| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angela R Bongiovanni, Pingwei Zhao, Saadet Inan, Sonita Wiah, Aryan Shekarabi, Daniel J Farkas, Mia N Watson, Mathieu E Wimmer, Michael R Ruff, Scott M Rawl. Multi-chemokine receptor antagonist RAP-103 inhibits opioid-derived respiratory depression, reduces opioid reinforcement and physical dependence, and normalizes opioid-induced dysregulation of mesolimbic chemokine receptors in rats. Drug and alcohol dependence. vol 238. 2022-07-17. PMID:35843139. |
ccr2 and cxcr4 were increased in the ventral tegmental area (vta), whereas ccr2 and ccr5 were reduced in the nucleus accumbens (nac). |
2022-07-17 |
2023-08-14 |
rat |
| A C Medina, A Kabani, C Reyes-Vasquez, N Dafn. Age differences to methylphenidate-NAc neuronal and behavioral recordings from freely behaving animals. Journal of neural transmission (Vienna, Austria : 1996). 2022-07-16. PMID:35842551. |
the nucleus accumbens (nac) is part of the motivation circuit implicated in drug-seeking behaviors. |
2022-07-16 |
2023-08-14 |
rat |
| Tom Macpherson, Ji Yoon Kim, Takatoshi Hikid. Nucleus Accumbens Core Dopamine D2 Receptor-Expressing Neurons Control Reversal Learning but Not Set-Shifting in Behavioral Flexibility in Male Mice. Frontiers in neuroscience. vol 16. 2022-07-15. PMID:35837123. |
the nucleus accumbens (nac) is a major downstream target of both the mpfc and the ofc; however, its role in controlling reversal learning and set-shifting abilities is still unclear. |
2022-07-15 |
2023-08-14 |
mouse |
| Aaron E Miller, Atul P Daiwile, Jean Lud Cade. Sex-Dependent Alterations in the mRNA Expression of Enzymes Involved in Dopamine Synthesis and Breakdown After Methamphetamine Self-Administration. Neurotoxicity research. 2022-07-14. PMID:35834057. |
to better understand the molecular bases for the differences in da metabolism, we measured the levels of mrnas of enzymes that catalyze da synthesis and breakdown in the prefrontal cortex (pfc), nucleus accumbens (nac), dorsal striatum (dstr), and hippocampus (hip) of rats that had self-administered meth. |
2022-07-14 |
2023-08-14 |
human |
| Caroline J Smith, Tania Lintz, Madeline J Clark, Karen E Malacon, Alia Abiad, Nicholas J Constantino, Veronica J Kim, Young C Jo, Yanaira Alonso-Caraballo, Staci D Bilbo, Elena H Chartof. Prenatal opioid exposure inhibits microglial sculpting of the dopamine system selectively in adolescent male offspring. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-07-14. PMID:35835992. |
indeed, we recently found that microglial phagocytosis of dopamine d1 receptors (d1r) in the nucleus accumbens (nac) is required for the natural developmental decline in nac-d1r that occurs between adolescence and adulthood in rats. |
2022-07-14 |
2023-08-14 |
rat |
| Xuhong Li, Yuqian Zheng, Xiaoxuan Zhao, Ruisi Cui, Xinwang L. Relationship between the role of muscarinic M Neuroscience letters. 2022-07-09. PMID:35809878. |
relationship between the role of muscarinic m opioid use disorder mainly results from functional defects in the brain reward loop, which includs the ventral tegmental area (vta) and nucleus accumbens (nac; consisting of shell and core, nacs and nacc). |
2022-07-09 |
2023-08-14 |
Not clear |
| Martin Löffler, Seth M Levine, Katrin Usai, Simon Desch, Mina Kandić, Frauke Nees, Herta Flo. Corticostriatal circuits in the transition to chronic back pain: The predictive role of reward learning. Cell reports. Medicine. 2022-07-07. PMID:35798001. |
connectivity between the nucleus accumbens (nac) and ventromedial prefrontal cortex (vmpfc) and reward learning independently predict the transition from acute to chronic back pain (cbp). |
