| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng Xue Du, Jian Liu, Yuan Guo, Li Zhang, Qiao Jun Zhan. Lesions of the lateral habenula improve working memory performance in hemiparkinsonian rats. Neuroscience letters. vol 662. 2018-06-29. PMID:29054431. |
these findings suggest that da depletion plays a key role in working memory impairment, and lesions of the lhb improve working memory in the mfb-lesioned rats, which involves in increases in the levels of da and 5-ht in the mpfc, hippocampus and amygdala. |
2018-06-29 |
2023-08-13 |
rat |
| Wan-Hui Lin, Xiao-Feng Li, Ming-Xing Lin, Ying Zhou, Hua-Pin Huan. Novel insights into the effect of paroxetine administration in pilocarpine‑induced chronic epileptic rats. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28983622. |
the aim of the present study was to investigate the role of paroxetine intervention in epilepsy, and its association with the expression of serotonin transporter (sert) and hippocampal apoptosis. |
2018-06-26 |
2023-08-13 |
rat |
| Victor Mathis, Lucas Lecourtie. Role of the lateral habenula in memory through online processing of information. Pharmacology, biochemistry, and behavior. vol 162. 2018-06-18. PMID:28709783. |
animal research has recently attracted attention on the lateral habenula which, as shown in rodents and non-human primates, seems to process information stemming in the main regions involved in memory processing, e.g., the medial prefrontal cortex, the hippocampus, the amygdala, the septal region, the basal ganglia, and participates in the control of key memory-related neurotransmitters systems, i.e., dopamine, serotonin, acetylcholine. |
2018-06-18 |
2023-08-13 |
Not clear |
| Pei Liu, Vincent Grenier, Wootack Hong, Vikram R Muller, Evan W Mille. Fluorogenic Targeting of Voltage-Sensitive Dyes to Neurons. Journal of the American Chemical Society. vol 139. issue 48. 2018-06-18. PMID:29154543. |
by targeting ple to neurons, vf-ex2 can interrogate the neuromodulatory effects of serotonin in cultured hippocampal neurons. |
2018-06-18 |
2023-08-13 |
Not clear |
| I V Karpova, E R Bychkov, V V Marysheva, V V Mikheev, P D Shabano. Effects of Oxytocin on the Levels and Metabolism of Monoamines in the Brain of White Outbred Mice during Long-Term Social Isolation. Bulletin of experimental biology and medicine. vol 163. issue 6. 2018-06-13. PMID:29063330. |
disappearance of initial right-sided asymmetry in the content of dopamine metabolites in the striatum, increased 5-hydroxyacetic acid content in the right striatum, and disappearance of the initial left-sided asymmetry in serotonin level in the cortex were noted; we also found a decrease in norepinephrine content in the left hippocampus with appearance of asymmetry and higher content in the right olfactory tubercle. |
2018-06-13 |
2023-08-13 |
mouse |
| Cindy S Tao, Prateek Dhamija, Linda Booij, Janet L Menar. Adversity in early adolescence promotes an enduring anxious phenotype and increases serotonergic innervation of the infralimbic medial prefrontal cortex. Neuroscience. vol 364. 2018-06-08. PMID:28893650. |
after behavioural testing, we used immunohistochemistry for the 5-ht transporter (sert) to evaluate 5-ht innervation profiles in the medial prefrontal cortex (mpfc) and ventral hippocampus (vh). |
2018-06-08 |
2023-08-13 |
rat |
| Christine Winter, Dana M Greene, Paraskevi Mavrogiorgou, Helge Schaper, Reinhard Sohr, Abel Bult-Ito, Georg Jucke. Altered serotonergic and GABAergic neurotransmission in a mice model of obsessive-compulsive disorder. Behavioural brain research. vol 337. 2018-06-08. PMID:28916503. |
the neurochemical investigation of several brain regions of the corticostriato-thalamocortical circuity, i.e., nucleus caudatus (cpu), nucleus accumbens (nac), globus pallidus (gp), hippocampus (hpc), amygdala (am), ventral tegmental area (vta) and substantia nigra (sn) was performed by electrochemical (serotonin and dopamine) and fluorescence (glutamate and gaba) hplc detection. |
2018-06-08 |
2023-08-13 |
mouse |
| Patrícia P Silveira, Irina Pokhvisneva, Carine Parent, Shirong Cai, Anu Sathyan Sathyapalan Rema, Birit F P Broekman, Anne Rifkin-Graboi, Michael Pluess, Kieran J O'Donnell, Michael J Meane. Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Development and psychopathology. vol 29. issue 5. 2018-06-06. PMID:29162172. |
a genetic score based on genes coexpressed with the serotonin transporter in the amygdala, hippocampus, and prefrontal cortex during prenatal life was constructed with an emphasis on functionally relevant single nucleotide polymorphisms, that is, expression quantitative trait loci. |
2018-06-06 |
2023-08-13 |
Not clear |
| Liangcai Gao, Xinnan Liu, Li Yu, Junlin Wu, Mingchu Xu, Yusi Li. Folic acid exerts antidepressant effects by upregulating brain-derived neurotrophic factor and glutamate receptor 1 expression in brain. Neuroreport. vol 28. issue 16. 2018-06-04. PMID:28906345. |
our results showed that cums caused significant depression-like behaviors, neuropathological changes, and decreased brain 5-ht concentration, bdnf, and glur1 expression in the hippocampus and association cortex. |
