| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingfei Xiao, Ying Zhao, Lei Ma, Rongli Pia. Orientin reverses acetaminophen-induced acute liver failure by inhibiting oxidative stress and mitochondrial dysfunction. Journal of pharmacological sciences. vol 149. issue 1. 2022-04-04. PMID:35369900. |
our results indicated that ori alleviated apap-induced hepatic pathological changes by reducing mouse mortality, inhibiting the expression of cytochrome p450 2e1 (cyp2e1), maintaining a normal liver structure, and reducing the levels of serum alanine transaminase (alt) and serum aspartate aminotransferase (ast). |
2022-04-04 |
2023-08-13 |
mouse |
| Shihao Xu, Xi Qiao, Peike Peng, Ziyi Zhu, Yaoting Li, Mengyuan Yu, Long Chen, Yin Cai, Jin Xu, Xinwei Shi, Christopher G Proud, Jianling Xie, Kaikai She. Da-Chai-Hu-Tang Protects From Acute Intrahepatic Cholestasis by Inhibiting Hepatic Inflammation and Bile Accumulation Frontiers in pharmacology. vol 13. 2022-04-04. PMID:35370715. |
anit (80 mg/kg) increased serum levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), direct bilirubin (dbil), total bilirubin (tbil), and total bile acids (tba) which was attenuated by dcht treatment in a dose-dependent manner. |
2022-04-04 |
2023-08-13 |
Not clear |
| Hong-Shuang Liu, Man-Yu Zhou, Xi Zhang, Ya-Lan Li, Jing-Wei Kong, Xin Gao, Dong-Yu Ge, Jia-Jing Liu, Pei-Guang Ma, Gui-Ying Peng, Yan Lia. Sagittaria sagittifolia polysaccharide protects against six-heavy-metal-induced hepatic injury associated with the activation of Nrf2 pathway to regulate oxidative stress and apoptosis. Journal of inorganic biochemistry. vol 232. 2022-04-03. PMID:35367820. |
ssp can alleviated hepatic injury, as evidenced by significantly decreased the activities of aspartate aminotransferase (ast), alanine aminotransferase (alt), and the malondialdehyde (mda) content, also increased the superoxide dismutase (sod) activity and glutathione (gsh), total sulphydryl (t-sh) contents. |
2022-04-03 |
2023-08-13 |
mouse |
| Shui-Fen Sun, Hui-Jie Zhong, Yun-Li Zhao, Xiu-Ying Ma, Jin-Bo Luo, Ling Zhu, Yu-Ting Zhang, Wen-Xue Wang, Xiao-Dong Luo, Jia-Wei Gen. Indole alkaloids of Alstonia scholaris (L.) R. Br. alleviated nonalcoholic fatty liver disease in mice fed with high-fat diet. Natural products and bioprospecting. vol 12. issue 1. 2022-04-02. PMID:35364708. |
the concentrations of low-density lipoprotein (ldl), triglyceride (tg), aspartate aminotransferase (ast) and alanine aminotransferase (alt) were also decreased significantly in ta-treated mice group, accompanied by an increase in high-density lipoprotein (hdl). |
2022-04-02 |
2023-08-13 |
mouse |
| Carla Diaz-Louzao, Lucia Barrera-Lopez, Maria Lopez-Rodriguez, Clara Casar, Nestor Vazquez-Agra, Hadrian Pernas-Pardavila, Ana Marques-Afonso, Martin Vidal-Vazquez, Jonathan G Montoya, Ariadna H Andrade, Ivan Fernandez-Castro, Pablo Varela, Arturo Gonzalez-Quintela, Esteban Otero, Francisco Gude, Carmen Cadarso-Suarez, Santiago Tom. Longitudinal relationship of liver injury with inflammation biomarkers in COVID-19 hospitalized patients using a joint modeling approach. Scientific reports. vol 12. issue 1. 2022-04-02. PMID:35365705. |
the patients who died showed a significant elevation in serum aspartate transaminase (ast) and alkaline phosphatase levels over time. |
2022-04-02 |
2023-08-13 |
Not clear |
| Wang Huo, Han Li, Lin Li, Ling Song, Yun-Hang Gao, Jian-Liang Li, Teng-Fei Chen, Hong-Ping Hou, Guang-Ping Zhang, Zu-Guang Y. [Study on regulation of CYP450 enzyme system to reduce liver toxicity through compatibility of Aconiti Kusnezoffii Radix Cocta with Chebulae Fructus and Glycyrrhizae Radix et Rhizoma]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 6. 2022-03-29. PMID:35347961. |
after continuous administration for 8 days, the activities of total bile acid(tba), alkaline phosphatase(alp), amino-transferase(alt) and aspartate aminotransferase(ast)in serum were detected, the pathological changes of liver tissue were observed, and the mrna and protein expression levels of cyp1 a2, cyp2 c11 and cyp3 a1 were observed. |