2022-07-07 |
2023-08-14 |
Not clear |
| Corey Baimel, Emily Jang, Samantha L Scudder, Kasra Manoocheri, Adam G Carte. Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens. Cell reports. vol 40. issue 1. 2022-07-06. PMID:35793623. |
cholinergic interneurons (chis) in the nucleus accumbens (nac) play a central role in motivated behaviors and associated disorders. |
2022-07-06 |
2023-08-14 |
Not clear |
| Larisa Montalvo-Martínez, Gabriela Cruz-Carrillo, Roger Maldonado-Ruiz, Marcela Cárdenas-Tueme, Sofia Bernal-Vega, Lourdes Garza-Ocañas, Rocío Ortiz-López, Diana Reséndez-Pérez, Alberto Camacho-Morale. Maternal high-dense diet programs interferon type I signaling and microglia complexity in the nucleus accumbens shell of rats showing food addiction-like behavior. Neuroreport. 2022-07-01. PMID:35776941. |
this study aimed to characterize the molecular immune networks and microglia reactivity in the nucleus accumbens (nac) shell affected by fetal nutritional programming leading to addiction-like behavior in the offspring of wistar rats. |
2022-07-01 |
2023-08-14 |
rat |
| Tong Zhang, Naoya Nishitani, Kazuhei Niitani, Ryoma Nishida, Yusaku Futami, Satoshi Deyama, Katsuyuki Kaned. A spatiotemporal increase of neuronal activity accompanies the motivational effect of wheel running in mice. Behavioural brain research. 2022-07-01. PMID:35777550. |
immunohistochemical analyses revealed that the number of c-fos (a neuronal activity marker)-positive cells increased in the medial prefrontal cortex (mpfc), core and shell of the nucleus accumbens (nac), dorsal striatum (str), and lateral septum (ls) at day 1, day 9, and days 20-24, in a time-dependent manner. |
2022-07-01 |
2023-08-14 |
mouse |
| Sujan C Das, Yusuf S Althobaiti, Alaa M Hammad, Fawaz Alasmari, Youssef Sar. Role of suppressing GLT-1 and xCT in ceftriaxone-induced attenuation of relapse-like alcohol drinking in alcohol-preferring rats. Addiction biology. vol 27. issue 4. 2022-06-27. PMID:35754102. |
alcohol dependence results in long-lasting neuroadaptive changes in meso-corticolimbic system, especially in the nucleus accumbens (nac), which drives relapse-like ethanol drinking upon abstinence or withdrawal. |
2022-06-27 |
2023-08-14 |
rat |
| Julie E Finnell, Carrie R Ferrari. Intra-NAc insulin reduces the motivation for food and food intake without altering cue-triggered food-seeking. Physiology & behavior. 2022-06-26. PMID:35753434. |
furthermore, insulin receptor activation alters dopamine and glutamate transmission within mesolimbic regions that influence food-seeking and feeding including the nucleus accumbens (nac). |
2022-06-26 |
2023-08-14 |
rat |
| Ling-Ling Xie, Chen Rui, Zhuang-Zhuang Li, Shan-Shan Li, Yong-Jian Fan, Man-Man Q. Melatonin mitigates traumatic brain injury-induced depression-like behaviors through HO-1/CREB signal in rats. Neuroscience letters. 2022-06-26. PMID:35753614. |
moreover, the activity of creb in the nucleus accumbens (nac) participates in reward and motivation, further contributing to depression induced by tbi. |
2022-06-26 |
2023-08-14 |
rat |
| Ying Liu, Huiping Zhan. RNA m6A Modification Changes in Postmortem Nucleus Accumbens of Subjects with Alcohol Use Disorder: A Pilot Study. Genes. vol 13. issue 6. 2022-06-24. PMID:35741720. |
the nucleus accumbens (nac) is a key brain structure mediating the rewarding effect of alcohol and drug abuse. |
2022-06-24 |
2023-08-14 |
human |
| Spencer B Huggett, Ami S Ikeda, John E McGeary, Karla R Kaun, Rohan H C Palme. Opioid Use Disorder and Alternative mRNA Splicing in Reward Circuitry. Genes. vol 13. issue 6. 2022-06-24. PMID:35741807. |
