| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asa Wallén, Thomas Perlman. Transcriptional control of dopamine neuron development. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846973. |
recent studies have identified several factors that influence the development of midbrain dopamine (da) neurons. |
2003-08-04 |
2023-08-12 |
Not clear |
| J Peter H Burbach, Simone Smits, Marten P Smid. Transcription factors in the development of midbrain dopamine neurons. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846974. |
transcription factors in the development of midbrain dopamine neurons. |
2003-08-04 |
2023-08-12 |
Not clear |
| J Peter H Burbach, Simone Smits, Marten P Smid. Transcription factors in the development of midbrain dopamine neurons. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846974. |
the development of midbrain dopamine (da) neurons follows a number of stages marked by distinct events. |
2003-08-04 |
2023-08-12 |
Not clear |
| Timothy J Collier, Kathy Steece-Collier, Susan McGuire, Caryl E Sortwel. Cellular models to study dopaminergic injury responses. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846983. |
the study of immature midbrain dopamine (da) neurons and dopaminergic cell lines in culture provides an opportunity to analyze mechanisms of cell death and avenues of potential intervention relevant to parkinson's disease (pd) in a controlled environment. |
2003-08-04 |
2023-08-12 |
Not clear |
| K Shimizu, K Matsubara, K Ohtaki, S Fujimaru, O Saito, H Shion. Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats. Brain research. vol 976. issue 2. 2003-07-28. PMID:12763259. |
the subchronic treatment with systemic paraquat significantly decreased brain dopamine content in the striatum and slightly in the midbrain and cortex, and was accompanied by the diminished level of its acidic metabolites in rats. |
2003-07-28 |
2023-08-12 |
rat |
| Santiago Canals, Maria José Casarejos, Sonsoles de Bernardo, Eulalia Rodríguez-Martín, Maria Angeles Men. Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase. The Journal of biological chemistry. vol 278. issue 24. 2003-07-22. PMID:12679339. |
we have previously shown that non-toxic inhibition of gsh synthesis with l-buthionine-(s,r)-sulfoximine in primary midbrain cultures transforms a nitric oxide (no) neurotrophic effect, selective for dopamine neurons, into a toxic effect with participation of guanylate cyclase (gc) and cgmp-dependent protein kinase (pkg) (canals, s., casarejos, m. j., de bernardo, s., rodríguez-martín, e., and mena, m. a. |
2003-07-22 |
2023-08-12 |
Not clear |
| Robert Hitzemann, Barbara Hitzemann, Seth Rivera, John Gatley, Peter Thanos, Lu Lu Siming Shou, Robert W William. Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes. Alcoholism, clinical and experimental research. vol 27. issue 1. 2003-07-01. PMID:12543998. |
the current study addresses this issue by measuring d2 dopamine (da) receptor binding, the expression of drd2, the number of midbrain da neurons in the bxd recombinant inbred (ri) series and then compares these strain means with those previously reported for a variety of ethanol and other drug-related phenotypes. |
2003-07-01 |
2023-08-12 |
Not clear |
| Stephen J Crocker, Patrice D Smith, Vernice Jackson-Lewis, Wiplore R Lamba, Shawn P Hayley, Erich Grimm, Steve M Callaghan, Ruth S Slack, Edon Melloni, Serge Przedborski, George S Robertson, Hymie Anisman, Zul Merali, David S Par. Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 10. 2003-06-25. PMID:12764095. |
the molecular mechanisms mediating degeneration of midbrain dopamine neurons in parkinson's disease (pd) are poorly understood. |
2003-06-25 |
2023-08-12 |
mouse |
| Wen-Xue Tang, Wendy H Fasulo, Deborah C Mash, Scott E Hemb. Molecular profiling of midbrain dopamine regions in cocaine overdose victims. Journal of neurochemistry. vol 85. issue 4. 2003-06-18. PMID:12716423. |
molecular profiling of midbrain dopamine regions in cocaine overdose victims. |
2003-06-18 |
2023-08-12 |
Not clear |
| Wen-Xue Tang, Wendy H Fasulo, Deborah C Mash, Scott E Hemb. Molecular profiling of midbrain dopamine regions in cocaine overdose victims. Journal of neurochemistry. vol 85. issue 4. 2003-06-18. PMID:12716423. |
to evaluate whether the alterations in gene expression in cocaine overdose victims are associated with specific dopamine populations in the midbrain, cdna arrays and western blotting were used to compare gene and protein expression patterns between cocaine overdose victims and age-matched controls in the ventral tegmental area (vta) and lateral substantia nigra (l-sn). |
