| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Ikemoto, I Nagatsu, A Nishimura, K Nishi, R Ara. Do all of human midbrain tyrosine hydroxylase neurons synthesize dopamine? Brain research. vol 805. issue 1-2. 1998-11-25. PMID:9733977. |
we examined whether all of human midbrain tyrosine hydroxylase (th) neurons substantially synthesize dopamine (da) using dual labeling immunohistochemical technique of th and aromatic l-amino acid decarboxylase (aadc). |
1998-11-25 |
2023-08-12 |
human |
| E D Clarkson, W M Zawada, F S Adams, K P Bell, C R Free. Strands of embryonic mesencephalic tissue show greater dopamine neuron survival and better behavioral improvement than cell suspensions after transplantation in parkinsonian rats. Brain research. vol 806. issue 1. 1998-11-20. PMID:9739108. |
tissue from ventral mesencephalon was transplanted into a single site in dopamine denervated striatum of unilateral 6-hydroxydopamine (6-ohda) lesioned rats. |
1998-11-20 |
2023-08-12 |
rat |
| S L Erickson, M Akil, A I Levey, D A Lewi. Postnatal development of tyrosine hydroxylase- and dopamine transporter-immunoreactive axons in monkey rostral entorhinal cortex. Cerebral cortex (New York, N.Y. : 1991). vol 8. issue 5. 1998-11-09. PMID:9722085. |
dopamine afferents from the mesencephalon appear to play a critical role in the normal development and cognitive functions of multiple areas of the primate cerebral cortex. |
1998-11-09 |
2023-08-12 |
monkey |
| G Di Giovanni, M Di Mascio, V Di Matteo, E Esposit. Effects of acute and repeated administration of amisulpride, a dopamine D2/D3 receptor antagonist, on the electrical activity of midbrain dopaminergic neurons. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765321. |
effects of acute and repeated administration of amisulpride, a dopamine d2/d3 receptor antagonist, on the electrical activity of midbrain dopaminergic neurons. |
1998-11-05 |
2023-08-12 |
Not clear |
| T E Madden, S W Johnso. Gamma-hydroxybutyrate is a GABAB receptor agonist that increases a potassium conductance in rat ventral tegmental dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765346. |
electrophysiological recordings of membrane voltage and current were made to characterize the effects of ghb on dopamine neurons in the ventral tegmental area of the rat midbrain slice. |
1998-11-05 |
2023-08-12 |
rat |
| M A Mena, V Davila, J Bogaluvsky, D Sulze. A synergistic neurotrophic response to l-dihydroxyphenylalanine and nerve growth factor. Molecular pharmacology. vol 54. issue 4. 1998-10-30. PMID:9765511. |
although short-term exposure (30 min) potentiates dopamine (da) release by elevating quantal size, longer term exposure to l-dopa (48 hr) promotes neurite outgrowth from midbrain da neurons in culture. |
1998-10-30 |
2023-08-12 |
Not clear |
| R C Dodel, Y Du, K R Bales, Z D Ling, P M Carvey, S M Pau. Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons. Neuroscience. vol 86. issue 3. 1998-10-29. PMID:9692710. |
here we extend recent work from our laboratory on the mechanisms mediating the neurotoxic actions of 1-methyl-4-phenylpyridinium using ventral mesencephalon cultures containing dopamine neurons. |
1998-10-29 |
2023-08-12 |
mouse |
| R C Dodel, Y Du, K R Bales, Z D Ling, P M Carvey, S M Pau. Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons. Neuroscience. vol 86. issue 3. 1998-10-29. PMID:9692710. |
moreover, pretreatment of ventral mesencephalon cultures with the tetrapeptide inhibitors of the caspase-3-like proteases zvad-fmk or ac-devd-cho specifically inhibit death of dopamine neurons induced by low concentrations of 1-methyl-4-phenylpyridinium, whereas the caspase-1-like inhibitor ac-yvad-cho was without effect. |
1998-10-29 |
2023-08-12 |
mouse |
| R C Dodel, Y Du, K R Bales, Z D Ling, P M Carvey, S M Pau. Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons. Neuroscience. vol 86. issue 3. 1998-10-29. PMID:9692710. |
our data indicate that exposure of cultured ventral mesencephalon dopamine neurons to low concentrations of 1-methyl-4-phenylpyridinium results in apoptotic death and that caspase-3-like proteases may mediate the neurotoxic apoptotic actions of 1-methyl-4-phenylpyridinium. |
1998-10-29 |
2023-08-12 |
mouse |
| T A Patterson, M D Brot, A Zavosh, J O Schenk, P Szot, D P Figlewic. Food deprivation decreases mRNA and activity of the rat dopamine transporter. Neuroendocrinology. vol 68. issue 1. 1998-10-23. PMID:9695934. |
we have hypothesized that the midbrain dopamine (da) neurons are a target for insulin action in the central nervous system (cns). |
1998-10-23 |
2023-08-12 |
rat |
| S Erhardt, B Andersson, H Nissbrandt, G Engber. Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by gamma-hydroxybutyric acid (GHBA) are specifically induced by activation of GABA(B) receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 6. 1998-10-16. PMID:9686936. |
