| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Elfoul. Improved Mathematical Models of Parkinson's Disease with Hopf Bifurcation and Huntington's Disease with Chaos. Acta biotheoretica. vol 72. issue 3. 2024-09-02. PMID:39223402. |
a decrease of gaba in the striatum or delayed excitation of the substantia nigra from the subthalamus may be a major cause of parkinson's disease. |
2024-09-02 |
2024-09-05 |
Not clear |
| Deepika Shukla, Anshika Goel, Pravat K Mandal, Shallu Joon, Khushboo Punjabi, Yashika Arora, Rajnish Kumar, Veer Singh Mehta, Padam Singh, Joseph C Maroon, Rishu Bansal, Kanika Sandal, Rimil Guha Roy, Avantika Samkaria, Shallu Sharma, Sandhya Sandhilya, Shradha Gaur, S Parvathi, Mallika Josh. Glutathione Depletion and Concomitant Elevation of Susceptibility in Patients with Parkinson's Disease: State-of-the-Art MR Spectroscopy and Neuropsychological Study. ACS chemical neuroscience. 2023-12-05. PMID:38050970. |
in the current study, we have investigated the impact of os in pd by measuring the antioxidant glutathione (gsh) levels from the substantia nigra (sn), left hippocampus (lh) and neurotransmitter γ-amino butyric acid (gaba) levels from sn region. |
2023-12-05 |
2023-12-10 |
Not clear |
| Mihai Gabriel Năstase, Ilinca Vlaicu, Simona Corina Trif. Genetic polymorphism and neuroanatomical changes in schizophrenia. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 63. issue 2. 2022-11-14. PMID:36374137. |
in schizophrenia, we find deficits of the γ-aminobutyric acid (gaba)ergic neurotransmitter, the dysfunctions being found predominantly at the level of the substantia nigra. |
2022-11-14 |
2023-08-14 |
Not clear |
| Yumi Kim, Jinyoung Jang, Hyun Jin Kim, Myoung Kyu Par. Regional difference in spontaneous firing inhibition by GABA The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 22. issue 6. 2020-09-30. PMID:30402033. |
regional difference in spontaneous firing inhibition by gaba gabaergic control over dopamine (da) neurons in the substantia nigra is crucial for determining firing rates and patterns. |
2020-09-30 |
2023-08-13 |
Not clear |
| Raghunandan Kumar Yadav, Mudasir Ahmad Khanday, Birendra Nath Mallic. Interplay of dopamine and GABA in substantia nigra for the regulation of rapid eye movement sleep in rats. Behavioural brain research. vol 376. 2020-09-17. PMID:31442548. |
interplay of dopamine and gaba in substantia nigra for the regulation of rapid eye movement sleep in rats. |
2020-09-17 |
2023-08-13 |
rat |
| Thomas N. Ferraro, Gregory T. Golden, Theodore A. Har. Repeated Electroconvulsive Shock Selectively Alters gamma-Aminobutyric Acid Levels in the Rat Brain: Effect of Electrode Placement. Convulsive therapy. vol 6. issue 3. 2019-11-20. PMID:11941068. |
gaba levels were increased in all brain regions examined in rats treated with auricular electrodes except the hippocampus and nucleus accumbens; rats treated with corneal electrodes exhibited gaba increases in the hippocampus, frontal cortex, hypothalamus, and olfactory bulbs; a significant decrease in nucleus accumbens; and no change in the substantia nigra and striatum. |
2019-11-20 |
2023-08-12 |
rat |
| Tetsufumi Ito, Takafumi Furuyama, Kazuma Hase, Kohta I Kobayasi, Shizuko Hiryu, Hiroshi Riquimarou. Organization of subcortical auditory nuclei of Japanese house bat (Pipistrellus abramus) identified with cytoarchitecture and molecular expression. The Journal of comparative neurology. vol 526. issue 17. 2019-10-28. PMID:30168138. |
in the nuclei of the lateral lemniscus (nll), the dorsal nucleus was found to be purely gabaergic, the intermediate nucleus was a mixture of glutamatergic and inhibitory neurons, the compact part of the ventral nucleus was purely glycinergic, and the multipolar part of the ventral nucleus expressed both gaba and glycine. |
2019-10-28 |
2023-08-13 |
