| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J P Bolam, Y Smit. The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat. Brain research. vol 529. issue 1-2. 1991-03-19. PMID:1704287. |
the gaba and substance p input to dopaminergic neurones in the substantia nigra of the rat. |
1991-03-19 |
2023-08-11 |
rat |
| J P Bolam, Y Smit. The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat. Brain research. vol 529. issue 1-2. 1991-03-19. PMID:1704287. |
in a second series of experiments sections of the substantia nigra were processed by the pre-embedding immunocytochemical technique for tyrosine hydroxylase and then the post-embedding immunogold technique for gamma-aminobutyric acid (gaba). |
1991-03-19 |
2023-08-11 |
rat |
| J P Bolam, Y Smit. The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat. Brain research. vol 529. issue 1-2. 1991-03-19. PMID:1704287. |
in a third series of experiments the combination of anterograde transport of lectin-conjugated horseradish peroxidase or biocytin with post-embedding gaba immunocytochemistry demonstrated that at least one of the sources of gaba-containing terminals in the substantia nigra is the striatum. |
1991-03-19 |
2023-08-11 |
rat |
| J P Bolam, Y Smit. The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat. Brain research. vol 529. issue 1-2. 1991-03-19. PMID:1704287. |
the results of the present study: (1) demonstrate that dopaminergic neurones in the substantia nigra receive symmetrical synaptic input from gabaergic and substance p-containing terminals, (2) show that a proportion of these terminals contain both substance p and gaba and (3) suggest that the major synaptic input to dopaminergic neurones is from gabaergic terminals and that a part of this innervation is derived from the striatum. |
1991-03-19 |
2023-08-11 |
rat |
| T Mennini, M Gobb. Regional distribution of low-affinity GABA receptors coupled to benzodiazepine receptor subtypes in rat brain: an autoradiographic evaluation. European journal of pharmacology. vol 189. issue 2-3. 1991-01-22. PMID:2174788. |
quantitative autoradiography of rat brain coronal sections show that maximum enhancement (more than 80%) of [3h]flunitrazepam binding by gaba occurs in brain regions particularly rich in type i benzodiazepine receptors (inferior colliculus, medium raphe, central gray and substantia nigra); conversely, brain areas where type ii predominates show the lowest enhancement by gaba (about 50%). |
1991-01-22 |
2023-08-11 |
rat |
| T Mennini, M Gobb. Regional distribution of low-affinity GABA receptors coupled to benzodiazepine receptor subtypes in rat brain: an autoradiographic evaluation. European journal of pharmacology. vol 189. issue 2-3. 1991-01-22. PMID:2174788. |
one possible explanation of these discrepancies is that the type ii receptors found in type i-enriched tissues (inferior colliculus, median raphe, central gray and substantia nigra) are associated with the alpha 3-subunit, while the type ii sites present in limbic and cortical regions represent a subpopulation carrying the alpha 2-subunit of the gabaa receptor, with lower gaba potentiation. |
1991-01-22 |
2023-08-11 |
rat |
| T L Perry, J M Wright, K Berry, S Hansen, T L Perr. Dominantly inherited apathy, central hypoventilation, and Parkinson's syndrome: clinical, biochemical, and neuropathologic studies of 2 new cases. Neurology. vol 40. issue 12. 1991-01-07. PMID:2247238. |
glutamate contents were low in frontal cortex and thalamus, and gamma-aminobutyric acid (gaba) contents were low in thalamus and substantia nigra of both patients. |
1991-01-07 |
2023-08-11 |
Not clear |
| H Czyzewska-Szafran, M Wutkiewicz, M Remiszewska, Z Jastrzebski, A Czarnecki, A Danys. Down-regulation of the GABA-ergic system in selected brain areas of spontaneously hypertensive rats (SHR). Polish journal of pharmacology and pharmacy. vol 41. issue 6. 1990-12-13. PMID:2562065. |
out of 9 brain areas studied the gaba content was significantly lower in the substantia nigra, hypothalamus, hypothalamus posterior and hippocampus of shr rats. |
1990-12-13 |
2023-08-11 |
rat |
| C Humpel, A Sari. Effects of GABA and L-glutamic acid on the potassium-evoked in vitro release of substance P- and neurokinin A-like immunoreactivities are different in the rat striatum and substantia nigra. Neuroscience letters. vol 105. issue 1-2. 1990-12-06. PMID:2484728. |
effects of gaba and l-glutamic acid on the potassium-evoked in vitro release of substance p- and neurokinin a-like immunoreactivities are different in the rat striatum and substantia nigra. |
1990-12-06 |
2023-08-11 |
rat |
| C Humpel, A Sari. Effects of GABA and L-glutamic acid on the potassium-evoked in vitro release of substance P- and neurokinin A-like immunoreactivities are different in the rat striatum and substantia nigra. Neuroscience letters. vol 105. issue 1-2. 1990-12-06. PMID:2484728. |
the potassium-evoked release of sp-li and nka-li was significantly, but not completely (by 25-70%) inhibited by simultaneous perfusion with l-glutamic acid (50 microm) and gamma-aminobutyric acid (gaba, 50 microm) in the substantia nigra. |
1990-12-06 |
2023-08-11 |
rat |
