| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anders Bjorklund, Jeffrey H Kordowe. Cell therapy for Parkinson's disease: what next? Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 1. 2013-08-21. PMID:23390097. |
further development of this therapeutic approach face numerous challenges, for example in the development of protocols that allow generation of fully functional and safe midbrain dopamine neurons from stem cells. |
2013-08-21 |
2023-08-12 |
human |
| Christopher D Fiorill. Two dimensions of value: dopamine neurons represent reward but not aversiveness. Science (New York, N.Y.). vol 341. issue 6145. 2013-08-16. PMID:23908236. |
here, i show that although dopamine neurons of the primate ventral midbrain are activated by evidence for reward and suppressed by evidence against reward, they are insensitive to aversiveness. |
2013-08-16 |
2023-08-12 |
Not clear |
| H Liu, Q Tao, H Deng, M Ming, Y Ding, P Xu, S Chen, Z Song, W L. Genetic analysis of NR4A2 gene in a large population of Han Chinese patients with Parkinson's disease. European journal of neurology. vol 20. issue 3. 2013-08-15. PMID:22827504. |
nr4a2 gene is a transcription factor crucial for differentiation and survival of midbrain dopamine (da) neurons, and several variants have been eported to be associated with parkinson's disease (pd) in the caucasian population. |
2013-08-15 |
2023-08-12 |
Not clear |
| Sudarshan Phani, Michael Jablonski, Josh Pelta-Heller, Jingli Cai, Lorraine Iacovitt. Gremlin is a novel VTA derived neuroprotective factor for dopamine neurons. Brain research. vol 1500. 2013-08-15. PMID:23348379. |
parkinson's disease and its characteristic symptoms are thought to arise from the progressive degeneration of specific midbrain dopamine (da) neurons. |
2013-08-15 |
2023-08-12 |
Not clear |
| Sangmi Chung, Chun-Hyung Kim, Kwang-Soo Ki. Lmx1a regulates dopamine transporter gene expression during ES cell differentiation and mouse embryonic development. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22564125. |
here, using an embryonic stem cell in vitro differentiation system and mutant dreher mouse, we showed that lmx1a, an early regulator of midbrain dopamine neural progenitor phenotype specification, is also involved in the regulation of midbrain dopaminergic maturation by regulating gene expression of the dopamine transporter. |
2013-08-14 |
2023-08-12 |
mouse |
| Sangmi Chung, Chun-Hyung Kim, Kwang-Soo Ki. Lmx1a regulates dopamine transporter gene expression during ES cell differentiation and mouse embryonic development. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22564125. |
furthermore, during mouse embryonic development, dopamine transporter was more severely affected by lmx1a mutation compared to other dopamine markers such as tyrosine hydroxylase and dopa decarboxylase, again supporting the role of lmx1a in midbrain dopaminergic maturation in vivo. |
2013-08-14 |
2023-08-12 |
mouse |
| Sangmi Chung, Chun-Hyung Kim, Kwang-Soo Ki. Lmx1a regulates dopamine transporter gene expression during ES cell differentiation and mouse embryonic development. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22564125. |
thus, this study demonstrates that dopamine transporter is a direct target of lmx1a and emphasizes a novel role of lmx1a as one of regulators of mature midbrain dopaminergic neurotransmitter phenotypes. |
2013-08-14 |
2023-08-12 |
mouse |
| Daniel P Czech, Joohyung Lee, Helena Sim, Clare L Parish, Eric Vilain, Vincent R Harle. The human testis-determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22568433. |
the human testis-determining factor sry localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism. |
2013-08-14 |
2023-08-12 |
human |
| Allison C Hoffman, Sarah E Evan. Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 15. issue 3. 2013-08-13. PMID:22990226. |
these include their effects on midbrain dopamine (da) levels, drug discrimination and substitution for known drugs of abuse, place conditioning, self-administration behavior, and somatic withdrawal symptoms. |
2013-08-13 |
2023-08-12 |
Not clear |
| Benjamin Pasquereau, Robert S Turne. Limited encoding of effort by dopamine neurons in a cost-benefit trade-off task. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 19. 2013-08-06. PMID:23658169. |
midbrain dopamine neurons have long been associated with the reward part of this equation, but it is unclear whether these neurons also estimate the costs of taking an action. |
2013-08-06 |
2023-08-12 |
monkey |
| Marco Bisaglia, Elisa Greggio, Mariano Beltramini, Luigi Bubacc. Dysfunction of dopamine homeostasis: clues in the hunt for novel Parkinson's disease therapies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 6. 2013-08-02. PMID:23463698. |
