| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takumi Noda, Ryuji Kato, Yasuyuki Ozato, Yuka Kawai, Masato Yamamoto, Yuya Kagawa, Misa Azuma, Kojiro Yamamoto, Mika Kusanagi, Kiyoaki Uryu, Hiromasa Harada, Yoshio Ijiri, Tetsuya Hayashi, Kazuhiko Tanak. Decreased plasma acetaminophen glucuronide/acetaminophen concentration ratio warns the onset of acetaminophen-induced liver injury. Biopharmaceutics & drug disposition. 2022-05-18. PMID:35508086. |
in a clinical study, we had a case in which aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels increased in a patient with a low ratio of apap glucuronide concentration (ap-g)/apap plasma concentration. |
2022-05-18 |
2023-08-16 |
rat |
| Qingqing Liu, Haixia Tian, Hao Yang, Xing Kang, Haixia Liu, Xiaodan Yang, Xuguang Luo, Weiping Fa. [Metformin activates AMPK to alleviate acute fulminant hepatitis induced by concanavalin A in mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 4. 2022-05-18. PMID:35583058. |
the serum levels of alanine aminotransferase (alt), aspartate aminotransferase (ast) and total bilirubin (tb) were detected; the pathological changes of mouse liver tissue were observed with he staining; the macrophage infiltration in liver tissue was detected with immunohistochemistry. |
2022-05-18 |
2023-08-13 |
mouse |
| Dhruba Das, Kalyan Sarma, Chethan Gollahalli Eregowda, Parimal Roychoudhury, Justus Babykutty Rajesh, Parthasarathi Behera, Hridayesh Prasad, Hniang Lalrinkima, Fatema Aktar, Nikitasha Bora, Champak Deka, Neeraj Thakur, Thingujam Chaa Tolenkhomb. Naturally occurring Anaplasma marginale infection in cattle: Molecular prevalence and associated risk factors, haemato-biochemical alterations, oxidant/antioxidant status and serum trace mineral levels. Microbial pathogenesis. 2022-05-17. PMID:35580762. |
the mean values of total erythrocyte count (tec), haemoglobin (hb), packed cell volume (pcv), total platelet count, total protein, albumin, superoxide dismutase (sod), glutathione (gsh), total antioxidant capacity (tac), copper (cu) and zinc (zn) were significantly (p < 0.05) lower, whereas the mean values of mean corpuscular volume (mcv), aspartate aminotransferase (ast), total bilirubin, indirect bilirubin, blood urea nitrogen (bun), creatinine and lipid hydroperoxide (lpo) were significantly (p < 0.05) higher in cattle infected with a. marginale. |
2022-05-17 |
2023-08-13 |
cattle |
| Supat Chupradit, Dmitry Bokov, Mohammad Yassin Zamanian, Mahsa Heidari, Elham Hakimizade. Hepatoprotective and therapeutic effects of resveratrol: A focus on anti-inflammatory and antioxidative activities. Fundamental & clinical pharmacology. vol 36. issue 3. 2022-05-16. PMID:34935193. |
additionally, it reduces oxidative stress in hepatic tissue by markedly reducing malondialdehyde (mda) and nitric oxide (no) contents and significantly increasing the levels of catalase (cat), superoxide dismutase (sod), and reduced hepatic glutathione (gsh), in addition to aspartate aminotransferase (ast) and alanine aminotransferase (alt), against toxic chemicals like cc14, as2o3, and tta. |
2022-05-16 |
2023-08-16 |
cat |
| Denise Battaglini, Miquéias Lopes-Pacheco, Hugo C Castro-Faria-Neto, Paolo Pelosi, Patricia R M Rocc. Laboratory Biomarkers for Diagnosis and Prognosis in COVID-19. Frontiers in immunology. vol 13. 2022-05-16. PMID:35572561. |
