| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M T Giralt, G Bonanno, M Raiter. GABA terminal autoreceptors in the pars compacta and in the pars reticulata of the rat substantia nigra are GABAB. European journal of pharmacology. vol 175. issue 2. 1990-04-26. PMID:2155793. |
the depolarization-evoked release of gamma-aminobutyric acid (gaba) and its modulation mediated by autoreceptors were studied in superfused synaptosomes prepared from the pars compacta and from the pars reticulata of the rat substantia nigra. |
1990-04-26 |
2023-08-11 |
rat |
| M T Giralt, G Bonanno, M Raiter. GABA terminal autoreceptors in the pars compacta and in the pars reticulata of the rat substantia nigra are GABAB. European journal of pharmacology. vol 175. issue 2. 1990-04-26. PMID:2155793. |
it is concluded that (a) gaba autoreceptors are sited on gabaergic nerve endings in both the pars compacta and pars reticulata of the rat substantia nigra; (b) these autoreceptors belong to the gabab type. |
1990-04-26 |
2023-08-11 |
rat |
| R M Jaspers, J W Berkelbach van der Sprenkel, C A Tulleken, A R Cool. Local as well as remote functional and metabolic changes after focal ischemia in cats. Brain research bulletin. vol 24. issue 1. 1990-04-26. PMID:2310944. |
immediately following occlusion, all tested cats started to display a sequence of different behaviors, characteristic for 1) an ipsilateral inhibition of dopaminergic activity in the caudate nucleus (cn); 2) an inhibition of gabaergic activity in the reticular substantia nigra (snr); 3) a stimulation of gaba receptors in the deeper layers of the colliculus superior (csdl) (starting-time of these phases: about 4, 12 and 25 min, respectively). |
1990-04-26 |
2023-08-11 |
Not clear |
| L P Gonzalez, J F Czachur. Reduced behavioral responses to intranigral muscimol following chronic ethanol. Physiology & behavior. vol 46. issue 3. 1990-03-26. PMID:2623072. |
these results suggest that gaba receptive cells within the substantia nigra or its vicinity may be functionally less responsive to gabaergic stimulation after chronic ethanol administration. |
1990-03-26 |
2023-08-11 |
rat |
| C F Baxter, J E Parsons, C C Oh, C G Wasterlain, R A Baldwi. Changes of amino acid gradients in brain tissues induced by microwave irradiation and other means. Neurochemical research. vol 14. issue 9. 1990-01-25. PMID:2594149. |
evidence has now been obtained, on the basis of altered concentration gradients for gaba and taurine from the substantia nigra (sn) to an adjacent dorsal area (adj), that fmi not only inactivates enzymes, but also facilitates rapid diffusion of small molecules from areas of high concentrations to adjacent areas of lower concentration. |
1990-01-25 |
2023-08-11 |
Not clear |
| P C Waldmeier, P Wicki, J J Feldtrauer, P A Bauman. Release of endogenous GABA from the substantia nigra is not controlled by GABA autoreceptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 4. 1990-01-08. PMID:2555718. |
release of endogenous gaba from the substantia nigra is not controlled by gaba autoreceptors. |
1990-01-08 |
2023-08-11 |
rat |
| P C Waldmeier, P Wicki, J J Feldtrauer, P A Bauman. Release of endogenous GABA from the substantia nigra is not controlled by GABA autoreceptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 4. 1990-01-08. PMID:2555718. |
the characteristics of the release of gaba from slices of the rat substantia nigra, elicited by electrical stimulation at frequencies of 0.5-48 hz and by elevated k+ concentrations ranging from 15-35 mmol/l, was studied. |
1990-01-08 |
2023-08-11 |
rat |
| W Löscher, D Hönack, M Grame. Use of inhibitors of gamma-aminobutyric acid (GABA) transaminase for the estimation of GABA turnover in various brain regions of rats: a reevaluation of aminooxyacetic acid. Journal of neurochemistry. vol 53. issue 6. 1989-12-21. PMID:2809589. |
a total and rapidly occurring inhibition of gaba-t in all regions was obtained with intraperitoneal injection of 100 mg/kg aoaa, whereas after lower doses, marked regional differences in the degree of gaba-t inhibition were found, thus leading to underestimation of gaba synthesis rates, e.g., in substantia nigra. |
1989-12-21 |
2023-08-11 |
rat |
| W Löscher, D Hönack, M Grame. Use of inhibitors of gamma-aminobutyric acid (GABA) transaminase for the estimation of GABA turnover in various brain regions of rats: a reevaluation of aminooxyacetic acid. Journal of neurochemistry. vol 53. issue 6. 1989-12-21. PMID:2809589. |
gaba turnover rates thus determined were correlated in a highly significant fashion with the gad activities determined in brain regions, with highest turnover rates measured in substantia nigra, hypothalamus, olfactory bulb, and tectum. |
1989-12-21 |
2023-08-11 |
rat |
| W Lösche. Valproate enhances GABA turnover in the substantia nigra. Brain research. vol 501. issue 1. 1989-12-20. PMID:2508993. |
valproate enhances gaba turnover in the substantia nigra. |
1989-12-20 |
