbil). |
2021-12-10 |
2023-08-13 |
Not clear |
| Karline da Costa Rodrigues, Renata Leivas de Oliveira, Julia da Silva Chaves, Vanessa Macedo Esteves da Rocha, Beatriz Fuzinato Dos Santos, Mariana Gallio Fronza, Nelson Luís de Campos Domingues, Lucielli Savegnago, Ethel Antunes Wilhelm, Cristiane Luches. A new arylsulfanyl-benzo-2,1,3-thiadiazoles derivative produces an anti-amnesic effect in mice by modulating acetylcholinesterase activity. Chemico-biological interactions. vol 351. 2021-12-10. PMID:34740600. |
on the tenth day, the animals were euthanized and blood was collected for the analysis of biochemical markers (creatinine, aspartate (ast), and alanine (alt) aminotransferase). |
2021-12-10 |
2023-08-13 |
mouse |
| Łukasz Krupa, Robert Staroń, Dorota Dulko, Natalia Łozińska, Alan R Mackie, Neil M Rigby, Adam Macierzanka, Aleksandra Markiewicz, Christian Jungnicke. Importance of Bile Composition for Diagnosis of Biliary Obstructions. Molecules (Basel, Switzerland). vol 26. issue 23. 2021-12-10. PMID:34885858. |
the concentration of eight bile salts, specifically sodium cholate, sodium glycocholate, sodium taurocholate, sodium glycodeoxycholate, sodium chenodeoxycholate, sodium glycochenodeoxycholate, sodium taurodeoxycholate, and sodium taurochenodeoxycholate as well as bile cholesterol were determined by hplc-ms. serum alanine aminotransferase (alt), aspartate transaminase (ast), and bilirubin were measured before the ercp. |
2021-12-10 |
2023-08-13 |
Not clear |
| Xiangjun Fu, Jie He, Deliang Zheng, Xuefeng Yang, Pan Wang, FangXu Tuo, Lin Wang, Shixu Li, Jie Xu, Jie Y. Association of endocrine disrupting chemicals levels in serum, environmental risk factors, and hepatic function among 5- to 14-year-old children. Toxicology. vol 465. 2021-12-09. PMID:34715266. |
serum alanine aminotransferase (alt), aspartate aminotransferase (ast), ast/alt, total bilirubin (tbil), direct bilirubin (dbil) and indirect bilirubin (ibil) were detected with automatic biochemical analyzer. |
2021-12-09 |
2023-08-13 |
human |
| William R Treem, Melissa Palmer, Isabelle Lonjon-Domanec, Daniel Seekins, Lara Dimick-Santos, Mark I Avigan, John F Marcinak, Ajit Dash, Arie Regev, Eric Maller, Meenal Patwardhan, James H Lewis, Don C Rockey, Adrian M Di Bisceglie, James W Freston, Raul J Andrade, Naga Chalasan. Consensus Guidelines: Best Practices for Detection, Assessment and Management of Suspected Acute Drug-Induced Liver Injury During Clinical Trials in Adults with Chronic Viral Hepatitis and Adults with Cirrhosis Secondary to Hepatitis B, C and Nonalcoholic Steatohepatitis. Drug safety. vol 44. issue 2. 2021-12-08. PMID:33141341. |
key conclusions and recommendations include (1) the importance of establishing laboratory criteria that signal potential dili events and that fit the disease indication being studied in the clinical trial based on knowledge of the natural history of test fluctuations in that disease; (2) establishing a pretreatment value that is based on more than one screening determination, and revising that baseline during the trial if a new nadir is achieved during treatment; (3) basing rules for increased monitoring and for stopping drug for potential dili on multiples of baseline liver test values and/or a threshold value rather than multiples of the upper limit of normal (uln) for that test; (4) making use of more sensitive tests of liver function, including direct bilirubin (db) or combined parameters such as aspartate transaminase:alanine transaminase (ast:alt) ratio or model for end-stage liver disease (meld) to signal potential dili, especially in studies of patients with cirrhosis; and (5) being aware of potential confounders related to complications of the disease being studied that may masquerade as dili events. |
2021-12-08 |
2023-08-13 |
Not clear |