| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Monica M Marcus, Kent Jardemark, Anna Malmerfelt, Jens Gertow, Asa Konradsson-Geuken, Torgny H Svensso. Augmentation by escitalopram, but not citalopram or R-citalopram, of the effects of low-dose risperidone: behavioral, biochemical, and electrophysiological evidence. Synapse (New York, N.Y.). vol 66. issue 4. 2012-05-21. PMID:22121030. |
we have recently shown that escitalopram, but not citalopram or r-citalopram, increases firing rate and burst firing of midbrain dopamine neurons, potentiates cortical n-methyl-d-aspartate (nmda) receptor-mediated transmission and enhances cognition, effects that might influence the outcome of concomitant antipsychotic medication. |
2012-05-21 |
2023-08-12 |
rat |
| Kohei Tanaka, Tomoyuki Furuyashiki, Shiho Kitaoka, Yuta Senzai, Yuki Imoto, Eri Segi-Nishida, Yuichi Deguchi, Richard M Breyer, Matthew D Breyer, Shuh Narumiy. Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 12. 2012-05-18. PMID:22442093. |
given the reported action of ep1 that augments gabaergic inputs to midbrain dopamine neurons, we analyzed dopaminergic response upon social defeat. |
2012-05-18 |
2023-08-12 |
mouse |
| Grażyna Jerzemowska, Karolina Plucińska, Michał Kulikowski, Weronika Trojniar, Danuta Wron. Locomotor response to novelty correlates with the number of midbrain tyrosine hydroxylase positive cells in rats. Brain research bulletin. vol 87. issue 1. 2012-05-17. PMID:22056623. |
there were no significant differences in the morphology of the midbrain dopamine neurons between hrs and lrs. |
2012-05-17 |
2023-08-12 |
rat |
| A Sánchez-Danés, A Consiglio, Y Richaud, I Rodríguez-Pizà, B Dehay, M Edel, J Bové, M Memo, M Vila, A Raya, J C Izpisua Belmont. Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells. Human gene therapy. vol 23. issue 1. 2012-05-10. PMID:21877920. |
to realize these opportunities, there is an urgent need to develop efficient protocols for the directed differentiation of hesc/ipsc into dopamine (da) neurons with the specific characteristics of the cell population lost to pd, i.e., a9-subtype ventral midbrain da neurons. |
2012-05-10 |
2023-08-12 |
mouse |
| Natalia Gorelova, Patrick J Mulholland, L Judson Chandler, Jeremy K Seaman. The glutamatergic component of the mesocortical pathway emanating from different subregions of the ventral midbrain. Cerebral cortex (New York, N.Y. : 1991). vol 22. issue 2. 2012-05-07. PMID:21666135. |
in the present study, anterograde tracer injections into 4 ventral midbrain subregions were coupled with immunohistochemical analysis of labeled axons in pfc for markers of dopamine (da; tyrosine hydroxylase [th]) and glutamate (vesicular glutamate transporter 2; vglut2). |
2012-05-07 |
2023-08-12 |
Not clear |
| Russell C Addis, Fu-Chun Hsu, Rebecca L Wright, Marc A Dichter, Douglas A Coulter, John D Gearhar. Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector. PloS one. vol 6. issue 12. 2012-04-23. PMID:22174877. |
the neurons exhibit expression profiles and electrophysiological characteristics consistent with midbrain dopaminergic neurons, notably including spontaneous pacemaking activity, stimulated release of dopamine, and calcium oscillations. |
2012-04-23 |
2023-08-12 |
Not clear |
| Ofelia M Littrell, Francois Pomerleau, Peter Huettl, Stewart Surgener, Jacqueline F McGinty, Lawrence D Middaugh, Ann-Charlotte Granholm, Greg A Gerhardt, Heather A Boge. Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:21144620. |
glial cell line-derived neurotrophic factor (gdnf) supports the viability of midbrain dopamine (da) neurons that degenerate in parkinson's disease. |
2012-04-19 |
2023-08-12 |
mouse |
| Yan-Na Wu, Adam C Munhall, Steven W Johnso. Mitochondrial uncoupling agents antagonize rotenone actions in rat substantia nigra dopamine neurons. Brain research. vol 1395. 2012-04-19. PMID:21550595. |
we reported previously that the mitochondrial poison rotenone enhanced currents evoked by n-methyl-d-aspartate (nmda) by a ros-dependent mechanism in rat midbrain dopamine neurons. |
2012-04-19 |
2023-08-12 |
rat |
| A M Oster, B S Gutki. A reduced model of DA neuronal dynamics that displays quiescence, tonic firing and bursting. Journal of physiology, Paris. vol 105. issue 1-3. 2012-04-17. PMID:21939761. |
midbrain dopaminergic neurons send numerous projections to cortical and sub-cortical areas, and in a manner dependent upon their activities, diffusely release dopamine (da) to their targets. |
2012-04-17 |
2023-08-12 |
Not clear |
| Rebecca L W Corwi. The face of uncertainty eats. Current drug abuse reviews. vol 4. issue 3. 2012-04-16. PMID:21999691. |
