| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ozlem Goker-Alpan, Joseph C Masdeu, Philip D Kohn, Angela Ianni, Grisel Lopez, Catherine Groden, Molly C Chapman, Brett Cropp, Daniel P Eisenberg, Emerson D Maniwang, Joie Davis, Edythe Wiggs, Ellen Sidransky, Karen F Berma. The neurobiology of glucocerebrosidase-associated parkinsonism: a positron emission tomography study of dopamine synthesis and regional cerebral blood flow. Brain : a journal of neurology. vol 135. issue Pt 8. 2012-10-17. PMID:22843412. |
in conclusion, the pattern of dopamine loss in patients with both parkinson and gaucher disease was similar to sporadic parkinson disease, indicating comparable damage in midbrain neurons. |
2012-10-17 |
2023-08-12 |
human |
| A Akaike, H Katsuki, T Kume, T Maed. Reactive oxygen species in NMDA receptor-mediated glutamate neurotoxicity. Parkinsonism & related disorders. vol 5. issue 4. 2012-10-02. PMID:18591141. |
in co-cultures of the mesencephalon and striatum, projection of mesencephalic dopamine neurons to the striatum attenuated n-methyl-d-aspartate (nmda)-induced cytotoxicity in dopamine neurons themselves. |
2012-10-02 |
2023-08-12 |
Not clear |
| M Fekete, G Hartmann, D Zakirov, L Halvax, K Lissá. Effect of dopamine on the hypothalamo-pituitary-adrenocortical system after injection in the nucleus raphe dorsalis. Neuroscience letters. vol 4. issue 3-4. 2012-10-02. PMID:19604944. |
dopamine (da) injected into the dorsal raphe nucleus (drn) increased plasma corticosterone (pcs) level as well as serotonin (5-ht) content in the mesencephalon and hippocampus 30 min after the administration. |
2012-10-02 |
2023-08-12 |
rat |
| M Fekete, M Bokor, B Penke, K Kovács, G Telegd. Effects of cholecystokinin octapeptide and its fragments on brain monoamines and plasma corticosterone. Neurochemistry international. vol 3. issue 2. 2012-10-02. PMID:20487821. |
the effects of intracerebroventricular administration of an 80 pmole dose of cholecystokinin octapeptide sulphate ester, unsulphated cholecystokinin octapeptide and their fragments were tested on the dopamine, norepinephrine and serotonin contents of the rat hypothalamus, mesencephalon, amygdala, septum, cerebral cortex and striatum, as well as on the plasma corticosterone level. |
2012-10-02 |
2023-08-12 |
rat |
| M Fekete, M Bokor, B Penke, K Kovács, G Telegd. Effects of cholecystokinin octapeptide and its fragments on brain monoamines and plasma corticosterone. Neurochemistry international. vol 3. issue 2. 2012-10-02. PMID:20487821. |
cholecystokinin octapeptide sulphate ester and the tyrosine-sulphate-methionine and tyrosine-sulphate-methionine-glycine fragments increased the dopamine and norepinephrine contents of the hypothalamus and mesencephalon. |
2012-10-02 |
2023-08-12 |
rat |
| T Kuriyama, J Taguchi, K Kuriyam. Functional alterations in striatal cholinergic and striato-nigral gabaergic neurons following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. Neurochemistry international. vol 16. issue 3. 2012-10-02. PMID:20504575. |
although the adminstration of mptp (50 mg/kg, once a day for 5 days) to male mice of dd strain did not induce the changes in choline and acethylcholine contents in the striatum, a decrement of gaba content in the midbrain, especially in the substantia nigra, was found in addition to a significant decrease of dopamine content in the striatum. |
2012-10-02 |
2023-08-12 |
mouse |
| Magen M Johnson, Sharon K Michelhaugh, Mohamad Bouhamdan, Carl J Schmidt, Michael J Banno. The Transcription Factor NURR1 Exerts Concentration-Dependent Effects on Target Genes Mediating Distinct Biological Processes. Frontiers in neuroscience. vol 5. 2012-10-02. PMID:22194714. |
the transcription factor nurr1 plays a pivotal role in the development and maintenance of neurotransmitter phenotype in midbrain dopamine neurons. |
2012-10-02 |
2023-08-12 |
human |
| Miriam Melis, Anna Lisa Muntoni, Marco Pisti. Endocannabinoids and the processing of value-related signals. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22347186. |
synapses onto midbrain dopamine (da) neurons in the ventral tegmental area (vta) make no exception to this rule. |
2012-10-02 |
2023-08-12 |
Not clear |
| Kjartan F Herrik, John P Redrobe, Dorte Holst, Charlotte Hougaard, Karin Sandager-Nielsen, Alexander N Nielsen, Huifang Ji, Nina M Holst, Hanne B Rasmussen, Elsebet Ø Nielsen, Dorte Strøbæk, Paul D Shepard, Palle Christopherse. CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22347859. |
dopamine (da) containing midbrain neurons play critical roles in several psychiatric and neurological diseases, including schizophrenia and attention deficit hyperactivity disorder, and the substantia nigra pars compacta neurons selectively degenerate in parkinson's disease. |
2012-10-02 |
2023-08-12 |
mouse |
| Matthew R Roesch, Daniel W Bryde. Impact of size and delay on neural activity in the rat limbic corticostriatal system. Frontiers in neuroscience. vol 5. 2012-10-02. PMID:22363252. |
since the creation of this task, we have recorded from several different brain areas including, orbitofrontal cortex, striatum, amygdala, substantia nigra pars reticulata, and midbrain dopamine neurons. |