the most used biomarkers in covid-19 include several proinflammatory cytokines, neuron-specific enolase (nse), lactate dehydrogenase (ldh), aspartate transaminase (ast), neutrophil count, neutrophils-to-lymphocytes ratio, troponins, creatine kinase (mb), myoglobin, d-dimer, brain natriuretic peptide (bnp), and its n-terminal pro-hormone (nt-probnp). |
2022-05-16 |
2023-08-13 |
Not clear |
| Simiao Pan, Xiaobo Yan, Xiaohui Dong, Tao Li, Xiangxiang Suo, Beiping Tan, Shuang Zhang, Zhihao Li, Yuanzhi Yang, Haitao Zhan. The positive effects of dietary inositol on juvenile hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu) fed high-lipid diets: Growth performance, antioxidant capacity and immunity. Fish & shellfish immunology. 2022-05-16. PMID:35577318. |
in the serum, superoxide dismutase (sod) of the j4 group became significantly active compared with that of the control group (p < 0.05), while aspartate transaminase (ast), alanine transaminase (alt) and alkaline phosphatase (akp) activities in the inositol-treated groups showed distinctly decreased compared with those of the control group (p < 0.05). |
2022-05-16 |
2023-08-13 |
cat |
| Rolf Teschke, Nahum Méndez-Sánchez, Axel Eickhof. Liver Injury in COVID-19 Patients with Drugs as Causatives: A Systematic Review of 996 DILI Cases Published 2020/2021 Based on RUCAM as Causality Assessment Method. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563242. |
a total of 6/200 reports with initially suspected 996 dili cases in covid-19 patients and using all rucam-based dili cases allowed for a clear description of clinical features of rucam-based dili cases among covid-19 patients: (1) the updated rucam published in 2016 was equally often used as the original rucam of 1993, with both identifying dili and other liver diseases as confounders; (2) rucam also worked well in patients treated with up to 18 drugs and provided for most dili cases a probable or highly probable causality level for drugs; (3) dili was preferentially caused by antiviral drugs given empirically due to their known therapeutic efficacy in other virus infections; (4) hepatocellular injury was more often reported than cholestatic or mixed injury; (5) maximum lt values were found for alanine aminotransferase (alt) 1.541 u/l and aspartate aminotransferase (ast) 1.076 u/l; (6) the alt/ast ratio was variable and ranged from 0.4 to 1.4; (7) the mean or median age of the covid-19 patients with dili ranged from 54.3 to 56 years; (8) the ratio of males to females was 1.8-3.4:1; (9) outcome was favorable for most patients, likely due to careful selection of the drugs and quick cessation of drug treatment with emerging dili, but it was fatal in 19 patients; (10) countries reporting rucam-based dili cases in covid-19 patients included china, india, japan, montenegro, and spain; (11) robust estimation of the percentage contribution of rucam-based dili for the increased lts in covid-19 patients is outside of the current scope. |
2022-05-14 |
2023-08-13 |
Not clear |
| Aneta Strachecka, Karolina Kuszewska, Krzysztof Olszewski, Patrycja Skowronek, Maciej Grzybek, Marcin Grabowski, Jerzy Paleolog, Michał Woyciechowsk. Activities of Antioxidant and Proteolytic Systems and Biomarkers in the Fat Body and Hemolymph of Young Animals : an open access journal from MDPI. vol 12. issue 9. 2022-05-14. PMID:35565549. |
we determined the activities of acidic, neutral, and alkaline proteases and their inhibitors, as well as superoxide dismutase (sod), catalase (cat), aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp), and the level of total antioxidant potential (tac). |
2022-05-14 |
