| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tadashi Saigusa, Yuri Aono, John L Waddingto. Integrative opioid-GABAergic neuronal mechanisms regulating dopamine efflux in the nucleus accumbens of freely moving animals. Pharmacological reports : PR. vol 73. issue 4. 2021-09-03. PMID:33743175. |
the nucleus accumbens (nac) is a terminal region of mesocorticolimbic dopamine (da) neuronal projections from the ventral tegmental area. |
2021-09-03 |
2023-08-13 |
Not clear |
| Nazanin Kahvandi, Zahra Ebrahimi, Seyed Asaad Karimi, Siamak Shahidi, Iraj Salehi, Marzieh Naderishahab, Abdolrahman Sarih. The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats. Behavioral and brain functions : BBF. vol 17. issue 1. 2021-09-02. PMID:33612106. |
the nucleus accumbens (nac) plays a principal role in drug reward. |
2021-09-02 |
2023-08-13 |
rat |
| Rie Shimoju, Hideshi Shibat. Simultaneous antagonism of dopamine D1/D2/D3 receptor in the NAc reduces 50-kHz ultrasonic calls in response to rhythmic tactile stroking. Behavioural brain research. vol 405. 2021-09-02. PMID:33652069. |
dopaminergic neurotransmission in the nucleus accumbens (nac) is required for tactile reward-induced 50-khz usvs; however, it is still unknown whether the accumbal dopaminergic system differentially modulates 50-khz usv call subtypes induced by rhythmic stroking. |
2021-09-02 |
2023-08-13 |
rat |
| Yukihiro Noda, Koki Soeda, Mizuki Uchida, Sakika Goto, Takahiro Ito, Shinji Kitagaki, Takayoshi Mamiya, Akira Yoshimi, Norio Ozaki, Akihiro Mour. Multiple nicotinic acetylcholine receptor subtypes regulate social or cognitive behaviors in mice repeatedly administered phencyclidine. Behavioural brain research. vol 408. 2021-09-02. PMID:33819533. |
mice that were repeatedly administered pcp showed impairments in social or cognitive behaviors; decreased expression of α7 and/or α4 nachr subunits in the prefrontal cortex (pfc); and increased expression of α7, α4, and β2 nachr subunits in the nucleus accumbens (nac). |
2021-09-02 |
2023-08-13 |
mouse |
| Claire Nguyen, Sarah Mondoloni, Tinaïg Le Borgne, Ines Centeno, Maxime Come, Joachim Jehl, Clément Solié, Lauren M Reynolds, Romain Durand-de Cuttoli, Stefania Tolu, Sébastien Valverde, Steve Didienne, Bernadette Hannesse, Jean-François Fiancette, Stéphanie Pons, Uwe Maskos, Véronique Deroche-Gamonet, Deniz Dalkara, Jean-Pierre Hardelin, Alexandre Mourot, Fabio Marti, Philippe Faur. Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety. Neuron. vol 109. issue 16. 2021-09-02. PMID:34242565. |
we found that nicotine injection drives opposite functional responses of two distinct populations of vta da neurons with anatomically segregated projections: it activates neurons that project to the nucleus accumbens (nac), whereas it inhibits neurons that project to the amygdala nuclei (amg). |
2021-09-02 |
2023-08-13 |
Not clear |
| Erin M Rhinehart, Madison Waldron, Hannah Kelly-Quigley, McKenzie Zellers, Abby Turco, Judith E Grise. β-Endorphin and sex differentially modulate the response to EtOH in a site-specific manner. Brain research. vol 1741. 2021-09-01. PMID:32315606. |
the number of c-fos immunoreactive cell nuclei, th-immunoreactivity, and th/c-fos-ir cells were quantified in the nucleus accumbens (nac), ventral tegmental area (vta), paraventricular nucleus (pvn), central nucleus of the amygdala (cea), paraventricular thalamic nucleus (pva) and edinger-westphal nucleus (ew). |
2021-09-01 |
2023-08-13 |
mouse |
| Kazuhiro Hada, Bolati Wulaer, Taku Nagai, Norimichi Itoh, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Daisuke Mori, Itaru Kushima, Toshitaka Nabeshima, Norio Ozaki, Kiyofumi Yamad. Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Molecular brain. vol 14. issue 1. 2021-09-01. PMID:33482876. |
