| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hasan Alhaddad, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Edward Melenski, Richard L Bell, Youssef Sar. Effects of a Novel Beta Lactam Compound, MC-100093, on the Expression of Glutamate Transporters/Receptors and Ethanol Drinking Behavior of Alcohol-Preferring Rats. The Journal of pharmacology and experimental therapeutics. vol 383. issue 3. 2022-11-17. PMID:36153003. |
chronic ethanol exposure affects the glutamatergic system in several brain reward regions including the nucleus accumbens (nac). |
2022-11-17 |
2023-11-20 |
rat |
| Iris Ka-Yi Chat, Erin E Dunning, Corinne P Bart, Ann L Carroll, Mora M Grehl, Katherine S F Damme, Lyn Y Abramson, Robin Nusslock, Lauren B Allo. The Interplay between Reward-Relevant Life Events and Trait Reward Sensitivity in Neural Responses to Reward Cues. Clinical psychological science : a journal of the Association for Psychological Science. vol 10. issue 5. 2022-11-16. PMID:36381350. |
greater exposure to goal-striving events was associated with higher nucleus accumbens (nac) reward anticipation among hrew participants and lower orbitofrontal cortex (ofc) reward anticipation among mrew participants. |
2022-11-16 |
2023-08-14 |
human |
| Subhash C Gupta, Ali Ghobbeh, Rebecca J Taugher-Hebl, Rong Fan, Jason B Hardie, Ryan T LaLumiere, John A Wemmi. Carbonic anhydrase 4 disruption decreases synaptic and behavioral adaptations induced by cocaine withdrawal. Science advances. vol 8. issue 46. 2022-11-16. PMID:36383659. |
cocaine use followed by withdrawal induces synaptic changes in nucleus accumbens (nac), which are thought to underlie subsequent drug-seeking behaviors and relapse. |
2022-11-16 |
2023-08-14 |
mouse |
| Andrey Sequeira-Cordero, Juan C Brene. Time course of plasticity-related alterations following the first exposure to amphetamine in juvenile rats. Pharmacology, biochemistry, and behavior. 2022-11-14. PMID:36375621. |
in a preclinical model with juvenile rats, we analyzed the time-dependent fluctuations in the expression of neuroplasticity-related genes like the brain-derived neurotrophic factor (bdnf), its tropomyosin receptor kinase b (trkb), the camp response element-binding protein (creb), the microrna-132, the rho gtpase-activating protein 32 (p250gap), the corticotropin-releasing factor (crf), and the neurotransmitters contents in the nucleus accumbens (nac) and the dorsal striatum (ds) 45, 90, and 180 min after an amphetamine (amph) injection. |
2022-11-14 |
2023-08-14 |
rat |
| Jinlan Zhao, Lihong Ye, Zuyi Liu, Yongfei Cui, Di Deng, Shasha Bai, Lei Yang, Yafei Shi, Zhongqiu Liu, Rong Zhan. Protective Effects of Resveratrol on Adolescent Social Isolation-Induced Anxiety-Like Behaviors via Modulating Nucleus Accumbens Spine Plasticity and Mitochondrial Function in Female Rats. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364807. |
the nucleus accumbens (nac) is an important reward center implicated in psychiatric disorders. |
2022-11-11 |
2023-08-14 |
rat |
| Jameel N Hamdan, Jorge A Sierra-Fonseca, Rodolfo J Flores, Sigifredo Saucedo, Manuel Miranda-Arango, Laura E O'Dell, Kristin L Gosselin. Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner. Frontiers in behavioral neuroscience. vol 16. 2022-11-07. PMID:36338879. |
the hippocampus (hipp), medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate putamen (cpu) were isolated from one subgroup of animals and subjected to western blot and protein quantitation for tyrosine hydroxylase (th), α-synuclein (alpha), nmda receptor (nmdar), dopamine receptor-1 (d1) and -2 (d2), dopamine transporter (dat), and postsynaptic density 95 (psd95). |
