| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wu Song, Yan Guo, Shuang Jiang, Lin Wei, Zhi Liu, Xiaoyan Wang, Ying S. Antidepressant Effects of the Ginsenoside Metabolite Compound K, Assessed by Behavioral Despair Test and Chronic Unpredictable Mild Stress Model. Neurochemical research. vol 43. issue 7. 2018-10-15. PMID:29790069. |
to investigate the underlying mechanism, the levels of endogenous noradrenaline, dopamine (da), 5-hydroxytryptamine (5-ht) and their metabolites in the prefrontal cortex (pfc) and hippocampus were detected by hplc coupled with electron detector. |
2018-10-15 |
2023-08-13 |
mouse |
| Ze-Qun Li, Zhi-Yuan Yan, Fu-Jun Lan, Yi-Qun Dong, Ye Xion. Suppression of NLRP3 inflammasome attenuates stress-induced depression-like behavior in NLGN3-deficient mice. Biochemical and biophysical research communications. vol 501. issue 4. 2018-10-09. PMID:29775613. |
cums up-regulated corticosterone (cort) in serum, and down-regulated serotonin (5-ht), norepinephrine (ne) and brain-derived neurotrophic factor (bdnf) in hippocampus of mice, which were significantly reversed by nlgn3 deficiency. |
2018-10-09 |
2023-08-13 |
mouse |
| Hiroshi Kawai, Megumi Machida, Takuya Ishibashi, Naomi Kudo, Yoichi Kawashima, Atsushi Mitsumot. Chronopharmacological Analysis of Antidepressant Activity of a Dual-Action Serotonin Noradrenaline Reuptake Inhibitor (SNRI), Milnacipran, in Rats. Biological & pharmaceutical bulletin. vol 41. issue 2. 2018-08-21. PMID:29386481. |
the serotonin turnover showed rhythms with a peak during zt18-zt22 in hippocampus. |
2018-08-21 |
2023-08-13 |
rat |
| Vandreza Cardoso Bortolotto, Franciane Cabral Pinheiro, Stífani Machado Araujo, Márcia Rósula Poetini, Bianca Santos Bertolazi, Mariane Trindade de Paula, Luana Barreto Meichtry, Francielli Polet de Almeida, Shanda de Freitas Couto, Cristiano Ricardo Jesse, Marina Prigo. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. European journal of pharmacology. vol 822. 2018-08-20. PMID:29355556. |
chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. |
2018-08-20 |
2023-08-13 |
mouse |
| Vandreza Cardoso Bortolotto, Franciane Cabral Pinheiro, Stífani Machado Araujo, Márcia Rósula Poetini, Bianca Santos Bertolazi, Mariane Trindade de Paula, Luana Barreto Meichtry, Francielli Polet de Almeida, Shanda de Freitas Couto, Cristiano Ricardo Jesse, Marina Prigo. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. European journal of pharmacology. vol 822. 2018-08-20. PMID:29355556. |
additionally, t3 and t4 levels were measured again, and serotonin (5ht), dopamine, and noradrenaline levels were analyzed in the prefrontal cortex and the hippocampus. |
2018-08-20 |
2023-08-13 |
mouse |
| Vandreza Cardoso Bortolotto, Franciane Cabral Pinheiro, Stífani Machado Araujo, Márcia Rósula Poetini, Bianca Santos Bertolazi, Mariane Trindade de Paula, Luana Barreto Meichtry, Francielli Polet de Almeida, Shanda de Freitas Couto, Cristiano Ricardo Jesse, Marina Prigo. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. European journal of pharmacology. vol 822. 2018-08-20. PMID:29355556. |
reduced levels of 5ht and dopamine in the prefrontal cortex and the hippocampus were observed in the hypothyroid mice than in the euthyroid mice. |
2018-08-20 |
2023-08-13 |
mouse |
| Vandreza Cardoso Bortolotto, Franciane Cabral Pinheiro, Stífani Machado Araujo, Márcia Rósula Poetini, Bianca Santos Bertolazi, Mariane Trindade de Paula, Luana Barreto Meichtry, Francielli Polet de Almeida, Shanda de Freitas Couto, Cristiano Ricardo Jesse, Marina Prigo. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. European journal of pharmacology. vol 822. 2018-08-20. PMID:29355556. |
