| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roland E Sur. TD models of reward predictive responses in dopamine neurons. Neural networks : the official journal of the International Neural Network Society. vol 15. issue 4-6. 2003-02-11. PMID:12371509. |
activity of midbrain dopamine neurons is phasically increased by stimuli that increase the animal's reward expectation and is decreased below baseline levels when the reward fails to occur. |
2003-02-11 |
2023-08-12 |
Not clear |
| Olaf Sporns, William H Alexande. Neuromodulation and plasticity in an autonomous robot. Neural networks : the official journal of the International Neural Network Society. vol 15. issue 4-6. 2003-02-11. PMID:12371525. |
the model is based on anatomical and physiological properties of midbrain diffuse ascending systems, in particular parts of the dopamine and noradrenaline systems. |
2003-02-11 |
2023-08-12 |
Not clear |
| Hitoshi Morikawa, Kamran Khodakhah, John T William. Two intracellular pathways mediate metabotropic glutamate receptor-induced Ca2+ mobilization in dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 1. 2003-01-27. PMID:12514211. |
activation of metabotropic glutamate receptors (mglurs) causes membrane hyperpolarization in midbrain dopamine neurons. |
2003-01-27 |
2023-08-12 |
Not clear |
| G L Forster, A J Falcon, A D Miller, G A Heruc, C D Blah. Effects of laterodorsal tegmentum excitotoxic lesions on behavioral and dopamine responses evoked by morphine and d-amphetamine. Neuroscience. vol 114. issue 4. 2003-01-10. PMID:12379238. |
cholinergic and glutamatergic projections from the laterodorsal tegmental nucleus (ldt) in the rat pons excite midbrain dopamine cells to directly modulate forebrain dopamine transmission. |
2003-01-10 |
2023-08-12 |
rat |
| P Akerud, P C Holm, G Castelo-Branco, K Sousa, F J Rodriguez, E Arena. Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease. Molecular and cellular neurosciences. vol 21. issue 2. 2003-01-07. PMID:12401443. |
moreover, midbrain dopamine neurons express its preferred receptor gfralpha4, allowing a cis type of action of psp on dopamine neurons. |
2003-01-07 |
2023-08-12 |
mouse |
| P Akerud, P C Holm, G Castelo-Branco, K Sousa, F J Rodriguez, E Arena. Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease. Molecular and cellular neurosciences. vol 21. issue 2. 2003-01-07. PMID:12401443. |
primary culture studies showed that psp is as potent and efficacious as gdnf at promoting both survival and neuritogenesis of midbrain dopamine neurons. |
2003-01-07 |
2023-08-12 |
mouse |
| P Akerud, P C Holm, G Castelo-Branco, K Sousa, F J Rodriguez, E Arena. Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease. Molecular and cellular neurosciences. vol 21. issue 2. 2003-01-07. PMID:12401443. |
thus, our findings are consistent with a direct action of psp on developing and adult midbrain dopamine neurons and suggest that the delivery of psp by nscs may constitute a very useful strategy in the treatment of parkinson's disease. |
2003-01-07 |
2023-08-12 |
mouse |
| Kazuo Matsubara, Koji Aoyama, Manabu Suno, Toshio Away. N-methylation underlying Parkinson's disease. Neurotoxicology and teratology. vol 24. issue 5. 2002-12-19. PMID:12200190. |
indeed, simple betacs, via n-methylation steps, induced bradykinesia with the decreased dopamine contents in the striatum and midbrain in c57/bl mice. |
2002-12-19 |
2023-08-12 |
mouse |
| Werner J Schmidt, Andreas Mayerhofer, Anja Meyer, Karl-A Kova. Ecstasy counteracts catalepsy in rats, an anti-parkinsonian effect? Neuroscience letters. vol 330. issue 3. 2002-12-13. PMID:12270640. |
parkinson's disease is due to a dopamine deficiency caused by the degeneration of midbrain dopamine neurons. |
2002-12-13 |
2023-08-12 |
rat |
| Angela De Iuliis, Alessandro P Burlina, Roberta Boschetto, Pamela Zambenedetti, Paola Arslan, Lauro Galzign. Increased dopamine peroxidation in postmortem Parkinsonian brain. Biochimica et biophysica acta. vol 1573. issue 1. 2002-12-09. PMID:12383943. |
we have previously reported the presence, in human midbrain, of an enzymatic activity which catalyzes the formation of dopaminochrome from dopamine (da) and hydrogen peroxide. |
2002-12-09 |
2023-08-12 |
human |
