| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruijing Liu, Boping Liu, Lingmin Tian, Xinwei Jiang, Xusheng Li, Dongbao Cai, Jianxia Sun, Weibin Bai, Yulong Ji. Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887390. |
moreover, a high dose of bpa caused a significant increase in serum alanine aminotransferase (alt), aspartate aminotransferase (ast), total cholesterol (tc), and low-density lipoprotein cholesterol (ldl-c), while high-density lipoprotein cholesterol (hdl-c) was significantly decreased in bpa-treated rats. |
2022-07-27 |
2023-08-14 |
rat |
| Yahui Zhang, Xiuying Tan, Yuan Cao, Xin An, Jihua Chen, Lina Yan. Punicalagin Protects against Diabetic Liver Injury by Upregulating Mitophagy and Antioxidant Enzyme Activities. Nutrients. vol 14. issue 14. 2022-07-27. PMID:35889739. |
simultaneously, the levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), total cholesterol (tc), triglyceride (tg), low-density lipoprotein cholesterol (ldl-c), free fatty acids (ffa), malondialdehyde (mda), and total superoxide dismutase (t-sod) in the serum and liver were significantly decreased, with reductions in fat lesions and inflammatory cells. |
2022-07-27 |
2023-08-14 |
mouse |
| Xiujing Dou, Di Yan, Siqi Liu, Lujia Gao, Anshan Sha. Thymol Alleviates LPS-Induced Liver Inflammation and Apoptosis by Inhibiting NLRP3 Inflammasome Activation and the AMPK-mTOR-Autophagy Pathway. Nutrients. vol 14. issue 14. 2022-07-27. PMID:35889766. |
in addition, elevated levels of the liver damage indicators (alanine transaminase (alt), aspartate transaminase (ast), and total bilirubin (tbil)) dropped after thymol administration. |
2022-07-27 |
2023-08-14 |
mouse |
| Doaa I Mohamed, Samar F Ezzat, Wael M Elayat, Omnyah A El-Kharashi, Hanaa F Abd El-Kareem, Hebatallah H Abo Nahas, Basel A Abdel-Wahab, Samar Zuhair Alshawwa, Asmaa Saleh, Yosra A Helmy, Eman Khairy, Essa M Saie. Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study. Pharmaceuticals (Basel, Switzerland). vol 15. issue 7. 2022-07-27. PMID:35890131. |
the biochemical analysis revealed that the ischemic liver injury following ahf significantly elevated the activity of alanine aminotransferase (alt), aspartate aminotransferase (ast), and alkaline phosphatase (alp) enzymes, the level of total and direct bilirubin, and the expression of hepatic mitogen-activated protein kinase (mapk), dynamin-1-like protein (dnm1l), and hepatic mirna-17. |
2022-07-27 |
2023-08-14 |
Not clear |
| Masood Khaksar Toroghi, Nidal Al-Huniti, John D Davis, A Thomas DiCioccio, Ronda Rippley, Alina Baum, Christos A Kyratsous, Sumathi Sivapalasingam, Joel Kantrowitz, Mohamed A Kama. A Drug-Disease Model for Predicting Survival in an Ebola Outbreak. Clinical and translational science. 2022-07-27. PMID:35895082. |
using discrete indirect response models, the antiviral mechanism of action was used as a forcing function to drive the reversal of key ebola disease hallmarks over time, e.g., liver and kidney damage (elevated alanine [alt] and aspartate aminotransferases [ast], blood urea nitrogen [bun] and creatinine), and hemorrhage (decreased platelet count). |
2022-07-27 |
2023-08-14 |
human |
| Guanghua Mao, Junjie Tang, Taotao Liao, Xiaoxiang Shi, FangYuan Dong, Weiwei Feng, Yao Chen, Ting Zhao, Xiangyang Wu, Liuqing Yan. Metabolism toxicity and susceptibility of decabromodiphenyl ether (BDE-209) exposure on BRL cells with insulin resistance. Environmental science and pollution research international. 2022-07-27. PMID:35896870. |
besides, it also could cause cell damage by increasing the levels of aspartate transaminase (ast), alanine aminotransferase (alt), and malondialdehyde (mda) in cells. |
2022-07-27 |
2023-08-14 |
human |
| Ziwei Xiong, Yushun Cui, Jiahui Wu, Lingyu Shi, Quan Wen, Shilin Yang, Yulin Fen. Luteolin-7-O-rutinoside from Pteris cretica L. var. nervosa attenuates LPS/D-gal-induced acute liver injury by inhibiting PI3K/AKT/AMPK/NF-κB signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2022-07-26. PMID:35881166. |
it was found that lut could not only reduce alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels, but also significantly reduce the release of tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), and interleukin-1β (il-1β), and inhibit pi3k/akt/ampk/nf-κb pathway. |
