| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Stevens, I Phillips, W J Freed, M Poltora. Cerebral transplants for seizures: preliminary results. Epilepsia. vol 29. issue 6. 1989-01-03. PMID:3191888. |
several critical brain regions have been identified in which application of gamma-aminobutyric acid (gaba) potentiating agents in small quantities can suppress or prevent generalized and kindled amygdala seizures, i.e., substantia nigra and deep prepiriform cortex. |
1989-01-03 |
2023-08-11 |
rat |
| D Samuel, U Kumar, A Nieoullo. gamma-Aminobutyric acid function in the rat striatum is under the double influence of nigrostriatal dopaminergic and thalamostriatal inputs: two modes of regulation? Journal of neurochemistry. vol 51. issue 6. 1988-12-20. PMID:3141584. |
glutamic acid decarboxylase (gad), gamma-[3h]-aminobutyric acid [( 3h]gaba) high-affinity uptake into synaptosomes, and endogenous gaba content were measured in the rat striatum 2-3 weeks following 6-hydroxydopamine injection in the ipsilateral substantia nigra to destroy the nigrostriatal dopaminergic pathway and after kainic acid injection into the centromedial-parafascicular complex of the ipsilateral thalamus to lesion the thalamostriatal input. |
1988-12-20 |
2023-08-11 |
rat |
| G Flügge, W Wuttke, E Fuch. Postnatal development of transmitter systems: sexual differentiation of the GABAergic system and effects of muscimol. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 4. issue 4. 1988-10-27. PMID:3455593. |
sex differences were observed only on day 10 in the medial preoptic area, with gaba being higher in males than in females; and also in the substantia nigra, where female gaba levels were higher than male. |
1988-10-27 |
2023-08-11 |
rat |
| G Flügge, W Wuttke, E Fuch. Postnatal development of transmitter systems: sexual differentiation of the GABAergic system and effects of muscimol. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 4. issue 4. 1988-10-27. PMID:3455593. |
on day 5, gaba concentrations were diminished only in the medial preoptic area, then on day 10, in the anterior hypothalamus and the substantia nigra, and still later, on day 15, in the caudato putamen. |
1988-10-27 |
2023-08-11 |
rat |
| C Silva-Barrat, S Brailowsky, D Riche, C Menin. Anticonvulsant effects of localized chronic infusions of GABA in cortical and reticular structures of baboons. Experimental neurology. vol 101. issue 3. 1988-10-24. PMID:3416984. |
the gaba infusion has partial anticonvulsant effects when applied to the motor cortex, reticular magnocellular nucleus (rmc), or substantia nigra (sn), but when directed to the prefrontal cortex (area 8) it has no effect. |
1988-10-24 |
2023-08-11 |
Not clear |
| B Floran, I Silva, C Nava, J Aceve. Presynaptic modulation of the release of GABA by GABAA receptors in pars compacta and by GABAB receptors in pars reticulata of the rat substantia nigra. European journal of pharmacology. vol 150. issue 3. 1988-10-18. PMID:2843383. |
presynaptic modulation of the release of gaba by gabaa receptors in pars compacta and by gabab receptors in pars reticulata of the rat substantia nigra. |
1988-10-18 |
2023-08-11 |
rat |
| B Floran, I Silva, C Nava, J Aceve. Presynaptic modulation of the release of GABA by GABAA receptors in pars compacta and by GABAB receptors in pars reticulata of the rat substantia nigra. European journal of pharmacology. vol 150. issue 3. 1988-10-18. PMID:2843383. |
the results suggest that the release of gaba from gabaergic terminals in the substantia nigra of the rat brain is modulated by gabaa autoreceptors in the pars compacta and by gabab receptors in the pars reticulata. |
1988-10-18 |
2023-08-11 |
rat |
| G D Frye, A S Finche. Effect of ethanol on gamma-vinyl GABA-induced GABA accumulation in the substantia nigra and on synaptosomal GABA content in six rat brain regions. Brain research. vol 449. issue 1-2. 1988-08-31. PMID:3395859. |
effect of ethanol on gamma-vinyl gaba-induced gaba accumulation in the substantia nigra and on synaptosomal gaba content in six rat brain regions. |
1988-08-31 |
2023-08-11 |
rat |
| G D Frye, A S Finche. Effect of ethanol on gamma-vinyl GABA-induced GABA accumulation in the substantia nigra and on synaptosomal GABA content in six rat brain regions. Brain research. vol 449. issue 1-2. 1988-08-31. PMID:3395859. |
gaba accumulation in the left substantia nigra zona reticulata (snr) following unilateral microinjection of gamma-vinyl gaba (gvg; 5 micrograms) was linear for at least 180 min while gaba concentrations in the uninjected right snr did not change over this period. |
1988-08-31 |
2023-08-11 |
rat |
| A Depaulis, M Vergnes, C Marescaux, B Lannes, J M Warte. Evidence that activation of GABA receptors in the substantia nigra suppresses spontaneous spike-and-wave discharges in the rat. Brain research. vol 448. issue 1. 1988-08-25. PMID:2839269. |
