| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jan Gründemann, Falk Schlaudraff, Birgit Lis. UV-laser microdissection and mRNA expression analysis of individual neurons from postmortem Parkinson's disease brains. Methods in molecular biology (Clifton, N.J.). vol 755. 2011-11-11. PMID:21761319. |
cell specificity of gene expression analysis is essential to avoid tissue sample related artifacts, in particular when the relative number of target cells present in the compared tissues varies dramatically, e.g., when comparing dopamine neurons in midbrain tissues from control subjects with those from parkinson's disease (pd) cases. |
2011-11-11 |
2023-08-12 |
human |
| Jan Gründemann, Falk Schlaudraff, Birgit Lis. UV-laser microdissection and mRNA expression analysis of individual neurons from postmortem Parkinson's disease brains. Methods in molecular biology (Clifton, N.J.). vol 755. 2011-11-11. PMID:21761319. |
among expression changes in a variety of dopamine neuron marker, maintenance, and cell-metabolism genes, we found that α-synuclein mrna levels were significantly elevated in individual neuromelanin-positive dopamine midbrain neurons from pd brains when compared to those from matched controls. |
2011-11-11 |
2023-08-12 |
human |
| Esther Aarts, Mieke van Holstein, Roshan Cool. Striatal Dopamine and the Interface between Motivation and Cognition. Frontiers in psychology. vol 2. 2011-11-10. PMID:21808629. |
animal work has revealed an arrangement of spiraling connections between the midbrain and the striatum that subserves a mechanism by which dopamine can direct information flow from ventromedial to more dorsal regions in the striatum. |
2011-11-10 |
2023-08-12 |
Not clear |
| Kazuki Enomoto, Naoyuki Matsumoto, Sadamu Nakai, Takemasa Satoh, Tatsuo K Sato, Yasumasa Ueda, Hitoshi Inokawa, Masahiko Haruno, Minoru Kimur. Dopamine neurons learn to encode the long-term value of multiple future rewards. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 37. 2011-11-09. PMID:21896766. |
midbrain dopamine neurons signal reward value, their prediction error, and the salience of events. |
2011-11-09 |
2023-08-12 |
monkey |
| Jeffrey Cockburn, Clay B Holroy. Focus on the positive: computational simulations implicate asymmetrical reward prediction error signals in childhood attention-deficit/hyperactivity disorder. Brain research. vol 1365. 2011-11-07. PMID:20875804. |
a number of hypotheses have suggested that the principal neurological dysfunction responsible for the behavioural symptoms associated with attention-deficit/hyperactive disorder (adhd) is likely rooted in abnormal phasic signals coded by the firing rate of midbrain dopamine neurons. |
2011-11-07 |
2023-08-12 |
rat |
| Paul W Glimche. Understanding dopamine and reinforcement learning: the dopamine reward prediction error hypothesis. Proceedings of the National Academy of Sciences of the United States of America. vol 108 Suppl 3. 2011-11-03. PMID:21389268. |
this intertwining of theory and experiment now suggests very clearly that the phasic activity of the midbrain dopamine neurons provides a global mechanism for synaptic modification. |
2011-11-03 |
2023-08-12 |
human |
| Alfonso Alfaro-Rodríguez, Antonio Bueno-Nava, Rigoberto González-Piña, Emilio Arch-Tirado, Javier Vargas-Sánchez, Alberto Avila-Lun. Chronic exposure to toluene changes the sleep-wake pattern and brain monoamine content in rats. Acta neurobiologiae experimentalis. vol 71. issue 2. 2011-11-03. PMID:21731073. |
dopamine (da) and noradrenaline (na) increased in the midbrain and striatum. |
2011-11-03 |
2023-08-12 |
rat |
| Rodrigo A España, Thomas E Scammel. Sleep neurobiology from a clinical perspective. Sleep. vol 34. issue 7. 2011-10-27. PMID:21731134. |
wakefulness is promoted by neurons in the pons, midbrain, and posterior hypothalamus that produce acetylcholine, norepinephrine, dopamine, serotonin, histamine, and orexin/hypocretin. |
2011-10-27 |
2023-08-12 |
Not clear |
| Mariella De Biasi, John A Dan. Reward, addiction, withdrawal to nicotine. Annual review of neuroscience. vol 34. 2011-10-25. PMID:21438686. |
acting mainly through nicotinic receptors containing the α4 and β2 subunits, often in combination with the α6 subunit, nicotine increases the firing rate and the phasic bursts by midbrain dopamine neurons. |
2011-10-25 |
2023-08-12 |
Not clear |
| Wei Li, William M Doyon, John A Dan. Acute in vivo nicotine administration enhances synchrony among dopamine neurons. Biochemical pharmacology. vol 82. issue 8. 2011-10-21. PMID:21684263. |
altered functional interactions among midbrain dopamine (da) neurons contribute to the reinforcing properties of environmental stimuli and addictive drugs. |
