| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Armando G Salinas, Jacob A Nadel, Yolanda Mateo, Thanh Huynh, Shana M Augustin, Karel Pacak, David M Lovinge. Chronic Ethanol Consumption Alters Presynaptic Regulation of Dorsal Striatal Dopamine Release in C57BL/6J Mice. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232321. |
clinical and preclinical research has shown that long-term ethanol exposure can alter dopamine release, though most of this work has focused on nucleus accumbens (nac). |
2022-10-14 |
2023-08-14 |
mouse |
| Kolter Grigsby, Courtney Ledford, Tanvi Batish, Snigdha Kanadibhotla, Delaney Smith, Evan Firsick, Alexander Tran, Kayla Townsley, Kaylee-Abril Vasquez Reyes, Katherine LeBlanc, Angela Ozbur. Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232380. |
therefore, the present study sought to test the effects of chronic binge-like drinking on diurnal circadian gene expression patterns in the master circadian pacemaker (scn), the ventral tegmental area (vta), and the nucleus accumbens (nac) in high drinking in the dark-1 (hdid-1) mice, a unique genetic risk model for drinking to intoxication. |
2022-10-14 |
2023-08-14 |
mouse |
| Xinjian Zhang, Daisuke Tsuboi, Yasuhiro Funahashi, Yukie Yamahashi, Kozo Kaibuchi, Taku Naga. Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232945. |
dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway, which projects dopamine neurons from the ventral tegmental area to the nucleus accumbens (nac). |
2022-10-14 |
2023-08-14 |
Not clear |
| Tong-Yu Liang, Hua Zhou, Yan-Gang Su. Distinct roles of dopamine receptor subtypes in the nucleus accumbens during itch signal processing. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-10-14. PMID:36241382. |
ventral tegmental area (vta) dopaminergic neurons, which are well known for their central roles in reward and motivation-related behaviors, have been shown to participate in itch processing via their projection to the nucleus accumbens (nac). |
2022-10-14 |
2023-08-14 |
mouse |
| Xu Wang, Haohong L. Chronic high-fat diet induces overeating and impairs synaptic transmission in feeding-related brain regions. Frontiers in molecular neuroscience. vol 15. 2022-10-13. PMID:36226318. |
subsequently, we also measured the synaptic activity of nucleus accumbens (nac) neurons, which play a vital role in the hedonic aspect of eating, and discovered that hfd diminished the frequency of both mepsc and mipsc in the nac. |
2022-10-13 |
2023-08-14 |
mouse |
| Ashley J McFalls, Christopher Jenney, Rachel S Stanford, Emma Woodward, Andras Hajnal, Patricia S Grigson, Kent E Vran. Greater Avoidance of a Saccharin Cue Paired with Passive Delivery of Heroin is Associated with a Select Increase in Expression of CRFR2 and CRFbp in the Hippocampus in Rats. Brain research bulletin. 2022-10-13. PMID:36228871. |
we then assessed gene expression for components of the crf pathway in the mpfc, hipp, vta, amygdala, and nucleus accumbens (nac). |
2022-10-13 |
2023-08-14 |
rat |
| Daozhong Jin, Hong Chen, Shao-Rui Chen, Hui-Lin Pa. α2δ-1 Protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens. Journal of neurochemistry. 2022-10-12. PMID:36222452. |
glutamate nmda receptors (nmdars) in the nucleus accumbens (nac) are critically involved in drug dependence and reward. |
2022-10-12 |
2023-08-14 |
mouse |
| Matthew B Pomrenze, Daniel F Cardozo Pinto, Peter A Neumann, Pierre Llorach, Jason M Tucciarone, Wade Morishita, Neir Eshel, Boris D Heifets, Robert C Malenk. Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal. Neuron. 2022-10-06. PMID:36202097. |
