| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Romain Bourdy, Michel Barro. A new control center for dopaminergic systems: pulling the VTA by the tail. Trends in neurosciences. vol 35. issue 11. 2013-04-05. PMID:22824232. |
the tail of the ventral tegmental area (tvta), also named the rostromedial tegmental nucleus (rmtg), is a recently defined midbrain structure considered to exert a major inhibitory drive on dopamine systems. |
2013-04-05 |
2023-08-12 |
Not clear |
| Matthieu Dacher, Shawn Gouty, Steven Dash, Brian M Cox, Fereshteh S Nugen. A-kinase anchoring protein-calcineurin signaling in long-term depression of GABAergic synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 6. 2013-04-01. PMID:23392692. |
using immunofluorescence and whole-cell patch-clamp recording in rat midbrain slices, we show that activation of postsynaptic d(2)-like family of dopamine (da) receptor in the ventral tegmental area (vta) induces long-term depression (ltd) of gabaergic synapses on da neurons through an inositol triphosphate receptor-mediated local rise in postsynaptic ca(2+) and can activation accompanied by pka inhibition, which requires akap150 as a bridging signaling molecule. |
2013-04-01 |
2023-08-12 |
rat |
| Seungmin Lee, Fredrik H Sterky, Arnaud Mourier, Mügen Terzioglu, Staffan Cullheim, Lars Olson, Nils-Göran Larsso. Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons. Human molecular genetics. vol 21. issue 22. 2013-03-26. PMID:22914740. |
mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons. |
2013-03-26 |
2023-08-12 |
mouse |
| Seungmin Lee, Fredrik H Sterky, Arnaud Mourier, Mügen Terzioglu, Staffan Cullheim, Lars Olson, Nils-Göran Larsso. Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons. Human molecular genetics. vol 21. issue 22. 2013-03-26. PMID:22914740. |
here, we address the importance of mfn1 and mfn2 in midbrain dopamine (da) neurons in vivo by characterizing mice with da neuron-specific knockout of mfn1 or mfn2. |
2013-03-26 |
2023-08-12 |
mouse |
| Rajeswara B Mythri, Gangadharappa Harish, M M Bharat. Therapeutic potential of natural products in Parkinson's disease. Recent patents on endocrine, metabolic & immune drug discovery. vol 6. issue 3. 2013-03-14. PMID:22827714. |
the central objective in treating patients with parkinson's disease (pd) is two-fold (i) to increase the striatal dopamine content and (ii) to prevent further degeneration of the surviving dopaminergic neurons in the substantia nigra region of the ventral midbrain. |
2013-03-14 |
2023-08-12 |
Not clear |
| Lindsay Hayes, Sherry Ralls, Hui Wang, Sohyun Ah. Duration of Shh signaling contributes to mDA neuron diversity. Developmental biology. vol 374. issue 1. 2013-03-14. PMID:23201023. |
sonic hedgehog (shh) signaling is critical for various developmental processes including specification of the midbrain dopamine (mda) neurons in the ventral mesencephalon (vmes). |
2013-03-14 |
2023-08-12 |
mouse |
| Pamela C Rodriguez, Daniela B Pereira, Anders Borgkvist, Minerva Y Wong, Candace Barnard, Mark S Sonders, Hui Zhang, Dalibor Sames, David Sulze. Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 3. 2013-03-14. PMID:23277566. |
here, we describe a ph-responsive ffn probe, ffn102, which as a polar dopamine transporter substrate selectively labels dopamine cell bodies and dendrites in ventral midbrain and dopaminergic synaptic terminals in dorsal striatum. |
2013-03-14 |
2023-08-12 |
Not clear |
| Feng Zhang, Yan-Ying Wang, Hang Liu, Yuan-Fu Lu, Qin Wu, Jie Liu, Jing-Shan Sh. Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2013-03-14. PMID:23304227. |
here, primary rat midbrain neuron-glia cultures were applied to investigate the neurotrophic effects mediated by resveratrol on dopamine (da) neurons and further explore the role of neurotrophic factors in its actions. |
2013-03-14 |
2023-08-12 |
rat |
| Tertia D Purves-Tyson, David J Handelsman, Kay L Double, Samantha J Owens, Sonia Bustamante, Cynthia Shannon Weicker. Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra. BMC neuroscience. vol 13. 2013-03-08. PMID:22867132. |
how midbrain dopamine neurons respond to sex steroids depends on the presence of sex steroid receptor(s) and the level of steroid conversion enzymes (aromatase and 5α-reductase). |
2013-03-08 |
2023-08-12 |
rat |
| Roger Cachope, Yolanda Mateo, Brian N Mathur, James Irving, Hui-Ling Wang, Marisela Morales, David M Lovinger, Joseph F Chee. Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing. Cell reports. vol 2. issue 1. 2013-03-04. PMID:22840394. |
dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors, and its release dynamics have traditionally been linked to changes in midbrain dopamine neuron activity. |