2022-07-26 |
2023-08-14 |
mouse |
| M Gharehbeglou, S Yazdani, K White, M R Haeri, N Masoumzade. Atorvastatin Rapidly Reduces Hepatitis B Viral Load in Combination with Tenofovir: A Prospective Clinical Trial. The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale. vol 2022. 2022-07-25. PMID:35873362. |
serum aspartate aminotransferase (ast), alanine aminotransferase (alt), and hbv dna copy numbers were measured at the beginning of the treatment and 1, 3, 6, 9, 12 months later. |
2022-07-25 |
2023-08-14 |
Not clear |
| Omotayo B Ilesanmi, Esther F Adeogun, Temitope T Odewale, Bruno Chiker. Lead exposure-induced changes in hematology and biomarkers of hepatic injury: protective role of TrévoTM supplement. Environmental analysis, health and toxicology. vol 37. issue 2. 2022-07-25. PMID:35878915. |
animals were sacrificed 24 h after the last administration and blood were collected via cardiac puncture and processed for hematological parameters and assessment of alanine aminotransferase (alt), aspartate aminotransferase (ast), and albumin (alb). |
2022-07-25 |
2023-08-14 |
human |
| Ying Lan, Chi Wang, Cheng Zhang, Pengju Li, Jinding Zhang, Hong Ji, Haibo Y. Dietary sea buckthorn polysaccharide reduced lipid accumulation, alleviated inflammation and oxidative stress, and normalized imbalance of intestinal microbiota that was induced by high-fat diet in zebrafish Danio rerio. Fish physiology and biochemistry. 2022-07-25. PMID:35879492. |
results showed that adding 2 and 4 g/kg of sp in the hfd significantly improved the survival rate of zebrafish; reduced the levels of serum triglyceride (tg), total cholesterol (tc), aspartate aminotransferase (ast), and alanine transaminase (alt); and alleviated the lipid accumulation in the liver of zebrafish. |
2022-07-25 |
2023-08-14 |
zebrafish |
| Wenjie Zhu, Meizhu Yan, Haibin Cao, Jun Zhou, Zhongqing X. Effects of Clostridium butyricum Capsules Combined with Rosuvastatin on Intestinal Flora, Lipid Metabolism, Liver Function and Inflammation in NAFLD Patients. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 2. 2022-07-23. PMID:35869734. |
moreover, the observation group had remarkably lower levels of total cholesterol (tc), triglyceride (tg), free fatty acids (ffa), total bilirubin (tbil), direct bilirubin (dbil), alanine aminotransferase (alt), aspartate aminotransferase (ast), procollagen iii peptide (piiip), collagen-iv (c-iv), hyaluronicacid (ha) and laminin (ln) as well as lower levels of tumor necrosis factor-alpha (tnf-α), catabolite activator protein (cap) and interleukin-6 (il-6) in serum than the control group (p<0.05). |
2022-07-23 |
2023-08-14 |
human |
| Zhicheng Li, Biao Jiang, Zhihong Zhong, Jizhen Cao, Han Li, Chenxi Wang, Anxing L. Skin transcriptomic analysis and immune-related gene expression of golden pompano (Trachinotus ovatus) after Amyloodinium ocellatum infection. Fish & shellfish immunology. 2022-07-23. PMID:35870749. |
in addition, the serum of the primary infection group had significantly higher concentrations of triglyceride (tg), higher alanine transaminase (alt), aspartate transaminase (ast), and lactate dehydrogenase (ldh) activities than the control group. |
2022-07-23 |
2023-08-14 |
Not clear |
| Cai Zhang, Sudan Meng, Qi Shao, Xueying Wang, Chenxu Li, Wenbin Chen, Yuanxiao Li, Shucheng Huang, Yanbo M. Protective effects of monoammonium glycyrrhizinate on fatty deposit degeneration induced in primary calf hepatocytes by sodium oleate administration in vitro. Research in veterinary science. vol 150. 2022-07-22. PMID:35868152. |
to evaluate the effect of mag on fat-induced degradation of primary hepatocytes, we evaluated lipid deposition, cell viability, apoptosis rate, alanine aminotransferase (alt) and aspartate aminotransferase (ast) activity in the culture supernatant, and expression of oxidant and antioxidant enzymes (ldh, mda, gsh, and cat), as well as the expression of lipid metabolism-related genes (pparα, srebp-1c, chrebp, cpt1, cpt2, and mtp) and apoptosis-related genes (cyt-c, caspase 9, caspase 8, caspase 3, bax, and bcl-2). |
2022-07-22 |
2023-08-14 |
cat |