evidence that activation of gaba receptors in the substantia nigra suppresses spontaneous spike-and-wave discharges in the rat. |
1988-08-25 |
2023-08-11 |
rat |
| A Depaulis, M Vergnes, C Marescaux, B Lannes, J M Warte. Evidence that activation of GABA receptors in the substantia nigra suppresses spontaneous spike-and-wave discharges in the rat. Brain research. vol 448. issue 1. 1988-08-25. PMID:2839269. |
these results demonstrate that activation of gaba receptors in the substantia nigra suppresses the occurrence of spike-and-wave discharges in an animal model of generalized non-convulsive epilepsy. |
1988-08-25 |
2023-08-11 |
rat |
| J Gerlach, D E Case. Tardive dyskinesia. Acta psychiatrica Scandinavica. vol 77. issue 4. 1988-08-08. PMID:2898870. |
the traditional dopamine hypersensitivity theory is no longer viable, whereby new hypotheses have been advanced: td can be due to the blockade of a subset of striatal dopamine receptors, while parkinsonism is due to the blockade of another such subset, and/or can be due to a reduced gaba turnover in a subgroup of neurons connecting striatum with globus pallidus and substantia nigra. |
1988-08-08 |
2023-08-11 |
Not clear |
| H Mitsushio, M Takashima, N Mataga, M Tor. Effects of chronic treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content in rat brain: a possible implication of substance P in affective disorders. The Journal of pharmacology and experimental therapeutics. vol 245. issue 3. 1988-07-29. PMID:2455042. |
carbamazepine also dose-dependently increased gamma-aminobutyric acid levels in the substantia nigra without altering the striatal dopamine turnover rate. |
1988-07-29 |
2023-08-11 |
rat |
| M Reid, M Herrera-Marschitz, T Hökfelt, L Terenius, U Ungersted. Differential modulation of striatal dopamine release by intranigral injection of gamma-aminobutyric acid (GABA), dynorphin A and substance P. European journal of pharmacology. vol 147. issue 3. 1988-07-25. PMID:2454197. |
it was found that both gaba and dynorphin a produced a dose-dependent decrease in the release of striatal da following injection into the ipsilateral substantia nigra, the pars reticulata. |
1988-07-25 |
2023-08-11 |
Not clear |
| D J Sirinathsinghji, S B Dunnett, O Isacson, D J Clarke, K Kendrick, A Björklun. Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:3380300. |
in vivo monitoring of gaba release in globus pallidus and substantia nigra. |
1988-07-18 |
2023-08-11 |
rat |
| D J Sirinathsinghji, S B Dunnett, O Isacson, D J Clarke, K Kendrick, A Björklun. Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:3380300. |
gaba release was recorded in vivo by push-pull perfusion from the globus pallidus and substantia nigra of control rats, rats with unilateral ibotenic acid lesions of the neostriatum, and rats with embryonic striatal tissue grafts implanted in the lesioned striatum. |
1988-07-18 |
2023-08-11 |
rat |
| D J Sirinathsinghji, S B Dunnett, O Isacson, D J Clarke, K Kendrick, A Björklun. Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:3380300. |
gaba release was substantially restored in both the globus pallidus and substantia nigra of the grafted rats, to 34 and 60%, respectively. |
1988-07-18 |
2023-08-11 |
rat |
| D J Sirinathsinghji, S B Dunnett, O Isacson, D J Clarke, K Kendrick, A Björklun. Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:3380300. |
peripheral injection of the dopaminergic stimulant methamphetamine induced a short (lasting approximately 20 min) 4-5 fold increase in gaba release in the intact globus pallidus and a longer (lasting longer than 80 min) increase in the substantia nigra. |
1988-07-18 |
2023-08-11 |
rat |
| b' F Artigas, E Mart\\xc3\\xadnez, L Cam\\xc3\\xb3n, E Rodr\\xc3\\xadguez Farr\\xc3\\xa. Synthesis and utilization of neurotransmitters: actions of subconvulsant doses of hexachlorocyclohexane isomers on brain monoamines. Toxicology. vol 49. issue 1. 1988-06-30. PMID:2453940.' |
these results are in agreement with the proposed role of lindane as a "picrotoxinin-like" substance acting as an antagonist at the gaba-a receptor complex and thus impairing the inhibitory tone exerted by gaba on a variety of neurons (serotonin in raphe nuclei and dopamine in substantia nigra). |
1988-06-30 |
2023-08-11 |
Not clear |
| L M Gunne, S E Bachus, K Gal. Oral movements induced by interference with nigral GABA neurotransmission: relationship to tardive dyskinesias. Experimental neurology. vol 100. issue 3. 1988-06-23. PMID:2835254. |
to explore the specificity of this relationship, we acutely interfered with nigral gaba transmission pharmacologically, by microinfusing either the gaba receptor antagonist, bicuculline, or the gaba-depleting agent, isoniazid, bilaterally into substantia nigra. |
1988-06-23 |
2023-08-11 |
rat |