we find that sociability deficits during protracted opioid withdrawal in mice require activation of kappa opioid receptors (kors) in the nucleus accumbens (nac) medial shell. |
2022-10-06 |
2023-08-14 |
mouse |
| Lili Chen, Junling Wang, Mingrui Xia, Lianglong Sun, Junyan Sun, Linlin Gao, Dongling Zhang, Tao W. Altered functional connectivity of nucleus accumbens subregions associates with non-motor symptoms in Parkinson's disease. CNS neuroscience & therapeutics. 2022-10-03. PMID:36184786. |
this study aimed to identify the functional connectivity (fc) changes of nucleus accumbens (nac) subregions and characterize the association of network changes and non-motor symptoms (nms) in parkinson's disease (pd). |
2022-10-03 |
2023-08-14 |
Not clear |
| Ji Sun Kim, Oc-Hee Kim, In Soo Ryu, Yong-Hyun Kim, Kyung Oh Jeon, Li-Na Lim, Tae Wan Kim, Sumin Sohn, Sunghyun Kim, Jeong-Wook Seo, Eun Sang Choe, Eun Young Jan. Challenge exposure to whole cigarette smoke condensate upregulates locomotor sensitization by stimulating α4β2 nicotinic acetylcholine receptors in the nucleus accumbens of rats. Pharmacology, biochemistry, and behavior. 2022-10-02. PMID:36183870. |
the present study determined that α4β2 nachrs regulate locomotor sensitization by altering dopamine concentration in the nucleus accumbens (nac) after systemic challenge exposure to whole cigarette smoke condensate (wcsc). |
2022-10-02 |
2023-08-14 |
rat |
| Anibal Araya, Scarlet Gallegos, Adolfo Maldonado, Mario Rivera-Meza, Ramesh Chandra, Mary Kay Lobo, Luis G Aguay. Overexpression of wild type glycine alpha 1 subunit rescues ethanol sensitivity in accumbal receptors and reduces binge drinking in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-09-29. PMID:36175550. |
the nucleus accumbens (nac) is a critical region in the brain reward system since it integrates abundant synaptic inputs contributing to the control of neuronal excitability in the circuit. |
2022-09-29 |
2023-08-14 |
mouse |
| Linjuan Feng, Hsuan Lo, Hanlin You, Wei Wu, Xiaojuan Cheng, Jiawei Xin, Zucheng Ye, Xiaochun Chen, Xiaodong Pa. Loss of cannabinoid receptor 2 promotes α-Synuclein-induced microglial synaptic pruning in nucleus accumbens by modulating the pCREB-c-Fos signaling pathway and complement system. Experimental neurology. 2022-09-26. PMID:36162511. |
the disruption of nucleus accumbens (nac) function impacts mood and learning behavior in α-synucleinopathy, in which microglial synaptic pruning plays a pivotal role in modulating the neuropathologic progression. |
2022-09-26 |
2023-08-14 |
Not clear |
| Monika Shpokayte, Olivia McKissick, Xiaonan Guan, Bingbing Yuan, Bahar Rahsepar, Fernando R Fernandez, Evan Ruesch, Stephanie L Grella, John A White, X Shawn Liu, Steve Ramire. Hippocampal cells segregate positive and negative engrams. Communications biology. vol 5. issue 1. 2022-09-26. PMID:36163262. |
additionally, optogenetic manipulation of tagged cell bodies in vhpc is not sufficient to drive appetitive or aversive behavior in real-time place preference, stimulation of tagged vhpc terminals projecting to the amygdala and nucleus accumbens (nac), but not the prefrontal cortex (pfc), showed the capacity drive preference and avoidance. |
2022-09-26 |
2023-08-14 |
Not clear |
| Hua-Chun Miao, Min Liu, Feng Wu, Huai-Bin L. Expression changes of c-Fos and D1R/p-ERK1/2 signal pathways in nucleus accumbens of rats after ketamine abuse. Biochemical and biophysical research communications. vol 629. 2022-09-24. PMID:36152451. |
we aimed to investigate the changes of dopamine d1 receptors (d1r), phosphorylation of extracellular-regulated protein kinase 1/2 (p-erk1/2), and c-fos expression in the nucleus accumbens (nac) of ketamine abuse rats. |
2022-09-24 |
2023-08-14 |
rat |