| Toussaint Rouamba, Paul Sondo, Isidore W Yerbanga, Adelaide Compaore, Maminata Traore-Coulibaly, Franck S Hien, Nassirou A Diande, Innocent Valea, Marc Christian Tahita, Rita Baiden, Fred Binka, Halidou Tint. Prospective observational study to evaluate the clinical and biological safety profile of pyronaridine-artesunate in a rural health district in Burkina Faso. Pharmacology research & perspectives. vol 10. issue 4. 2022-07-20. PMID:35855566. |
additionally, the study focused on aes of special interest (aesi), namely clinical signs related to hepatotoxicity and increased alanine aminotransferase (alt) and aspartate aminotransferase (ast). |
2022-07-20 |
2023-08-14 |
Not clear |
| Souvik Dhara, H P Gupta, Sunil Kumar, R K Sharma, Swati Thaku. Effects of Heterologous Bovine Seminal Plasma-Supplemented Egg Yolk-Based Extender on Cryosurvivability of Pantja Buck Semen. Biopreservation and biobanking. 2022-07-20. PMID:35856825. |
alanine aminotransferase (alt), aspartate aminotransferase (ast), malondialdehyde (mda) concentration, and glutathione peroxidase (gsh-px) activity were measured at post-thaw. |
2022-07-20 |
2023-08-14 |
cattle |
| Yucheng Wu, Fang Li. Aspartate aminotransferase to alanine aminotransferase ratio and the risk of diabetic nephropathy progression in patients with type 2 diabetes mellitus: A biopsy-based study. Journal of diabetes and its complications. 2022-07-19. PMID:35853763. |
to study the relationship between baseline serum aspartate aminotransferase (ast) to alanine aminotransferase (alt) ratio (aar) in both clinicopathological features and renal outcome among type 2 diabetes mellitus (t2dm) patients with biopsy-confirmed diabetic nephropathy (dn). |
2022-07-19 |
2023-08-14 |
Not clear |
| Anjali Athanerey, Neha Rani Verma, Piyush Bhargava, Dnyanesh Amle, P K Patra, Awanish Kuma. Biochemical aspects of effects of mesenchymal stem cell treatment in chronic wounds progressive healing. Cell and tissue banking. 2022-07-18. PMID:35849224. |
various biochemical parameters like random blood glucose, serum urea, serum creatinine, bilirubin (total and direct), aspartate aminotransferase (ast), alanine aminotransferase (alt), total protein, albumin levels, and association of other factors/conditions such as age, sex, addiction of drug/alcohol were also evaluated/compared with complete and without complete healing. |
2022-07-18 |
2023-08-14 |
Not clear |
| Miao Weng, Wencong Zhang, Zhou Zhang, Yuhang Tang, Wencong Lai, Zhijie Dan, Yongtao Liu, Jichang Zheng, Shengnan Gao, Kangsen Mai, Qinghui A. Effects of dietary lysolecithin on growth performance, serum biochemical indexes, antioxidant capacity, lipid metabolism and inflammation-related genes expression of juvenile large yellow croaker (Larimichthys crocea). Fish & shellfish immunology. 2022-07-17. PMID:35843522. |
meanwhile, serum aspartate transaminase (ast) and alanine transaminase (alt) activities in fish fed diets with lysolecithin were remarkably lower than those in the control diet (p < 0.05). |
2022-07-17 |
2023-08-14 |
Not clear |
| Yong Zheng, Hongning Shi, Yahao Zhou, Ayong Wang, Dufu Kang, Limin Kan. Effects of endoplasmic reticulum stress, liver function, insulin resistance and vascular endothelial function in patients with nonalcoholic fatty liver disease. Cellular and molecular biology (Noisy-le-Grand, France). vol 67. issue 5. 2022-07-12. PMID:35818251. |
the expression level of glucose-regulated protein 94 (grp94) and biochemical indicators such as alanine aminotransferase (alt), free fatty acids (ffa), triglycerides (tg), gamma-glutamyl transferase (ggt), aspartate aminotransferase (ast), fasting blood glucose (fbg), and fasting insulin (fins) were measured. |
2022-07-12 |
2023-08-14 |
Not clear |
| Zhanwei Fan, Jianjiang Dong, Yindong Mu, Xian Li. Nesfatin-1 protects against diabetic cardiomyopathy in the streptozotocin-induced diabetic mouse model via the p38-MAPK pathway. Bioengineered. vol 13. issue 6. 2022-07-12. PMID:35818327. |
nesfatin-1 ameliorated the diabetes-related myocardial hypertrophy and heart dysfunction, as revealed by the reduced hypertrophy index, heart rate, mean arterial pressure (map), creatine kinase (ck)-mb, and aspartate aminotransferase (ast) levels. |
2022-07-12 |
2023-08-14 |
mouse |