| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuefeng Shen, Xiaoguo Ruan, Hua Zha. Stimulation of midbrain dopaminergic structures modifies firing rates of rat lateral habenula neurons. PloS one. vol 7. issue 4. 2012-07-27. PMID:22485164. |
lateral habenula (lhb) is considered as a negative reward source and it is reported that stimulation of the lhb rapidly induces inhibition of firing in midbrain dopamine neurons. |
2012-07-27 |
2023-08-12 |
rat |
| Andrew M Clark, Sebastien Bouret, Adrienne M Young, Barry J Richmon. Intersection of reward and memory in monkey rhinal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 20. 2012-07-27. PMID:22593056. |
signals related to reward prediction and valuation are believed to be encoded in a circuit centered around midbrain dopamine neurons and their targets in the prefrontal cortex and basal ganglia. |
2012-07-27 |
2023-08-12 |
monkey |
| Houbo Jiang, Yong Ren, Eunice Y Yuen, Ping Zhong, Mahboobe Ghaedi, Zhixing Hu, Gissou Azabdaftari, Kazuhiro Nakaso, Zhen Yan, Jian Fen. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nature communications. vol 3. 2012-07-26. PMID:22314364. |
parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. |
2012-07-26 |
2023-08-12 |
mouse |
| Houbo Jiang, Yong Ren, Eunice Y Yuen, Ping Zhong, Mahboobe Ghaedi, Zhixing Hu, Gissou Azabdaftari, Kazuhiro Nakaso, Zhen Yan, Jian Fen. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nature communications. vol 3. 2012-07-26. PMID:22314364. |
the results suggest that parkin controls dopamine utilization in human midbrain da neurons by enhancing the precision of da neurotransmission and suppressing dopamine oxidation. |
2012-07-26 |
2023-08-12 |
mouse |
| James G Green. Current status and future directions of gene expression profiling in Parkinson's disease. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:21056669. |
motor symptoms are primarily caused by selective degeneration of substantia nigra dopamine (snda) neurons in the midbrain; non-motor symptoms may be referable to well-described pathology at multiple levels of the neuraxis. |
2012-07-23 |
2023-08-12 |
Not clear |
| Hiromasa Takemura, Kazuyuki Samejima, Rufin Vogels, Masamichi Sakagami, Jiro Okud. Stimulus-dependent adjustment of reward prediction error in the midbrain. PloS one. vol 6. issue 12. 2012-07-20. PMID:22164273. |
previous reports have described that neural activities in midbrain dopamine areas are sensitive to unexpected reward delivery and omission. |
2012-07-20 |
2023-08-12 |
human |
| Salvatore Lecca, Miriam Melis, Antonio Luchicchi, Anna Lisa Muntoni, Marco Pisti. Inhibitory inputs from rostromedial tegmental neurons regulate spontaneous activity of midbrain dopamine cells and their responses to drugs of abuse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 5. 2012-07-20. PMID:22169942. |
inhibitory inputs from rostromedial tegmental neurons regulate spontaneous activity of midbrain dopamine cells and their responses to drugs of abuse. |
2012-07-20 |
2023-08-12 |
rat |
| Ewoud R E Schmidt, Francesca Morello, R Jeroen Pasterkam. Dissection and culture of mouse dopaminergic and striatal explants in three-dimensional collagen matrix assays. Journal of visualized experiments : JoVE. issue 61. 2012-07-13. PMID:22473326. |
midbrain dopamine (mdda) neurons project via the medial forebrain bundle towards several areas in the telencephalon, including the striatum(1). |
2012-07-13 |
2023-08-12 |
mouse |
| R Al-Hasani, J D Foster, A Metaxas, C Ledent, S M O Hourani, I Kitchen, Y Che. Increased desensitization of dopamine D₂ receptor-mediated response in the ventral tegmental area in the absence of adenosine A(2A) receptors. Neuroscience. vol 190. 2012-07-05. PMID:21669258. |
spontaneous activity of dopamine neurons was recorded in midbrain slices, and concentration-dependent effects of the dopamine d₂ receptor agonist, quinpirole, was compared between wild-type and a(2a) knockout mice. |
2012-07-05 |
2023-08-12 |
mouse |
| R Al-Hasani, J D Foster, A Metaxas, C Ledent, S M O Hourani, I Kitchen, Y Che. Increased desensitization of dopamine D₂ receptor-mediated response in the ventral tegmental area in the absence of adenosine A(2A) receptors. Neuroscience. vol 190. 2012-07-05. PMID:21669258. |
the a(2a) receptor agonist, cgs21680, did not exert any effect on dopamine neuron firing or response to quinpirole, revealing a novel non-pharmacological interaction between adenosine a(2a) receptors and dopaminergic neurotransmission in midbrain dopamine neurons. |
2012-07-05 |
2023-08-12 |
mouse |
| Ikuo Odano, Andrea Varrone, Ivanka Savic, Carolina Ciumas, Per Karlsson, Aurelija Jucaite, Christer Halldin, Lars Fard. Quantitative PET analyses of regional [11C]PE2I binding to the dopamine transporter--application to juvenile myoclonic epilepsy. NeuroImage. vol 59. issue 4. 2012-07-03. PMID:22056530. |