2022-11-07 |
2023-08-14 |
rat |
| Jakkrit Nukitram, Ekkasit Kumarnsit, Dania Cheah. A 1:1 ratio of cannabidiol: tetrahydrocannabinol attenuates methamphetamine conditioned place preference in mice: A prospective study of antidopaminergic mechanism. Brain research bulletin. 2022-11-06. PMID:36336144. |
male icr mice were implanted with the lfp electrode in the ventral tegmental area (vta) and the nucleus accumbens (nac). |
2022-11-06 |
2023-08-14 |
mouse |
| Peter J Vollbrecht, Kathryn M Nesbitt, Victoria M Addis, Keenan M Boulnemour, Daniel A Micheli, Kendall B Smith, Darleen A Sandoval, Robert T Kennedy, Carrie R Ferrari. Differential Regulation of Nucleus Accumbens Glutamate and GABA in Obesity-Prone and Obesity-Resistant Rats. Journal of neurochemistry. 2022-11-06. PMID:36336816. |
studies from humans and rodent models suggest that inherent differences in the function of brain motivation centers, including the nucleus accumbens (nac), contribute to overeating and thus obesity. |
2022-11-06 |
2023-08-14 |
rat |
| Blake L Elliott, Kimberlee D'Ardenne, Vishnu P Murty, Gene A Brewer, Samuel M McClur. Midbrain-Hippocampus Structural Connectivity Selectively Predicts Motivated Memory Encoding. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-11-04. PMID:36332978. |
functional mri studies show that interactions between the dopaminergic midbrain (sn/vta), hippocampus, and nucleus accumbens (nac) are critical for motivated memory encoding. |
2022-11-04 |
2023-08-14 |
human |
| William C Griffin, Marcelo F Lopez, John J Woodward, Howard C Becke. Alcohol Dependence and the Ventral Hippocampal Influence on Alcohol Drinking in Male Mice. Alcohol (Fayetteville, N.Y.). 2022-11-03. PMID:36328184. |
facilitated by its connectivity with other parts of the brain such as the nucleus accumbens (nac), the ventral hippocampus (vhc) supports many behaviors, including those related to reward seeking and addiction. |
2022-11-03 |
2023-08-14 |
mouse |
| Tehila Beiser, Elvira Lisniansky, Moriya Weitz, Alexey Bingor, Etty Grad, Kobi Rosenblum, Claire Thornton, Rami Yak. A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference. Translational psychiatry. vol 12. issue 1. 2022-11-02. PMID:36319619. |
phosphorylated eef2 was decreased one day after psychomotor sensitization and returned to baseline at seven days in the nucleus accumbens (nac) of wt mice, but not in eef2k-ki mice. |
2022-11-02 |
2023-08-14 |
mouse |
| Aram Parsegian, M Julia García-Fuster, Elaine Hebda-Bauer, Stanley J Watson, Shelly B Flagel, Huda Aki. Adolescent cocaine differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypes. Frontiers in psychiatry. vol 13. 2022-10-31. PMID:36311521. |
in bhrs, decreased h3k9me3 and increased ach3k9 in the nucleus accumbens (nac) core associated with cocaine sensitization. |
2022-10-31 |
2023-08-14 |
rat |
| Kyle B Bills, Dallin Z Otteson, Gavin C Jones, James N Brundage, Emily K Baldwin, Christina A Small, Hee Young Kim, Jordan T Yorgason, Jonathan D Blotter, Scott C Steffense. Mechanical Stimulation Alters Chronic Ethanol-Induced Changes to VTA GABA Neurons, NAc DA Release and Measures of Withdrawal. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293482. |
it has been previously shown to modulate the firing rate of neurons in the ventral tegmental area (vta) and dopamine (da) release in the nucleus accumbens (nac), an area of interest in alcohol-use disorder (aud). |
2022-10-27 |
2023-08-14 |
rat |
| Benjamin Wong, Alexa R Zimbelman, Mike Milovanovic, Marina E Wolf, Michael T Stefani. GluA2-lacking AMPA receptors in the nucleus accumbens core and shell contribute to the incubation of oxycodone craving in male rats. Addiction biology. vol 27. issue 6. 2022-10-27. PMID:36301206. |