we examined the spatiotemporal expression of arhgap10 mrna in the brain and found the highest expression levels in the cerebellum, striatum, and nucleus accumbens (nac), followed by the frontal cortex in adolescent mice. |
2021-09-01 |
2023-08-13 |
mouse |
| Claire E Stelly, Kasey S Girven, Merridee J Lefner, Kaitlyn M Fonzi, Matthew J Wana. Dopamine release and its control over early Pavlovian learning differs between the NAc core and medial NAc shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 10. 2021-08-27. PMID:33452431. |
specifically, a cue that always follows the previous reward by a short delay (high reward rate) evokes a larger dopamine response in the nucleus accumbens (nac) core relative to a distinct cue that always follows the prior reward by a long delay (low reward rate). |
2021-08-27 |
2023-08-13 |
rat |
| Alena Kozlova, Robert R Butler, Siwei Zhang, Thomas Ujas, Hanwen Zhang, Stephan Steidl, Alan R Sanders, Zhiping P Pang, Paul Vezina, Jubao Dua. Sex-specific nicotine sensitization and imprinting of self-administration in rats inform GWAS findings on human addiction phenotypes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 10. 2021-08-27. PMID:34007041. |
transcriptional profiling in the ventral tegmental area (vta) and nucleus accumbens (nac) core and shell further revealed sex- and brain region-specific transcriptomic signatures of sst and sa. |
2021-08-27 |
2023-08-13 |
human |
| Sohini Dutta, Jasmin Beaver, Carly J Halcomb, Aaron M Jasno. Dissociable roles of the nucleus accumbens core and shell subregions in the expression and extinction of conditioned fear. Neurobiology of stress. vol 15. 2021-08-27. PMID:34355048. |
the nucleus accumbens (nac), consisting of core (nacc) and shell (nacs) sub-regions, has primarily been studied as a locus mediating the effects of drug reward and addiction. |
2021-08-27 |
2023-08-13 |
mouse |
| Antoine Cherix, Thomas Larrieu, Jocelyn Grosse, João Rodrigues, Bruce McEwen, Carla Nasca, Rolf Gruetter, Carmen Sand. Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine. eLife. vol 9. 2021-08-26. PMID:31922486. |
energy metabolic changes in the nucleus accumbens (nac) were recently related to hierarchical status and vulnerability to develop depression-like behavior. |
2021-08-26 |
2023-08-13 |
mouse |
| Sumin Sohn, Sunghyun Kim, Ju Hwan Yang, Eun Sang Cho. Linking of NMDA receptors and mGluR5 in the nucleus accumbens core to repeated cocaine-induced 50-kHz ultrasonic vocalization in rats. Addiction biology. 2021-08-25. PMID:34378829. |
this study demonstrated the linking of glutamate receptors in the nucleus accumbens (nac) to vocal expression of 50-khz usv calls after repeated cocaine administration in freely moving rats. |
2021-08-25 |
2023-08-13 |
rat |
| Javier Novoa, Carlos J Rivero, Enrique U Pérez-Cardona, Jaime A Freire-Arvelo, Juan Zegers, Héctor E Yarur, Iván G Santiago-Marerro, José L Agosto-Rivera, Jorge L González-Pérez, Katia Gysling, Annabell C Segarr. Social isolation of adolescent male rats increases anxiety and K The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:34097788. |
this study investigated the effects of social isolation after weaning on anxiety, body weight and locomotion, and on extracellular dopamine (da) and glutamate (glu) in the nucleus accumbens (nac) and their modulation by corticotropin releasing factor receptor 1. |
2021-08-20 |
2023-08-13 |
rat |
