| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Richter-Levin, M Sega. The effects of serotonin depletion and raphe grafts on hippocampal electrophysiology and behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 11. issue 6. 1991-07-15. PMID:1646296. |
the effects of serotonin depletion and raphe grafts on hippocampal electrophysiology and behavior. |
1991-07-15 |
2023-08-11 |
rat |
| R Andrade, Y Chapu. 5-Hydroxytryptamine4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 257. issue 3. 1991-07-12. PMID:2046027. |
5-hydroxytryptamine4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus. |
1991-07-12 |
2023-08-11 |
rat |
| T Alexi, E C Azmiti. Ethanol stimulates [3H]5-HT high-affinity uptake by rat forebrain synaptosomes: role of 5-HT receptors and voltage channel blockers. Brain research. vol 544. issue 2. 1991-07-11. PMID:1645610. |
we report that a dose of ethanol which causes general anesthesia in humans (54 mm) applied in vitro enhanced rat synaptosomal [3h]5-ht uptake after 5 min at 37 degrees c. similar levels of stimulation by 54 mm ethanol were seen in hippocampal, cerebral cortex and brainstem synaptosomes. |
1991-07-11 |
2023-08-11 |
rat |
| R Nagata, K Izumi, S Iwata, T Shimizu, T Fukud. Mechanisms of veratramine-induced 5-HT syndrome in mice. Japanese journal of pharmacology. vol 55. issue 1. 1991-07-10. PMID:1710298. |
a similar tendency to decrease 5-ht and 5-hiaa contents was observed in the hypothalamus and hippocampus without increase in the contents of dopamine and its metabolites. |
1991-07-10 |
2023-08-11 |
mouse |
| Y Kumagae, Y Matsui, N Iwat. Deamination of norepinephrine, dopamine, and serotonin by type A monoamine oxidase in discrete regions of the rat brain and inhibition by RS-8359. Japanese journal of pharmacology. vol 55. issue 1. 1991-07-10. PMID:1904113. |
in conclusion, ne, da, and 5ht are exclusively or preferentially deaminated by mao-a in the cortex, hippocampus, and striatum of rats, and rs-8359 exhibits a reversible mao-a inhibitory action in all three regions tested in vivo. |
1991-07-10 |
2023-08-11 |
rat |
| L Rényi, L G Larsson, S Berg, B E Svensson, G Thorell, S B Ros. Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 343. issue 1. 1991-06-19. PMID:1674359. |
in vivo, isamoltane significantly increased the concentration of 5-hydroxyindoleacetic acid in hypothalamus and hippocampus indicating an increased 5-ht turnover with a maximal effect at 3 mg/kg s.c. a higher dose produced a less pronounced effect. |
1991-06-19 |
2023-08-11 |
rat |
| M P Johnson, X M Huang, R Oberlender, J F Nash, D E Nichol. Behavioral, biochemical and neurotoxicological actions of the alpha-ethyl homologue of p-chloroamphetamine. European journal of pharmacology. vol 191. issue 1. 1991-06-17. PMID:1982656. |
a 10 mg/kg dose of pca caused an 80% decrease in cortical and hippocampal serotonergic markers, while an equimolar dose of cab decreased only hippocampal 5-ht and 5-hydroxyindoleacetic acid (5-hiaa) levels. |
1991-06-17 |
2023-08-11 |
Not clear |
| S Y Yeh, E B De Souz. Lack of neurochemical evidence for neurotoxic effects of repeated cocaine administration in rats on brain monoamine neurons. Drug and alcohol dependence. vol 27. issue 1. 1991-06-14. PMID:1709403. |
the concentrations of norepinephrine (ne), dopamine (da), serotonin (5-ht) and their metabolites, assayed by hplc-ec, in frontal cortex, hippocampus, striatum, hypothalamus, midbrain, pons-medulla and spinal cord were not significantly different from those in the saline-injected controls at any of the time points examined. |
1991-06-14 |
2023-08-11 |
rat |
| J B Fishman, J B Rubins, J C Chen, B F Dickey, L Volice. Modification of brain guanine nucleotide-binding regulatory proteins by tryptamine-4,5-dione, a neurotoxic derivative of serotonin. Journal of neurochemistry. vol 56. issue 6. 1991-06-12. PMID:1902871. |
we have recently characterized a novel oxidation product of serotonin (5-hydroxytryptamine, 5-ht), tryptamine-4,5-dione, which increases 5-ht efflux from striatum and hippocampus and causes selective neuronal death. |
1991-06-12 |
2023-08-11 |
Not clear |
| J C Cassel, R Jackisch, M Duschek, J M Hornsperger, M H Richards, C Kelche, G Hertting, B Wil. Long term effects of septohippocampal lesions and intrahippocampal grafts on acetylcholine concentration, muscarinic stimulated formation of inositol phospholipids and electrically evoked release of neurotransmitters in the rat hippocampus. Experimental brain research. vol 83. issue 3. 1991-06-07. PMID:2026203. |
the long term (8-10 months post-surgery) effects of these treatments were examined in the hippocampus for the following variables: concentration of hippocampal acetylcholine (ach), muscarinic-stimulated (carbachol) formation of inositol monophosphate, accumulation of tritiated choline, noradrenaline (3h-na) and serotonin (3h-5-ht), electrically evoked release of 3h-acetylcholine (3h-ach), 3h-na and 3h-5-ht, and choline acetyltransferase (chat) activity. |
