| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Nakamura, Y Wada, H Hasegawa, N Yamaguch. [Serotonergic mechanisms in hippocampal kindled seizures--inhibitory effects of L-5-hydroxytryptophan and 8-hydroxy-2-(di-n-propylamino)tetralin]. No to shinkei = Brain and nerve. vol 44. issue 11. 1993-04-27. PMID:1296723. |
to clarify the role of the 5-ht system in epilepsy, we examined the effects of 5-hydroxytryptophan (5-htp), a precursor which elevates brain 5-ht, and 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), a 5-ht 1 a receptor agonist, on seizures kindled from the feline hippocampus (hip). |
1993-04-27 |
2023-08-11 |
Not clear |
| A Castaño, M L Vizuete, J Cano, A Machad. Turnover of monoamines in hippocampus of rats fed on vitamin E-deficient diet. Brain research. vol 604. issue 1-2. 1993-04-26. PMID:7681343. |
turnover of noradrenaline (na), dopamine (da), serotonin (5-hydroxytryptamine; 5-ht) and their metabolites has been measured after a 15-day vitamin e-deficient diet in adult hippocampus. |
1993-04-26 |
2023-08-12 |
rat |
| A Castaño, M L Vizuete, J Cano, A Machad. Turnover of monoamines in hippocampus of rats fed on vitamin E-deficient diet. Brain research. vol 604. issue 1-2. 1993-04-26. PMID:7681343. |
moreover, we have measured in vitro receptor binding of [3h]5-ht in hippocampal membranes from control and vitamin e-deficient rats. |
1993-04-26 |
2023-08-12 |
rat |
| J C Cassel, B Neufang, C Kelche, H Jeltsch, B E Will, G Hertting, R Jackisc. Effects of grafts containing cholinergic and/or serotonergic neurons on cholinergic, serotonergic and noradrenergic markers in the denervated rat hippocampus. Brain research. vol 604. issue 1-2. 1993-04-26. PMID:7681347. |
six months after grafting, high affinity synaptosomal uptake of choline (hacu) and serotonin (hasu), choline acetyltransferase (chat) activity and, using hplc, the content of serotonin ([5-ht]), 5-hydroxyindolacetic acid ([5-hiaa]) and noradrenaline ([na]) were determined in three rostro-caudal segments of the hippocampus (designated hereafter as the dorsal, the 'middle' and the ventral segments). |
1993-04-26 |
2023-08-12 |
rat |
| J C Cassel, B Neufang, C Kelche, H Jeltsch, B E Will, G Hertting, R Jackisc. Effects of grafts containing cholinergic and/or serotonergic neurons on cholinergic, serotonergic and noradrenergic markers in the denervated rat hippocampus. Brain research. vol 604. issue 1-2. 1993-04-26. PMID:7681347. |
in all three segments of the dorsal hippocampus, septohippocampal lesions decreased hacu, chat activity, hasu and [5-ht]; [5-hiaa] was decreased only in the middle and ventral hippocampal segments. |
1993-04-26 |
2023-08-12 |
rat |
| J C Cassel, B Neufang, C Kelche, H Jeltsch, B E Will, G Hertting, R Jackisc. Effects of grafts containing cholinergic and/or serotonergic neurons on cholinergic, serotonergic and noradrenergic markers in the denervated rat hippocampus. Brain research. vol 604. issue 1-2. 1993-04-26. PMID:7681347. |
raphe grafts increased hasu, [5-ht] and [5-hiaa] in the dorsal and middle hippocampal segments, had no effects on cholinergic markers and did not affect the lesion-induced increase of [na]. |
1993-04-26 |
2023-08-12 |
rat |
| H Hörtnagl, L Hansen, G Kindel, B Schneider, A el Tamer, I Hani. Sex differences and estrous cycle-variations in the AF64A-induced cholinergic deficit in the rat hippocampus. Brain research bulletin. vol 31. issue 1-2. 1993-04-22. PMID:8095840. |
the influence of gender and stage of the estrous cycle on the levels of acetylcholine, serotonin, and noradrenaline in the hippocampus and on the susceptibility of the cholinergic septo-hippocampal pathway to the neurotoxic effect of ethylcholine aziridinium (af64a) was investigated in the rat. |
1993-04-22 |
2023-08-12 |
rat |
| L Acsády, K Halasy, T F Freun. Calretinin is present in non-pyramidal cells of the rat hippocampus--III. Their inputs from the median raphe and medial septal nuclei. Neuroscience. vol 52. issue 4. 1993-04-15. PMID:7680801. |
the subcortical innervation of a recently described subpopulation of non-pyramidal neurons, containing the calcium binding protein, calretinin, was investigated in the rat hippocampus using the anterograde tracer phaseolus vulgaris-leucoagglutinin and double immunocytochemistry for calretinin and serotonin at the light and electron microscopic levels. |
1993-04-15 |
2023-08-12 |
rat |
| P Jäkälä, J Sirviö, P Riekkinen, P J Riekkine. Effects of p-chlorophenylalanine and methysergide on the performance of a working memory task. Pharmacology, biochemistry, and behavior. vol 44. issue 2. 1993-04-07. PMID:8446673. |
p-cpa (500 mg/kg/day x 3) induced an almost total depletion (> 97%) of frontal cortical and hippocampal serotonin and its major metabolite 5-hydroxyindoleacetic acid and slightly affected noradrenergic and dopaminergic systems. |
1993-04-07 |
2023-08-12 |
rat |
| G F Molodtsova, L V Loskutov. [Monoaminoxidase activity and serotonin metabolism in the brain of rats during latent inhibition]. Biulleten' eksperimental'noi biologii i meditsiny. vol 114. issue 12. 1993-04-02. PMID:1284037. |
