| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J D Elsworth, M S Brittan, J R Taylor, J R Sladek, D E Redmond, R B Innis, Y Zea-Ponce, R H Rot. Upregulation of striatal D2 receptors in the MPTP-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: an autoradiographic study. Brain research. vol 795. issue 1-2. 1998-08-19. PMID:9622593. |
these data, in addition to those from a previous autoradiographic study on dopamine uptake site density in these monkeys, strongly supports the hypothesis that ectopically placed ventral mesencephalon not only produces, but maintains the release of sufficient levels of dopamine to restore postsynaptic dopamine transmission in regions influenced by graft-derived dopamine. |
1998-08-19 |
2023-08-12 |
monkey |
| D N Ruskin, S S Rawji, J R Walter. Effects of full D1 dopamine receptor agonists on firing rates in the globus pallidus and substantia nigra pars compacta in vivo: tests for D1 receptor selectivity and comparisons to the partial agonist SKF 38393. The Journal of pharmacology and experimental therapeutics. vol 286. issue 1. 1998-08-03. PMID:9655869. |
this study characterizes the effects of four full d1 agonists, skf 82958 (chloro-apb), skf 81297 (6-chloro-pb), dihydrexidine and a-77636, on the firing rates of midbrain dopamine and globus pallidus neurons. |
1998-08-03 |
2023-08-12 |
rat |
| D N Ruskin, S S Rawji, J R Walter. Effects of full D1 dopamine receptor agonists on firing rates in the globus pallidus and substantia nigra pars compacta in vivo: tests for D1 receptor selectivity and comparisons to the partial agonist SKF 38393. The Journal of pharmacology and experimental therapeutics. vol 286. issue 1. 1998-08-03. PMID:9655869. |
dihydrexidine, skf 81297 and a-77636 were free of rate effects on midbrain dopamine neurons (up to 10.2 mg/kg) and also did not antagonize the inhibitory effects of quinpirole. |
1998-08-03 |
2023-08-12 |
rat |
| O K Rønnekleiv, Y Fang, W S Choi, L Cha. Changes in the midbrain-rostral forebrain dopamine circuitry in the cocaine-exposed primate fetal brain. Annals of the New York Academy of Sciences. vol 846. 1998-07-31. PMID:9668406. |
however, by day 60 the midbrain of monkeys exposed to cocaine had significantly reduced expression of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
1998-07-31 |
2023-08-12 |
monkey |
| C D Fiorillo, J T William. Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons. Nature. vol 394. issue 6688. 1998-07-20. PMID:9665131. |
in ventral midbrain dopamine neurons, activation of metabotropic glutamate receptors (mglur1) mobilized calcium from caffeine/ryanodine-sensitive stores and increased an apamin-sensitive potassium conductance. |
1998-07-20 |
2023-08-12 |
Not clear |
| J T Kuikka, J L Baulieu, J Hiltunen, C Halldin, K A Bergström, L Farde, P Emond, S Chalon, M Yu, T Nikula, T Laitinen, J Karhu, E Tupala, T Hallikainen, V Kolehmainen, L Mauclaire, B Maziere, J Tiihonen, D Guillotea. Pharmacokinetics and dosimetry of iodine-123 labelled PE2I in humans, a radioligand for dopamine transporter imaging. European journal of nuclear medicine. vol 25. issue 5. 1998-07-16. PMID:9575250. |
there was no significant uptake of [123i]pe2i in serotonin-rich regions such as the midbrain, hypothalamus and anterior gingulus, suggesting that in vivo binding is specific for the dopamine transporter. |
1998-07-16 |
2023-08-12 |
human |
| J W Lindsey, A E Jung, T K Narayanan, G D Ritchi. Acute effects of a bicyclophosphate neuroconvulsant on monoamine neurotransmitter and metabolite levels in the rat brain. Journal of toxicology and environmental health. Part A. vol 54. issue 5. 1998-07-09. PMID:9650574. |
levels of the monoamine neurotransmitters norepinephrine (ne), epinephrine (epi), dopamine (da), and serotonin (5-ht) and the major metabolites 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva), and 5-hydroxyindoleacetic acid (5-hiaa) were assayed in forebrain, midbrain, hindbrain, cerebellum and brainstem regions. |
1998-07-09 |
2023-08-12 |
rat |
| D Sulzer, M P Joyce, L Lin, D Geldwert, S N Haber, T Hattori, S Raypor. Dopamine neurons make glutamatergic synapses in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 12. 1998-07-08. PMID:9614234. |
several lines of evidence have suggested that the ventral midbrain dopamine neurons that give rise to the major cns dopaminergic projections may also be glutamatergic. |
1998-07-08 |
2023-08-12 |
rat |
| D Sulzer, M P Joyce, L Lin, D Geldwert, S N Haber, T Hattori, S Raypor. Dopamine neurons make glutamatergic synapses in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 12. 1998-07-08. PMID:9614234. |
to examine this possibility, we double immunostained ventral midbrain sections from rat and monkey for the dopamine-synthetic enzyme tyrosine hydroxylase and for glutamate; we found that most dopamine neurons immunostained for glutamate, both in rat and monkey. |
1998-07-08 |
2023-08-12 |
rat |
| W M Zawada, D J Zastrow, E D Clarkson, F S Adams, K P Bell, C R Free. Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats. Brain research. vol 786. issue 1-2. 1998-06-12. PMID:9554968. |
