| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Zheng, S W Johnso. Metabotropic glutamate and muscarinic cholinergic receptor-mediated preferential inhibition of N-methyl-D-aspartate component of transmissions in rat ventral tegmental area. Neuroscience. vol 116. issue 4. 2003-04-30. PMID:12617942. |
our laboratory recently reported that presynaptic gaba(b) and adenosine a(1) receptors mediate a preferential inhibition on n-methyl-d-aspartate receptor-mediated excitatory postsynaptic currents recorded in rat midbrain dopamine neurons. |
2003-04-30 |
2023-08-12 |
rat |
| F Zheng, S W Johnso. Metabotropic glutamate and muscarinic cholinergic receptor-mediated preferential inhibition of N-methyl-D-aspartate component of transmissions in rat ventral tegmental area. Neuroscience. vol 116. issue 4. 2003-04-30. PMID:12617942. |
together with the evidence for gaba(b) and adenosine a(1) receptor-mediated preferential inhibition of the n-methyl-d-aspartate component, the present results suggest that limiting glutamate spillover onto postsynaptic n-methyl-d-aspartate receptors may be a general rule for presynaptic modulation in midbrain dopamine neurons. |
2003-04-30 |
2023-08-12 |
rat |
| Tatiana Ivanova, Cordian Beye. Estrogen regulates tyrosine hydroxylase expression in the neonate mouse midbrain. Journal of neurobiology. vol 54. issue 4. 2003-04-22. PMID:12555275. |
taken together, our data strongly suggest that estrogen controls dopamine synthesis in the developing nigrostriatal dopaminergic system and support the concept that estrogen is implicated in the regulation of ontogenetic steps but also in the function of midbrain dopamine neurons. |
2003-04-22 |
2023-08-12 |
mouse |
| D P Figlewicz, S B Evans, J Murphy, M Hoen, D G Baski. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain research. vol 964. issue 1. 2003-04-18. PMID:12573518. |
we hypothesize that midbrain dopamine neurons, which have been implicated to be critical in the mediation of motivational and reward aspects of stimuli, contribute to these behavioral effects of insulin and leptin. |
2003-04-18 |
2023-08-12 |
rat |
| D P Figlewicz, S B Evans, J Murphy, M Hoen, D G Baski. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain research. vol 964. issue 1. 2003-04-18. PMID:12573518. |
as one approach to evaluate this hypothesis, we used double-labeling fluorescence immunohistochemistry to determine whether the midbrain dopamine neurons express insulin receptors or leptin receptors. |
2003-04-18 |
2023-08-12 |
rat |
| D P Figlewicz, S B Evans, J Murphy, M Hoen, D G Baski. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain research. vol 964. issue 1. 2003-04-18. PMID:12573518. |
these findings suggest that midbrain dopamine neurons are direct targets of insulin and leptin, and that they participate in mediating the effects of these hormones on reward-seeking behavior. |
2003-04-18 |
2023-08-12 |
rat |
| Fu-Ming Zhou, Charles Wilson, John A Dan. Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 9. issue 1. 2003-04-16. PMID:12580337. |
the striatum and its dense dopaminergic innervation originating in the midbrain, primarily from the substantia nigra pars compacta and the ventral tegmental area, compose the mesostriatal dopamine (da) systems. |
2003-04-16 |
2023-08-12 |
Not clear |
| Stanislaw J Chrapusta, Michael F Egan, Richard J Wyatt, Daniel R Weinberger, Barbara K Lipsk. Neonatal ventral hippocampal damage modifies serum corticosterone and dopamine release responses to acute footshock in adult Sprague-Dawley rats. Synapse (New York, N.Y.). vol 47. issue 4. 2003-04-08. PMID:12539200. |
some of these aberrations implicate malfunction of the midbrain dopamine systems. |
2003-04-08 |
2023-08-12 |
rat |
| Diana Martinez, Mark Slifstein, Allegra Broft, Osama Mawlawi, Dah-Ren Hwang, Yiyun Huang, Thomas Cooper, Lawrence Kegeles, Eric Zarahn, Anissa Abi-Dargham, Suzanne N Haber, Marc Laruell. Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 23. issue 3. 2003-04-08. PMID:12621304. |
dopamine projections ascending from the midbrain provide important modulatory input to these striatal subregions. |
2003-04-08 |
2023-08-12 |
human |
| Diana Martinez, Mark Slifstein, Allegra Broft, Osama Mawlawi, Dah-Ren Hwang, Yiyun Huang, Thomas Cooper, Lawrence Kegeles, Eric Zarahn, Anissa Abi-Dargham, Suzanne N Haber, Marc Laruell. Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 23. issue 3. 2003-04-08. PMID:12621304. |
the mechanisms potentially accounting for these regional differences in amphetamine-induced dopamine release within the striatum remain to be elucidated, but may be related to the asymmetrical feed-forward influences mediating the integration of limbic, cognitive, and sensorimotor striatal function via dopamine cell territories in the ventral midbrain. |