| Cordian Beyer, Tatiana Ivanova, Magdalena Karolczak, Eva Küpper. Cell type-specificity of nonclassical estrogen signaling in the developing midbrain. The Journal of steroid biochemistry and molecular biology. vol 81. issue 4-5. 2002-12-02. PMID:12361721. |
in the midbrain, estrogens promote the survival, maturation, and function of neurons and, in particular, of dopamine cells. |
2002-12-02 |
2023-08-12 |
Not clear |
| J B Eells, B K Lipska, S K Yeung, J A Misler, V M Nikode. Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity. Behavioural brain research. vol 136. issue 1. 2002-11-29. PMID:12385813. |
nurr1, an orphan nuclear receptor, is essential for the differentiation of the midbrain dopamine (da) neurons; however, its function in adult midbrain da neurons has not been determined. |
2002-11-29 |
2023-08-12 |
mouse |
| B I Hyland, J N J Reynolds, J Hay, C G Perk, R Mille. Firing modes of midbrain dopamine cells in the freely moving rat. Neuroscience. vol 114. issue 2. 2002-11-26. PMID:12204216. |
firing modes of midbrain dopamine cells in the freely moving rat. |
2002-11-26 |
2023-08-12 |
rat |
| B I Hyland, J N J Reynolds, J Hay, C G Perk, R Mille. Firing modes of midbrain dopamine cells in the freely moving rat. Neuroscience. vol 114. issue 2. 2002-11-26. PMID:12204216. |
we examined this by recording from the midbrain dopamine cell fields using chronically implanted microwire electrodes. |
2002-11-26 |
2023-08-12 |
rat |
| Scott E Counts, Susan O McGuire, Caryl E Sortwell, Jacqueline N Crawley, Timothy J Collier, Elliott J Mufso. Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neurons. Journal of neurochemistry. vol 83. issue 2. 2002-11-20. PMID:12423254. |
galanin (gal) inhibits midbrain dopamine (da) activity in several experimental paradigms, yet the mechanism underlying this inhibition is unclear. |
2002-11-20 |
2023-08-12 |
rat |
| John L Beard, Keith M Erikson, Byron C Jone. Neurobehavioral analysis of developmental iron deficiency in rats. Behavioural brain research. vol 134. issue 1-2. 2002-11-19. PMID:12191838. |
iron deficient rats also showed significant decrements in brain iron content in the corpus striatum, prefrontal cortex, and midbrain and decreases in dopamine receptors and the transporter in the same areas. |
2002-11-19 |
2023-08-12 |
rat |
| John L Beard, Keith M Erikson, Byron C Jone. Neurobehavioral analysis of developmental iron deficiency in rats. Behavioural brain research. vol 134. issue 1-2. 2002-11-19. PMID:12191838. |
multiple regression analysis showed ventral midbrain iron concentration and dopamine d(1) receptor density to be highly associated with exploration and repeated movements, respectively. |
2002-11-19 |
2023-08-12 |
rat |
| Hideki Miura, Hong Qiao, Tatsuro Oht. Influence of aging and social isolation on changes in brain monoamine turnover and biosynthesis of rats elicited by novelty stress. Synapse (New York, N.Y.). vol 46. issue 2. 2002-11-19. PMID:12211090. |
changes in brain monoamines and their metabolites such as dopamine (da), serotonin (5-ht), dihydroxyphenylacetic acid (dopac), homovanilic acid (hva), and 5-hydroxyindoleacetic acid (5-hiaa) were measured in six regions: the prefrontal cortex, nucleus accumbens, hippocampus, amygdala, midbrain, and raphe nuclei. |
2002-11-19 |
2023-08-12 |
human |
| Gaylord Elliso. Neural degeneration following chronic stimulant abuse reveals a weak link in brain, fasciculus retroflexus, implying the loss of forebrain control circuitry. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 12. issue 4. 2002-11-15. PMID:12126867. |
a variety of drugs which predominantly potentiate dopamine, including d-amphetamine, methamphetamine, mdma, cocaine, and cathinone, all induce degeneration in axons from lateral habenula, through the sheath of fr, to midbrain cells such as sn, vta, and raphe. |
2002-11-15 |
2023-08-12 |
Not clear |
| Fang Zheng, Steven W Johnso. Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro. Brain research. vol 948. issue 1-2. 2002-10-30. PMID:12383971. |
metabotropic glutamate receptor (mglur) agonist t-acpd produced concentration-dependent enhancement of nmda/apamin-induced burst firing and membrane oscillations in dopamine cells, recorded intracellularly from ventral tegmental area in the rat midbrain slice. |
2002-10-30 |
2023-08-12 |
rat |