Not clear |
| Christine Winter, Dana M Greene, Paraskevi Mavrogiorgou, Helge Schaper, Reinhard Sohr, Abel Bult-Ito, Georg Jucke. Altered serotonergic and GABAergic neurotransmission in a mice model of obsessive-compulsive disorder. Behavioural brain research. vol 337. 2018-06-08. PMID:28916503. |
the neurochemical investigation of several brain regions of the corticostriato-thalamocortical circuity, i.e., nucleus caudatus (cpu), nucleus accumbens (nac), globus pallidus (gp), hippocampus (hpc), amygdala (am), ventral tegmental area (vta) and substantia nigra (sn) was performed by electrochemical (serotonin and dopamine) and fluorescence (glutamate and gaba) hplc detection. |
2018-06-08 |
2023-08-13 |
mouse |
| Andrea Herrera, Patricia Muñoz, Irmgard Paris, Gabriela Díaz-Veliz, Sergio Mora, Jose Inzunza, Kjell Hultenby, Cesar Cardenas, Fabián Jaña, Rita Raisman-Vozari, Katia Gysling, Jorge Abarca, Harry W M Steinbusch, Juan Segura-Aguila. Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson's disease. Cellular and molecular life sciences : CMLS. vol 73. issue 18. 2017-08-23. PMID:27001668. |
the unilateral injection of aminochrome into rat striatum resulted in (1) contralateral rotation when the animals are stimulated with apomorphine; (2) absence of significant loss of tyrosine hydroxylase-positive neuronal elements both in substantia nigra and striatum; (3) cell shrinkage; (4) significant reduction of dopamine release; (5) significant increase in gaba release; (6) significant decrease in the number of monoaminergic presynaptic vesicles; (7) significant increase of dopamine concentration inside of monoaminergic vesicles; (8) significant increase of damaged mitochondria; (9) significant decrease of atp level in the striatum (10) significant decrease in basal and maximal mitochondrial respiration. |
2017-08-23 |
2023-08-13 |
rat |
| Wojciech Roczniak, Joanna M Oswiecimska, Barbara Brodziak-Dopierala, Elzbieta Cipora, Przemyslaw G Nowak, Magdalena Babuska-Rocznia. Evaluation of the analgesic effect of morphine on models of acute nociceptive pain in rats with a central noradrenergic system lesion. Neuro endocrinology letters. vol 37. issue 3. 2017-01-13. PMID:27618597. |
furthermore, opioids stimulate the noradrenergic descending pathways originating from the substantia nigra by presynaptic inhibition of the gaba neuron ends. |
2017-01-13 |
2023-08-13 |
rat |
| Juliana Almeida da Silva, Audrey Francisco Biagioni, Rafael Carvalho Almada, José Alexandre de Souza Crippa, Jaime Eduardo Cecílio Hallak, Antônio Waldo Zuardi, Norberto Cysne Coimbr. Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulata, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon. European journal of pharmacology. vol 758. 2016-04-26. PMID:25841876. |
many studies suggest that the substantia nigra, pars reticulata (snpr), a tegmental mesencephalic structure rich in γ-aminobutyric acid (gaba)- and cannabinoid receptor-containing neurons, is involved in the complex control of defensive responses through the neostriatum-nigral disinhibitory and nigro-tectal inhibitory gabaergic pathways during imminently dangerous situations. |
2016-04-26 |
2023-08-13 |
Not clear |
| S A Lukina, M R Timofeev. [Metabolic lung function upon activation of the substantia nigra and in conditions of gabaergic mediation of the amygdala and brainstem structures]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 100. issue 1. 2015-01-20. PMID:25464724. |
the study presents a comprehensive assessment of the integration of metabolic functions of the lungs when the focus of pathologic activity forms in the substantia nigra and when gaba is introduced into the central nucleus of the amygdala and into the giant cell reticular nucleus of the medulla oblongata. |
2015-01-20 |
2023-08-13 |
rat |
