| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C F Baxter, C C Oh, C G Wasterlain, L K Ozaki, R A Baldwi. Alterations of GABA metabolism and seizure susceptibility in the substantia nigra of the kindled rat acclimating to changes in osmotic state. Neurochemical research. vol 16. issue 3. 1992-03-10. PMID:1780028. |
seizure susceptibility and gaba metabolism were altered in the substantia nigra [sn] of adult male sprague dawley rats when these animals were acclimating to an altered plasma osmolality. |
1992-03-10 |
2023-08-11 |
rat |
| C R Gerfe. Substance P (neurokinin-1) receptor mRNA is selectively expressed in cholinergic neurons in the striatum and basal forebrain. Brain research. vol 556. issue 1. 1991-12-03. PMID:1718557. |
these neurons make synaptic contact with striatal cholinergic neurons, which are shown here to express the substance p receptor, and with other gabaergic neurons in the striatum and substantia nigra, which express gaba receptors but not substance p receptors. |
1991-12-03 |
2023-08-11 |
rat |
| W Löscher, D Hönack, C P Taylo. Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. Neuroscience letters. vol 128. issue 2. 1991-12-02. PMID:1945036. |
regions in which the time course of the increase in gaba accumulation was similar to the anticonvulsant time course of gabapentin included substantia nigra, amygdala and thalamus. |
1991-12-02 |
2023-08-11 |
rat |
| M H Bureau, R W Olse. Taurine acts on a subclass of GABAA receptors in mammalian brain in vitro. European journal of pharmacology. vol 207. issue 1. 1991-11-01. PMID:1655497. |
the taurine-sensitive gaba sites are enriched in dentate gyrus, substantia nigra, cerebellum molecular layer, median thalamic nuclei, and hippocampal field ca3; these areas are also enriched in mrna for the gaba-binding beta 2 subunit subtype. |
1991-11-01 |
2023-08-11 |
Not clear |
| Z A Bortolotto, C Heim, M Sieklucka, F Block, K H Sontag, E A Cavalheir. Effects of bilateral clamping of carotid arteries on hippocampal kindling in rats. Physiology & behavior. vol 49. issue 4. 1991-10-01. PMID:1881967. |
up to two weeks chronic increased gaba contents in hippocampus, substantia nigra and frontal cortex could be observed. |
1991-10-01 |
2023-08-11 |
rat |
| I Rektor, C Silva-Barrat, P Barthuel, C Ménin. Drugs influencing the GABAergic neurotransmission have no effect on the non-epileptic myoclonus of baboons. Electroencephalography and clinical neurophysiology. vol 79. issue 2. 1991-09-09. PMID:1713829. |
in the same way, localized chronic injections of gaba into various cerebral structures (prefrontal and motor cortical areas, reticular magnocellular nucleus and substantia nigra) had no effect. |
1991-09-09 |
2023-08-11 |
Not clear |
| R Maggio, E Sohn, K Gal. Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models. Brain research. vol 547. issue 1. 1991-09-05. PMID:1650283. |
lack of proconvulsant action of gaba depletion in substantia nigra in several seizure models. |
1991-09-05 |
2023-08-11 |
rat |
| R Maggio, E Sohn, K Gal. Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models. Brain research. vol 547. issue 1. 1991-09-05. PMID:1650283. |
the striatum, origin of gabaergic projections to substantia nigra, is a region in which application of gaba antagonists have been found to be anticonvulsant in several seizure models. |
1991-09-05 |
2023-08-11 |
rat |
| N Lantin Le Boulch, N A Truong-Ngoc, C Gauch. Role of dendritic dopamine of the substantia nigra in the modulation of nigrocollicular gamma-aminobutyric acid release: in vivo studies in the rat. Journal of neurochemistry. vol 57. issue 3. 1991-09-04. PMID:1677673. |
role of dendritic dopamine of the substantia nigra in the modulation of nigrocollicular gamma-aminobutyric acid release: in vivo studies in the rat. |
1991-09-04 |
2023-08-11 |
rat |
| N Lantin Le Boulch, N A Truong-Ngoc, C Gauch. Role of dendritic dopamine of the substantia nigra in the modulation of nigrocollicular gamma-aminobutyric acid release: in vivo studies in the rat. Journal of neurochemistry. vol 57. issue 3. 1991-09-04. PMID:1677673. |
when neuronal activity of the substantia nigra was enhanced by nigral application of k+ (30 mm) or bicuculline (10(-4) m), a persistent increase of the collicular [3h]gaba release was observed (60 and 80%, respectively). |
1991-09-04 |
2023-08-11 |
rat |
| H Zhang, H C Rosenberg, E I Tiet. Anticonvulsant actions and interaction of GABA agonists and a benzodiazepine in pars reticulata of substantia nigra. Epilepsy research. vol 8. issue 1. 1991-08-02. PMID:2060499. |