for these psychostimulants, incubation is associated with strengthening of excitatory synapses in the nucleus accumbens (nac) through incorporation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors that lack the glua2 subunit and are therefore ca |
2022-10-27 |
2023-08-14 |
rat |
| Meimei Guo, Yuxiang Wu, Danhao Zheng, Lei Chen, Bingrui Xiong, Jinfeng Wu, Ke Li, Li Wang, Kangguang Lin, Zongze Zhang, Anne Manyande, Fuqiang Xu, Jie Wang, Mian Pen. Preoperative Acute Sleep Deprivation Causes Postoperative Pain Hypersensitivity and Abnormal Cerebral Function. Neuroscience bulletin. 2022-10-25. PMID:36282466. |
the functional connectivity (fc) between the nucleus accumbens (nac, a subregion of the ventral striatum) and the ventrolateral periaqueductal gray (vlpag) was significantly reduced, and the c-fos expression in the nac and the vlpag was suppressed. |
2022-10-25 |
2023-08-14 |
rat |
| Kuikui Zhou, Hua Xu, Shanshan Lu, Shaolei Jiang, Guoqiang Hou, Xiaofei Deng, Miao He, Yingjie Zh. Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice. Nature communications. vol 13. issue 1. 2022-10-21. PMID:36271048. |
the nucleus accumbens (nac) is critical in mediating reward seeking and is also involved in negative emotion processing, but the cellular and circuitry mechanisms underlying such opposing behaviors remain elusive. |
2022-10-21 |
2023-08-14 |
mouse |
| Roxanna Nahvi, Arax Tanelian, Chiso Nwokafor, Arthur Godino, Eric Parise, Molly Estill, LiShen, Eric J Nestler, Esther L Sabba. Transcriptome Profiles Associated with Resilience and Susceptibility to Single Prolonged Stress in the Locus Coeruleus and Nucleus Accumbens in Male Sprague-Dawley Rats. Behavioural brain research. 2022-10-18. PMID:36257560. |
here we examined different transcriptome profiles within the locus coeruleus (lc) and nucleus accumbens (nac) that may contribute to stress susceptibility. |
2022-10-18 |
2023-08-14 |
rat |
| Bowen Tan, Tobias Nöbauer, Caleb J Browne, Eric J Nestler, Alipasha Vaziri, Jeffrey M Friedma. Dynamic processing of hunger and thirst by common mesolimbic neural ensembles. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 43. 2022-10-17. PMID:36252036. |
the nucleus accumbens (nac) is a canonical reward center that regulates feeding and drinking but it is not known whether these behaviors are mediated by same or different neurons. |
2022-10-17 |
2023-08-14 |
mouse |
| Xiaoting Sun, Min Liu, Xinyu Xu, Chennan Shi, Liping Zhang, Zhimo Yao, Jiangfan Chen, Qin Wan. Accumbal adenosine A Neuropharmacology. 2022-10-17. PMID:36252615. |
numerous studies have identified nucleus accumbens (nac) as an important locus for cbdm control but their neuromodulatory and behavioral mechanisms remain largely under-explored. |
2022-10-17 |
2023-08-14 |
human |
| Collin D Teague, Joseph A Picone, William J Wright, Caleb J Browne, Gabriella M Silva, Rita Futamura, Angélica Minier-Toribio, Molly E Estill, Aarthi Ramakrishnan, Freddyson J Martinez-Rivera, Arthur Godino, Eric M Parise, Kyra H Schmidt, Nathalia V Pulido, Zachary S Lorsch, Jee Hyun Kim, Li Shen, Rachael L Neve, Yan Dong, Eric J Nestler, Peter J Hamilto. CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use. Biological psychiatry. 2022-10-17. PMID:36253194. |
the function of the transcription factor creb (camp response element binding protein) within the nucleus accumbens (nac) has been well documented in opposing the rewarding properties of many classes of drugs, yet the gene targets through which creb causally manifests these lasting neuroadaptations remain unknown. |
2022-10-17 |
2023-08-14 |
mouse |