| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aurélie De Groote, Alban de Kerchove d'Exaerd. Thalamo-Nucleus Accumbens Projections in Motivated Behaviors and Addiction. Frontiers in systems neuroscience. vol 15. 2021-08-03. PMID:34335197. |
the ventral striatum, also called nucleus accumbens (nac), has long been known to integrate information from cortical, thalamic, midbrain and limbic nuclei to mediate goal-directed behaviors. |
2021-08-03 |
2023-08-13 |
Not clear |
| Yasaman Razavi, Sara Karimi, Saeideh Karimi-Haghighi, Soghra Hesam, Abbas Haghparas. Changes in c-fos and p-CREB signaling following exposure to forced swim stress or exogenous corticosterone during morphine-induced place preference are dependent on glucocorticoid receptor in the basolateral amygdala. Canadian journal of physiology and pharmacology. vol 98. issue 11. 2021-08-02. PMID:32574519. |
neural circuitry comprising the nucleus accumbens (nac), prefrontal cortex (pfc), amygdala (amy), and hippocampus (hip) are the main components of the reward circuit. |
2021-08-02 |
2023-08-13 |
rat |
| Evelyn Ordoñes Sanchez, Charlotte C Bavley, Andre U Deutschmann, Rachel Carpenter, Drew R Peterson, Reza Karbalaei, James Flowers, Charleanne M Rogers, Miranda G Langrehr, Cory S Ardekani, Sydney T Famularo, Angela R Bongiovanni, Melissa C Knouse, Stan B Floresco, Lisa A Briand, Mathieu E Wimmer, Debra A Bangasse. Early life adversity promotes resilience to opioid addiction-related phenotypes in male rats and sex-specific transcriptional changes. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 8. 2021-08-02. PMID:33593913. |
because the nucleus accumbens (nac) mediates these behaviors, we tested whether lbn altered nac physiology in drug-naïve and morphine-exposed rats. |
2021-08-02 |
2023-08-13 |
rat |
| Rui Liu, Yun Wang, Xiongying Chen, Zhifang Zhang, Le Xiao, Yuan Zho. Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder. NeuroImage. Clinical. vol 30. 2021-07-30. PMID:33662708. |
the nucleus accumbens (nac) is an important region in reward circuit that has been linked with anhedonia, which is a characteristic symptom of major depressive disorder (mdd). |
2021-07-30 |
2023-08-13 |
Not clear |
| Klara Danielsson, Oona Lagström, Mia Ericson, Bo Söderpalm, Louise Adermar. Subregion-specific effects on striatal neurotransmission and dopamine-signaling by acute and repeated amphetamine exposure. Neuropharmacology. vol 194. 2021-07-28. PMID:34116108. |
to test this theory, acute and long-lasting changes in dopaminergic neurotransmission were assessed in the nucleus accumbens (nac) and the dorsomedial striatum (dms) following amphetamine exposure in wistar rats. |
2021-07-28 |
2023-08-13 |
rat |
| Marcos Brandão Contó, Nilton Barreto Dos Santos, Carolina Demarchi Munhoz, Tania Marcourakis, Vânia D'Almeida, Rosana Camarin. Exposure to Running Wheels Prevents Ethanol Rewarding Effects: The Role of CREB and Deacetylases SIRT-1 and SIRT-2 in the Nucleus Accumbens and Prefrontal Cortex. Neuroscience. vol 469. 2021-07-27. PMID:34175423. |
the expression of creb, sirt-1 and sirt-2 were evaluated in the prefrontal cortex (pfc) and nucleus accumbens (nac). |
2021-07-27 |
2023-08-13 |
mouse |
| Mi Yang, Chang-Hao Luo, Ying-Qi Zhu, Yuan-Chu Liu, Ye-Juan An, Javed Iqbal, Zhe-Zhi Wang, Xin-Ming M. 7, 8-Dihydroxy-4-methylcoumarin reverses depression model-induced depression-like behaviors and alteration of dendritic spines in the mood circuits. Psychoneuroendocrinology. vol 119. 2021-07-21. PMID:32563935. |
the aim of this study was to investigate whether dhmc alleviates chronic unpredictable mild stress (cums)-induced depression-like behaviors and reverses cums-induced alterations in dendritic spines of principal neurons in brain areas of the emotional circuits including the hippocampus, medial prefrontal cortex (mpfc), nucleus accumbens (nac) and basolateral amygdala (bla) in male rats. |