anticonvulsant actions and interaction of gaba agonists and a benzodiazepine in pars reticulata of substantia nigra. |
1991-08-02 |
2023-08-11 |
Not clear |
| H Zhang, H C Rosenberg, E I Tiet. Anticonvulsant actions and interaction of GABA agonists and a benzodiazepine in pars reticulata of substantia nigra. Epilepsy research. vol 8. issue 1. 1991-08-02. PMID:2060499. |
in a previous study, infusion of flurazepam and midazolam, but not gaba or muscimol into the pars reticulata of substantia nigra (snpr), blocked the tonus induced by a high dose of pentylenetetrazol (ptz). |
1991-08-02 |
2023-08-11 |
Not clear |
| R Tapia, J Flores-Hernánde. Circling behavior induced by intranigral administration of ruthenium red and 4-aminopyridine in the rat. Neuroscience. vol 39. issue 3. 1991-07-23. PMID:1711171. |
the release of [3h]gaba in slices of the ruthenium red-injected substantia nigra was not altered. |
1991-07-23 |
2023-08-11 |
rat |
| J Aceves, B Floran, D Martinez-Fong, A Sierra, S Hernandez, S Marisca. L-dopa stimulates the release of [3H]gamma-aminobutyric acid in the basal ganglia of 6-hydroxydopamine lesioned rats. Neuroscience letters. vol 121. issue 1-2. 1991-05-29. PMID:1902287. |
in substantia nigra, l-dopa stimulation (ec50 = 1 microm) of [3h]gaba release was dose-dependently blocked (ic50 = 0.1 microm for the stimulation caused by 10 microm l-dopa) by the d1 antagonist sch 23390, but was not affected by (-)-sulpiride, a d2 antagonist. |
1991-05-29 |
2023-08-11 |
rat |
| M Sieklucka, Z Bortolotto, C Heim, F Block, K H Sonta. Decreased susceptibility to seizures induced by bicuculline after transient bilateral clamping of the carotid arteries in rats. Journal of neural transmission. General section. vol 83. issue 1-2. 1991-05-28. PMID:1850283. |
an analysis of the gaba content showed a significant increase in the hippocampus (hpc), frontal cortex (fcx), parietal cortex and substantia nigra in bcca animals compared with controls. |
1991-05-28 |
2023-08-11 |
rat |
| H Nakayama, A Tamura, I Kanazawa, K San. Time-sequential change of amino acid neurotransmitters--GABA, aspartate and glutamate--in the rat basal ganglia following middle cerebral artery occlusion. Neurological research. vol 12. issue 4. 1991-05-10. PMID:1982166. |
gaba and aspartate content decreased in the ipsilateral substantia nigra from the second to the 28 th postoperative day. |
1991-05-10 |
2023-08-11 |
rat |
| H Nakayama, A Tamura, I Kanazawa, K San. Time-sequential change of amino acid neurotransmitters--GABA, aspartate and glutamate--in the rat basal ganglia following middle cerebral artery occlusion. Neurological research. vol 12. issue 4. 1991-05-10. PMID:1982166. |
in the contralateral side, gaba increased significantly in the substantia nigra throughout the experimental period and in the striatum during the first seven days. |
1991-05-10 |
2023-08-11 |
rat |
| H Nakayama, A Tamura, I Kanazawa, K San. Time-sequential change of amino acid neurotransmitters--GABA, aspartate and glutamate--in the rat basal ganglia following middle cerebral artery occlusion. Neurological research. vol 12. issue 4. 1991-05-10. PMID:1982166. |
these results indicate that the destruction of strionigral tract by focal ischaemia induced the decrease of inhibitory gaba in the ipsilateral substantia nigra. |
1991-05-10 |
2023-08-11 |
rat |
| U Wahnschaffe, W Lösche. Effect of selective bilateral destruction of the substantia nigra on antiepileptic drug actions in kindled rats. European journal of pharmacology. vol 186. issue 2-3. 1991-04-03. PMID:1963144. |
the substantia nigra (sn) is thought to be involved in the regulation of seizure activity and there is evidence that the nigra might be a site of anticonvulsant drug action, especially in the case of drugs that act by potentiating gamma-aminobutyric acid (gaba)-mediated neurotransmission. |
1991-04-03 |
2023-08-11 |
rat |
| M S Reid, M Herrera-Marschitz, T Hökfelt, N Lindefors, H Persson, U Ungersted. Striatonigral GABA, dynorphin, substance P and neurokinin A modulation of nigrostriatal dopamine release: evidence for direct regulatory mechanisms. Experimental brain research. vol 82. issue 2. 1991-03-22. PMID:1704847. |
this was investigated by measuring extracellular dopamine levels in the striatum, using microdialysis, after injections of gaba (300 nmol/0.2 microliters), dynorphin a (0.5 nmol/0.2 microliters), substance p (0.07 mnol/0.2 microliters) or neurokinin a (0.09 nmol/0.2 microliters) into the ipsilateral substantia nigra, pars reticulata (snr). |
1991-03-22 |
2023-08-11 |
rat |