| Dominik Thuberg, Lars Buentjen, Martin Holtkamp, Jürgen Voges, Hans-Jochen Heinze, Harim Lee, Ann-Yasmin Kitay, Friedhelm C Schmit. Deep Brain Stimulation for Refractory Focal Epilepsy: Unraveling the Insertional Effect up to Five Months Without Stimulation. Neuromodulation : journal of the International Neuromodulation Society. vol 24. issue 2. 2021-08-18. PMID:33577139. |
we examined the occurrence and duration of this ie in a group of patients with focal epilepsy following electrode implantation in the anterior nuclei of the thalamus (ant) and/or nucleus accumbens (nac) for dbs treatment. |
2021-08-18 |
2023-08-13 |
Not clear |
| Hao-Ran Wang, Su-Wan Hu, Song Zhang, Yu Song, Xiao-Yi Wang, Lei Wang, Yang-Yang Li, Yu-Mei Yu, He Liu, Di Liu, Hai-Lei Ding, Jun-Li Ca. KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice. Neuroscience bulletin. vol 37. issue 5. 2021-08-18. PMID:33900570. |
here, we found that chronic constructive injury (cci) in mice increased the firing activity and decreased the kcnq channel-mediated m-currents in ventral tegmental area (vta) da neurons projecting to the nucleus accumbens (nac). |
2021-08-18 |
2023-08-13 |
mouse |
| Xiao-Bo Wu, Qian Zhu, Yong-Jing Ga. CCL2/CCR2 Contributes to the Altered Excitatory-inhibitory Synaptic Balance in the Nucleus Accumbens Shell Following Peripheral Nerve Injury-induced Neuropathic Pain. Neuroscience bulletin. vol 37. issue 7. 2021-08-18. PMID:34003466. |
the medium spiny neurons (msns) in the nucleus accumbens (nac) integrate excitatory and inhibitory synaptic inputs and gate motivational and emotional behavior output. |
2021-08-18 |
2023-08-13 |
mouse |
| Katherine E Savell, Jennifer J Tuscher, Morgan E Zipperly, Corey G Duke, Robert A Phillips, Allison J Bauman, Saakshi Thukral, Faraz A Sultan, Nicholas A Goska, Lara Ianov, Jeremy J Da. A dopamine-induced gene expression signature regulates neuronal function and cocaine response. Science advances. vol 6. issue 26. 2021-08-17. PMID:32637607. |
drugs of abuse elevate dopamine levels in the nucleus accumbens (nac) and alter transcriptional programs believed to promote long-lasting synaptic and behavioral adaptations. |
2021-08-17 |
2023-08-13 |
rat |
| R R Campbell, E A Kramár, L Pham, J H Beardwood, A S Augustynski, A J López, O S Chitnis, G Delima, J Banihani, D P Matheos, M A Woo. HDAC3 Activity within the Nucleus Accumbens Regulates Cocaine-Induced Plasticity and Behavior in a Cell-Type-Specific Manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 13. 2021-08-17. PMID:33602824. |
this includes the class i histone deacetylase (hdac) hdac3, known to act as a negative regulator of cocaine-associated memory formation within the nucleus accumbens (nac). |
2021-08-17 |
2023-08-13 |
mouse |
| Xiao Jiang, Jian-Jun Zhang, Sen Song, Yonghui Li, Nan Su. The duration of withdrawal affects the muscarinic signaling in the nucleus accumbens after chronic morphine exposure in neonatal rats. Journal of neurophysiology. vol 125. issue 6. 2021-08-17. PMID:33978485. |
the infants experience withdrawal from opiates, and time-dependent adaptations in neuronal activity of nucleus accumbens (nac) may be crucial for this process. |
2021-08-17 |
2023-08-13 |
rat |
| Qing Shang, Jing Xiao, Baoyao Gao, Min Liang, Jing Wang, Hongyan Qian, Zhijia Xi, Tao Li, Xinshe Li. D1R/PP2A/p-CaMKIIα signaling in the caudate putamen is involved in acute methamphetamine-induced hyperlocomotion. Neuroscience letters. vol 760. 2021-08-17. PMID:34237414. |
the protein levels of methylated pp2a-c (m-pp2a-c, leucine [leu] 309), phosphorylated pp2a-c (p-pp2a-c, tyrosine [tyr] 307), pp2a-c, p-camkiiα (thr 286), and camkiiα in the prefrontal cortex (pfc), nucleus accumbens (nac), and caudate putamen (cpu) were measured. |
2021-08-17 |
2023-08-13 |
mouse |