2011-10-21 |
2023-08-12 |
rat |
| Johan Alsiö, Karin Nordenankar, Emma Arvidsson, Carolina Birgner, Souha Mahmoudi, Briac Halbout, Casey Smith, Guillaume M Fortin, Lars Olson, Laurent Descarries, Louis-Éric Trudeau, Klas Kullander, Daniel Lévesque, Asa Wallén-Mackenzi. Enhanced sucrose and cocaine self-administration and cue-induced drug seeking after loss of VGLUT2 in midbrain dopamine neurons in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 35. 2011-10-21. PMID:21880920. |
enhanced sucrose and cocaine self-administration and cue-induced drug seeking after loss of vglut2 in midbrain dopamine neurons in mice. |
2011-10-21 |
2023-08-12 |
mouse |
| Taco R Werkman, Andrew C McCreary, Chris G Kruse, Wytse J Wadma. NK3 receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21218451. |
nk3 receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig. |
2011-10-18 |
2023-08-12 |
rat |
| Taco R Werkman, Andrew C McCreary, Chris G Kruse, Wytse J Wadma. NK3 receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21218451. |
this in vitro study investigates and compares the effects of nk3 receptor ligands on the firing rate of rat and guinea pig midbrain dopamine neurons. |
2011-10-18 |
2023-08-12 |
rat |
| Taco R Werkman, Andrew C McCreary, Chris G Kruse, Wytse J Wadma. NK3 receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21218451. |
in vitro midbrain slice preparations of both species were used to record (extracellularly) the firing rates of dopamine neurons located in the substantia nigra (sn) and ventral tegmental area (vta). |
2011-10-18 |
2023-08-12 |
rat |
| Damian Refojo, Martin Schweizer, Claudia Kuehne, Stefanie Ehrenberg, Christoph Thoeringer, Annette M Vogl, Nina Dedic, Marion Schumacher, Gregor von Wolff, Charilaos Avrabos, Chadi Touma, David Engblom, Günther Schütz, Klaus-Armin Nave, Matthias Eder, Carsten T Wotjak, Inge Sillaber, Florian Holsboer, Wolfgang Wurst, Jan M Deussin. Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science (New York, N.Y.). vol 333. issue 6051. 2011-10-18. PMID:21885734. |
selective deletion of crhr1 in midbrain dopaminergic neurons increases anxiety-like behavior and reduces dopamine release in the prefrontal cortex. |
2011-10-18 |
2023-08-12 |
Not clear |
| Nian Xiong, Jing Xiong, Ghanshyam Khare, Chunnuan Chen, Jinsha Huang, Ying Zhao, Zhentao Zhang, Xian Qiao, Yuan Feng, Harrish Reesaul, Yongxue Zhang, Shenggang Sun, Zhicheng Lin, Tao Wan. Edaravone guards dopamine neurons in a rotenone model for Parkinson's disease. PloS one. vol 6. issue 6. 2011-10-17. PMID:21677777. |
here we showed that a five-week treatment with edaravone abolished rotenone's activity to induce catalepsy, damage mitochondria and degenerate dopamine neurons in the midbrain of rotenone-treated rats. |
2011-10-17 |
2023-08-12 |
rat |
| Damien Toulorge, Serge Guerreiro, Audrey Hild, Uwe Maskos, Etienne C Hirsch, Patrick P Miche. Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 8. 2011-10-14. PMID:21507900. |
neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic ca2+. |
2011-10-14 |
2023-08-12 |
mouse |
| Damien Toulorge, Serge Guerreiro, Audrey Hild, Uwe Maskos, Etienne C Hirsch, Patrick P Miche. Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 8. 2011-10-14. PMID:21507900. |
to address this question, we established rat midbrain cultures maintained in experimental conditions that favor the selective and spontaneous loss of dopamine neurons. |
2011-10-14 |
2023-08-12 |
mouse |
| Kazuhiro Kurokawa, Koji Mizuno, Emi Kiyokage, Masahiro Shibasaki, Kazunori Toida, Seitaro Ohkum. Dopamine D1 receptor signaling system regulates ryanodine receptor expression after intermittent exposure to methamphetamine in primary cultures of midbrain and cerebral cortical neurons. Journal of neurochemistry. vol 118. issue 5. 2011-10-14. PMID:21707617. |
dopamine d1 receptor signaling system regulates ryanodine receptor expression after intermittent exposure to methamphetamine in primary cultures of midbrain and cerebral cortical neurons. |
2011-10-14 |
2023-08-12 |
mouse |
| Qiaolin Deng, Elisabet Andersson, Eva Hedlund, Zhanna Alekseenko, Eva Coppola, Lia Panman, James H Millonig, Jean-Francois Brunet, Johan Ericson, Thomas Perlman. Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development (Cambridge, England). vol 138. issue 16. 2011-10-14. PMID:21752929. |
the severe disorders associated with a loss or dysfunction of midbrain dopamine neurons (dns) have intensified research aimed at deciphering developmental programs controlling midbrain development. |
2011-10-14 |
2023-08-12 |
Not clear |