the finding indicates impaired dopamine uptake in the midbrain of jme patients. |
2012-07-03 |
2023-08-12 |
human |
| David J Graber, Abigail Snyder-Keller, David A Lawrence, James N Turne. Neurodegeneration by activated microglia across a nanofiltration membrane. Journal of biochemical and molecular toxicology. vol 26. issue 2. 2012-06-12. PMID:21308894. |
products released from activated microglia that were separated from primary ventral mesencephalon cells beneath the nanofiltering membrane were able to kill the dopamine neurons. |
2012-06-12 |
2023-08-12 |
Not clear |
| M Decressac, B Mattsson, M Lundblad, P Weikop, A Björklun. Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons. Neurobiology of disease. vol 45. issue 3. 2012-06-07. PMID:22182688. |
progressive neurodegenerative and behavioural changes induced by aav-mediated overexpression of α-synuclein in midbrain dopamine neurons. |
2012-06-07 |
2023-08-12 |
human |
| M Decressac, B Mattsson, M Lundblad, P Weikop, A Björklun. Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons. Neurobiology of disease. vol 45. issue 3. 2012-06-07. PMID:22182688. |
using a more efficient adeno-associated viral (aav) vector construct, which includes a wpre enhancer element and uses the neuron-specific synapsin-1 promoter to drive the expression of human wild-type α-synuclein, we have now been able to achieve increased levels of α-synuclein in the transduced midbrain dopamine neurons sufficient to induce profound deficits in motor function, accompanied by reduced expression of proteins involved in dopamine neurotransmission and a time-dependent loss of nigral dopamine neurons, that develop progressively over 2-4 months after vector injection. |
2012-06-07 |
2023-08-12 |
human |
| Milan Joksimovic, Meera Patel, Makoto Mark Taketo, Randy Johnson, Rajeshwar Awatraman. Ectopic Wnt/beta-catenin signaling induces neurogenesis in the spinal cord and hindbrain floor plate. PloS one. vol 7. issue 1. 2012-06-04. PMID:22276170. |
the fp is largely non-neurogenic at the hindbrain and spinal cord levels, but generates large numbers of dopamine (mda) neurons at the midbrain levels. |
2012-06-04 |
2023-08-12 |
Not clear |
| R B Mythri, M M Srinivas Bharat. Curcumin: a potential neuroprotective agent in Parkinson's disease. Current pharmaceutical design. vol 18. issue 1. 2012-05-31. PMID:22211691. |
the motor symptoms in pd arise due to selective degeneration of dopaminergic neurons in the substantia nigra of the ventral midbrain thereby depleting the dopamine levels in the striatum. |
2012-05-31 |
2023-08-12 |
Not clear |
| Xi-Biao He, Sang-Hoon Yi, Yong-Hee Rhee, Hyemin Kim, Yong-Mahn Han, Suk-Ho Lee, Hyunsu Lee, Chang-Hwan Park, Yong-Sung Lee, Eric Richardson, Byung-Woo Kim, Sang-Hun Le. Prolonged membrane depolarization enhances midbrain dopamine neuron differentiation via epigenetic histone modifications. Stem cells (Dayton, Ohio). vol 29. issue 11. 2012-05-29. PMID:21922608. |
prolonged membrane depolarization enhances midbrain dopamine neuron differentiation via epigenetic histone modifications. |
2012-05-29 |
2023-08-12 |
Not clear |
| Xi-Biao He, Sang-Hoon Yi, Yong-Hee Rhee, Hyemin Kim, Yong-Mahn Han, Suk-Ho Lee, Hyunsu Lee, Chang-Hwan Park, Yong-Sung Lee, Eric Richardson, Byung-Woo Kim, Sang-Hun Le. Prolonged membrane depolarization enhances midbrain dopamine neuron differentiation via epigenetic histone modifications. Stem cells (Dayton, Ohio). vol 29. issue 11. 2012-05-29. PMID:21922608. |
understanding midbrain dopamine (da) neuron differentiation is of importance, because of physiological and clinical implications of this neuronal subtype. |
2012-05-29 |
2023-08-12 |
Not clear |
| Katarzyna Derwińska, Hanna Mierzewska, Alicja Goszczańska, Elżbieta Szczepanik, Zhilian Xia, Katarzyna Kuśmierska, Jolanta Tryfon, Anna Kutkowska-Kaźmierczak, Ewa Bocian, Tadeusz Mazurczak, Ewa Obersztyn, Paweł Stankiewic. Clinical improvement of the aggressive neurobehavioral phenotype in a patient with a deletion of PITX3 and the absence of L-DOPA in the cerebrospinal fluid. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 2. 2012-05-22. PMID:22223473. |
the development of midbrain dopamine (da) neurons is regulated by several transcription factors, including nurr1, wnt1, lmx1a/1b, en1, en2, foxa1, foxa2, and pitx3. |
2012-05-22 |
2023-08-12 |
mouse |
| Jeffrey H Kordower, Hemraj B Dodiya, Adam M Kordower, Brian Terpstra, Katrina Paumier, Lalitha Madhavan, Caryl Sortwell, Kathy Steece-Collier, Timothy J Collie. Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat. Neurobiology of disease. vol 43. issue 3. 2012-05-21. PMID:21600984. |
to test whether the former hypothesis was possible, we grafted fetal rat ventral mesencephalon into the dopamine depleted striatum of rats that had previously received 6-hydroxydopamine lesions. |
2012-05-21 |
2023-08-12 |
human |