1991-06-07 |
2023-08-11 |
rat |
| M Daoust, P Compagnon, E Legrand, P Boucl. Ethanol intake and 3H-serotonin uptake I: A study in Fawn-Hooded rats. Life sciences. vol 48. issue 20. 1991-06-05. PMID:2023528. |
ethanol intake increased the vmax of serotonin uptake in fawn-hooded rats in hippocampus and cortex, but not in thalamus. |
1991-06-05 |
2023-08-11 |
rat |
| M Daoust, P Compagnon, E Legrand, P Boucl. Ethanol intake and 3H-serotonin uptake I: A study in Fawn-Hooded rats. Life sciences. vol 48. issue 20. 1991-06-05. PMID:2023528. |
ethanol intake reduced the vmax of serotonin uptake in fawn-hooded rats in hippocampus and cortex. |
1991-06-05 |
2023-08-11 |
rat |
| S Hjorth, T Shar. Effect of the 5-HT1A receptor agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis. Life sciences. vol 48. issue 18. 1991-05-30. PMID:1826937. |
to further study the putative differences in regulation between ascending 5-ht projections from the raphe nuclei we have used microdialysis to measure the release of 5-ht in ventral hippocampus, globus pallidus, dorsal hippocampus, frontal cortex, nucleus accumbens and medial septum, following systemic administration of the specific 5-ht1a agonist 8-oh-dpat. |
1991-05-30 |
2023-08-11 |
rat |
| A Varrault, V Leviel, J Bockaer. 5-HT1A-sensitive adenylyl cyclase of rodent hippocampal neurons: effects of antidepressant treatments and chronic stimulation with agonists. The Journal of pharmacology and experimental therapeutics. vol 257. issue 1. 1991-05-24. PMID:2020001. |
the effects of chronic treatment with desimipramine (a tricyclic antidepressant), fluoxetine [a specific 5-hydroxytryptamine (5-ht) uptake inhibitor], clorgyline (a specific monoamine oxydase inhibitor of a type), ipsapirone (a specific 5-ht1a receptor agonist) as well as electroconvulsive shock treatment were investigated on rat hippocampal 5-ht1a receptors negatively coupled to adenylyl cyclase. |
1991-05-24 |
2023-08-11 |
rat |
| A Varrault, V Leviel, J Bockaer. 5-HT1A-sensitive adenylyl cyclase of rodent hippocampal neurons: effects of antidepressant treatments and chronic stimulation with agonists. The Journal of pharmacology and experimental therapeutics. vol 257. issue 1. 1991-05-24. PMID:2020001. |
in contrast, chronic treatment with clorgyline and electroconvulsive shock treatment induced a slight but significant reduction of 5-ht's ability to inhibit hippocampal adenylyl cyclase. |
1991-05-24 |
2023-08-11 |
rat |
| A Varrault, V Leviel, J Bockaer. 5-HT1A-sensitive adenylyl cyclase of rodent hippocampal neurons: effects of antidepressant treatments and chronic stimulation with agonists. The Journal of pharmacology and experimental therapeutics. vol 257. issue 1. 1991-05-24. PMID:2020001. |
this was verified in vitro on murine hippocampal neurons in culture, by measuring the effects of intense stimulation (1 and 2 hours), with 5-ht, ipsapirone and 8-hydroxy-2-(di-n-propylamino)tetralin. |
1991-05-24 |
2023-08-11 |
rat |
| P Galanopoulou, G Giannacopoulos, C Theophanopoulos, M K Couvaris, D Varono. Behavioural changes on diet selection and serotonin (5-HT) turnover in rats under pizotifen treatment. Pharmacology, biochemistry, and behavior. vol 37. issue 3. 1991-05-23. PMID:1708144. |
5-ht and 5-hiaa in the hypothalamus (hy), striatum (st) and hippocampus (hi) were assayed on the 8th day of the experiment. |
1991-05-23 |
2023-08-11 |
rat |
| D E Nichols, M P Johnson, R Oberlende. 5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine. Pharmacology, biochemistry, and behavior. vol 38. issue 1. 1991-05-23. PMID:1826785. |
in rat hippocampus, pia gave significant decreases in all serotonin markers examined, while 5-iai slightly but significantly decreased only 5-ht levels. |
1991-05-23 |
2023-08-11 |
rat |
| S E Gartside, P J Cowen, S Hjort. Effects of MDL 73005EF on central pre- and postsynaptic 5-HT1A receptor function in the rat in vivo. European journal of pharmacology. vol 191. issue 3. 1991-05-23. PMID:1964908. |
mdl 73005ef dose dependently decreased the hippocampal 5-ht output measured by in vivo microdialysis in chloral hydrate-anaesthetised rats and this response was antagonised by the 5-ht1a/b receptor antagonist, pindolol. |
1991-05-23 |
2023-08-11 |
rat |
| S E Gartside, P J Cowen, S Hjort. Effects of MDL 73005EF on central pre- and postsynaptic 5-HT1A receptor function in the rat in vivo. European journal of pharmacology. vol 191. issue 3. 1991-05-23. PMID:1964908. |
local administration of mdl 73005ef had no effect on the hippocampal 5-ht output. |
1991-05-23 |
2023-08-11 |
rat |