| Bo Hao, Bu-Fang Fan, Can-Can Cao, Lu Liu, Shou-Min Xuan, Li Wang, Zhen-Jie Gao, Yan-Wei Shi, Xiao-Guang Wang, Hu Zha. Genes and pathways associated with fear discrimination identified by genome-wide DNA methylation and RNA-seq analyses in nucleus accumbens in mice. Progress in neuro-psychopharmacology & biological psychiatry. 2022-09-24. PMID:36152737. |
in this study, we found that the nucleus accumbens (nac) was indispensable for the formation of cued fear memory in mice, during which the expression of dna methyltransferase 3a gene (dnmt3a) increased. |
2022-09-24 |
2023-08-14 |
mouse |
| Juan Zegers-Delgado, Alejandro Aguilera-Soza, Florencia Calderón, Harley Davidson, Daniel Verbel-Vergara, Hector E Yarur, Javier Novoa, Camila Blanlot, Cristian P Bastias, María Estela Andrés, Katia Gyslin. Type 1 Corticotropin-Releasing Factor Receptor Differentially Modulates Neurotransmitter Levels in the Nucleus Accumbens of Juvenile versus Adult Rats. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142716. |
juvenile and adult rats exposed to social isolation show differences in anxiety-like behaviors and significant changes in dopamine (da) neurotransmission in the nucleus accumbens (nac). |
2022-09-23 |
2023-08-14 |
rat |
| Tiffany Garrett, Ingrid Tulloch, Michael T McCoy, Bruce Ladenheim, Subramaniam Jayanthi, Irina Krasnova, Genevieve Beauvais, Amber Hodges, Carolyn Davis, Jean Lud Cade. Chronic Methamphetamine Causes Differential Expression of Immediate Early Genes in the Nucleus Accumbens and Midbrain of Rats. Journal of drug and alcohol research. vol 1. issue 1. 2022-09-23. PMID:36147517. |
the acute meth challenge increased expression of members of activator protein 1 (ap-1) and nr4a ieg families in the nucleus accumbens (nac) and midbrain of saline-pretreated rats. |
2022-09-23 |
2023-08-14 |
rat |
| Ezio Carboni, Anna R Cart. BDNF Alterations in Brain Areas and the Neurocircuitry Involved in the Antidepressant Effects of Ketamine in Animal Models, Suggest the Existence of a Primary Circuit of Depression. Journal of integrative neuroscience. vol 21. issue 5. 2022-09-22. PMID:36137960. |
in this review we have examined the role of several brain areas: namely, the hippocampus, the medial prefrontal cortex (mpfc), the nucleus accumbens (nac), the lateral habenula (lhb), the amygdala and the bed nucleus of stria terminalis (bnst). |
2022-09-22 |
2023-08-14 |
Not clear |
| Qi Wang, Jia-Jie Zhu, Lizhao Wang, Yan-Peng Kan, Yan-Mei Liu, Yan-Jiao Wu, Xue Gu, Xin Yi, Ze-Jie Lin, Qin Wang, Jian-Fei Lu, Qin Jiang, Ying Li, Ming-Gang Liu, Nan-Jie Xu, Michael X Zhu, Lu-Yang Wang, Siyu Zhang, Wei-Guang Li, Tian-Le X. Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways. Nature communications. vol 13. issue 1. 2022-09-21. PMID:36130959. |
using an auditory fear-conditioning and extinction paradigm in male mice, here we discovered that two distinct projection neuron subpopulations in physical proximity within the insular cortex (ic), targeting the central amygdala (cea) and nucleus accumbens (nac), respectively, to encode fear and extinction memories. |
2022-09-21 |
2023-08-14 |
mouse |
| Kobra Askari, Shahrbanoo Oryan, Akram Eidi, Jalal Zaringhalam, Abbas Haghparas. Blockade of the orexin receptors in the ventral tegmental area could attenuate the stress-induced analgesia: A behavioral and molecular study. Progress in neuro-psychopharmacology & biological psychiatry. 2022-09-18. PMID:36116673. |
the current study examined the modulatory role of the ventral tegmental area (vta) orexinergic system in the restraint sia and extracellular signal-regulated kinase (erk) activation in the nucleus accumbens (nac). |
2022-09-18 |
2023-08-14 |
rat |