5-ht metabolism was not altered in the hippocampus. |
1993-04-02 |
2023-08-11 |
rat |
| C Bolden-Watson, E Richelso. Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes. Life sciences. vol 52. issue 12. 1993-04-02. PMID:8445992. |
inhibitor constants (kis) for uptake blockade were obtained from competitive uptake studies with [3h]norepinephrine, [3h]5-hydroxytryptamine, and [3h]dopamine in rat brain synaptosomes prepared from hippocampus, frontal cortex, and striatum, respectively. |
1993-04-02 |
2023-08-12 |
rat |
| A M Andrews, D L Murph. Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP. Journal of neurochemistry. vol 60. issue 3. 1993-03-24. PMID:8094744. |
sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-nh2-mptp): a comparative study with 2'-ch3-mptp and mptp. |
1993-03-24 |
2023-08-12 |
mouse |
| A M Andrews, D L Murph. Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP. Journal of neurochemistry. vol 60. issue 3. 1993-03-24. PMID:8094744. |
unlike 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), which produces consistent decreases in levels of striatal dopamine (da) with considerably smaller and more variable effects on mouse brain levels of serotonin (5-ht) and norepinephrine (ne), a novel amine-substituted mptp analogue, 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-nh2-mptp), administered in a standard mouse dosing paradigm for mptp (20 mg/kg x 4) did not affect striatal da but led to marked reductions (60-70%) in levels of 5-ht, 5-hydroxyindoleacetic acid (5-hiaa), and ne measured in frontal cortex and hippocampus 1 week after treatment. |
1993-03-24 |
2023-08-12 |
mouse |
| A M Andrews, D L Murph. Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP. Journal of neurochemistry. vol 60. issue 3. 1993-03-24. PMID:8094744. |
another 2'-substituted mptp analogue, 1-methyl-4-(2'-methylphenyl)-1,2,3,6- tetrahydropyridine, affected cortical and hippocampal 5-ht, 5-hiaa, and ne only minimally, while markedly reducing the da content in striatum (90%), thus indicating that the substituent (-nh2 versus -ch3) at the 2' position is important for the differential effects of these mptp analogues. |
1993-03-24 |
2023-08-12 |
mouse |
| A M Andrews, D L Murph. Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP. Journal of neurochemistry. vol 60. issue 3. 1993-03-24. PMID:8094744. |
in a replication study with a 3-week end point, hippocampal and cortical 5-ht, 5-hiaa,, and ne levels remained depressed with no indication of recovery. |
1993-03-24 |
2023-08-12 |
mouse |
| K P Lesch, C S Aulakh, B L Wolozin, T J Tolliver, J L Hill, D L Murph. Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants. Brain research. Molecular brain research. vol 17. issue 1-2. 1993-03-16. PMID:8381906. |
while 5-ht transporter mrna is abundantly expressed in the midbrain raphe complex, lower concentrations were also found in frontal cortex, hippocampus, and neostriatum using a combination of reverse transcriptase-polymerase chain reaction (rt-pcr), southern hybridization, and sequence analysis. |
1993-03-16 |
2023-08-12 |
rat |
| P Blier, C Bouchar. Functional characterization of a 5-HT3 receptor which modulates the release of 5-HT in the guinea-pig brain. British journal of pharmacology. vol 108. issue 1. 1993-03-09. PMID:8428202. |
the aims of the present study were to confirm the modulation by 5-ht3 receptors of the electrically evoked release of tritium from slices preloaded with [3h]-5-ht of guinea-pig frontal cortex, hippocampus and hypothalamus, and to assess their functional role in 5-ht release. |
1993-03-09 |
2023-08-12 |
Not clear |
| A Biegon, C Mathi. Evaluation of [3H]paroxetine as an in vivo ligand for serotonin uptake sites: a quantitative autoradiographic study in the rat brain. Synapse (New York, N.Y.). vol 13. issue 1. 1993-03-02. PMID:8427010. |
only a relatively small proportion of cortical and hippocampal binding (20-40%) could be blocked by excess unlabeled paroxetine, indicating that most of the radioactivity in these regions is not associated with serotonin terminals or uptake sites. |
1993-03-02 |
2023-08-12 |
human |
| J L Katz, J W Griffiths, L G Sharpe, E B De Souza, J M Witki. Cocaine tolerance and cross-tolerance. The Journal of pharmacology and experimental therapeutics. vol 264. issue 1. 1993-02-23. PMID:8093724. |
tolerant rats showed no change in specific binding of [3h]sch 23390 to d1 receptors, [3h]spiperone to d2 receptors, [3h]gbr 12935 to dopamine uptake sites in striatum, [3h]paroxetine to serotonin uptake sites or [3h]mazindol to norepinephrine uptake sites in cortex or hippocampus. |
1993-02-23 |
2023-08-12 |
rat |
| S Dey, R H Singh, P K De. Exercise training: significance of regional alterations in serotonin metabolism of rat brain in relation to antidepressant effect of exercise. Physiology & behavior. vol 52. issue 6. 1993-02-17. PMID:1283013. |
in hippocampus, a delayed effect was observed, because 5ht level was unaltered immediately after the training, but its turnover decreased after 1 week rest. |
1993-02-17 |
2023-08-11 |
rat |