chrysin treatment recovered 5ht content in both structures and dopamine content only in the hippocampus. |
2018-08-20 |
2023-08-13 |
mouse |
| Ning Jiang, Bei-Yue Zhang, Li-Ming Dong, Jing-Wei Lv, Cong Lu, Qiong Wang, Lin-Xi Fan, Hong-Xia Zhang, Rui-Le Pan, Xin-Min Li. Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress-induced depressive mice. Phytotherapy research : PTR. vol 32. issue 6. 2018-08-20. PMID:29468732. |
biochemical analysis of brain tissue and serum showed that ds treatment restored the decreased hippocampal neurotransmitter concentrations of serotonin, dopamine, norepinephrine (noradrenaline), and gamma-aminobutyric acid, and decreased the elevated of serum hormone levels (corticotrophin releasing factor, adrenocorticotrophic hormone, and corticosterone) induced by cums. |
2018-08-20 |
2023-08-13 |
mouse |
| Yanli Zhang, Kai Fan, Yanna Liu, Gang Liu, Xiaohan Yang, Jianmei M. Cathepsin C Aggravates Neuroinflammation Involved in Disturbances of Behaviour and Neurochemistry in Acute and Chronic Stress-Induced Murine Model of Depression. Neurochemical research. vol 43. issue 1. 2018-08-16. PMID:28623605. |
the results showed that cat c overexpression (cat c oe) promoted peripheral and central inflammatory response with significantly increased tnfα, il-1β and il-6 in serum, hippocampus and prefrontal cortex, and resultant upregulation of ido and downregulation of 5ht expression in brain, and thereby aggravated depression-like behaviours accessed by open field test, forced swim test and tail suspension test. |
2018-08-16 |
2023-08-13 |
mouse |
| Leandro Cattelan Souza, Cristiano R Jesse, Marcelo Gomes de Gomes, Lucian Del Fabbro, André Tiago Rossito Goes, Franciele Donato, Silvana Peterini Boeir. Activation of Brain Indoleamine-2,3-dioxygenase Contributes to Depressive-Like Behavior Induced by an Intracerebroventricular Injection of Streptozotocin in Mice. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28631232. |
1-mt abrogates kynurenine production and normalizes brain-derived neurotrophic factor (bdnf) and the kynurenine/tryptophan ratio, but does not protect the biomarkers of the serotonin (5-ht) system in the hippocampus of stz-injected mice. |
2018-08-07 |
2023-08-13 |
mouse |
| Anastasia Diamantopoulou, Theodora Kalpachidou, Georgios Aspiotis, Ioannis Gampierakis, Fotini Stylianopoulou, Antonios Stamataki. An early experience of mild adversity involving temporary denial of maternal contact affects the serotonergic system of adult male rats and leads to a depressive-like phenotype and inability to adapt to a chronic social stress. Physiology & behavior. vol 184. 2018-08-01. PMID:29127070. |
the depressive-like and anxious phenotype of the der males was accompanied by changes in the serotonergic system, such as lower serotonin levels, higher serotonin turnover and higher levels of the type 1 serotonin receptor in the hippocampus. |
2018-08-01 |
2023-08-13 |
rat |
| P S Rojas, F Aguayo, D Neira, M Tejos, E Aliaga, J P Muñoz, C S Parra, J L Fiedle. Dual effect of serotonin on the dendritic growth of cultured hippocampal neurons: Involvement of 5-HT Molecular and cellular neurosciences. vol 85. 2018-07-25. PMID:28974382. |
dual effect of serotonin on the dendritic growth of cultured hippocampal neurons: involvement of 5-ht serotonin acts through its receptors (5-htrs) to shape brain networks during development and modulates essential functions in mature brain. |
2018-07-25 |
2023-08-13 |
Not clear |
| Sha Liao, Jinpeng Lv, Jia Zhou, Praveen Kumar Kalavagunta, Jing Shan. Effects of two chronic stresses on mental state and hair follicle melanogenesis in mice. Experimental dermatology. vol 26. issue 11. 2018-07-20. PMID:28480983. |