parkinson's disease is characterized by the preferential death of a subset of neurons in the mesencephalon that use dopamine as neurotransmitter for synaptic communication. |
2013-08-02 |
2023-08-12 |
Not clear |
| b' Arjun V Raman, Vivian P Chou, Jennifer Atienza-Duyanen, Donato A Di Monte, Frederick P Bellinger, Amy B Manning-Bo\\xc4\\x9. Evidence of oxidative stress in young and aged DJ-1-deficient mice. FEBS letters. vol 587. issue 10. 2013-07-25. PMID:23587484.' |
ventral midbrain from young dj-1-deficient mice revealed no change in 4-hydroxy-2-nonenal (4-hne), but hsp60, hsp40 and striatal dopamine turnover were significantly elevated compared to wildtype. |
2013-07-25 |
2023-08-12 |
mouse |
| Jehan S Al-Amri, Magda M Hagras, Mujallid Mohamed . Effect of epigallocatechin-3-gallate on inflammatory mediators release in LPS-induced Parkinson's disease in rats. Indian journal of experimental biology. vol 51. issue 5. 2013-07-22. PMID:23821823. |
degeneration of dopamine (da)-containing neurons in the substantia nigra of the midbrain causes parkinson's disease (pd). |
2013-07-22 |
2023-08-12 |
rat |
| Mickael Decressac, Bengt Mattsson, Pia Weikop, Martin Lundblad, Johan Jakobsson, Anders Björklun. TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 19. 2013-07-19. PMID:23610405. |
tfeb-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity. |
2013-07-19 |
2023-08-12 |
human |
| Mickael Decressac, Bengt Mattsson, Pia Weikop, Martin Lundblad, Johan Jakobsson, Anders Björklun. TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 19. 2013-07-19. PMID:23610405. |
the changes in lysosomal function, observed in the rat model as well as in human pd midbrain, were reversed by overexpression of tfeb, which afforded robust neuroprotection via the clearance of α-synuclein oligomers, and were aggravated by microrna-128-mediated repression of tfeb in both a9 and a10 dopamine neurons. |
2013-07-19 |
2023-08-12 |
human |
| b' Susanne B\\xc3\\xa4ck, Mari Raki, Raimo K Tuominen, Atso Raasmaja, Kim Bergstr\\xc3\\xb6m, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. High correlation between in vivo [123I]\\xce\\xb2-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats. EJNMMI research. vol 3. issue 1. 2013-06-27. PMID:23758882.' |
6-hydroxydopamine (6-ohda) is widely used in pre-clinical animal studies to induce degeneration of midbrain dopamine neurons to create animal models of parkinson's disease. |
2013-06-27 |
2023-08-12 |
rat |
| Christie L Burton, Zoë Rizos, Mustansir Diwan, José N Nobrega, Paul J Fletche. Antagonizing 5-HT₂A receptors with M100907 and stimulating 5-HT₂C receptors with Ro60-0175 blocks cocaine-induced locomotion and zif268 mRNA expression in Sprague-Dawley rats. Behavioural brain research. vol 240. 2013-06-17. PMID:23201361. |
the 5-ht system modulates the activity of midbrain dopamine (da) systems, and the behavioural effects of psychostimulants mediated by these systems. |
2013-06-17 |
2023-08-12 |
rat |
| Jyoti C Patel, Margaret E Ric. Monitoring axonal and somatodendritic dopamine release using fast-scan cyclic voltammetry in brain slices. Methods in molecular biology (Clifton, N.J.). vol 964. 2013-06-06. PMID:23296788. |
topics covered include preparation and calibration of carbon-fiber microelectrodes for use with fast-scan cyclic voltammetry, preparation of midbrain and forebrain slices, and procedures of eliciting and recording electrically evoked dopamine release from in vitro brain slices. |
2013-06-06 |
2023-08-12 |
Not clear |
| Hong-Hua Yuan, Ren-Jin Chen, Yu-Hua Zhu, Chang-Ling Peng, Xiao-Rong Zh. The neuroprotective effect of overexpression of calbindin-D(28k) in an animal model of Parkinson's disease. Molecular neurobiology. vol 47. issue 1. 2013-06-04. PMID:22923348. |
transgenic mice cabp-28 k overexpression and the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced mouse models were generated, and the effect of midbrain dopamine neurons in ethology was also assessed. |
2013-06-04 |
2023-08-12 |
mouse |
| M Jabbi, T Nash, P Kohn, A Ianni, D Rubinstein, T Holroyd, F W Carver, J C Masdeu, J Shane Kippenhan, S E Robinson, R Coppola, K F Berma. Midbrain presynaptic dopamine tone predicts sustained and transient neural response to emotional salience in humans: fMRI, MEG and FDOPA PET. Molecular psychiatry. vol 18. issue 1. 2013-05-30. PMID:22411228. |
midbrain presynaptic dopamine tone predicts sustained and transient neural response to emotional salience in humans: fmri, meg and fdopa pet. |
2013-05-30 |
2023-08-12 |
Not clear |