2023-08-11 |
rat |
| W Lösche. Valproate enhances GABA turnover in the substantia nigra. Brain research. vol 501. issue 1. 1989-12-20. PMID:2508993. |
however, significant increases in gaba accumulation were found in corpus striatum and, more marked, in substantia nigra. |
1989-12-20 |
2023-08-11 |
rat |
| W Lösche. Valproate enhances GABA turnover in the substantia nigra. Brain research. vol 501. issue 1. 1989-12-20. PMID:2508993. |
since the substantia nigra has been identified as a substrate for the anticonvulsant action of gabaergic drugs, the data may indicate that the effect of vpa on gaba synthesis rate in this region may be involved in its mechanism of anticonvulsant action. |
1989-12-20 |
2023-08-11 |
rat |
| E Sanna, M Serra, S Pepitoni, G Biggi. Dramatic increase in nigral t-[35S]butylbicyclophosphorothionate binding sites elicited by the degeneration of the striato-nigral GABAergic pathway: reversal by diazepam. Brain research. vol 501. issue 1. 1989-12-20. PMID:2553212. |
in rats, the degeneration of the striato-nigral gabaergic pathway caused by the intrastriatal injection of kainic acid induced a marked decrease (65%) of gaba content and glutamic acid decarboxylase (gad) activity and a dramatic increase (225%) in the binding of t-[35s]butylbicyclophosphorothionate [( 35s]tbps) to a membrane preparation from the substantia nigra homolateral to the injected striatum. |
1989-12-20 |
2023-08-11 |
rat |
| A Depaulis, O C Snead, C Marescaux, M Vergne. Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents. Brain research. vol 498. issue 1. 1989-11-08. PMID:2551457. |
these results confirm that activation of gaba receptors in the substantia nigra suppresses the occurrence of spike-and-wave discharges in animal models of generalized non-convulsive epilepsy. |
1989-11-08 |
2023-08-11 |
rat |
| R Maggio, K Gal. Seizures evoked from area tempestas are subject to control by GABA and glutamate receptors in substantia nigra. Experimental neurology. vol 105. issue 2. 1989-09-01. PMID:2568946. |
seizures evoked from area tempestas are subject to control by gaba and glutamate receptors in substantia nigra. |
1989-09-01 |
2023-08-11 |
human |
| H Zhang, H C Rosenberg, E I Tiet. Injection of benzodiazepines but not GABA or muscimol into pars reticulata substantia nigra suppresses pentylenetetrazol seizures. Brain research. vol 488. issue 1-2. 1989-08-14. PMID:2743142. |
injection of benzodiazepines but not gaba or muscimol into pars reticulata substantia nigra suppresses pentylenetetrazol seizures. |
1989-08-14 |
2023-08-11 |
rat |
| Y Masuo, I Kanazaw. Effects of the unilateral striatal lesion on neurotransmitter markers in the contralateral striatum and both substantia nigrae of the rat. Neuroscience. vol 27. issue 3. 1989-08-01. PMID:2908058. |
two types of changes were observed: (1) the first ones were long-lasting (up to 56 post-operative days) effects and consisted in a decrease of gaba content and tyrosine hydroxylase activity in the ipsilateral substantia nigra due to the anterograde and retrograde degeneration of striatal efferent and afferent fibres, respectively, and in a marked increase of glutamate and gaba contents in the contralateral striatum resulting possibly from a modified activity of the collaterals of the glutamatergic corticostriatal fibres and a subsequent secondary increase of gaba. |
1989-08-01 |
2023-08-11 |
rat |
| Y Masuo, I Kanazaw. Effects of the unilateral striatal lesion on neurotransmitter markers in the contralateral striatum and both substantia nigrae of the rat. Neuroscience. vol 27. issue 3. 1989-08-01. PMID:2908058. |
the latter interpretation was supported by the finding that the changes observed were abolished by an additional callosal transection; (2) the second series of changes were transient (only found at 3-7 post-operative days) effects represented by an increase in gaba content, a decrease of tyrosine hydroxylase activity, and a decrease of dopamine content, which mostly appeared in the contralateral substantia nigra. |
1989-08-01 |
2023-08-11 |
rat |
| Y Masuo, I Kanazaw. Effects of the unilateral striatal lesion on neurotransmitter markers in the contralateral striatum and both substantia nigrae of the rat. Neuroscience. vol 27. issue 3. 1989-08-01. PMID:2908058. |
the decrease of dopamine markers may be a subsequent secondary effect of the increase of gaba in the substantia nigra. |
1989-08-01 |
2023-08-11 |
rat |
| A S Ficalora, R R Miz. The neurons of the substantia nigra and zona incerta which project to the cat superior colliculus are GABA immunoreactive: a double-label study using GABA immunocytochemistry and lectin retrograde transport. Neuroscience. vol 29. issue 3. 1989-07-31. PMID:2739902. |
the neurons of the substantia nigra and zona incerta which project to the cat superior colliculus are gaba immunoreactive: a double-label study using gaba immunocytochemistry and lectin retrograde transport. |
1989-07-31 |
2023-08-11 |
cat |