| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K B Reynolds, L MacGillivray, M Zettler, P I Rosebush, M F Mazure. Role of the dopamine transporter in mediating the neuroleptic-induced reduction of tyrosine hydroxylase-immunoreactive midbrain neurons. Brain research. vol 1394. 2011-10-11. PMID:21396352. |
role of the dopamine transporter in mediating the neuroleptic-induced reduction of tyrosine hydroxylase-immunoreactive midbrain neurons. |
2011-10-11 |
2023-08-12 |
rat |
| K B Reynolds, L MacGillivray, M Zettler, P I Rosebush, M F Mazure. Role of the dopamine transporter in mediating the neuroleptic-induced reduction of tyrosine hydroxylase-immunoreactive midbrain neurons. Brain research. vol 1394. 2011-10-11. PMID:21396352. |
these results indicate a role for the active dopamine transporter in mediating the suppression of th expression in midbrain dopaminergic neurons by antipsychotic drugs. |
2011-10-11 |
2023-08-12 |
rat |
| Simon Hong, Thomas C Jhou, Mitchell Smith, Kadharbatcha S Saleem, Okihide Hikosak. Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedial tegmental nucleus in primates. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 32. 2011-10-04. PMID:21832176. |
lateral habenula (lhb) neurons signal negative "reward-prediction errors" and inhibit midbrain dopamine (da) neurons. |
2011-10-04 |
2023-08-12 |
rat |
| Makiko Kuwagata, Katsumasa Muneoka, Tetsuo Ogawa, Seiji Shiod. Effects of the genotoxic agent 5-bromo-2'-deoxyuridine with or without pre-pubertal gonadectomy on brain monoamines and their metabolites in female rats. Brain research bulletin. vol 85. issue 3-4. 2011-09-30. PMID:21414389. |
brdu-treated females showed elevations of dopamine and 5-ht levels in the striatum; reductions in dopamine, dihydroxyphenylacetic acid, or homovanillic acid (hva) in the hypothalamus or the midbrain; and elevated hva and 5-ht in the hippocampus. |
2011-09-30 |
2023-08-12 |
rat |
| Rong Gong, Cheng Ding, Ji Hu, Yao Lu, Fei Liu, Elizabeth Mann, Fuqiang Xu, Mitchell B Cohen, Minmin Lu. Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science (New York, N.Y.). vol 333. issue 6049. 2011-09-28. PMID:21835979. |
midbrain dopamine neurons regulate many important behavioral processes, and their dysfunctions are associated with several human neuropsychiatric disorders such as attention deficit hyperactivity disorder (adhd) and schizophrenia. |
2011-09-28 |
2023-08-12 |
mouse |
| Rong Gong, Cheng Ding, Ji Hu, Yao Lu, Fei Liu, Elizabeth Mann, Fuqiang Xu, Mitchell B Cohen, Minmin Lu. Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science (New York, N.Y.). vol 333. issue 6049. 2011-09-28. PMID:21835979. |
these results indicate important behavioral and physiological functions for the gc-c/pkg signaling pathway within the brain and suggest new therapeutic targets for neuropsychiatric disorders related to the malfunctions of midbrain dopamine neurons. |
2011-09-28 |
2023-08-12 |
mouse |
| Mehdi Keramati, Amir Dezfouli, Payam Pira. Speed/accuracy trade-off between the habitual and the goal-directed processes. PLoS computational biology. vol 7. issue 5. 2011-09-27. PMID:21637741. |
neurobiologically, by assuming that phasic and tonic activities of midbrain dopamine neurons carry the reward prediction error and the average reward signals used by the model, respectively, the model predicts that whereas phasic dopamine indirectly affects behaviour through reinforcing stimulus-response associations, tonic dopamine can directly affect behaviour through manipulating the competition between the habitual and the goal-directed systems and thus, affect reaction time. |
2011-09-27 |
2023-08-12 |
Not clear |
| Dianne P Figlewicz, Alfred J Sipol. Energy regulatory signals and food reward. Pharmacology, biochemistry, and behavior. vol 97. issue 1. 2011-09-15. PMID:20230849. |
specifically, insulin and leptin can decrease food reward behaviors and modulate the function of neurotransmitter systems and neural circuitry that mediate food reward, the midbrain dopamine (da) and opioidergic pathways. |
2011-09-15 |
2023-08-12 |
Not clear |
| Martin Bellander, Yvonne Brehmer, Helena Westerberg, Sari Karlsson, Daniel Fürth, Olle Bergman, Elias Eriksson, Lars Bäckma. Preliminary evidence that allelic variation in the LMX1A gene influences training-related working memory improvement. Neuropsychologia. vol 49. issue 7. 2011-09-13. PMID:21435346. |
lmx1a is a transcription factor involved in the development of dopamine (da)-producing neurons in midbrain. |
2011-09-13 |
2023-08-12 |
Not clear |
| Wiebke Potjans, Markus Diesmann, Abigail Morriso. An imperfect dopaminergic error signal can drive temporal-difference learning. PLoS computational biology. vol 7. issue 5. 2011-09-09. PMID:21589888. |
experimental evidence that supports the hypothesis that the mammalian brain performs temporal-difference learning includes the resemblance of the phasic activity of the midbrain dopaminergic neurons to the td error and the discovery that cortico-striatal synaptic plasticity is modulated by dopamine. |