2003-04-08 |
2023-08-12 |
human |
| John F Staropoli, Caroline McDermott, Cécile Martinat, Brenda Schulman, Elena Demireva, Asa Abeliovic. Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron. vol 37. issue 5. 2003-04-07. PMID:12628165. |
mutations in parkin, which encodes a ring domain protein associated with ubiquitin ligase activity, lead to autosomal recessive parkinson's disease characterized by midbrain dopamine neuron loss. |
2003-04-07 |
2023-08-12 |
Not clear |
| John F Staropoli, Caroline McDermott, Cécile Martinat, Brenda Schulman, Elena Demireva, Asa Abeliovic. Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron. vol 37. issue 5. 2003-04-07. PMID:12628165. |
furthermore, parkin overexpression attenuates the accumulation of cyclin e in toxin-treated primary neurons, including midbrain dopamine neurons, and protects them from apoptosis. |
2003-04-07 |
2023-08-12 |
Not clear |
| Fang Zheng, David K Grandy, Steven W Johnso. Actions of orphanin FQ/nociceptin on rat ventral tegmental area neurons in vitro. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145107. |
in the present study we investigated responses of non-dopamine and dopamine neurons, recorded intracellularly in the rat midbrain slice, to orphanin fq/nociceptin, the endogenous ligand for opioid receptor-like orphan receptors. |
2003-03-31 |
2023-08-12 |
rat |
| Chih Chang Chao, Yun Li Ma, Kuan Yu Chu, Eminy H Y Le. Integrin alphav and NCAM mediate the effects of GDNF on DA neuron survival, outgrowth, DA turnover and motor activity in rats. Neurobiology of aging. vol 24. issue 1. 2003-03-26. PMID:12493556. |
glial cell line-derived neurotrophic factor (gdnf) is a specific neurotrophic factor for midbrain dopamine (da) neurons, but the mechanism underlying the neurotrophic action of gdnf is not well known. |
2003-03-26 |
2023-08-12 |
rat |
| Analía Bortolozzi, Ricardo Duffard, Ana María Evangelista de Duffar. Asymmetrical development of the monoamine systems in 2,4-dichlorophenoxyacetic acid treated rats. Neurotoxicology. vol 24. issue 1. 2003-03-21. PMID:12564390. |
the decreased dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac) and homovallinic acid (hva) contents in cerebellum, midbrain, ventral tegmental area (vta) and prefrontal cortex (pfc) showed an alteration in the mesocorticolimbic system. |
2003-03-21 |
2023-08-12 |
rat |
| Yoshinori Masuo, Masami Ishido, Masatoshi Morita, Syuichi Ok. Effects of neonatal 6-hydroxydopamine lesion on the gene expression profile in young adult rats. Neuroscience letters. vol 335. issue 2. 2003-03-20. PMID:12459514. |
expression of the dopamine receptor d4 gene and dopamine transporter gene was also increased in the midbrain. |
2003-03-20 |
2023-08-12 |
human |
| Yaichiro Kotak. [Tetrahydroisoquinoline derivatives as possible Parkinson's disease-inducing substances]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 122. issue 11. 2003-03-18. PMID:12440154. |
1bntiq decreased the dopamine content in the mesencephalon in both dose- and time-dependent manners and it irreversibly reduced the dopamine content. |
2003-03-18 |
2023-08-12 |
mouse |
| Daniel Saal, Yan Dong, Antonello Bonci, Robert C Malenk. Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron. vol 37. issue 4. 2003-03-07. PMID:12597856. |
here, we demonstrate that in vivo administration of drugs of abuse with different molecular mechanisms of action as well as acute stress both increase strength at excitatory synapses on midbrain dopamine neurons. |
2003-03-07 |
2023-08-12 |
Not clear |
| Sangmi Chung, Kai-C Sonntag, Therese Andersson, Lars M Bjorklund, Jae-Joon Park, Dong-Wook Kim, Un Jung Kang, Ole Isacson, Kwang-Soo Ki. Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. The European journal of neuroscience. vol 16. issue 10. 2003-03-05. PMID:12453046. |
several lines of evidence suggest that these neurons may represent midbrain da neuronal phenotypes; firstly, they coexpress midbrain da markers such as aromatic l-amino acid decarboxylase, calretinin, and dopamine transporter, in addition to tyrosine hydroxylase and secondly, they do not coexpress other neurotransmitters such as gaba or serotonin. |
2003-03-05 |
2023-08-12 |
mouse |
| Alan L Whone, Robert Y Moore, Paola P Piccini, David J Brook. Plasticity of the nigropallidal pathway in Parkinson's disease. Annals of neurology. vol 53. issue 2. 2003-02-28. PMID:12557287. |
in this (18)f-dopa positron emission tomography study, we demonstrate compensatory changes in pd in another midbrain dopamine projection to the basal ganglia, the nigropallidal projection to the internal segment of the globus pallidus (gpi). |
2003-02-28 |
2023-08-12 |
Not clear |