2018-06-04 |
2023-08-13 |
rat |
| Dong-Sheng Wang, Jing Han, Shuo Li, Ting Sun, Yan-Yan Guo, Wen-Bo Kang, Zhen Tian, Jian-Ning Zhao, Gang Liu, Shui-Bing Liu, Ming-Gao Zha. Antidepressant-Like and Anxiolytic-Like Effects of ZBD-2, a Novel Ligand for the Translocator Protein (18 kDa). Neuromolecular medicine. vol 19. issue 1. 2018-05-28. PMID:27544207. |
treatment of zbd-2 reversed the decrease in biogenic amines (norepinephrine, dopamine, and serotonin) in the brain region of hippocampus in the ucms mice. |
2018-05-28 |
2023-08-13 |
mouse |
| Masatoshi Yamashita, Takanobu Yamamot. Tryptophan circuit in fatigue: From blood to brain and cognition. Brain research. vol 1675. 2018-05-22. PMID:28893581. |
results showed that compared to control group, presynaptic levels of tryptophan, kynurenine, and kynurenic acid, but not serotonin, in the cfsd group were higher in the hypothalamus and hippocampus. |
2018-05-22 |
2023-08-13 |
rat |
| A Sheldrick, S Camara, M Ilieva, P Riederer, T M Miche. Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals - a proof of concept study. European psychiatry : the journal of the Association of European Psychiatrists. vol 46. 2018-05-18. PMID:29102768. |
therefore, we examined the concentration of brain-derived neurotrophic factor (bdnf) and neurotrophin 3 (nt3) in different brain regions (cortex, cingulate gyrus, thalamus, hippocampus, putamen and nucleus caudatus) of 21 individuals - 7 patients of which 4 patients with major depressive disorder (mdd) and overall age 86.8±5 years who received antidepressant pharmacotherapy (selective serotonin re-uptake inhibitors [ssri]; tricyclic antidepressants [tca]), 3 patients with mdd without antidepressant treatment and overall age 84.3±5 years versus 14 unaffected subjects at age 70.3±13.8. |
2018-05-18 |
2023-08-13 |
human |
| Gisela H Maia, Cátia S Brazete, Joana I Soares, Liliana L Luz, Nikolai V Lukoyano. Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy. Brain research bulletin. vol 134. 2018-05-07. PMID:28716398. |
loss of hippocampal neurons and spatial memory deficits associated with kainic acid treatment were exacerbated by prior depletion of serotonin. |
2018-05-07 |
2023-08-13 |
rat |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
behavioral (ambulatory and rearing activity and immobility time), neurochemical [serotonin (5-ht), dopamine (da), norepinephrine (ne) and brain derived neurotrophic factor (bdnf) level], biochemical (mda formation, il-6, tnf-α and antioxidants) changes in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2018-05-01 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
rats subjected to obx elicited significant increase in immobility time, ambulatory and rearing behaviors, reduced bdnf level, 5-ht, da, ne and antioxidant parameters along with increased serum corticosterone, mda formation, il-6, and tnf-α in hippocampus and cerebral cortex compared to sham operated rats. |
2018-05-01 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
administration of with silymarin significantly attenuated immobility time, ambulatory and rearing behaviors, serum corticosterone and improved bdnf expression, 5-ht, da, ne and antioxidant paradigms in cerebral cortex as well as hippocampus. |
2018-05-01 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
thus, silymarin exhibits anti-depressant-like activity in obx rats due to alterations in several neurotransmitters, endocrine and immunologic systems, including bdnf, 5-ht, da, ne, mda formation, il-6, and tnf-α in hippocampus and cerebral cortex as well as serum corticosterone. |
2018-05-01 |
2023-08-13 |
mouse |
| Yuki Asai, Yukiko Sakakibara, Masayuki Nadai, Miki Kato. Effect of carbamazepine on expression of UDP-glucuronosyltransferase 1A6 and 1A7 in rat brain. Drug metabolism and pharmacokinetics. vol 32. issue 6. 2018-05-01. PMID:29158009. |
ugt1a6 and ugt1a7 mrnas were induced by cbz in the cerebellum, piriform cortex, and hippocampus (ugt1a6: 3.1-, 2.4-, and 1.9-fold, respectively, ugt1a7: 2.3-, 1.6-, and 3.1-fold, respectively); serotonin glucuronidation, which is catalyzed by ugt1a6, was also increased by 2.8-, 1.7-, and 1.8-fold in these regions, respectively. |
2018-05-01 |
2023-08-13 |
rat |
| Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kuliko. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience letters. vol 653. 2018-04-27. PMID:28579486. |
fluoxetine significantly attenuated 5-ht levels in the cortex and striatum, 5-hiaa concentrations in the cortex, hippocampus, striatum and midbrain, and tph2 gene expression in the midbrain. |
2018-04-27 |
2023-08-13 |
mouse |
| Mary Gemmel, Mariah Hazlett, Eszter Bögi, Sonsoles De Lacalle, Lesley A Hill, Nikolaos Kokras, Geoffrey L Hammond, Christina Dalla, Thierry D Charlier, Jodi L Pawlusk. Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress. Psychoneuroendocrinology. vol 84. 2018-04-24. PMID:28735226. |
perinatal fluoxetine also increased serum corticosteroid binding globulin levels, 5-ht levels in the hippocampus, and pre-synaptic density assessed via synaptophysin in the dentate gyrus. |
2018-04-24 |
2023-08-13 |
rat |