2011-09-09 |
2023-08-12 |
Not clear |
| Xiaoying Cui, Matthew Pelekanos, Thomas H J Burne, John J McGrath, Darryl W Eyle. Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon. Neuroscience letters. vol 486. issue 3. 2011-09-06. PMID:20884326. |
maternal vitamin d deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon. |
2011-09-06 |
2023-08-12 |
rat |
| Gunasingh J Masilamoni, James W Bogenpohl, David Alagille, Kristen Delevich, Gilles Tamagnan, John R Votaw, Thomas Wichmann, Yoland Smit. Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys. Brain : a journal of neurology. vol 134. issue Pt 7. 2011-08-26. PMID:21705423. |
these behavioural observations were consistent with in vivo positron emission tomography dopamine transporter imaging data, and with post-mortem stereological counts of midbrain dopaminergic neurons, as well as striatal intensity measurements of dopamine transporter and tyrosine hydroxylase immunoreactivity, which were all significantly higher in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/3-[(2-methyl-1,3-thiazol-4-yl) ethynyl] pyridine-treated animals than in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/vehicle-treated monkeys. |
2011-08-26 |
2023-08-12 |
monkey |
| Irina N Krasnova, Bruce Ladenheim, Amber B Hodges, Nora D Volkow, Jean Lud Cade. Chronic methamphetamine administration causes differential regulation of transcription factors in the rat midbrain. PloS one. vol 6. issue 4. 2011-08-25. PMID:21547080. |
when administered in large doses, meth can cause depletion of striatal dopamine terminals, with preservation of midbrain dopaminergic neurons. |
2011-08-25 |
2023-08-12 |
rat |
| Irina N Krasnova, Bruce Ladenheim, Amber B Hodges, Nora D Volkow, Jean Lud Cade. Chronic methamphetamine administration causes differential regulation of transcription factors in the rat midbrain. PloS one. vol 6. issue 4. 2011-08-25. PMID:21547080. |
interestingly, meth challenges elicited increases in dopamine transporter mrna levels in the midbrain in the presence but not in the absence of meth pretreatment. |
2011-08-25 |
2023-08-12 |
rat |
| Nicole Gennet, Emily Gale, Xinsheng Nan, Emma Farley, Katalin Takacs, Barbara Oberwallner, David Chambers, Meng L. Doublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 22. 2011-08-23. PMID:21576465. |
gain- and loss-of-function studies in esc demonstrate that dmrt5 is critically involved in the specification of ventral-medial neural progenitor cell fate and the subsequent generation of dopamine neurons expressing essential midbrain characteristics. |
2011-08-23 |
2023-08-12 |
Not clear |
| Stephan Lammel, Daniela I Ion, Jochen Roeper, Robert C Malenk. Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron. vol 70. issue 5. 2011-08-23. PMID:21658580. |
midbrain dopamine (da) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. |
2011-08-23 |
2023-08-12 |
mouse |
| Yong-Hee Rhee, Ji-Yun Ko, Mi-Yoon Chang, Sang-Hoon Yi, Dohoon Kim, Chun-Hyung Kim, Jae-Won Shim, A-Young Jo, Byung-Woo Kim, Hyunsu Lee, Suk-Ho Lee, Wonhee Suh, Chang-Hwan Park, Hyun-Chul Koh, Yong-Sung Lee, Robert Lanza, Kwang-Soo Kim, Sang-Hun Le. Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. The Journal of clinical investigation. vol 121. issue 6. 2011-08-17. PMID:21576821. |
parkinson disease (pd) involves the selective loss of midbrain dopamine (mda) neurons and is a possible target disease for stem cell-based therapy. |
2011-08-17 |
2023-08-12 |
human |
| Yuriko Iwakura, Ran Wang, Yuichi Abe, Ying-Shan Piao, Yuji Shishido, Shigeki Higashiyama, Nobuyuki Takei, Hiroyuki Naw. Dopamine-dependent ectodomain shedding and release of epidermal growth factor in developing striatum: target-derived neurotrophic signaling (Part 2). Journal of neurochemistry. vol 118. issue 1. 2011-08-12. PMID:21534959. |
therefore, the activation of striatal dopamine receptors induces shedding and release of egf to provide a retrograde neurotrophic signal to midbrain dopaminergic neurons. |
2011-08-12 |
2023-08-12 |
rat |
| Timothy J Collier, Nicholas M Kanaan, Jeffrey H Kordowe. Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates. Nature reviews. Neuroscience. vol 12. issue 6. 2011-08-05. PMID:21587290. |
however, the current dogma holds that cellular mechanisms that are associated with ageing of midbrain dopamine neurons and those that are related to dopamine neuron degeneration in parkinson's disease are unrelated. |
2011-08-05 |
2023-08-12 |
Not clear |
| Daniel A Berg, Matthew Kirkham, Heng Wang, Jonas Frisén, András Simo. Dopamine controls neurogenesis in the adult salamander midbrain in homeostasis and during regeneration of dopamine neurons. Cell stem cell. vol 8. issue 4. 2011-07-29. PMID:21474106. |
dopamine controls neurogenesis in the adult salamander midbrain in homeostasis and during regeneration of dopamine neurons. |
2011-07-29 |
2023-08-12 |
Not clear |