| Seung-Nam Kim, Ah-Reum Doo, Ji-Yeun Park, Hyunwoo J Choo, Insop Shim, Jongbae J Park, Younbyoung Chae, Bena Lee, Hyejung Lee, Hi-Joon Par. Combined treatment with acupuncture reduces effective dose and alleviates adverse effect of L-dopa by normalizing Parkinson's disease-induced neurochemical imbalance. Brain research. vol 1544. 2014-08-19. PMID:24321617. |
the combination treatment also significantly reduces the abnormal increase of gaba contents in the substantia nigra compared to the standard l-dopa treatment. |
2014-08-19 |
2023-08-12 |
mouse |
| Mark A Rossi, David Fan, Joseph W Barter, Henry H Yi. Bidirectional modulation of substantia nigra activity by motivational state. PloS one. vol 8. issue 8. 2014-04-01. PMID:23936522. |
these results suggest that signals related to the current motivational state bidirectionally modulate behavior and the magnitude of phasic response of both da and gaba neurons in the substantia nigra. |
2014-04-01 |
2023-08-12 |
mouse |
| B Glenthøj, R Hemmingsen, T G Bolwi. Kindling: a model for the development of tardive dyskinesia? Behavioural neurology. vol 1. issue 1. 2014-02-04. PMID:24486899. |
several experimental results link td with kindling: both conditions involve repeated stimulations, both seem to involve increased receptor responsiveness and in both conditions does depression in gaba transmission in snr (substantia nigra; pars reticulata) play an important role. |
2014-02-04 |
2023-08-12 |
Not clear |
| C Ortez, C Jou, E Cortès-Saladelafont, J Moreno, A Pérez, A Ormazábal, C Pérez-Cerdá, B Pérez, R Artuch, V Cusi, A García-Cazorl. Infantile parkinsonism and GABAergic hypotransmission in a patient with pyruvate carboxylase deficiency. Gene. vol 532. issue 2. 2013-12-24. PMID:23973720. |
both gamma-aminobutyric acid and dopamine markers were found coexisting in individual neurons of the substantia nigra. |
2013-12-24 |
2023-08-12 |
Not clear |
| Flavia di Michele, Sabina Luchetti, Giorgio Bernardi, Elena Romeo, Patrizia Longon. Neurosteroid and neurotransmitter alterations in Parkinson's disease. Frontiers in neuroendocrinology. vol 34. issue 2. 2013-12-16. PMID:23563222. |
the substantia nigra of the human brain expresses high concentrations of allopregnanolone (3α, 5αtetrahydroprogesterone), a neurosteroid that positively modulates the action of gaba at gabaa receptors and of 5α-dihydroprogesterone, a neurosteroid acting at the genomic level. |
2013-12-16 |
2023-08-12 |
human |
| Hidekazu Sotoyama, Hisaaki Namba, Satomi Chiken, Atsushi Nambu, Hiroyuki Naw. Exposure to the cytokine EGF leads to abnormal hyperactivity of pallidal GABA neurons: implications for schizophrenia and its modeling. Journal of neurochemistry. vol 126. issue 4. 2013-10-23. PMID:23437767. |
we also monitored extracellular gaba concentrations in the substantia nigra, one of the targets of pallidal efferents. |
2013-10-23 |
2023-08-12 |
rat |
| J A Childs, K Gal. Neurochemical evidence for a nigrotegmental GAbAergic projection. Brain research. vol 258. issue 1. 2013-10-22. PMID:24010171. |
axonal transport of [3h]gaba from substantia nigra to the pontomesencephalic tegmentum was demonstrated in rats pretreated with the gaba-transaminase inhibitor, gamma-vinyl-gaba. |
2013-10-22 |
2023-08-12 |
rat |
| P M Abedi, C Delaville, P De Deurwaerdère, W Benjelloun, A Benazzou. Intrapallidal administration of 6-hydroxydopamine mimics in large part the electrophysiological and behavioral consequences of major dopamine depletion in the rat. Neuroscience. vol 236. 2013-08-26. PMID:23376117. |
in addition to gaba and glutamate innervations, the globus pallidus (gp) receives dopamine afferents from the pars compacta of the substantia nigra (snc), and in turn, sends inhibitory gabaergic efferents to the subthalamic nucleus (stn) and the pars reticulata of the substantia nigra (snr). |
2013-08-26 |
2023-08-12 |
rat |