| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel A Berg, Matthew Kirkham, Heng Wang, Jonas Frisén, András Simo. Dopamine controls neurogenesis in the adult salamander midbrain in homeostasis and during regeneration of dopamine neurons. Cell stem cell. vol 8. issue 4. 2011-07-29. PMID:21474106. |
ablation of midbrain dopamine neurons leads to complete regeneration in salamanders. |
2011-07-29 |
2023-08-12 |
Not clear |
| Daniel A Berg, Matthew Kirkham, Heng Wang, Jonas Frisén, András Simo. Dopamine controls neurogenesis in the adult salamander midbrain in homeostasis and during regeneration of dopamine neurons. Cell stem cell. vol 8. issue 4. 2011-07-29. PMID:21474106. |
the findings establish a role for dopamine in the reversible suppression of neurogenesis in the midbrain and have implications for regenerative strategies in parkinson's disease. |
2011-07-29 |
2023-08-12 |
Not clear |
| Sabina Anwar, Owen Peters, Steven Millership, Natalia Ninkina, Natalie Doig, Natalie Connor-Robson, Sarah Threlfell, Gurdeep Kooner, Robert M Deacon, David M Bannerman, J Paul Bolam, Sreeganga S Chandra, Stephanie J Cragg, Richard Wade-Martins, Vladimir L Buchma. Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 20. 2011-07-21. PMID:21593311. |
our data uniquely reveal the importance of the synuclein proteins in regulating neurotransmitter release from specific populations of midbrain dopamine neurons through mechanisms that differ from those reported in other neurons. |
2011-07-21 |
2023-08-12 |
mouse |
| Boris Mileykovskiy, Marisela Morale. Duration of inhibition of ventral tegmental area dopamine neurons encodes a level of conditioned fear. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 20. 2011-07-21. PMID:21593330. |
it is widely accepted that midbrain dopamine (da) neurons encode actual and expected reward values by phasic alterations in firing rate. |
2011-07-21 |
2023-08-12 |
rat |
| F M Corrigan, J J Fisher, D J Nut. Autonomic dysregulation and the Window of Tolerance model of the effects of complex emotional trauma. Journal of psychopharmacology (Oxford, England). vol 25. issue 1. 2011-07-18. PMID:20093318. |
animal models of depression frequently use traumatic experiences of pain, isolation or social defeat to induce changes in mesolimbic and mesocortical dopamine systems which may alter prefrontal cortical control of midbrain defence responses. |
2011-07-18 |
2023-08-12 |
Not clear |
| Jonathan Moss, Mark A Ungless, J Paul Bola. Dopaminergic axons in different divisions of the adult rat striatal complex do not express vesicular glutamate transporters. The European journal of neuroscience. vol 33. issue 7. 2011-07-18. PMID:21375596. |
midbrain dopamine neurons signal rapid information about rewards and reward-related events. |
2011-07-18 |
2023-08-12 |
rat |
| Susanne Graef, Guido Biele, Lea K Krugel, Frank Marzinzik, Michael Wahl, Johann Wotka, Fabian Klostermann, Hauke R Heekere. Differential influence of levodopa on reward-based learning in Parkinson's disease. Frontiers in human neuroscience. vol 4. 2011-07-14. PMID:21048900. |
the mesocorticolimbic dopamine (da) system linking the dopaminergic midbrain to the prefrontal cortex and subcortical striatum has been shown to be sensitive to reinforcement in animals and humans. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jean-Luc Dreye. New insights into the roles of microRNAs in drug addiction and neuroplasticity. Genome medicine. vol 2. issue 12. 2011-07-14. PMID:21205279. |
recent studies have identified changes of several specific mirna expression profiles and polymorphisms affecting the interactions between mirnas and their targets in various brain disorders, including addiction: mir-16 causes adaptive changes in production of the serotonin transporter; mir-133b is specifically expressed in midbrain dopaminergic neurons, and regulates the production of tyrosine hydroxylase and the dopamine transporter; mir-212 affects production of striatal brain-derived neurotrophic factor and synaptic plasticity upon cocaine. |
2011-07-14 |
2023-08-12 |
Not clear |
| Darcy Litteljohn, Emily Mangano, Melanie Clarke, Jessica Bobyn, Kerry Moloney, Shawn Hayle. Inflammatory mechanisms of neurodegeneration in toxin-based models of Parkinson's disease. Parkinson's disease. vol 2011. 2011-07-14. PMID:21234362. |
indeed, toxin exposure has been repeatedly demonstrated to induce the release of oxidative and inflammatory factors from immunocompetent microglia, leading to damage and death of midbrain dopamine (da) neurons. |
2011-07-14 |
2023-08-12 |
Not clear |
| Frederick P Bellinger, Miyoko T Bellinger, Lucia A Seale, Andrea S Takemoto, Arjun V Raman, Takanori Miki, Amy B Manning-Boğ, Marla J Berry, Lon R White, G Webster Ros. Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain. Molecular neurodegeneration. vol 6. issue 1. 2011-07-14. PMID:21255396. |
parkinson's disease is a neurodegenerative disorder characterized pathologically by the loss of nigrostriatal dopamine neurons that project from the substantia nigra in the midbrain to the putamen and caudate nuclei, leading to the clinical features of bradykinesia, rigidity, and rest tremor. |