previous studies have shown that administration of gamma-hydroxybutyric acid (ghba) or the gaba(b) receptor agonist baclofen are associated with a decrease in firing rate, a regularisation of firing pattern and a decrease in burst activity of midbrain dopamine (da) neurons in the substantia nigra (sn). |
1998-10-16 |
2023-08-12 |
rat |
| B A Bennett, C K Hollingsworth, R S Martin, S R Childers, R E Ehrenkaufer, L J Porrino, H M Davie. Prolonged dopamine and serotonin transporter inhibition after exposure to tropanes. Neuropharmacology. vol 37. issue 1. 1998-10-08. PMID:9680265. |
in vitro, using primary rat brain cultures of either midbrain or raphe regions, the recovery of the ability to transport either [3h]dopamine or [3h]serotonin, respectively was evaluated at 0, 3, 24, 48, 120 and 240 h after a 1 h exposure to cocaine and tropane analogs. |
1998-10-08 |
2023-08-12 |
rat |
| C Beyer, H Raa. Nongenomic effects of oestrogen: embryonic mouse midbrain neurones respond with a rapid release of calcium from intracellular stores. The European journal of neuroscience. vol 10. issue 1. 1998-10-08. PMID:9753134. |
oestrogens have been shown to modulate the differentiation and function of embryonic midbrain dopaminergic neurones by stimulating neurite outgrowth, expression of tyrosine hydroxylase mrna, dopamine uptake and release in spite of the fact that dopaminergic cells in the prenatal midbrain do not express the classical oestrogen receptor. |
1998-10-08 |
2023-08-12 |
mouse |
| D M Gash, Z Zhang, G Gerhard. Neuroprotective and neurorestorative properties of GDNF. Annals of neurology. vol 44. issue 3 Suppl 1. 1998-10-07. PMID:9749583. |
adult midbrain dopamine neurons stimulated by gdnf show increased cell size, neurite extent, and expression of phenotypic markers. |
1998-10-07 |
2023-08-12 |
monkey |
| B Gronier, K Rasmusse. Activation of midbrain presumed dopaminergic neurones by muscarinic cholinergic receptors: an in vivo electrophysiological study in the rat. British journal of pharmacology. vol 124. issue 3. 1998-09-16. PMID:9647468. |
these cholinoceptors would be able to influence the activity of the midbrain dopamine system greatly and may play a role in, and/or be a therapeutic target for, brain disorders in which dopamine is involved (e.g., parkinson's disease, drug addiction and schizophrenia). |
1998-09-16 |
2023-08-12 |
rat |
| K L Ellis, J Spee. Pharmacologic management of movement disorder after midbrain haemorrhage. Brain injury. vol 12. issue 7. 1998-09-15. PMID:9653526. |
dopamine agonist trials of appropriate duration appear indicated in cases of movement disorder (paucity or excess) following midbrain lesions. |
1998-09-15 |
2023-08-12 |
Not clear |
| J F Bowyer, L T Frame, P Clausing, K Nagamoto-Combs, C A Osterhout, C R Sterling, A W Tan. Long-term effects of amphetamine neurotoxicity on tyrosine hydroxylase mRNA and protein in aged rats. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694971. |
our results suggest that even though there is a partial recovery of striatal dopamine levels, which occurs within 4 months after amphetamine treatment, this recovery is not associated with increased th gene expression in the midbrain. |
1998-09-02 |
2023-08-12 |
rat |
| W Schult. Predictive reward signal of dopamine neurons. Journal of neurophysiology. vol 80. issue 1. 1998-08-25. PMID:9658025. |
the effects of lesions, receptor blocking, electrical self-stimulation, and drugs of abuse suggest that midbrain dopamine systems are involved in processing reward information and learning approach behavior. |
1998-08-25 |
2023-08-12 |
Not clear |
| Y Minabe, E L Gardner, C R Ashb. Differential effects of chronic haloperidol administration on midbrain dopamine neurons in Sprague-Dawley, Fischer 344, and Lewis rats: an in vivo electrophysiological study. Synapse (New York, N.Y.). vol 29. issue 3. 1998-08-20. PMID:9635897. |
differential effects of chronic haloperidol administration on midbrain dopamine neurons in sprague-dawley, fischer 344, and lewis rats: an in vivo electrophysiological study. |
1998-08-20 |
2023-08-12 |
rat |
| T J Counihan, J B Penne. Regional dopamine transporter gene expression in the substantia nigra from control and Parkinson's disease brains. Journal of neurology, neurosurgery, and psychiatry. vol 65. issue 2. 1998-08-20. PMID:9703165. |
to test the hypothesis that differential regional dopamine transporter (dat) gene expression may underlie the selective vulnerability of certain nigral dopaminergic neurons in parkinson's disease, dat mrna expression was examined in neuronal subpopulations of human postmortem ventral mesencephalon from patients with parkinson's disease and controls. |
1998-08-20 |
2023-08-12 |
human |