2022-03-29 |
2023-08-13 |
rat |
| Mohammad Moradzad, Mohammad Abdi, Farshad Sheikh Esmaeili, Dana Ghaderi, Khaled Rahmani, Mohammad Raman Moloudi, Zakaria Vahabzade. Possible correlation between high circulatory levels of trimethylamine-N-oxide and 2177G>C polymorphisms of hepatic flavin containing monooxygenase 3 in Kurdish Population with non-alcoholic fatty liver disease. Molecular biology reports. 2022-03-29. PMID:35348964. |
methods and results: in 85 confirmed nafld patients and 30 healthy individuals, triglycerides (tg), total cholesterol (chol), low-density lipoprotein (ldl), high-density lipoprotein (hdl), alanine aminotransferase (alt), and aspartate aminotransferase (ast) activities were measured. |
2022-03-29 |
2023-08-13 |
Not clear |
| Okunola Adenrele Alabi, Oluwatoyin Folake Olukunle, Opeyemi Febisara Ojo, Janet Busayo Oke, Taiwo Cosmas Adeb. Comparative study of the reproductive toxicity and modulation of enzyme activities by crude oil-contaminated soil before and after bioremediation. Chemosphere. 2022-03-28. PMID:35341768. |
the levels of total testosterone (tt), follicle stimulating hormone (fsh), and luteinizing hormone (lh); and activities of catalase (cat), alkaline phosphatase (alp), superoxide dismutase (sod), aspartate aminotransferase (ast), and alanine aminotransferase (alt) were determined. |
2022-03-28 |
2023-08-13 |
mouse |
| Sofia Nogueira, Fernanda Garcez, Susana Sá, Luís C Moutinho, Armando Cardoso, Raquel Soares, Bruno M Fonseca, Sandra Lea. Early unhealthy eating habits underlie morpho-functional changes in the liver and adipose tissue in male rats. Histochemistry and cell biology. 2022-03-28. PMID:35344087. |
our results revealed that serum levels of glucose, creatinine, aspartate transaminase (ast), alanine transaminase (alt), and lipid profile were increased in rats red high-sugar and high-energy diets. |
2022-03-28 |
2023-08-13 |
rat |
| Aliah R Alshanwani, Hanan Hagar, Sameerah Shaheen, Ahlam M Alhusaini, Maha M Arafah, Laila M Faddah, Fatima Mb Alharbi, Arun K Sharma, Amira M Bad. A promising antifibrotic drug, pyridoxamine attenuates thioacetamide-induced liver fibrosis by combating oxidative stress, advanced glycation end products, and balancing matrix metalloproteinases. European journal of pharmacology. 2022-03-27. PMID:35339478. |
thioacetamide treatment resulted in hepatic dysfunction manifested by increased serum levels of bilirubin, gamma-glutamyl transferase (ggt), alanine aminotransferase (alt), and aspartate aminotransferase (ast). |
2022-03-27 |
2023-08-13 |
Not clear |
| Anca Trifan, Ermina Stratina, Adrian Rotaru, Remus Stafie, Sebastian Zenovia, Robert Nastasa, Laura Huiban, Catalin Sfarti, Camelia Cojocariu, Tudor Cuciureanu, Cristina Muzica, Stefan Chiriac, Irina Girleanu, Ana-Maria Singeap, Carol Stanci. Changes in Liver Steatosis Using Controlled Attenuation Parameter among Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals Therapy Who Achieved Sustained Virological Response. Diagnostics (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35328255. |
regarding the changes in biological parameters, including liver enzymes such as alanine aminotransferase (alt) and aspartate aminotransferase (ast), reduced to normal levels at svr12 compared to the baseline (28.72 ± 24.71 u/l vs. 40.72 ± 27.34 u/l for alt, |
2022-03-25 |
2023-08-13 |
Not clear |
| Ghada M Shafey, Engy R Rashed, Hala F Zaki, Amina S Attia, Mona A El-Ghazal. Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy. BioFactors (Oxford, England). 2022-03-25. PMID:35332953. |
then, the serum activities of aspartate transaminase (ast) and alanine transaminase (alt) together with ammonia concentration were estimated to assess the liver function. |
2022-03-25 |
2023-08-13 |
rat |
| Sarah Schettle, Andrew Rosenbaum, Daniel Goodman, John Stula. De Ritis-adjusted AST Provides Comparable Efficacy to Lactate Dehydrogenase as a Biomarker for Detection of LVAD Hemolysis or Thrombosis. Artificial organs. 2022-03-23. PMID:35318681. |