2011-07-14 |
2023-08-12 |
Not clear |
| Kelly R Tan, Uwe Rudolph, Christian Lüsche. Hooked on benzodiazepines: GABAA receptor subtypes and addiction. Trends in neurosciences. vol 34. issue 4. 2011-07-14. PMID:21353710. |
these data reveal how benzodiazepines, acting through specific gaba(a) receptor subtypes, activate midbrain dopamine neurons, and how this could hijack the mesolimbic reward system. |
2011-07-14 |
2023-08-12 |
Not clear |
| Wenbo Zhou, Kathryn Bercury, Jessica Cummiskey, Nancy Luong, Jacob Lebin, Curt R Free. Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease. The Journal of biological chemistry. vol 286. issue 17. 2011-07-14. PMID:21372141. |
parkinson disease is caused by the death of midbrain dopamine neurons from oxidative stress, abnormal protein aggregation, and genetic predisposition. |
2011-07-14 |
2023-08-12 |
mouse |
| Billy T Chen, Jyoti C Patel, Kimberly A Moran, Margaret E Ric. Differential calcium dependence of axonal versus somatodendritic dopamine release, with characteristics of both in the ventral tegmental area. Frontiers in systems neuroscience. vol 5. 2011-07-14. PMID:21716634. |
midbrain dopamine (da) neurons in the substantia nigra pars compacta (snc) and ventral tegmental area (vta) exhibit somatodendritic release of da. |
2011-07-14 |
2023-08-12 |
Not clear |
| Elyssa B Margolis, Allison R Coker, Joseph R Driscoll, Anne-Iris Lemaître, Howard L Field. Reliability in the identification of midbrain dopamine neurons. PloS one. vol 5. issue 12. 2011-07-05. PMID:21151605. |
reliability in the identification of midbrain dopamine neurons. |
2011-07-05 |
2023-08-12 |
mouse |
| Elyssa B Margolis, Allison R Coker, Joseph R Driscoll, Anne-Iris Lemaître, Howard L Field. Reliability in the identification of midbrain dopamine neurons. PloS one. vol 5. issue 12. 2011-07-05. PMID:21151605. |
a prime example of this difficulty is the identification of dopamine (da) neurons in the midbrain ventral tegmental area (vta). |
2011-07-05 |
2023-08-12 |
mouse |
| Zhiqiang Liu, Jing Han, Lintao Jia, Jean-Christian Maillet, Guang Bai, Lin Xu, Zhengping Jia, Qiaohua Zheng, Wandong Zhang, Robert Monette, Zul Merali, Zhou Zhu, Wei Wang, Wei Ren, Xia Zhan. Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning. PloS one. vol 5. issue 12. 2011-07-05. PMID:21187978. |
recent studies suggest ltp expression in locally activated glutamate synapses onto dopamine neurons (local glu-da synapses) of the midbrain ventral tegmental area (vta) following a single or chronic exposure to many drugs of abuse, whereas a single exposure to cannabinoid did not significantly affect synaptic plasticity at these synapses. |
2011-07-05 |
2023-08-12 |
rat |
| Jon F Davis, Derrick L Choi, Jennifer D Schurdak, Maureen F Fitzgerald, Deborah J Clegg, Jack W Lipton, Dianne P Figlewicz, Stephen C Benoi. Leptin regulates energy balance and motivation through action at distinct neural circuits. Biological psychiatry. vol 69. issue 7. 2011-07-01. PMID:21035790. |
the current study asked whether leptin signaling within the lateral hypothalamus (lh) and midbrain is involved in effort-based responding for food rewards and/or the modulation of mesolimbic dopamine. |
2011-07-01 |
2023-08-12 |
Not clear |
| Larry S Zweifel, Jonathan P Fadok, Emmanuela Argilli, Michael G Garelick, Graham L Jones, Tavis M K Dickerson, James M Allen, Sheri J Y Mizumori, Antonello Bonci, Richard D Palmite. Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety. Nature neuroscience. vol 14. issue 5. 2011-07-01. PMID:21499253. |
dopamine neurons of the ventral midbrain exhibit heterogeneous responses to aversive stimuli that are thought to provide a critical modulatory signal to facilitate orientation to environmental changes and assignment of motivational value to unexpected events. |
2011-07-01 |
2023-08-12 |
mouse |
| Annika Vaarmann, Sonia Gandhi, Alexander V Gourine, Andrey Y Abramo. Novel pathway for an old neurotransmitter: dopamine-induced neuronal calcium signalling via receptor-independent mechanisms. Cell calcium. vol 48. issue 2-3. 2011-06-27. PMID:20846720. |
in cultured neurons from midbrain, cortex and hippocampus, dopamine uptake via dopamine or monoamine transporters induces plasmalemmal membrane depolarization, leading to opening of voltage gated calcium channels and a cytosolic calcium signal. |
2011-06-27 |
2023-08-12 |
rat |
| Jon F Davis, Derrick L Choi, Jennifer D Shurdak, Eric G Krause, Maureen F Fitzgerald, Jack W Lipton, Randall R Sakai, Stephen C Benoi. Central melanocortins modulate mesocorticolimbic activity and food seeking behavior in the rat. Physiology & behavior. vol 102. issue 5. 2011-06-21. PMID:21172367. |
in particular, we predicted that central administration of the melanocortin antagonist agouti-related peptide (agrp) would activate midbrain dopamine neurons, increase mesolimbic dopamine turnover, and alter food seeking behaviors. |
2011-06-21 |
2023-08-12 |
rat |