uncertainty may stimulate consumption of optional fatty and sugary treats due to differential firing of midbrain dopamine neurons, activation of the stress axis, and involvement of orexin signaling. |
2012-04-16 |
2023-08-12 |
Not clear |
| Victor de Lafuente, Ranulfo Rom. Dopamine neurons code subjective sensory experience and uncertainty of perceptual decisions. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 49. 2012-04-13. PMID:22106310. |
midbrain dopamine (da) neurons respond to sensory stimuli associated with future rewards. |
2012-04-13 |
2023-08-12 |
human |
| M Giorgi, G Melchiorri, V Nuccetelli, V D'Angelo, A Martorana, R Sorge, V Castelli, G Bernardi, G Sancesari. PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: a key step in parkinsonism physiopathology. Neurobiology of disease. vol 43. issue 1. 2012-04-09. PMID:21515371. |
pde10a and pde10a-dependent camp catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: a key step in parkinsonism physiopathology. |
2012-04-09 |
2023-08-12 |
rat |
| Holden D Brown, James E McCutcheon, Jackson J Cone, Michael E Ragozzino, Mitchell F Roitma. Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum. The European journal of neuroscience. vol 34. issue 12. 2012-04-04. PMID:22122410. |
unpredicted reward and reward-predictive cues evoke phasic increases in the firing rate of the majority of midbrain dopamine neurons--results that predict uniformly broadcast increases in dopamine concentration throughout the striatum. |
2012-04-04 |
2023-08-12 |
rat |
| Holden D Brown, James E McCutcheon, Jackson J Cone, Michael E Ragozzino, Mitchell F Roitma. Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum. The European journal of neuroscience. vol 34. issue 12. 2012-04-04. PMID:22122410. |
unlike the responses of midbrain dopamine neurons, unpredicted food reward and reward-predictive cues evoked a phasic increase in dopamine that was subregion specific. |
2012-04-04 |
2023-08-12 |
rat |
| Tomás R Guilart. Manganese and Parkinson's disease: a critical review and new findings. Ciencia & saude coletiva. vol 16. issue 11. 2012-04-03. PMID:22124833. |
the overwhelming evidence shows that mn-induced parkinsonism does not involve degeneration of midbrain dopamine neurons and that l-dopa is not an effective therapy. |
2012-04-03 |
2023-08-12 |
human |
| Zhen Zhang, Keke Zhang, Xinrui Du, Yanbin L. Neuroprotection of desferrioxamine in lipopolysaccharide-induced nigrostriatal dopamine neuron degeneration. Molecular medicine reports. vol 5. issue 2. 2012-03-30. PMID:22076309. |
here, we report that the iron concentration in the ventral midbrain significantly increased following intrastriatal injection of lps, and administration of dfo improved behavior deficits, attenuated dopamine (da) neuron loss and striatal da reduction, and alleviated microglial activation in the sn. |
2012-03-30 |
2023-08-12 |
mouse |
| H Morikawa, C A Paladin. Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms. Neuroscience. vol 198. 2012-03-22. PMID:21872647. |
dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms. |
2012-03-22 |
2023-08-12 |
Not clear |
| J A Goldberg, H Bergma. Computational physiology of the neural networks of the primate globus pallidus: function and dysfunction. Neuroscience. vol 198. 2012-03-22. PMID:21925240. |
finally, degeneration of midbrain dopaminergic neurons and striatal dopamine depletion (as in parkinson's disease) lead to augmentation of striatal excitability and competitive dynamics. |
2012-03-22 |
2023-08-12 |
Not clear |
| N D Volkow, G-J Wang, J H Newcorn, S H Kollins, T L Wigal, F Telang, J S Fowler, R Z Goldstein, N Klein, J Logan, C Wong, J M Swanso. Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Molecular psychiatry. vol 16. issue 11. 2012-03-05. PMID:20856250. |
to evaluate this hypothesis, we performed secondary analyses to assess the correlation between the pet measures of dopamine d2/d3 receptor and dopamine transporter availability (obtained with [(11)c]raclopride and [(11)c]cocaine, respectively) in the dopamine reward pathway (midbrain and nucleus accumbens) and a surrogate measure of trait motivation (assessed using the achievement scale on the multidimensional personality questionnaire or mpq) in 45 adhd participants and 41 controls. |
2012-03-05 |
2023-08-12 |
human |
| Masayuki Matsumoto, Okihide Hikosak. Electrical stimulation of the primate lateral habenula suppresses saccadic eye movement through a learning mechanism. PloS one. vol 6. issue 10. 2012-02-28. PMID:22039537. |
neurons in the lhb are excited by unpleasant events such as reward omission and aversive stimuli, and transmit these signals to midbrain dopamine neurons which are involved in learning and motivation. |
2012-02-28 |
2023-08-12 |
monkey |