| C Humpel, A Sari. Effects of GABA and L-glutamic acid on the potassium-evoked in vitro release of substance P- and neurokinin A-like immunoreactivities are different in the rat striatum and substantia nigra. Neuroscience letters. vol 105. issue 1-2. 1990-12-06. PMID:2484728. |
the present data indicate a differential regulation of tachykinins in the striatum and substantia nigra by l-glutamic acid and gaba. |
1990-12-06 |
2023-08-11 |
rat |
| J Wenzel, K Kuschinsk. Effects of morphine on gamma-aminobutyric acid turnover in the basal ganglia. Possible correlation with its biphasic action on motility. Arzneimittel-Forschung. vol 40. issue 7. 1990-11-02. PMID:2171542. |
during the first, depressory phase only, gaba turnover was increased in the substantia nigra. |
1990-11-02 |
2023-08-11 |
Not clear |
| M S Reid, W T O'Connor, M Herrera-Marschitz, U Ungersted. The effects of intranigral GABA and dynorphin A injections on striatal dopamine and GABA release: evidence that dopamine provides inhibitory regulation of striatal GABA neurons via D2 receptors. Brain research. vol 519. issue 1-2. 1990-10-16. PMID:1975763. |
the effects of injections of gamma-aminobutyric acid (gaba) and dynorphin a into the substantia nigra, pars reticulata on the levels of extracellular dopamine (da) and gaba in the ipsilateral striatum of halothane-anaesthetized rats were studied using microdialysis. |
1990-10-16 |
2023-08-11 |
rat |
| S Simler, L Ciesielski, J Clement, P Mande. Amino acid neurotransmitter alterations in three sublines of Rb mice differing by their susceptibility to audiogenic seizures. Neurochemical research. vol 15. issue 7. 1990-10-11. PMID:1975652. |
seizure severity (rb1/rb2) seems to correlate, in some areas, with additional lower amounts of gaba already reported and, to a lower extent, of asp (-19% in striatum, inferior colliculus and cerebellum), of tau and gly; a tendency for a rise in gln content was observed in certain others (10-20% in olfactory bulb, thalamus, hypothalamus, substantia nigra, and frontal, temporal and occipital cortex). |
1990-10-11 |
2023-08-11 |
mouse |
| K Nakamura, T Matsumoto, M Hirano, H Uchimur. Changes in GABA content and turnover in discrete regions of rat brain after systemic administration of caerulein. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:2343075. |
caerulein decreased gaba levels in the nucleus accumbens, tuberculum olfactorium and substantia nigra and diminished gaba turnover rates in the striatum, nucleus accumbens and substantia nigra, as estimated from the rate of gaba accumulation after inhibition of gaba transaminase by aminooxyacetic acid (aoaa). |
1990-06-27 |
2023-08-11 |
rat |
| R D O'Neil. Uric acid levels and dopamine transmission in rat striatum: diurnal changes and effects of drugs. Brain research. vol 507. issue 2. 1990-06-20. PMID:2337766. |
the unilateral infusion of gamma-aminobutyric acid, taurine and haloperidol into the substantia nigra caused increases in the height of both the uric acid and hva peak in the ipsilateral striatum; the size of these changes showed a significant correlation. |
1990-06-20 |
2023-08-11 |
rat |
| N Lindefors, S Brené, H Persso. Increased expression of glutamic acid decarboxylase mRNA in rat substantia nigra after an ibotenic acid lesion in the caudate-putamen. Brain research. Molecular brain research. vol 7. issue 3. 1990-06-14. PMID:2159580. |
the increased gad mrna expression in the deafferented substantia nigra suggests a disinhibition of nigral gaba neurons, resulting in an increased utilization of gaba in these substantia nigra neurons. |
1990-06-14 |
2023-08-11 |
rat |
| A Depaulis, C Marescaux, Z Liu, M Vergne. The GABAergic nigro-collicular pathway is not involved in the inhibitory control of audiogenic seizures in the rat. Neuroscience letters. vol 111. issue 3. 1990-06-08. PMID:2336202. |
involvement of the gabaergic nigro-collicular pathway in the control of audiogenic seizures was examined in genetically sensitive rats by studying the effects of bilateral injections into the substantia nigra of muscimol, a gamma-aminobutyric acid (gaba) agonist, and those of bilateral injections into the superior colliculus of picrotoxin, a gaba antagonist, and of muscimol. |
1990-06-08 |
2023-08-11 |
rat |
| R Radian, O P Ottersen, J Storm-Mathisen, M Castel, B I Kanne. Immunocytochemical localization of the GABA transporter in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 4. 1990-05-25. PMID:2329379. |
polyclonal antibodies were raised against the gaba transporter (gaba-tp) purified from rat brain tissue (radian et al., 1986) and used for immunocytochemical localization of the antigen in several rat brain areas, including the cerebellum, hippocampus, substantia nigra, and cerebral cortex. |
1990-05-25 |
2023-08-11 |
rat |
| M T Giralt, G Bonanno, M Raiter. GABA terminal autoreceptors in the pars compacta and in the pars reticulata of the rat substantia nigra are GABAB. European journal of pharmacology. vol 175. issue 2. 1990-04-26. PMID:2155793. |
gaba terminal autoreceptors in the pars compacta and in the pars reticulata of the rat substantia nigra are gabab. |
1990-04-26 |
2023-08-11 |
rat |