we found that stress changed hippocampal morphology, decreased 5-ht level in brain and skin and down-regulated 5-ht1a receptor expression in hippocampal ca1 region and skin. |
2018-07-20 |
2023-08-13 |
mouse |
| N Kokras, N Pastromas, D Papasava, C de Bournonville, C A Cornil, C Dall. Sex differences in behavioral and neurochemical effects of gonadectomy and aromatase inhibition in rats. Psychoneuroendocrinology. vol 87. 2018-07-13. PMID:29054014. |
the hippocampus and prefrontal cortex (pfc) were analyzed for monoamine (noradrenaline, dopamine and serotonin), as well as amino acid (gaba, glutamate, glycine, taurine, alanine and histidine) levels. |
2018-07-13 |
2023-08-13 |
human |
| Darcy Litteljohn, Chris Rudyk, Zach Dwyer, Kyle Farmer, Teresa Fortin, Shawn Hayle. The impact of murine LRRK2 G2019S transgene overexpression on acute responses to inflammatory challenge. Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28893563. |
indeed, g2019s mice had altered basal levels and turnover of dopamine within the striatum, along with changes in hippocampal serotonin and norepinephrine activity in response to lps and ifn-γ. |
2018-07-11 |
2023-08-13 |
mouse |
| Nasrin Hashemi-Firouzi, Alireza Komaki, Sara Soleimani Asl, Siamak Shahid. The effects of the 5-HT7 receptor on hippocampal long-term potentiation and apoptosis in a rat model of Alzheimer's disease. Brain research bulletin. vol 135. 2018-07-05. PMID:28987281. |
long-term potentiation (ltp) of synaptic function is a model of learning- and memory-related neural plasticity, of which serotonin (5-ht) is a key modulator in the hippocampus. |
2018-07-05 |
2023-08-13 |
rat |
| Jaya Thomas, Razia Khanam, Divya Vohor. Activation of indoleamine 2, 3- dioxygenase pathway by olanzapine augments antidepressant effects of venlafaxine in mice. Psychiatry research. vol 258. 2018-07-03. PMID:28911850. |
swiss albino mice were subjected to chronic forced-swim stress and evaluation for antidepressant-like activity was performed on 7th, 14th and 21st day following which serum levels of pro-inflammatory cytokines (il-1β and il-6 levels) and the levels of hippocampal kynurenine (kyn), tryptophan (trp) and serotonin (5ht) were estimated. |
2018-07-03 |
2023-08-13 |
mouse |
| Yuan Liu, Dexiang Liu, Jingjing Xu, Hong Jiang, Fang Pa. Early adolescent stress-induced changes in prefrontal cortex miRNA-135a and hippocampal miRNA-16 in male rats. Developmental psychobiology. vol 59. issue 8. 2018-07-02. PMID:28944448. |
mirna-135a in the prefrontal cortex (pfc) and mirna-16 in the hippocampus (hip) are closely related to the 5-ht neurotransmitter system. |
2018-07-02 |
2023-08-13 |
rat |
| Xi Jiang, Qizhi Yan, Fuhe Liu, Changfeng Jing, Lianshu Ding, Lijin Zhang, Cong Pan. Chronic trans-astaxanthin treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with chronic pain. Neuroscience letters. vol 662. 2018-07-02. PMID:28982597. |
subsequent study indicated that indoleamine 2,3-dioxygenase (ido) expression increased after cci surgery in hippocampus and spinal cord, accompanied by increase of kynurenine (kyn)/tryptophan (try) ratio, decrease of serotonin (5-ht)/try ratio and decrease of 5-ht/5-hiaa ratio. |
2018-07-02 |
2023-08-13 |
mouse |
| Cheng Xue Du, Jian Liu, Yuan Guo, Li Zhang, Qiao Jun Zhan. Lesions of the lateral habenula improve working memory performance in hemiparkinsonian rats. Neuroscience letters. vol 662. 2018-06-29. PMID:29054431. |
neurochemical results found that lesions of the lhb increased da levels in the mpfc, hippocampus and amygdala in the mfb and lhb lesion group, as well as serotonin (5-ht) level in the mpfc. |
2018-06-29 |
2023-08-13 |
rat |