2021-07-21 |
2023-08-13 |
rat |
| Andre U Deutschmann, Julia M Kirkland, Lisa A Brian. Adolescent social isolation induced alterations in nucleus accumbens glutamate signalling. Addiction biology. 2021-07-19. PMID:34278652. |
excitatory afferents to the nucleus accumbens (nac) mediate responses to both stressful and rewarding stimuli. |
2021-07-19 |
2023-08-13 |
mouse |
| Mitra-Sadat Sadat-Shirazi, Haniyeh Soltani, Neda Nikpour, Masoud Haghshenas, Solmaz Khalifeh, Azarakhsh Mokri, Mohammad-Reza Zarrindas. Alteration of orexin-A and PKCα in the postmortem brain of pure-opioid and multi-drug abusers. Neuropeptides. vol 83. 2021-07-16. PMID:32741526. |
the medial prefrontal cortex (mpfc), lateral prefrontal cortex (lpfc), orbitofrontal cortex (ofc), nucleus accumbens (nac), and amygdala were dissected from fresh brain, frozen with liquid nitrogen and kept at -80 °c. |
2021-07-16 |
2023-08-13 |
Not clear |
| Adelis M Cruz, Tabitha H Kim, Rachel J Smit. Monosynaptic Retrograde Tracing From Prelimbic Neuron Subpopulations Projecting to Either Nucleus Accumbens Core or Rostromedial Tegmental Nucleus. Frontiers in neural circuits. vol 15. 2021-07-16. PMID:33732114. |
these seemingly opposing functions may be mediated by different efferent targets of pl projections, such as the nucleus accumbens (nac) core and rostromedial tegmental nucleus (rmtg), which have contrasting roles in reward-seeking behaviors. |
2021-07-16 |
2023-08-13 |
rat |
| Andrew Chih Wei Huang, Ying Hao Yu, Alan Bo Han He, Chen Yin O. Interactions between prelimbic cortex and basolateral amygdala contribute to morphine-induced conditioned taste aversion in conditioning and extinction. Neurobiology of learning and memory. vol 172. 2021-07-14. PMID:32407964. |
the consequences of exciting or destroying the prelimbic cortex (prl) or the basolateral amygdala (bla) remain unclear, including the effects on morphine-induced conditioned taste aversion (cta) in the conditioning and extinction phases, plasma corticosterone (cort) levels, and c-fos/p-erk expressions in the subareas of the medial prefrontal cortex (i.e., prl, infralimbic cortex [il], cingulate cortex 1 [cg1]), basolateral amygdala (bla), central amygdala (cea), hippocampus (i.e., ca1, ca2, ca3, and dentate gyrus [dg]), nucleus accumbens (nac), lateral hypothalamus (lh), and piriform cortex (pc). |
2021-07-14 |
2023-08-13 |
Not clear |
| Hee-Dae Kim, Jing Wei, Tanessa Call, Nicole Teru Quintus, Alexander J Summers, Samantha Carotenuto, Ross Johnson, Xiaokuang Ma, Chenxi Xu, Jin G Park, Shenfeng Qiu, Deveroux Ferguso. Shisa6 mediates cell-type specific regulation of depression in the nucleus accumbens. Molecular psychiatry. 2021-07-13. PMID:34253865. |
in the reward circuitry, the nucleus accumbens (nac) is a key brain region of depression pathophysiology, possibly based on differential activity of d1- or d2- medium spiny neurons (msns). |
2021-07-13 |
2023-08-13 |
mouse |
| Gal Warhaftig, Noa Zifman, Chaya Mushka Sokolik, Renaud Massart, Orshay Gabay, Daniel Sapozhnikov, Farida Vaisheva, Yehuda Lictenstein, Noa Confortti, Hadas Ahdoot, Avi Jacob, Tzofnat Bareli, Moshe Szyf, Gal Yadi. Reduction of DNMT3a and RORA in the nucleus accumbens plays a causal role in post-traumatic stress disorder-like behavior: reversal by combinatorial epigenetic therapy. Molecular psychiatry. 2021-07-13. PMID:34253866. |
using an animal ptsd model, we show distinct dna methylation profiles of ptsd susceptibility in the nucleus accumbens (nac). |
2021-07-13 |
2023-08-13 |
Not clear |