aspartate aminotransferase (ast) and alanine aminotransferase (alt) are common laboratory tests that can be used to calculate the de ritis ratio and the de ritis adjusted ast. |
2022-03-23 |
2023-08-13 |
Not clear |
| Wangyang Chen, Weibo Wang, Lingling Zhou, Jun Zhou, Lianping He, Jiayi Li, Xinyue Xu, Jixi Wang, Liangyou Wan. Elevated AST/ALT ratio is associated with all-cause mortality and cancer incident. Journal of clinical laboratory analysis. 2022-03-23. PMID:35318741. |
the aspartate transaminase (ast)-to-alanine aminotransferase (alt) ratio, which is used to measure liver injury, has been found to be associated with some chronic diseases and mortality. |
2022-03-23 |
2023-08-13 |
Not clear |
| Bilal Onur, Kültiğin Çavuşoğlu, Emine Yalçin, Ali Aca. Paraquat toxicity in different cell types of Swiss albino mice. Scientific reports. vol 12. issue 1. 2022-03-22. PMID:35314741. |
body weight, liver and kidney organ weights, aspartate aminotransferase (ast) and alanine aminotransferase (alt) enzyme activities, blood urea nitrogen (bun) and creatinine levels, malondialdehyde (mda) and glutathione (gsh) levels in liver and kidney, micronucleus (mn) formation in buccal mucosal epithelium, erythrocyte and leukocyte cells and chromosomal aberrations (cas) in bone marrow cells, viability of liver and kidney cells were investigated. |
2022-03-22 |
2023-08-13 |
mouse |
| Haolong Li, Haoting Zhan, Linlin Cheng, Songxin Yan, Li Wang, Yongzhe L. Imbalanced distribution of group 2 innate lymphoid cells (ILCs) and ILC precursors in peripheral blood of patients with primary biliary cholangitis. Scandinavian journal of immunology. 2022-03-22. PMID:35315090. |
ilc2 proportion was negatively correlated with gamma-glutamyl transpeptidase (ggt), alanine aminotransferase (alt), and aspartate aminotransferase (ast). |
2022-03-22 |
2023-08-13 |
Not clear |
| Krystal Hasel, Ahlaa Salim, Sandeep Verma, Christopher D'Adamo, Denise Arrup, Rakesh Vinayek, Sudhir K Dutt. Prevalence of Gastrointestinal Symptoms, Hepatic Dysfunction, and Outcomes in Hospitalized Patients With COVID-19 Infection: An Early Experience. Cureus. vol 14. issue 2. 2022-03-21. PMID:35308711. |
the most common liver function abnormality was elevated serum aspartate aminotransferase (ast). |
2022-03-21 |
2023-08-13 |
Not clear |
| Seda Askin, Hakan Askin, Elifnur Dursun, Esra Palabiyik, Handan Uguz, Özge Cakmak, Kubra Ko. The hepato-renal protective potential of walnut seed skin extract against acute renal ischemia/reperfusion damage. Cytokine. vol 153. 2022-03-20. PMID:35306426. |
in serum samples, aspartate aminotransferase (ast), alanine aminotransferase (alt), lactate dehydrogenase (ldh), urea and creatinine values were determined separately for the administration groups. |
2022-03-20 |
2023-08-13 |
rat |
| Lianqun Qiu, Sa A Wang, Francisco Vega, Joseph D Khoury, Zhenya Tang, Sofia Garces, L Jeffrey Medeiros, Beenu Thakra. From the archives of MD Anderson Cancer Center: Intravascular large B-cell lymphoma with numerous circulating lymphoma cells. Annals of diagnostic pathology. vol 58. 2022-03-17. PMID:35299081. |
elevation of liver transaminases preferentially affecting aspartate aminotransferase (ast, 3/3, 100%), hepatosplenomegaly (4/5, 80%), thrombocytopenia (100%), cd5 positivity (100%) and monotypic lambda light chain predominance (3/4, 75%) were common features. |
2022-03-17 |
2023-08-13 |
Not clear |
| B Ahmad, W Khan, T U Haq, S Ahmad, M Zahoor, A Alotaibi, R Ulla. Beneficial effects of coconut oil (Cocos nucifera) on hematobiochemicl and histopathological markers in CCL4-intoxicated rabbits. Brazilian journal of biology = Revista brasleira de biologia. vol 84. 2022-03-16. PMID:35293540. |
the coconut oil (200 ml/kg body weight) significantly (p<0.05) reduced the elevated serum levels of alanine transaminase (alt), aspartate transaminase (ast) and alkaline phosphatase (alp) when compared to a toxic control rabbits. |
2022-03-16 |
2023-08-13 |
Not clear |