2003-06-18 |
2023-08-12 |
Not clear |
| H L Alderson, L F H Faulconbridge, L P Gregory, M P Latimer, P Win. Behavioural sensitisation to repeated d-amphetamine: effects of excitotoxic lesions of the pedunculopontine tegmental nucleus. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699767. |
the pptg has direct and indirect connections with the nucleus accumbens and prefrontal cortex, and also influences midbrain dopamine activity through direct projections to substantia nigra and ventral tegmental area. |
2003-06-16 |
2023-08-12 |
rat |
| I A Moroz, H Rajabi, D Rodaros, J Stewar. Effects of sex and hormonal status on astrocytic basic fibroblast growth factor-2 and tyrosine hydroxylase immunoreactivity after medial forebrain bundle 6-hydroxydopamine lesions of the midbrain dopamine neurons. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699782. |
effects of sex and hormonal status on astrocytic basic fibroblast growth factor-2 and tyrosine hydroxylase immunoreactivity after medial forebrain bundle 6-hydroxydopamine lesions of the midbrain dopamine neurons. |
2003-06-16 |
2023-08-12 |
rat |
| I A Moroz, H Rajabi, D Rodaros, J Stewar. Effects of sex and hormonal status on astrocytic basic fibroblast growth factor-2 and tyrosine hydroxylase immunoreactivity after medial forebrain bundle 6-hydroxydopamine lesions of the midbrain dopamine neurons. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699782. |
the present findings show that hormonal events early in life can alter the response of midbrain dopamine neurons to insult and injury in adult life and suggest that the slow degeneration of these neurons may release signals triggering a sustained activation of adjacent astrocytes which, in turn, may lead to induction of astrocytic fgf-2. |
2003-06-16 |
2023-08-12 |
rat |
| Deborah C Mash, Qinjie Ouyang, John Pablo, Margaret Basile, Sari Izenwasser, Abraham Lieberman, Richard J Perri. Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684441. |
here we present evidence that alpha-synuclein levels are elevated in midbrain dopamine (da) neurons of chronic cocaine abusers. |
2003-05-30 |
2023-08-12 |
human |
| Julian R A Wooltorton, Volodymyr I Pidoplichko, Ron S Broide, John A Dan. Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 8. 2003-05-30. PMID:12716925. |
differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas. |
2003-05-30 |
2023-08-12 |
mouse |
| Julian R A Wooltorton, Volodymyr I Pidoplichko, Ron S Broide, John A Dan. Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 8. 2003-05-30. PMID:12716925. |
these results suggest that nicotine, as obtained from tobacco, can have multiple effects on the midbrain areas by differentially influencing dopamine neurons of the vta and snc and differentially desensitizing alpha7* and non-alpha7 nachrs. |
2003-05-30 |
2023-08-12 |
mouse |
| Todd S Braver, Joshua W Brow. Principles of pleasure prediction: specifying the neural dynamics of human reward learning. Neuron. vol 38. issue 2. 2003-05-28. PMID:12718849. |
accumulating evidence from nonhuman primates suggests that midbrain dopamine cells code reward prediction errors and that this signal subserves reward learning in dopamine-receiving brain structures. |
2003-05-28 |
2023-08-12 |
human |
| Y Kotake, S Ohta, I Kanazawa, M Sakura. Neurotoxicity of an endogenous brain amine, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, in organotypic slice co-culture of mesencephalon and striatum. Neuroscience. vol 117. issue 1. 2003-05-21. PMID:12605893. |
here, it decreased the dopamine content of the cultured mesencephalon in both dose- (10-100 microm) and time- (24 h to 7 days) dependent manners. |
2003-05-21 |
2023-08-12 |
mouse |
| Carlos A Paladini, Siobhan Robinson, Hitoshi Morikawa, John T Williams, Richard D Palmite. Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12604788. |
changes in the firing pattern of midbrain dopamine neurons are thought to encode information for certain types of reward-related learning. |
2003-05-13 |
2023-08-12 |
mouse |
| Sue Yu, Yee-Yung Ng, Zhi-Hong Jian, Chien-Chih Chen, Mei-Shiun Lu, Hsi-Yen Lu, Chih-Pang Ch. Neurotransmitter levels in brains of chronically Jiawey Siwu-treated rats. The American journal of Chinese medicine. vol 30. issue 4. 2003-05-07. PMID:12568278. |
levels of norepinephrine (ne) and epinephrine (epi) in cerebral cortex; epi, vanillylmandelic acid (vma), dopamine (da) and 5-hydroxytryptamine (5-ht) in medulla oblongata; da in midbrain; ne and 5-ht in amygdala; and 5-ht in hypothalamus had decreased in js-treated rats. |
2003-05-07 |
2023-08-12 |
rat |