| Mateen Noori, Ahmed Hasbi, Meenalochani Sivasubramanian, Marija Milenkovic, Susan R Georg. Maternal Separation Model of Postpartum Depression: Potential Role for Nucleus Accumbens Dopamine D1-D2 Receptor Heteromer. Neurochemical research. vol 45. issue 12. 2021-07-12. PMID:33057844. |
dopamine pathways in the limbic regions of the brain such as the nucleus accumbens (nac) have been shown to be involved in the etiology of depressive disorders. |
2021-07-12 |
2023-08-13 |
rat |
| Cherie N Barnes, Conner W Wallace, Brielle S Jacobowitz, Steve C Fordah. Reduced phasic dopamine release and slowed dopamine uptake occur in the nucleus accumbens after a diet high in saturated but not unsaturated fat. Nutritional neuroscience. 2021-07-10. PMID:31914869. |
this study sought to determine whether fat type, saturated vs. unsaturated, differentially affected body weight, blood glucose regulation, locomotor behavior, and control of dopamine release and uptake at dopamine neuron terminals in the nucleus accumbens (nac). |
2021-07-10 |
2023-08-13 |
mouse |
| Cajsa Aranäs, Jesper Vestlund, Sarah Witley, Christian E Edvardsson, Aimilia Lydia Kalafateli, Elisabet Jerlha. Salmon Calcitonin Attenuates Some Behavioural Responses to Nicotine in Male Mice. Frontiers in pharmacology. vol 12. 2021-07-09. PMID:34234676. |
here, we evaluated the effects of salmon calcitonin (sct), an amylin and calcitonin receptor (ctr) agonist, on nicotine-induced locomotor stimulation and sensitisation as well as dopamine release in the nucleus accumbens (nac) shell. |
2021-07-09 |
2023-08-13 |
mouse |
| Shi-Hao Gao, Lin-Lin Shen, Hui-Zhong Wen, Yan-Dong Zhao, Peng-Hui Chen, Huai-Zhen Rua. The projections from the anterior cingulate cortex to the nucleus accumbens and ventral tegmental area contribute to neuropathic pain-evoked aversion in rats. Neurobiology of disease. vol 140. 2021-07-08. PMID:32251841. |
using anterograde and retrograde tracings, we confirmed that a subgroup of acc neurons projected to the nucleus accumbens (nac) and ventral tegmental area (vta), which are two crucial nodes of the mesolimbic dopamine system. |
2021-07-08 |
2023-08-13 |
rat |
| Caroline E Strong, Mohamed Kabba. Neural Mechanisms Underlying the Rewarding and Therapeutic Effects of Ketamine as a Treatment for Alcohol Use Disorder. Frontiers in behavioral neuroscience. vol 14. 2021-07-08. PMID:33362485. |
to do this, the focus will be on reward-related brain regions such as the nucleus accumbens (nac), dorsal striatum, prefrontal cortex (pfc), hippocampus, and ventral tegmental area (vta) to understand how acute vs. chronic exposure will alter reward signaling over time. |
2021-07-08 |
2023-08-13 |
human |
| Theresa M Carbonaro, Vien Nguyen, Michael J Forster, Michael B Gatch, Laszlo Proka. Carisoprodol pharmacokinetics and distribution in the nucleus accumbens correlates with behavioral effects in rats independent from its metabolism to meprobamate. Neuropharmacology. vol 174. 2021-07-07. PMID:32479814. |
additionally, pharmacokinetics of carisoprodol and meprobamate with and without co-administration of cimetidine were assessed via in vivo microdialysis combined with liquid-chromatography-tandem mass spectrometry from blood and nucleus accumbens (nac). |
2021-07-07 |
2023-08-13 |
rat |
| Yi Zhang, Huan Gui, Lang Hu, Chengxi Li, Jie Zhang, Xiaoli Lian. Dopamine D1 receptor in the NAc shell is involved in delayed emergence from isoflurane anesthesia in aged mice. Brain and behavior. vol 11. issue 1. 2021-06-30. PMID:33094567. |
the nucleus accumbens (nac) is a crucial arousal-related nucleus, in which activating medium spiny neurons (msns) expressing dopamine d1 receptor (d1r) could facilitate the arousal from natural sleep. |
2021-06-30 |
2023-08-13 |
mouse |