2013-03-04 |
2023-08-12 |
Not clear |
| Roger Cachope, Yolanda Mateo, Brian N Mathur, James Irving, Hui-Ling Wang, Marisela Morales, David M Lovinger, Joseph F Chee. Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing. Cell reports. vol 2. issue 1. 2013-03-04. PMID:22840394. |
this mechanism occurs via direct actions on dopamine terminals, does not require changes in neuron firing within the midbrain, and is dependent on glutamatergic receptor activity. |
2013-03-04 |
2023-08-12 |
Not clear |
| Kay M Tye, Julie J Mirzabekov, Melissa R Warden, Emily A Ferenczi, Hsing-Chen Tsai, Joel Finkelstein, Sung-Yon Kim, Avishek Adhikari, Kimberly R Thompson, Aaron S Andalman, Lisa A Gunaydin, Ilana B Witten, Karl Deisserot. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature. vol 493. issue 7433. 2013-03-04. PMID:23235822. |
we found that bidirectional control (inhibition or excitation) of specified midbrain dopamine neurons immediately and bidirectionally modulates (induces or relieves) multiple independent depression symptoms caused by chronic stress. |
2013-03-04 |
2023-08-12 |
Not clear |
| Dipesh Chaudhury, Jessica J Walsh, Allyson K Friedman, Barbara Juarez, Stacy M Ku, Ja Wook Koo, Deveroux Ferguson, Hsing-Chen Tsai, Lisa Pomeranz, Daniel J Christoffel, Alexander R Nectow, Mats Ekstrand, Ana Domingos, Michelle S Mazei-Robison, Ezekiell Mouzon, Mary Kay Lobo, Rachael L Neve, Jeffrey M Friedman, Scott J Russo, Karl Deisseroth, Eric J Nestler, Ming-Hu Ha. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature. vol 493. issue 7433. 2013-03-04. PMID:23235832. |
rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. |
2013-03-04 |
2023-08-12 |
mouse |
| Jiajie Xi, Yan Liu, Huisheng Liu, Hong Chen, Marina E Emborg, Su-Chun Zhan. Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem cells (Dayton, Ohio). vol 30. issue 8. 2013-02-28. PMID:22696177. |
specification of midbrain dopamine neurons from primate pluripotent stem cells. |
2013-02-28 |
2023-08-12 |
human |
| Jiajie Xi, Yan Liu, Huisheng Liu, Hong Chen, Marina E Emborg, Su-Chun Zhan. Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem cells (Dayton, Ohio). vol 30. issue 8. 2013-02-28. PMID:22696177. |
by sequentially applying sonic hedgehog (c25ii) and chir99021 (gsk3β inhibitor) to induce the midbrain floor plate (fp) progenitors and fibroblast growth factor 8 (fgf8) to promote dopaminergic differentiation in a chemically defined medium, we have established a robust system for the generation of midbrain dopamine (da) neurons from human and rhesus monkey embryonic stem cells and induced pluripotent stem cells (pscs). |
2013-02-28 |
2023-08-12 |
human |
| Edita Navratilova, Jennifer Y Xie, Alec Okun, Chaoling Qu, Nathan Eyde, Shuang Ci, Michael H Ossipov, Tamara King, Howard L Fields, Frank Porrec. Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 50. 2013-02-28. PMID:23184995. |
importantly, place preference is associated with increased activity in midbrain dopaminergic neurons and blocked by dopamine antagonists injected into the nucleus accumbens. |
2013-02-28 |
2023-08-12 |
Not clear |
| Krys S Bankiewicz, Rosario Sanchez-Pernaute, Yoshitsugu Oiwa, Malgorzata Kohutnicka, Alex Cummins, Jamie Eberlin. Preclinical models of Parkinson's disease. Current protocols in toxicology. vol Chapter 1. 2013-02-25. PMID:23045097. |
parkinson's disease (pd) is a neurodegenerative disorder in which pigmented midbrain neurons progressively die producing a dopamine (da) deficit in the striatum, which manifests as an akinetic movement disorder. |
2013-02-25 |
2023-08-12 |
Not clear |
| Debra Ellisor, Caroline Rieser, Bettina Voelcker, Jason T Machan, Mark Zerva. Genetic dissection of midbrain dopamine neuron development in vivo. Developmental biology. vol 372. issue 2. 2013-02-21. PMID:23041116. |
genetic dissection of midbrain dopamine neuron development in vivo. |
2013-02-21 |
2023-08-12 |
mouse |
| Debra Ellisor, Caroline Rieser, Bettina Voelcker, Jason T Machan, Mark Zerva. Genetic dissection of midbrain dopamine neuron development in vivo. Developmental biology. vol 372. issue 2. 2013-02-21. PMID:23041116. |
midbrain dopamine (mbda) neurons are partitioned into medial and lateral cohorts that control complex functions. |
2013-02-21 |
2023-08-12 |
mouse |
| Yuan-Yuan Liu, Tian-Ya Liu, Wei-Min Qu, Zong-Yuan Hong, Yoshihiro Urade, Zhi-Li Huan. Dopamine is involved in food-anticipatory activity in mice. Journal of biological rhythms. vol 27. issue 5. 2013-02-19. PMID:23010662. |
consistently, the levels of dopamine and its metabolites in the striatum and midbrain were significantly increased during faa, even with the pretreatment of d(1)r and d(2)r antagonists. |
2013-02-19 |
2023-08-12 |
mouse |