2012-10-02 |
2023-08-12 |
rat |
| Diana C Ferrari, Baya J Mdzomba, Nathalie Dehorter, Catherine Lopez, François J Michel, Frédéric Libersat, Constance Hammon. Midbrain dopaminergic neurons generate calcium and sodium currents and release dopamine in the striatum of pups. Frontiers in cellular neuroscience. vol 6. 2012-10-02. PMID:22408606. |
midbrain dopaminergic neurons generate calcium and sodium currents and release dopamine in the striatum of pups. |
2012-10-02 |
2023-08-12 |
mouse |
| Sarah Threlfell, Tatjana Lalic, Nicola J Platt, Katie A Jennings, Karl Deisseroth, Stephanie J Crag. Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron. vol 75. issue 1. 2012-10-01. PMID:22794260. |
to understand dopamine function, much attention has focused on how midbrain dopamine neurons modulate their firing patterns. |
2012-10-01 |
2023-08-12 |
Not clear |
| George Stoica, Gina Lungu, Nicole L Bjorklund, Giulio Taglialatela, Xing Zhang, Veronica Chiu, Herbert H Hill, James O Schenk, Ian Murra. Potential role of α-synuclein in neurodegeneration: studies in a rat animal model. Journal of neurochemistry. vol 122. issue 4. 2012-09-27. PMID:22639889. |
decrease dopamine (da) and overexpression of α-syn in the brain mesencephalon may provide a naturally occurring animal model for parkinson's disease (pd) and other synucleinopathies that reproduces significant pathological, neurochemical, and behavioral features of the human disease. |
2012-09-27 |
2023-08-12 |
human |
| Patrick J Mulhollan. K(Ca)2 channels: novel therapeutic targets for treating alcohol withdrawal and escalation of alcohol consumption. Alcohol (Fayetteville, N.Y.). vol 46. issue 4. 2012-09-25. PMID:22464787. |
k(ca)2 channel activity can modulate the magnitude of excitation of midbrain dopamine neurons induced by acute alcohol exposure. |
2012-09-25 |
2023-08-12 |
mouse |
| Matthew Benskey, Bahareh Behrouz, Johan Sunryd, Samuel S Pappas, Seung-Hoon Baek, Marianne Huebner, Keith J Lookingland, John L Goudrea. Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression. Neurotoxicology. vol 33. issue 3. 2012-09-18. PMID:22342763. |
hypothalamic tuberoinfundibular dopamine (tida) neurons remain unaffected in parkinson disease (pd) while there is significant degeneration of midbrain nigrostriatal dopamine (nsda) neurons. |
2012-09-18 |
2023-08-12 |
mouse |
| Ping-Yue Pan, Timothy A Rya. Calbindin controls release probability in ventral tegmental area dopamine neurons. Nature neuroscience. vol 15. issue 6. 2012-09-17. PMID:22544312. |
relatively little is known about the molecular control of midbrain dopamine release. |
2012-09-17 |
2023-08-12 |
Not clear |
| Teemu Aitta-aho, Tommi P Möykkynen, Anne E Panhelainen, Olga Yu Vekovischeva, Pia Bäckström, Esa R Korp. Importance of GluA1 subunit-containing AMPA glutamate receptors for morphine state-dependency. PloS one. vol 7. issue 5. 2012-09-17. PMID:22675452. |
however, the knockout mice failed to show increased ampa/nmda receptor current ratios in the ventral tegmental area dopamine neurons of midbrain slices after a single injection of morphine (10 mg/kg, s.c., sliced prepared 24 h afterwards), in contrast to the wildtype mice. |
2012-09-17 |
2023-08-12 |
mouse |
| Garrett E Alexande. Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder. Dialogues in clinical neuroscience. vol 6. issue 3. 2012-09-10. PMID:22033559. |
the characteristic motor impairments - bradykinesia, rigidity, and resting tremor - result from degenerative loss of midbrain dopamine (da) neurons in the substantia nigra, and are responsive to symptomatic treatment with dopaminergic medications and functional neurosurgery. |
2012-09-10 |
2023-08-12 |
human |
| Michael Nocker, Klaus Seppi, Eveline Donnemiller, Irene Virgolini, Gregor K Wenning, Werner Poewe, Christoph Scherfle. Progression of dopamine transporter decline in patients with the Parkinson variant of multiple system atrophy: a voxel-based analysis of [123I]β-CIT SPECT. European journal of nuclear medicine and molecular imaging. vol 39. issue 6. 2012-09-05. PMID:22460689. |
we characterized the progression of dopamine transporter (dat) decline in the striatum and extrastriatal regions including the midbrain and pons of patients with the parkinson variant of multiple system atrophy (msa-p) and compared longitudinally collected spect results with those in a cohort of patients with parkinson's disease (pd). |
2012-09-05 |
2023-08-12 |
Not clear |
| Inmaculada Tasset, Ismael Quero, Ángel D García-Mayórgaz, Manuel Causse del Río, Isaac Túnez, Pedro Montill. Changes caused by haloperidol are blocked by music in Wistar rat. Journal of physiology and biochemistry. vol 68. issue 2. 2012-08-30. PMID:22371013. |
this study sought to evaluate the effect of classical music, using mozart's sonata for two pianos (k. 448), on changes in dopamine (da) levels in the striatal nucleus (sn), prefrontal cortex (pfc) and mesencephalon, and on prolactin (prl) and corticosterone secretion in adult male wistar rats. |
2012-08-30 |
2023-08-12 |
human |