to improve the survival of dopamine neurons in grafts, strands of e15 rat ventral mesencephalon were pretreated with a combination of gdnf, igf-i, and bfgf and then transplanted into 6-hydroxydopamine-lesioned rats. |
1998-06-12 |
2023-08-12 |
rat |
| b' J Moisan, P P Rompr\\xc3\\xa. Electrophysiological evidence that a subset of midbrain dopamine neurons integrate the reward signal induced by electrical stimulation of the posterior mesencephalon. Brain research. vol 786. issue 1-2. 1998-06-12. PMID:9554987.' |
electrophysiological evidence that a subset of midbrain dopamine neurons integrate the reward signal induced by electrical stimulation of the posterior mesencephalon. |
1998-06-12 |
2023-08-12 |
rat |
| b' J Moisan, P P Rompr\\xc3\\xa. Electrophysiological evidence that a subset of midbrain dopamine neurons integrate the reward signal induced by electrical stimulation of the posterior mesencephalon. Brain research. vol 786. issue 1-2. 1998-06-12. PMID:9554987.' |
this study was aimed at determining whether midbrain dopamine (da) neurons are trans-synaptically activated by rewarding electrical stimulation applied near the midline in the posterior mesencephalon (pm), and in the affirmative, whether the increase in firing was proportional to the rewarding effectiveness of the stimulation. |
1998-06-12 |
2023-08-12 |
rat |
| M E Wol. The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Progress in neurobiology. vol 54. issue 6. 1998-06-08. PMID:9560846. |
while behavioral sensitization likely involves complex neuronal circuits, with eaas participating at several points within this circuitry, eaa projections originating in prefrontal cortex may play a particularly important role in the development of sensitization, perhaps via their regulatory effects on midbrain dopamine neurons. |
1998-06-08 |
2023-08-12 |
Not clear |
| E N Pothos, V Davila, D Sulze. Presynaptic recording of quanta from midbrain dopamine neurons and modulation of the quantal size. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 11. 1998-06-04. PMID:9592091. |
presynaptic recording of quanta from midbrain dopamine neurons and modulation of the quantal size. |
1998-06-04 |
2023-08-12 |
Not clear |
| E N Pothos, V Davila, D Sulze. Presynaptic recording of quanta from midbrain dopamine neurons and modulation of the quantal size. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 11. 1998-06-04. PMID:9592091. |
we adapted amperometric methods to observe quantal release directly from axonal varicosities of midbrain dopamine neurons that predominantly contain small synaptic vesicles. |
1998-06-04 |
2023-08-12 |
Not clear |
| W M Zawada, J B Cibelli, P K Choi, E D Clarkson, P J Golueke, S E Witta, K P Bell, J Kane, F A Ponce de Leon, D J Jerry, J M Robl, C R Freed, S L Stic. Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats. Nature medicine. vol 4. issue 5. 1998-05-29. PMID:9585230. |
dopamine cells collected from the ventral mesencephalon of the cloned fetuses 42 to 50 days post-conception survived transplantation into immunosuppressed parkinsonian rats and cells from cloned and wild-type embryos improved motor performance. |
1998-05-29 |
2023-08-12 |
human |
| K Yoshimoto, T Yoshida, A Hirano, S Ued. 6R-L-erythro-5,6,7,8-tetrahydrobiopterin is involved in brain vulnerability of senescence-accelerated mouse during the processes of aging. Growth, development, and aging : GDA. vol 61. issue 3-4. 1998-05-27. PMID:9546106. |
the effects of age on the dopamine (da) turnover and 6r-l-erythro-5,6,7,8-tetrahydrobiopterin (6r-bh4), a cofactor for monooxygenases, were investigated in the striatum and midbrain of the senescence accelerated mouse (sam) at 6, 12 and 15 months old. |
1998-05-27 |
2023-08-12 |
mouse |
| S J Cragg, C Holmes, C R Hawkey, S A Greenfiel. Dopamine is released spontaneously from developing midbrain neurons in organotypic culture. Neuroscience. vol 84. issue 2. 1998-05-22. PMID:9539208. |
dopamine is released spontaneously from developing midbrain neurons in organotypic culture. |
1998-05-22 |
2023-08-12 |
Not clear |
| S J Cragg, C Holmes, C R Hawkey, S A Greenfiel. Dopamine is released spontaneously from developing midbrain neurons in organotypic culture. Neuroscience. vol 84. issue 2. 1998-05-22. PMID:9539208. |
this study is the first attempt to monitor directly and in real-time, the release of dopamine from midbrain neurons developing as an isolated organotypic slice culture. |
1998-05-22 |
2023-08-12 |
Not clear |
| S J Cragg, C Holmes, C R Hawkey, S A Greenfiel. Dopamine is released spontaneously from developing midbrain neurons in organotypic culture. Neuroscience. vol 84. issue 2. 1998-05-22. PMID:9539208. |
the observed release of dopamine was both spontaneous and synchronized and occurred with an average periodicity that is two orders of magnitude longer than the characteristic neuronal discharge activity of midbrain dopamine cells. |
1998-05-22 |
2023-08-12 |
Not clear |