2023-08-13 |
cat |
| Juan-Fen Mo, Jia-Yuan Wu, Li Zheng, Ya-Wei Yu, Tian-Xin Zhang, Li Guo, Yi Ba. Therapeutic efficacy of polydatin for nonalcoholic fatty liver disease RSC advances. vol 8. issue 54. 2022-05-13. PMID:35548751. |
pd also downregulated the serum levels of triglyceride (tg), low density lipoprotein (ldl), aspartate aminotransferase (ast) and alanine aminotransferase (alt), and upregulated high density lipoprotein (hdl). |
2022-05-13 |
2023-08-13 |
mouse |
| Baohuan Lian, Lijun Cai, Zhaoqiang Zhang, Fen Lin, Zongxi Li, Xiao-Kun Zhang, Fuquan Jian. The anti-inflammatory effect of Pien Tze Huang in non-alcoholic fatty liver disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-13. PMID:35550529. |
our results showed that pth could exert hepatoprotective effects by improving liver weight and steatosis and reducing the fibrosis and serum levels of alanine transaminase (alt) and aspartate transaminase (ast) in both animal models. |
2022-05-13 |
2023-08-13 |
mouse |
| Mukharram M Bikbov, Timur R Gilmanshin, Rinat M Zainullin, Gyulli M Kazakbaeva, Ellina M Iakupova, Albina A Fakhretdinova, Azaliia M Tuliakova, Songhomitra Panda-Jonas, Leisan I Gilemzianova, Dinar A Khakimov, Liana A Miniazeva, Jost B Jona. Prevalence of non-alcoholic fatty liver disease in the Russian Ural Eye and Medical Study and the Ural Very Old Study. Scientific reports. vol 12. issue 1. 2022-05-13. PMID:35551494. |
defining nafld by an absence of regular alcohol consumption, and by abnormally high alanine transaminase (alt) and aspartate transaminase (ast) concentrations or an ast/alt ratio of > 1.0, 2341 out of 5852 uems participants (40.0%; 95% confidence intervals (ci) 38.8, 41.3) had nafld. |
2022-05-13 |
2023-08-13 |
human |
| Jennyfer Andrea Aldana-Mejía, Aline Mayrink de Miranda, Gari V Ccana-Ccapatinta, Luciana Silva de Araújo, Denise C Tavares, Fernando S Ramalho, Jairo K Basto. Long-term Effects of Brazilian Red Propolis Ethanolic Extract on Biochemistry and Histopathological Parameters of Wistar Rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554657. |
the alanine aminotransferase (alt) levels increased on the red propolis group, and the aspartate aminotransferase (ast) values increased on the satellite group. |
2022-05-13 |
2023-08-13 |
rat |
| Chloe G Henderson, Mark L Plamper, Thomas A Mayer, Jermaine A Ward, Shauna M Ward, Lisa R Leon, Kentaro Ok. Passive Heating after Heat- and Exercise-Induced Collapse in Mice Induces a Severe Exertional Heat Stroke Phenotype that More Accurately Recapitulates Human Cases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560302. |
a subset of the mice were sacrificed at 48 hours following the exercise/heat bout (n=10-12/group); in these mice, student's t-tests indicated that serum aspartate aminotransferase (ast) and alanine aminotransferase (alt) was elevated in ehs vs. exc while ast was elevated in ehs vs. ehi, suggesting ehs mice exhibited the most hepatic damage. |
2022-05-13 |
2023-08-13 |
mouse |
| Qiong-Hui Huang, Xue Wu, Xiao-Hong Chen, Jia-Zhen Wu, Zi-Ren Su, Jia-Li Liang, Yu-Cui Li, Xiao-Ping Lai, Jian-Nan Chen, Yu-Hong Li. Patchouli oil isolated from the leaves of RSC advances. vol 8. issue 43. 2022-05-11. PMID:35539211. |
our results showed that po pretreatment could dramatically decrease the levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp) and lactate dehydrogenase (ldh) in serum, paralleled by an improvement of histopathology alterations. |
2022-05-11 |
2023-08-13 |
rat |