using publicly available rna-sequencing data, our study investigated the possible role of alternative mrna splicing in human brain tissue (dorsal-lateral prefrontal cortex (dlpfc), nucleus accumbens (nac), and midbrain) of 90 individuals with oud or matched controls. |
2022-06-24 |
2023-08-14 |
human |
| b' Mathieu Di Miceli, Maud Martinat, Mo\\xc3\\xafra Rossitto, Agn\\xc3\\xa8s Aubert, Shoug Alashmali, Cl\\xc3\\xa9mentine Bosch-Bouju, Xavier Fioramonti, Corinne Joffre, Richard P Bazinet, Sophie Lay\\xc3\\xa. Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Na\\xc3\\xafve and Chronically Stressed Mice. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743093.' |
in the present study, we studied the effect of a two-month exposure to isocaloric diets containing n-3 pufas in the form of relatively short-chain (sc) (6% of rapeseed oil, enriched in α-linolenic acid (ala)) or lc (6% of tuna oil, enriched in eicosapentaenoic acid (epa) and docosahexaenoic acid (dha)) pufas on behavior and synaptic plasticity of mice submitted or not to a chronic social defeat stress (csds), previously reported to alter emotional and social behavior, as well as synaptic plasticity in the nucleus accumbens (nac). |
2022-06-24 |
2023-08-14 |
mouse |
| Ting Wang, Yu-Nu Ma, Chen-Chen Zhang, Xiao Liu, Ya-Xin Sun, Hong-Li Wang, Han Wang, Yu-Heng Zhong, Yun-Ai Su, Ji-Tao Li, Tian-Mei S. The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse. Neuroscience bulletin. 2022-06-24. PMID:35750984. |
as the corticotropin-releasing hormone (crh)-corticotropin-releasing hormone receptor 1 (crhr1) system and nucleus accumbens (nac) play important roles in both stress responses and sleep-wake regulation, in this study we investigated whether the nac crh-crhr1 system mediates early-life stress-induced abnormalities in sleep-wake behavior in adult mice. |
2022-06-24 |
2023-08-14 |
mouse |
| Favio A Krapacher, Diana Fernández-Suárez, Annika Andersson, Alvaro Carrier-Ruiz, Carlos F Ibáñe. Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization. The EMBO journal. 2022-06-22. PMID:35730718. |
here, we report that dopamine d1 receptor signaling synergizes with the activin/alk4/smad3 pathway to potentiate the generation of Δfosb mrna in medium spiny neurons (msns) of the nucleus accumbens (nac) via activation of the rna-binding protein pcbp1, a regulator of mrna splicing. |
2022-06-22 |
2023-08-14 |
mouse |
| D R Rossato, H Z Rosa, J L O Rosa, L H Milanesi, V G Metz, L F D'Àvila, M E Burge. Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus accumbens Preventing Amphetamine Relapse. Molecular neurobiology. 2022-06-22. PMID:35732868. |
considering the beneficial influences of tactile stimulation (ts) in different diseases that affect the central nervous system (cns), here we evaluated if ts applied in adult rats could prevent or minimize the amph-relapse behavior also accessing molecular neuroadaptations in the nucleus accumbens (nac). |
2022-06-22 |
2023-08-14 |
rat |
| Nikki Le, Sarah Sayers, Veronica Mata-Pacheco, Edward J Wagne. The PACAP Paradox: Dynamic and Surprisingly Pleiotropic Actions in the Central Regulation of Energy Homeostasis. Frontiers in endocrinology. vol 13. 2022-06-20. PMID:35721722. |
in addition, pacap is also abundantly expressed in the hypothalamic areas like the ventromedial and arcuate nuclei (vmn and arc, respectively), as well as other brain regions such as the nucleus accumbens (nac), bed nucleus of stria terminalis (bnst), and ventral tegmental area (vta) - suggesting that pacap is capable of regulating energy homeostasis |
2022-06-20 |
2023-08-14 |
Not clear |