| Ezhil Gurusamy, S Mahalakshmi, Gurumoorthy Kaarthikeyan, K Ramadevi, Parkavi Arumugam, M S Gayathr. Biochemical predictors for Sars-Cov-2 severity. Bioinformation. vol 17. issue 9. 2022-05-11. PMID:35539890. |
it is of interest to assess the inflammatory marker profile in sars-cov-2 patients and to correlate the levels of systemic inflammatory biomarkers such as neutrophil-to-lymphocyte ratio (nlr), c-reactive protein crp, ferritin, creatine kinase (ck), lactate dehydrogenase (ldh) and liver function analytes total serum proteins, albumin, total bilirubin, direct bilirubin, alkaline phosphatase, aspartate aminotransferase (ast) and alanine aminotransferase (alt) with the severity of sars-cov-2 infections. |
2022-05-11 |
2023-08-13 |
Not clear |
| Ezhil Gurusamy, S Mahalakshmi, Gurumoorthy Kaarthikeyan, K Ramadevi, Parkavi Arumugam, M S Gayathr. Biochemical predictors for Sars-Cov-2 severity. Bioinformation. vol 17. issue 9. 2022-05-11. PMID:35539890. |
laboratory assessments consisted of nlr (neutrophil-lymphocyte ratio) by cell counter, c reactive protein (crp) by immunoturbidimetry, ferritin by electrochemiluminescence (eclia) and creatine kinase (ck), lactate dehydrogenase (ldh), alkaline phosphatase (alp), aspartate aminotransferase (ast), alanine aminotransferase (alt), total bilirubin, direct bilirubin, total protein and albumin by spectrophotometry. |
2022-05-11 |
2023-08-13 |
Not clear |
| Saide Mehrabadi, Mohammad Miri, Moslem Lari Najafi, Mina Ghalenovi, Abolfazl Adli, Nasim Sadat Pajohanfar, Albert Ambrós, Afishin Dovlatabadi, Elahe Hasannejad Estiri, Mina Abroudi, Lucia Alonso, Malihe Sadat Bazghandi, Payam Dadvan. Green space exposure during pregnancy and umbilical cord blood levels of liver enzymes. Environmental science and pollution research international. 2022-05-11. PMID:35545744. |
hence, this study investigated the relationship between exposure to greenspace during the entire pregnancy and gamma-glutamyl transferase (ggt), alkaline phosphatase (alp), alanine aminotransferase (alt), and aspartate aminotransferase (ast) levels in cord blood samples. |
2022-05-11 |
2023-08-13 |
human |
| Nanda Chhavi, Sachi Ojha, Ashish Awasthi, Shalimar, Amit Goe. Serum Level of Alanine- and Aspartate-Aminotransferase Levels in Newborns in India. Journal of clinical and experimental hepatology. vol 12. issue 2. 2022-05-10. PMID:35535103. |
serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) ≤40 iu/l is normal. |
2022-05-10 |
2023-08-13 |
Not clear |
| Maryam Arabloei Sani, Parichehreh Yaghmaei, Zahra Hajebrahimi, Nasim Hayati Roodbar. Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats. Journal of obesity. vol 2022. 2022-05-09. PMID:35528246. |
data have shown that p-cymene can improve serum levels of glu, total cholesterol (tc), triglycerides (tg), high-density lipoprotein cholesterol (hdl-c), low-density lipoprotein (ldl), very-low-density lipoprotein (vldl), alkaline phosphatase (alp), alanine aminotransferase (alt), aspartate aminotransferase (ast), malondialdehyde (mda), and the expression of mtor, akt, and phospho-akt protein in diabetic animals. |
2022-05-09 |
2023-08-13 |
rat |
| Nikhil Reddy, Fadi S Odish, Sangeeta Agrawa. Macro-Aspartate Aminotransferase: A Benign Cause of Abnormal Laboratory Findings. Cureus. vol 14. issue 4. 2022-05-09. PMID:35530879. |
isolated, persistent elevations of aspartate aminotransferase (ast) without plausible explanation may lead to diagnostic confusion. |
2022-05-09 |
2023-08-13 |
Not clear |